We wi yɛri di wɔd "tumor" na wi ed, ɔlman kin fred wantɛm wantɛm, nɔto so? Dat na nɔmal tin. Bɔt di impɔtant tin we wi nid fɔ ɔndastand na dat nɔto ɔl di tumbu dɛn we kin kam na di ed kin gɛt kansa. Tide wi go tɔk bɔt wan tumbu we de divɛlɔp na wan smɔl gland ɔnda wi bren, bɔt bɔku tɛm i nɔ kin gɛt kansa. Dɛn kɔl dis pituitary adenoma insay mɛdikal sayɛns. So lɛ wi tɔk bɔt dis ditayli, rili simpul wan.
Fɔs, lɛ wi si, wetin na Pituitary Adenoma?
Fɔ tɔk am simpul wan, pituitary adenoma na wan tumor we de divɛlɔp na yu pituitary gland. Bɔt na wan tumbu we nɔ gɛt wan prɔblɛm . Dat min se i nɔ de skata to ɔda pat na di bɔdi lɛk kansa. Bɔt as dɛn tumbu ya de gro, dɛn kin prɛs di tisu ɛn nerv dɛn we de rawnd am. Na da tɛm de difrɛn sayn dɛn kin bigin fɔ sho.
So, wetin na dis pituitary gland?
di pituitary gland na smɔl gland we tan lɛk bon we de jɔs dɔŋ di bren, biɛn di nos. I gɛt kɔnekshɔn to di haypothalamus we de na di bren. dis sכmכl gland gεt tu pat dεm, di antεriכr lכb εn di posita lכb. Dɛn tu pat ya kin mek bɔku ɔmon dɛn we rili impɔtant fɔ wi bɔdi.
Ɔmon dɛn tan lɛk mɛsenja dɛn na wi bɔdi. Dɛn kin travul tru di blɔd ɛn tɛl wi ɔgan dɛn, mɔsul dɛn, ɛn ɔda tisu dɛn fɔ du difrɛn wok dɛn.
Na sɔm pan di men ɔmon dɛn we di pituitary gland de mek:
- Adrɛnokɔtikotropik ɔmon (ACTH) .
- Ɔmon we de mek pɔsin nɔ gɛt wata (ADH) .
- Fɔlikul stimulat ɔmon (FSH) .
- Ɔmon we de mek pɔsin gro (GH) .
- Ɔmon we de mek pɔsin gɛt luteinizing (LH) .
- Oksitosin we dɛn kɔl
- Prolaktin we dɛn kɔl prolaktin
- Ɔmon we de mek pɔsin gɛt tayroyd (TSH) .
Dɔn bak, di pituitary gland de gi sayn to ɔda ɛndokrin gland dɛn na wi bɔdi fɔ mek dɛn mek ɔmon dɛn. I tan lɛk se na ed ɔfis. So we tumbu fɔm na dis gland, di wok we wan ɔ mɔ pan dɛn ɔmon ya de du kin rili chenj.
Aw dɛn kin klas di pituitary adenomas?
Dɔktɔ dɛn kin sheb dɛn tumbu ya to tu men kayn: bay we dɛn de mek ɛkstra ɔmon ɔ nɔ de mek, ɛn bay dɛn saiz.
| Klasifikɛshɔn bays pan ɔmon prodakshɔn | |
|---|---|
| Tayp fɔ di tumbu | Simpul ɛksplen |
| di adenoma dεm we de wok (sekret). (tכmכro dεm we de kכl כmon) . | dis kayn tכmכro dεm de mek εkstra pituitary hכmon dεm. Dipen pan di ɔmon we pasmak we dɛn mek, difrɛn sayn ɛn kɔndishɔn dɛn kin apin. |
| adenoma dεm we nכ de wok (we nכ de kכmכt). (Tɔmɔr dɛn we nɔ gɛt ɔmon) . | Dɛn tumbu ya nɔ de mek ɔmon. Bɔt as dɛn de gro, dɛn kin mek dɛn gɛt sayn dɛn bay we dɛn de prɛs di nerv ɛn tisu dɛn we de rawnd dɛn. Dis na di kayn tumbu we kin bɔku pas ɔl. |
| Sɔt bay di sayz | |
|---|---|
| Tayp fɔ di tumbu | Simpul ɛksplen |
| Maykroadenoma dɛn (Maykroadenoma) . | Dɛn tin ya na nɛt we smɔl pas 10 milimita, ɔ 1 sɛntimita. |
| Makrodenɔma dɛn (Big adenoma) . | dis na tכmכro dεm we big pas 10 milimita. Dɛn kin kɔmɔn lɛk tu tɛm pas di maykroadenoma dɛn. dis big big tכmכro dεm kin pwεl di pituitary gland, we kin mek di כmon lεvεl dכn dכn pas nכmal. Dɛn kɔl dis sik we dɛn kɔl hypopituitarism . |
Dɛn kin tek dis as tumbu na di bren?
Yɛs. di pituitary gland nכto teknikal pat pan di bren, bכt na εndokrin gland we de atak di bren. Bɔt dɔktɔ dɛn kin tek pituitary adenoma as bren tumor. dis kayn tכmכro de mek כnli 10% pan di tכmכro dεm we de divεlכp insay di sכkul.
di tin we impɔtant pas ɔl fɔ mɛmba na dat pan ɔl we dɛn kɔl dis "bren tumor," i nɔto kansa.
Wetin na di sayn dɛm we de sho se pɔsin gɛt pituitary adenoma?
Di sayn dɛm fɔ dɛn tumbu ya kin difrɛn bad bad wan, i kin difrɛn frɔm sɔm tin dɛm:
- if di tכmכro de gro εn de damej di tisu we de rawnd כ di pituitary gland insεf (dεn kכl dis mas ifekt).
- Yu tink se na tumbu we de wok ɛn we de pul ɔmon, ɛn if na so, us ɔmon we de kɔmɔt pasmak?
Di simptom dɛm fɔ prɛshɔn bikɔs ɔf di tumor big (Mass Effect) .
dis simptom dεm kin kכmכn spεshal wan pan makroadenomas (big tכmכro dεm).
- Prɔblɛm fɔ si: Dis na di men sayn. 40%-60% pan di sik pipul dεm kin gεt di vishכn lכs (blכr vishכn, dכbl vishכn). dis na biכs as di tכmכro de gro, i de prεs pan di optik chiasm, usay di optik nεv dεm we de kכmכt na wi yay de mit. Dis kin mek yu nɔ ebul fɔ si di say we yu de si, mɔ na di yay .
- Ɛd we de at: Ɛd kin at we di tɔŋ de prɛs pan di tisu we de rawnd am. Bɔt bikɔs ed pen kin rili bɔku, i kin apin bak fɔ ɔda rizin dɛn.
- Hypopituitarism: Big tכmכro kin pwεl di sεl dεm na di pituitary gland, we kin mek wan כ mכr כmon dεm nכ de mek. Di sayn dɛn we de sho se ɛni ɔmon nɔ de wok fayn kin difrɛn.
- di LH εn FSH כmon dεm: Dis kin mek di εstrojen lεvεl dכn lכw pan uman dεm εn di tεstostεron lεvεl lכw pan man dεm. Dɛn kɔl dis haypogonadism . Di sayn dɛm na we i nɔ kin gɛt mɔnt, we i nɔ kin want fɔ du mami ɛn dadi biznɛs, we i kin taya, ɛn we man dɛn nɔ kin ebul fɔ du mami ɛn dadi biznɛs fayn.
- TSH ɔmon we nɔ de: Dis kin mek di tayroyd ɔmon we de mek di tayroyd nɔ de wok fayn. Dɛn kɔl dis haypotayroydism . Dis kin mek yu taya, gɛt bɛlɛ, yu skin kin dray, ɛn yu at kin bit sloslo.
- ACTH ɔmon we nɔ de: Dis kin mek di ɔmon we dɛn kɔl kɔtisol nɔ bɔku. Dɛn kɔl dis adrenal insufficiency . Sɔm sayn dɛm lɛk fɔ lɛ yu blɔd prɛshɔn go dɔŋ, yu nɔs, yu de vɔmit, yu bɛlɛ de pen, ɛn yu nɔr de want fɔ it.
- GH ɔmon dɛfisiɛns: Di simptom dɛm fɔ growth ɔmon dɛfisiɛns kin difrɛn wit di ej. Big pipul dɛn kin taya ɛn dɛn mɔsul dɛn kin wik.
di simptom dεm we de kכmכt frכm di tכmכro dεm we de mek εkstra כmon dεm (Functioning Adenomas) .
Dɛn kayn tɔŋ ya kin mek wan ɔ mɔ ɔmon dɛn tumɔs, we kin mek pɔsin gɛt difrɛn wɛlbɔdi prɔblɛm dɛn.
| Tayp fɔ di tumbu | Di kɔndishɔn ɛn di kɔmɔn sayn dɛm |
|---|---|
| Prolaktinoma dɛn (I de mek tumɔs prolaktin) | dis na di kayn tכmכro we kכmכn pas כl na di pituitary tכmכro. di lεvεl dεm fכ di כmon prolaktin (hyperprolactinemia) kin mek man εn uman dεn nכ bכn pikin. pan tap dat, uman dεm we nכ bεlε kin gεt milk dischaj frכm dεn brεst (galactorrhea). |
| Somatotrof adenoma dɛn (I de mek mɔ ɔmon we de mek pɔsin gro) | Insay big pipul dɛn, dis kin mek dɛn gɛt wan sik we dɛn kɔl akromɛgali . Dis kin mek di an, fut, fes, ɛn ed big pasmak. If dis sik apin to pikin ɛn yɔŋ pipul dɛn, dɛn kin lɔng pasmak. Dɛn kɔl dis gigantism . |
| Kɔtikotrof adenɔma dɛn (de prodyuz mɔ ACTH) | Tumɔs ACTH kin mek di kɔtisol ɔmon go ɔp, ɛn dis kin mek pɔsin gɛt wan sik we dɛn kɔl Cushing’s syndrome . Di sayn dɛm na di blɔd prɛshɔn, di mɔsul dɛm wik, i izi fɔ brus, strɛch mak, ɛn tayp 2 dayabitis. |
| Tayrotrof adenoma dɛn (I de prodyuz mɔ TSH) | Dɛn tin ya nɔ kin apin so ɔltɛm. Tumɔs TSH kin mek di tayroyd ɔmon dɛn bɔku, ɛn dis kin mek pɔsin gɛt wan sik we dɛn kɔl haypa tayroyd . Di sayn dɛm na di at we de bit, we i de lɔs in wet, we i de swet, in an dɛn we de shek shek, ɛn we i nɔ de rɛst. |
Wetin mek di pituitary adenomas de divεlכp?
Sayɛnsman dɛn stil nɔ no di rayt tin we kin mek wi gɛt dis sik, bɔt dɛn biliv se bɔku tɛm na di chenj dɛn we kin apin (muteshɔn) we kin apin na wi DNA . dis chenj dεm de mek di sεl dεm na di pituitary gland de gro we dεn nכ de kכntrכl εn fכm tכmכro.
Sɔntɛnde, dɛn tin ya kin gɛt fɔ du wit di jɛnɛtik kɔndishɔn dɛn we kin pas tru jɛnɛreshɔn, bɔt bɔku tɛm dɛn kin apin randomly.
Aw fɔ no bɔt dis sik?
Yu dɔktɔ go ɔda fɔ du tɛst fɔ no dis bay di sayn dɛm we yu gɛt. Sɔntɛnde, dɛn kin si dɛn tumbu ya bay aksidɛnt we dɛn de skan ed fɔ ɔda rizin.
If yu dɔktɔ sɔspɛkt dis sik, dɛn kin ɔda fɔ du dɛn tɛst ya:
- Blɔd tɛst: Dɛn kin ɔda fɔ du blɔd tɛst fɔ chɛk difrɛn ɔmon lɛvɛl dɛn, i kin dipen pan di sayn dɛn we yu gɛt.
- Imej tɛst: We dɛn du MRI (Magnetic Resonance Imaging) ɔ CT (Computed Tomography) skan na di ed, dat kin mek dɛn no se dis tɔŋ de.
- Ay ɛgzam: If yu gɛt prɔblɛm wit yu yay, dɛn go du wan vishɔnal fil tɛst fɔ chɛk aw yu yay de wok.
Wetin na di tritmɛnt dɛn?
Bɔku tɛm, tri tritmɛnt dɛn de fɔ dis: ɔpreshɔn, mɛrɛsin, ɛn redyushɔn tɛrapi. Yu mɛdikal tim go disayd us tritmɛnt go fayn fɔ yu bay di kayn, saiz, ɛn di sayn dɛm fɔ yu tumbu.
1. Ɔpreshɔn: If di tumbu de mek di ɔmon nɔ balans ɔ i de mek i nɔ ebul fɔ si fayn, di dɔktɔ kin se dɛn fɔ du ɔpreshɔn fɔ pul ɔl ɔ pat pan di tumbu.
- di mכst kכmכn (95%) mεtכd we dεn kin yuz fכ dis na transsphenoidal surgery , we dεn kin put sכmכl kεmεra εn instrכmεnt dεm tru di nos fכ pul di tכmכro.
- If di tכmכro rili big, i kin nid fכ du transkranial כpεrayshכn, we dεn kin du tru di sכkul.
2. Mɛrɛsin: Sɔm kayn tumbu, mɔ Prolactinomas , dɛn kin trit wit mɛrɛsin. Dɛn mɛrɛsin ya kin mek di tumbu smɔl ɛn kɔntrol di sik dɛn. Bɔrku tɛm, dɛn kin gi mɛrɛsin lɛk kabɛrgɔlin ɔ bromokriptin fɔ dis. 80% pan di sik pipul dεm kin gεt gud rizulyt wit dεn mεdikeshכn ya.
3. Rɛdieshɔn tɛrapi: Dis kin min fɔ yuz ɛkstrem rayt we gɛt bɔku ɛnaji fɔ mek di tumbu smɔl ɔ fɔ stɔp am fɔ gro. Dɛn kin du dis bay we dɛn de yuz wan spɛshal we we dɛn kɔl stereotactic radiosurgery . dis involv fכ tכk di tכmכro wit rεdyushכn bim dεm we dεn de minimiz di damej to di hεlty tisu we de rawnd am.
Wetin kin apin afta dɛn dɔn trit am? Prognosis we dɛn kin tɔk bɔt
Di we aw pipul dɛn de si dis rili fayn. Afta dɛn dɔn pul di tumbu kpatakpata wit tritmɛnt, bɔku pipul dɛn kin liv ful, wɛlbɔdi layf.
Sɔntɛnde, ɔpreshɔn ɔ redyushɔn tɛrapi kin pwɛl di pituitary gland, we kin mek di ɔmon lɛvɛl smɔl (hypopituitarism). If na so i bi, yu go nid fɔ tek ɔmon riplesmɛnt pils fɔ di res ɔf yu layf fɔ tek di ɔmon we nɔ bɔku.
Sɔntɛnde, dɛn tumbu ya kin kam bak, so i rili impɔtant fɔ go na dɔktɔ ɔltɛm ivin afta dɛn dɔn trit yu.
Us prɔblɛm dɛn kin apin if dɛn nɔ trit am?
If dɛn nɔ trit am, mɔ di big big tumbu dɛn (macropadenomas) ɛn di tumor dɛn we de mek ɔmon (functioning adenomas) kin mek yu gɛt siriɔs wɛlbɔdi prɔblɛm.
Wan prɔblɛm we nɔ kin apin so ɔltɛm bɔt we rili denja na pituitary apoplexy . Dis na wan sik wae nid fɔ gɛt mɛrɛsin kwik kwik wan.
Wetin kin apin ya na we di tumbu kin blɔd wantɛm wantɛm insay ɔ kɔmɔt na di tumbu. Di tumbu kin gro wantɛm wantɛm ɛn i kin pwɛl di pituitary gland. Di sayn dɛm fɔ dis kin apin wantɛm wantɛm.
- Wan ed we kin at bad bad wan ɛn we kin at wantɛm wantɛm.
- dכbl vishכn כ we yu nכ ebul fכ opin di aylid dεm bikoz di ay mכsul dεm nכ de wok fayn.
- Wantɛm we yu nɔ de si ɔ yu nɔ de si na di sayd.
- Blɔd prɛshɔn go dɔŋ wantɛm wantɛm, nɔs ɛn vɔmit.
If yu gɛt wan ɔ mɔ pan dɛn sik ya, yu fɔ go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu ɛn nɔ de te. Dis na imejensi we kin mek pɔsin in layf de pan denja.
Na nɔmal tin fɔ fil fɔ fred we dɛn no se yu gɛt pituitary adenoma. Bɔt mɛmba se bɔku tɛm dɛn tin ya nɔto kansa. Ɛn, wit di advans tritmɛnt dɛn tide, dɛn kin wɛl kpatakpata. Tɔk wit yu dɔktɔ opin wan ɛn aks ɔl yu kwɛstyɔn dɛn.
Mɛsej we dɛn kin kɛr go na os
- Pituitary adenoma kin bi wan benign tumor, so nɔ fɔ alarm we yu nɔ nid.
- Di sayn dɛm kin bi mɔ bikɔs di tumbu de big, di prɛshɔn pan di nerv dɛm we de rawnd am, ɔ di chenj na di ɔmon lɛvɛl.
- Nɔ ignore di prɔblɛm dɛn we de wit di we aw yu de si (especially dikɛd peripheral vision) ɛn di ed we de at we de kɔntinyu. Go to dɔktɔ wantɛm wantɛm.
- Tritmɛnt dɛn de we rili fayn fɔ dis, lɛk ɔpreshɔn, mɛrɛsin, ɛn redyushɔn tɛrapi.
- If dɛn dɔn no se yu gɛt dis sik, i rili impɔtant fɔ fala yu dɔktɔ in advays ɛn go de chɛk-ap ɔltɛm.
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