Na di ansa to yu kwɛstyɔn dɛn bɔt dis rare tumor we dɛn kɔl Paraganglioma!

Sɔntɛnde, yu kin fil wantɛm wantɛm se yu de swet bɔku bɔku wan, yu at de bit fast, yu ed de bit? Ɔ yu kin fil lɛk se yu blɔd prɛshɔn de go ɔp wantɛm wantɛm fɔ natin? Pan ɔl we yu go tink se dɛn tin ya na jɔs random tin, sɔntɛnde ɔda rizin kin de biɛn dis. Paraganglioma na wan pan dɛn kayn tin ya we nɔ kin apin so ɔltɛm bɔt we impɔtant fɔ no bɔt.

So, wetin na dis paraganglioma?

Fɔ tɔk am simpul wan, paragangliomas na tɔmɔs dɛn we nɔ kin bɔku ɛn we kin fɔm na yu bɔdi. Bɔku tɛm dɛn kin kam nia di carotid artery, we na wan big blɔd vesel na yu nɛk, along di nerves na yu ed ɛn nek, ɔ ɔdasay na yu bɔdi. dis tכmכro dεm na wan spεshal kayn sεl we dεn kכl kromafin sεl dεm . Dɛn sɛl dɛn ya kin mek ɔmon dɛn we dɛn kɔl katekolamin ɛn dɛn kin pul dɛn na yu blɔd.

Yu no se di adrenal gland dɛn we de ɔp wi kidni dɛn kin mek bɔku kayn ɔmon dɛn? Dɛn katekolamin ya na ɔmon dɛn we de kɔntrol sɔm rili impɔtant wok dɛn na wi bɔdi. Yu no wetin dɛn bi?

• Yu at rit.
• Blɔd prɛshɔn.
• Blɔd shuga lɛvɛl (`blɔd glukɔs`).
• Aw wi bɔdi kin biev we wi strɛs.

di men kayn katekolamin dεm we imכtant na:

• Dopamin we dɛn kɔl Dopamin.
• Epinephrine (dis na wetin wi kin kɔl bak adrenaline).
• Norepinephrine (dɛn kin kɔl am bak noradrenaline).

pan ɔl we paragangliomas nɔ de divɛlɔp na di adrenal gland dɛm, dɛn tכmכro dεm ya de fכm frכm di tisu we de na di adrenal gland dεm. So, apat frɔm dɛn paragangliomas ya, di katekolamin ɔmon dɛn kin gɛda bak na di blɔd. Na da tɛm de difrɛn sayn dɛn kin bigin fɔ sho.

Wetin na di difrɛns bitwin Paraganglioma ɛn Pheochromocytoma?

Dɛn tu nem ya kin mek pɔsin kɔnfyus smɔl, nɔto so? Paraganglioma εn pheochromocytoma na dεn tu tכmכro dεm we nכ kin kכmכt frכm di kromafin sεl dεm we wi bin dכn tכk bכt. di men difrεns bitwin dεn tu na usay dεn de fכm na di bכdi.

di fiokromosaytoma dεm de divεlכp na di midul pat pan yu adrenal gland, we dεn kכl di adrenal mεdula. Paragangliomas de divεlכp na do na di adrenal gland. Bɔku tɛm dɛn kin si dɛn nia di at ɔ di nɛf dɛn na di nɛk. na dat mek sכmtεm dεn kin kכl di paraganglioma dεm ‘εkstra-adrenal fεochromocytomas’.

Yu tink se Paraganglioma na kansa?

Dis na prɔblɛm we bɔku pipul dɛn gɛt. Dɛn tumbu ya we dɛn kɔl paragangliomas , kin bi kansa (malignant) ɔ nɔ gɛt kansa (benign).fכ tכk roughly, lεk 20% pan di paraganglioma dεm na kεnsar.

Bɔt di prɔblɛm we de ya na dat, sɔntɛnde i kin at fɔ mek dɔktɔ dɛn no fɔ tru if di tumbu gɛt kansa ɔ nɔ gɛt kansa. Dat min se ivin if dɛn du ɔpreshɔn fɔ pul di tumbu ɛn chɛk in tisu ɔnda maykroskɔp, sɔntɛnde i nɔ pɔsibul fɔ tɔk fɔ tru. So, dɛn kin tek paraganglioma as kansa pan dɛn kayn tin ya:

• if di tכmכro dכn spre to di tisu dεm we de rawnd (dεn kכl dis `rijכnal spred fכ paraganglioma`).
• if i dכn spre to di כgan dεm we de fa, lεk yu lכng כ bon dεm (dεn kכl dis `mεtastasized`).
• If i dɔn kam bak afta dɛn dɔn trit am fɔs ɛn mɛn am (dɛn kɔl dis `rikɔr`).

If na kansa, aw i kin skata?

If dis paraganglioma na kansa, no standad stej sistεm de fכ am. Bifo dat, dɛn tɔk bɔt am lɛk dis:

• Localized paraganglioma: Di tumor de na wan ples nɔmɔ.
• Rijinal paraganglioma: Di kansa dɔn spre to limf no dɛm ɔ ɔda tisu dɛm nia usay i fɔs bigin.
• Metastatic paraganglioma: Di kansa dɔn spre to ɔda pat dɛn na yu bɔdi, lɛk yu liva, yu lɔng, yu bon, ɔ yu limf no dɛm we de fa. bitwin 35% εn 50% pan di kεnsar paragangliomas kin spre (mεtastasayz) dis we.
• Paraganglioma we kin kam bak: Di kansa dɔn kam bak afta dɛn dɔn trit am ɛn wɛl. I kin de na di sem ples we i bin de bifo, ɔ i kin de na difrɛn pat na di bɔdi.

Aw fast dɛn nɛt ya kin gro?

Bɔku tɛm, paraganglioma dɛn kin gro sloslo. Bɔt dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm pipul dɛn kin gro kwik kwik wan.

Udat dis tin kin afɛkt mɔ?

Dis sik we dɛn kɔl paraganglioma , kin kam pan ɛni ej. Bɔt i kin bɔku pan pipul dɛn we ol bitwin 30 ɛn 50. Dɔn bak, dɛn kin ripɔt lɛk 10% pan di kes dɛm pan pikin dɛm.

Aw kɔmɔn tin fɔ Paraganglioma?

Dis na rili wan tumbu we nɔ kin apin so ɔltɛm. Statistikin, dɛn se na lɛk tu pipul dɛn nɔmɔ pan wan milyɔn kin gɛt paraganglioma. So yu kin imajin aw dis nɔ kin apin so ɔltɛm.

Wetin na di sayn dɛm fɔ Paraganglioma?

Di sayn dɛm fɔ paragangliomas na bikɔs di tumbu de rilis tumɔs pan di adrenaline ɔ noradrenaline we wi bin dɔn tɔk bɔt na yu blɔd. Bɔt sɔm paragangliomas nɔ kin mek dis ɛkstra ɔmon, ɛn dat mek dɛn nɔ kin mek ɛni sayn (dɛn kɔl dɛn asymptomatic).

Di sayn dɛm wae dɛn kin si mɔrNa:

• Wantɛm we pɔsin kin gɛt ay blɔd prɛshɔn (haypa prɛshɔn).
• Ed de at.
• Fɔ swet pasmak fɔ natin.
• Wan at we de bit kwik kwik wan ɛn we nɔ de bit ɔltɛm ɛn we so lawd we yu kin yɛri di at de bit.
• Fɔ fil lɛk se yu bɔdi de shek.

Apat frɔm dɛn wan ya, sɔm sayn dɛn de bak we nɔ kin bɔku :

• Fɔ bi bɔku paler pas aw yu kin luk.
• Nɔs ɛn/ɔ vɔmit.
• Rɔnbɛlɛ.
• Banbɛlɛ.
• Di blɔd shuga lɛvɛl (haypa glycemia).
• Wan blɔd prɛshɔn we kin go dɔŋ wantɛm wantɛm we kin mek yu ed de tɔn we yu tinap (dɛn kɔl dis ɔrtɔstatik haypɔtɛnshɔn).
• Fɔ bi tin fɔ no rizin.

Sɔm pipul kin gɛt dɛn kayn sik ya nɔr kin bɔrku, ɔr kin bɔrku. Imajin, sɔntɛnde, natin nɔr kin bad, dɔn dɛn sayn ya kin kam wantɛm wantɛm, dɔn dɛn kin dɔn afta sɔm tɛm. Dis na di rizin we mek sɔntɛnde i kin let fɔ no dis.

Wetin kin mek pɔsin gɛt paraganglioma?

Bɔrku tɛm, nɔr patikyula kɔz nɔr de fɔ paragangliomas. Dat min se, dɛn kin apin randomly. כltu, lεk 25% to 35% pan pipul dεm kin gεt paragangliomas as a rizulεt fכ wan jεnεtik kכndishכn we de rכn insay famili (hεridita kכndishכn). Sɔm pan dɛn tin ya na:

• mכltipכl εndokrin niכplasia 2 sεndrכm, tayp A εn B (MEN2A εn MEN2B)).
• Von Hippel-Lindau (VHL) sik we dɛn kɔl di sik.
• Nyurofibromatosis tayp 1 (NF1).
• Sindrom we dɛn kɔl paraganglioma we dɛn kin gɛt frɔm dɛn mama ɛn papa.
• Carney-Stratakis dyad (we paraganglioma kin kam wit gastrointestinal stromal tumor (GIST)).
• Carney triad (we kin inklud paraganglioma, GIST, ɛn wan kayn lכng tכmכro we dεn kכl pulmonary chondroma).

Aw dɛn kin no se pɔsin gɛt Paraganglioma?

I kin tranga fɔ no bɔt paraganglioma bikɔs na wan tumbu we nɔ kin bɔku ɛn sɔntɛnde i nɔ kin gɛt ɛni sayn. Sɔntɛnde, dɔktɔ dɛn kin fɛn paragangliomas we dɛn de du tɛst fɔ ɔda rizin.

Dɔktɔ kin tink se i gɛt paraganglioma afta i dɔn tink bɔt dɛn tin ya:

• Yu kɔmplit mɛdikal istri, mɔ if ɛnibɔdi na yu famili dɔn ɛva gɛt pheochromocytoma ɔ paraganglioma.
• Wan kɔmplit ɛgzam fɔ bɔdi ɛn mɛrɛsin.
• Di kayn we aw sɔm sayn dɛn kin gɛt. Fɔ ɛgzampul, if yu gɛt ay blɔd prɛshɔn we nɔmal tritmɛnt nɔ kin kɔntrol.

Us tɛst dɛn kin du fɔ dis?

Yu dɔktɔ kin yuz dɛn tɛst ɛn tin ya fɔ no if yu gɛt paraganglioma:

• Fɔ chɛk yu bɔdi: Yu dɔktɔ go chɛk yu ɛn chɛk yu jenɛral wɛlbɔdi, lɛk yu blɔd prɛshɔn. I go aks bak bɔt yu ɛn yu famili in mɛdikal istri, mɔ ɛni prɔblɛm we gɛt fɔ du wit ɔmon.
• 24 awa urine test: Dis na fɔ gɛda wan sampul pan yu urine fɔ 24 awa ɛn mɛzhɔ di amount ɔf adrenal ɔmon dɛn we dɛn kɔl katekolamin. I de luk bak fɔ tin dɛn we kin mek we dɛn ɔmon ya brok. If dɛn katekolamin ya de na yu urine we pas di nɔmal lɛvɛl, i kin bi sayn fɔ paraganglioma.
• Blɔd katekolamin tɛst: Dɛn tɛst ya de mɛzhɔ di lɛvɛl we di katekolamin de na yu blɔd. As wi bin dɔn tɔk, dɛn kin luk bak fɔ tin dɛn we kin mek we dɛn ɔmon dɛn ya brok. If dɛn tin ya de insay di blɔd we pas di nɔmal wan, i kin bi sayn bak fɔ paraganglioma.
• PET skan (positron emission tomography scan): PET skan na fɔ injekt wan sef redioaktiv kemikal (radiotracer) insay yu bɔdi ɛn tek pikchɔ fɔ yu ɔgan ɛn tisu dɛn bay we yu yuz wan tin we dɛn kɔl PET skan. dis skan de sho di sεl dεm we de wok bכku εn di tכmכro dεm we de abzכp di kεmikכl. Dis kin ɛp fɔ no if wɛlbɔdi prɔblɛm de. Dis skan fayn mɔ fɔ no usay paraganglioma de.
• CT skan (kɔmpyuta tomografi skan): CT skan na we dɛn kin tek sɔm ɛkstrem rayt frɔm difrɛn angul dɛn fɔ mek yu gɛt ditayla pikchɔ dɛn bɔt di insay pat na yu bɔdi. Yu dɔktɔ kin tɛl yu fɔ du CT skan fɔ ɛp fɔ no usay di tumbu de (bɔku tɛm na di nɛk).
• MRI skan (magnetic resonance imaging): MRI de yuz magnet, redio wev, ɛn kɔmpyuta fɔ mek sɔm pikchɔ dɛn we de insay yu bɔdi. Yu dɔktɔ kin tɛl yu fɔ du MRI fɔ mek yu ebul fɔ si di say we di tumbu de fayn fayn wan.

Afta yu dɔktɔ dɔn no se yu gɛt paraganglioma, dɛn kin du ɔda tɛst fɔ si if i dɔn skata to ɔda pat dɛn na yu bɔdi.

Yu tink se i nid fɔ tɛst di jɛnɛtiks?

If dɛn no se yu gɛt paraganglioma, yu dɔktɔ go se yu fɔ gɛt kɔyl fɔ yu jenɛtiks fɔ no if yu gɛt wan sik we yu gɛt frɔm yu mama ɛn papa ɛn yu de pan denja fɔ gɛt ɔda kansa dɛn we gɛt fɔ du wit am.

Yu dɔktɔ kin se yu fɔ tɛst yu jɛnɛtiks pan dɛn kayn tin ya:

• If yu ɔ sɔmbɔdi na yu famili gɛt sɔm kayn sik wae gɛt fɔ du wit hereditary pheochromocytoma ɔ paraganglioma syndrome.
• If yu gɛt sayn dɛm fɔ di katekolamin dɛm we pas di nɔmal wan na yu blɔd ɔ yu gɛt sayn dɛm fɔ kansa paraganglioma.
• If yu dɔn gɛt paraganglioma bifo yu ol 40 ia.

If yu jenɛtik kɔlnɔ si ɛni jin chenj na yu tɛst rizɔlt, i go mɔs se ɔda pipul dɛn na yu famili (ivin di wan dɛn we nɔ gɛt ɛni sayn bɔt we de pan denja) fɔ du tɛst bak.

Aw dɛn kin trit Paraganglioma?

Di tritmɛnt fɔ paraganglioma de dipen pan sɔm tin dɛn, lɛk:

• Di saiz fɔ di tumbu.
• If di tumbu gɛt kansa (malignant) ɔ benign (benign).
• If yu gɛt di sayn dɛm bikɔs ɔf di ɛlevɛt lɛvɛl dɛm fɔ katekolamin.
• Na wan ples nɔmɔ di tumbu de, ɔ i dɔn skata (metastasized) to ɔda pat dɛn na di bɔdi?
• If na di fɔs tɛm dɛn bin no di tumbu, ɔ if dɛn bin dɔn wɛl bifo tɛm ɛn afta dat i kam bak.

If yu gɛt paraganglioma we de mek yu gɛt di sik bikɔs ɔf di ɔmon we pasmak, yu dɔktɔ go gi yu mɛrɛsin fɔ kɔntrol dɛn sik dɛn de. Dɛn mɛrɛsin ya kin bi:

• Mɛrɛsin dɛn we de kɔntrol yu blɔd prɛshɔn, fɔ ɛgzampul, alfa-blɔk .
• Mεdisin dεm fכ kip yu at rεt na nכmal lεvεl, fכ egzampl beta-blכk dεm .
• Mεdikeshכn dεm we de blכk di ifekt dεm fכ di כmon dεm we yu adrenal gland (dεn) de kכmכt pasmak.

Di tritmɛnt opshɔn dɛm fɔ paraganglioma na:

• Ɔpreshɔn fɔ pul di tumbu.
• Redyushɔn tɛrapi.
• Kimotɛrapi.
• Ablashɔn tɛrapi.
• Targeted therapy.

Yu ɛn yu mɛdikal tim go disayd di tritmɛnt plan we go fayn fɔ yu ɛn yu sik.

Ɔpreshɔn fɔ pul di tumbu

Di men tritmɛnt fɔ paraganglioma na ɔpreshɔn. We dɛn de du di ɔpreshɔn fɔ pul di tumbu, yu dɔktɔ go chɛk di tisu ɛn di limf no dɛn we de rawnd fɔ si if di tumbu dɔn skata. If i dɔn du am, di dɔktɔ we de du di ɔpreshɔn go pul di tisu we afɛkt, if i pɔsibul.

Bɔku pan di paraganglioma dɛn kin kɔmɔt bay we dɛn yuz tin dɛn we nɔ kin ambɔg di bɔdi, lɛk ɔpreshɔn we dɛn kin du wit laparoskopik . Dis min se yu fɔ kɔt sɔm smɔl smɔl tin dɛn na yu skin ɛn pul di tumbu wit spɛshal tin dɛn. Bɔt di big big tumbu dɛn kin nid fɔ gɛt tradishɔnal opin ɔpreshɔn.

Afta dɛn dɔn du di ɔpreshɔn, yu dɔktɔ go chɛk di lɛvɛl dɛn we di katekolamin dɛn de na yu blɔd ɔ yu urine. if di lεvεl dεm fכ di katekolamin dεm go bak to nכmal, dis na sayn fכ se dεn dכn pul כl di paraganglioma sεl dεm.

Rɛdieshɔn Tɛrapi

Rɛdieshɔn tɛrapi na kansa tritmɛnt we de yuz ay ɛnaji bim ɔf redyushɔn fɔ kil kansa sɛl ɔ stɔp dɛn fɔ gro. Dɛn kin du dis we dɛn nɔ de pwɛl di wɛlbɔdi tisu we de rawnd am.

Tu kayn we dɛn de fɔ mɛn pipul dɛn we gɛt raytin:

• External radiation therapy: Dis na fɔ yuz mashin we de na do na yu bɔdi fɔ dayrɛkt redyushɔn to di say we di kansa de.
• Intanɛt rɛdyushɔn tɛrapi: Dis kin min fɔ put wan redioaktiv tin insay nidul, sid, waya, ɔ kateshɔn, we dɔktɔ kin put dairekt insay ɔ nia di tumbu.

Di kayn redyushɔn tɛrapi we yu dɔktɔ go tɛl yu fɔ du, dipen pan if yu kansa de na di say we yu de, na di say we yu de, i de fa, ɔ i dɔn kam bak. Dɔktɔ dɛn kin yuz ɛksternal bim raytin tɛrapi ɛn/ɔ 131I-MIBG tɛrapi fɔ trit kansa paragangliomas. 131I-MIBG tεrapi na wan we fכ gi wan redioaktiv sכbstans to sכm kayn kεnsar sεl dεm, we dεn kin injεkt insay di bכdi εn di rεdyushכn we i de kכmכt de kil di sεl dεm.

Kimotɛrapi

Di standad tritmɛnt fɔ mɛtastas paraganglioma na kemotɛrapi. Dis kin min fɔ yuz drɔgs fɔ kil di kansa sɛl dɛn, fɔ stɔp dɛn fɔ sheb, ɔ fɔ stɔp dɛn fɔ mek dɛn nɔ gro. Bɔku tɛm, dɛn kin gi dɛn kemotɛrapi insay di bɛlɛ. Pan ɔl we dis kin bi fayn tritmɛnt, i kin mek pɔsin gɛt bad bad tin dɛn.

Ablashɔn Tɛrapi

Ablashɔn tɛrapi na tritmɛnt opshɔn we nɔ kin tek bɔku tin ɛn we kin yuz rili ay ɔ rili lɔw tɛmpracha fɔ pwɛl di tɔŋ dɛn. Ablashɔn tritmɛnt dɛm we de ɛp fɔ kil kansa sɛl dɛm ɛn abnɔmal sɛl dɛm na:

• Radiofrequency ablation: Dis na fɔ yuz redio wev fɔ ɔt ɛn pwɛl kansa sɛl dɛn ɛn abnɔmal sɛl dɛn. Dɛn kin sɛn di redio wev dɛn tru ilɛktrɔd (smɔl tin dɛn we de kɔndɔkt ilɛktrishɔn).
• Cryoablation: Dis tritmɛnt de yuz likwid naytrɔjen ɔ likwid kabɔn dayɔgzayd fɔ friz ɛn pwɛl kansa sɛl dɛn ɛn abnɔmal sɛl dɛn.

Tɛrapi we dɛn de tɔk bɔt

Targeted therapy na tritmɛnt opshɔn wae de yuz drɔgs ɔr ɔda tin fɔ atak sɔm patikyula kansa sɛl dɛm nɔmɔ, we nɔ go ambɔg di wɛlbɔdi sɛl dɛm. Dɔktɔ dɛn kin yuz targeted therapy fɔ trit paragangliomas we de fa ɛn we kin kam bak.

Naw, risechar dεm de invεstigat wan tyrosine kinase inhibitor we dεn kכl sunitinib.Dɛn de stɔdi wan kayn mɛrɛsin fɔ si aw i kin trit di paraganglioma we de fa fawe fayn fayn wan. Tyrosine kinase inhibitor therapy na wan kayn tεrapi we dεn de tכk we de stכp di tכmכro gro.

Yu tink se dɛn kin stɔp di divɛlɔpmɛnt fɔ paraganglioma?

Bɔt i sɔri fɔ no se dɛn nɔ kin ebul fɔ stɔp paragangliomas. Bɔt if yu gɛt sɔm inhɛrit sindrom ɛn jin dɛm we de put yu pan denja fɔ gɛt paragangliomas, jenɛtik kɔyl kin ɛp yu fɔ gɛt tɛst fɔ paragangliomas ɛn sɔntɛm yu kin kech am kwik.

Tɔk to yu dɔktɔ if yu fɔs digri fambul dɛm (brɔda ɛn sista ɛn mama ɛn papa) dɔn gɛt paraganglioma ɔ pheochromocytoma, ɛn/ɔ if yu gɛt ɛni wan pan dɛn jenɛtik kɔndishɔn ya:

• Mכltipכl εndokrin niכplasia 2 sεndrכm.
• Von Hippel-Lindau (VHL) sik we dɛn kɔl di sik.
• Nyurofibromatosis tayp 1.
• Sindrom we dɛn kɔl paraganglioma we dɛn kin gɛt frɔm dɛn mama ɛn papa.
• Carney-Stratakis dyad we dɛn kɔl Carney-Stratakis.
• Carney triad we dɛn kɔl Carney.

Wetin na di prɔgnosis na dis sityueshɔn?

Di luk fɔ paragangliomas, dat na di chans fɔ wɛl ɛn fɔ liv, kin difrɛn difrɛn wan bay sɔm tin dɛn. Sɔm pan dɛn:

• Usay di tumbu de na yu bɔdi ɛn aw i big.
• Ilɛksɛf na kansa ɔ i dɔn skata to ɔda pat dɛn na di bɔdi.
• Dɛn bin du ɔpreshɔn pan di tumbu, ɛn if na so, ɔmɔs pan di tumbu dɛn bin pul we dɛn bin de du di ɔpreshɔn?

Pipul dεm we gεt sכm paraganglioma we nכ spre to כda pat dεm na di bכdi (we nכ mεtastas) gεt fayv ia sכvayv rεt we na lεk 95%. Bɔt pipul dɛn we gɛt paraganglioma we dɔn kam bak afta di fɔs tritmɛnt ɔ we dɔn spre to ɔda pat dɛn na dɛn bɔdi (we dɔn mɛtastas) gɛt fayv ia layf we de bitwin 34% ɛn 60% .

Dɔn bak, sɔm bad bad paraganglioma dɛn de we ivin if dɛn nɔ skata fa, dɛn nɔ kin ebul fɔ pul am ɔl bay ɔpreshɔn bikɔs dɛn dɔn spre fa fawe insay di tisu we de rawnd. Insay dɛn kayn tin ya, di bɔku bɔku adrenaline ɛn noradrenaline we de kɔmɔt kin denja ɛn i nɔ kin izi fɔ trit.

di tin we impɔtant pas ɔl na dat, paragangliomas, ilɛksɛf na kansa ɔ nɔto kansa, if dɛn nɔ trit am, i kin mek siriɔs, ivin prɔblɛm dɛn we kin mek pɔsin in layf de pan denja bikɔs ɔf di bɔku bɔku adrenaline ɛn noradrenaline we dɛn kin pul.

Sɔm pan dɛn prɔblɛm ya na:

• Di sik we de na di at mɔsul (cardiomyopathy).
• Inflameshɔn na yu at mɔsul (`myocarditis`).
• Blɔd we nɔ de kɔntrol na yu bren (sɛribra blɔd we de kɔmɔt na yu bren).
• Fluid we de bɔku na yu lכng (pulmonary edema).
• Hat atak (`mayokardial infarkshɔn`).
• Strok.
• Kɔma.
• Day.

Ustɛm a fɔ go to dɔktɔ?

If dɛn no se yu gɛt paraganglioma ɛn yu gɛt sɔm kayn sayn dɛn we yu go sɔprayz, go to yu dɔktɔ wantɛm wantɛm.

If yu gɛt sɔm sayn dɛm fɔ paraganglioma, lɛk ay blɔd prɛshɔn ɛn ed we de at, tɔk to yu dɔktɔ. Bikɔs paraganglioma nɔ kin bɔku, i stil impɔtant fɔ trit ay blɔd prɛshɔn, ivin if i nɔ go izi fɔ yu gɛt am.

If yu kam fɔ no se wan pan yu fɔs digri fambul dɛm (brɔda ɛn sista, mama ɛn papa) gɛt jenɛtik sindrom lɛk ``Multiple endocrine neoplasia 2 syndrome`` ɔ ``Von Hippel-Lindau (VHL) disease``, aks yu dɔktɔ bɔt jenɛtik tɛst, bikɔs dis kin mek yu gɛt paraganglioma.

Us kwɛstyɔn dɛn yu fɔ aks yu dɔktɔ?

If dɛn no se yu gɛt paraganglioma, i go fayn fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Wetin mek a bin gɛt paraganglioma?
• Mi pikin ɛn/ɔ mi fambul dɛn kin gɛt paraganglioma?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Wetin na di sayd ɛfɛkt dɛm we difrɛn tritmɛnt dɛn kin gɛt?
• Aw a go ebul fɔ kɔntrol mi sik dɛn?

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Paraganglioma na wan sik wae nɔr kin bɔrku, bɔt i impɔtant fɔ no bɔt am. If yu gɛt sɔm sayn dɛn we nɔ de chenj we nɔ izi fɔ ɔndastand, mɔ we yu gɛt ay blɔd prɛshɔn wantɛm wantɛm, we yu de swet, ɔ we yu at de bit kwik kwik wan, i go fayn fɔ mek yu go to dɔktɔ pas fɔ dismis dɛn as jɔs wan fluk.

Pan ɔl we bɔku tɛm dɛn nɔ kin no wetin kin mek pɔsin gɛt paraganglioma, i gɛt fɔ du wit sɔm tin dɛn we pɔsin kin gɛt frɔm in mama ɛn papa. So if sɔmbɔdi na yu famili dɔn gɛt paraganglioma ɔ pheochromocytoma, tɛst fɔ no bɔt yu jenɛtiks kin ɛp yu fɔ no if yu gɛt ɔda prɔblɛm dɛn wit yu wɛlbɔdi. If yu gɛt ɛni kwɛstyɔn bɔt dis, nɔ shek fɔ tɔk to yu dɔktɔ. Dɛn de ya fɔ ɛp yu.

` Paraganglioma, Paraganglioma, Pheochromocytoma, Kromafin sel dεm, Katekolamin dεm, Hכmon dεm, Tכmכr dεm, Kεnsar, Simptom dεm, Ay Blכd Prεshכn, Jεnεtik Sik dεm