Yu de wɔri se blɔd go klɔt? Lɛ wi tɔk bɔt Protein C Deficiency

Yu dɔn ɛva fil lɛk se yu de kam gɛt blɔd? Ɔ yu dɔn fil wantɛm wantɛm se yu leg dɔn swel ɛn yu de fil pen? Di rizin fɔ dɛn tin ya kin difrɛn frɔm wetin yu tink. Tide wi de tɔk bɔt wan kɔndishɔn we nɔ kin bɔku bɔt we rili impɔtant fɔ no bɔt. Dat na di Protɛin C Dɛfisiɛns . Pan ɔl we di nem kin tan lɛk se i strenj, i gɛt sɔntin fɔ du wit di we aw blɔd kin klɔt na wi bɔdi. Lɛ wi si wetin i bi, wetin mek i kin apin, ɛn wetin yu kin du bɔt am.

Wetin rili na Protein C Deficiency?

Fɔ tɔk am simpul wan, Protein C Deficiency na wan sik we wi blɔd kin klɔt pas aw i nid, ɔ insay wan we we nɔrmal. Na dis na smɔl ɛksplen.

Imajin se yu gɛt wund sɔmsay na yu bɔdi. Dɔn, fɔ mek di blɔd nɔ de kɔmɔt, sɔm blɔd nid fɔ klɔt. Dat na nɔmal tin. Na di we aw wi bɔdi de fɛt. Bɔt wetin go apin if dis blɔd we de klɔt nɔ ebul fɔ kɔntrol am ɛn i pasmak? Na de di prɔblɛm bigin.

Bɔku natura l tin dɛn de na wi blɔd we de kɔntrol dis we aw blɔd de klɔt, lɛk di brek sistɛm na motoka. Protein C na wan pan dɛn kayn tin ya, na wan rili impɔtant protin we de kɔntrol di blɔd we de klɔt. Dɛn kɔl dis natura ‘anti-clotting agent’ ɔ anticoagulant . Dat min se na sɔntin we de mek blɔd nɔ klɔt.

Naw yu ɔndastand, nɔto so? Protein C Deficiency min se yu nɔ gɛt inof pan dis protin na yu blɔd. We dat apin, di brek we de kɔntrol di we aw blɔd de klɔt nɔ de wok fayn. Di tin we kin apin na dat blɔd kin bigin fɔ klɔt na di blɔd vesel dɛn. Blɔd we kin klɔt dis kayn we kin mek pɔsin gɛt prɔblɛm dɛn we rili denja, ivin we kin mek pɔsin in layf de pan denja. fכ egzampl, bכdi kin fכm na di dip vein dεm na di leg dεm (Deep Vein Thrombosis) εn k כndishכn dεm lεk da bכdi kכlכt de brok εn stכk na di lכng dεm (Pulmonary Embolism) .

Aw dis sik kin kɔmɔn?

Dis na rili nɔto sɔntin we rili kɔmɔn, bɔt i nɔ kin apin lɛk aw wi kin tink.

• Mild form: Dɛn se dis kin afɛkt wan pan ɔl 200 to 500 pipul dɛm na di jenɛral pipul dɛm.
• Sivεr fכm: Dis na di fכm we nכ kin bכku. I kin afɛkt lɛk wan pan ɛvri 500,000 to 750,000 pipul dɛn. Bɔt di tru nɔmba kin bɔku pas dɛn tin ya.

Dis sik kin afɛkt man ɛn uman ikwal wan.

Wetin na di sayn dɛm fɔ dis?

De sayn dɛm fɔ dis sik kin difrɛn difrɛn wan fɔ no if i nɔr kin pasmak ɔr i bad. Lɛ wi luk di tebul we de dɔŋ fɔ ɔndastand dis klia wan.

Wetin na di tin dɛn we kin mek pɔsin nɔ gɛt bɛtɛ prɔtin C?

di men rizin fכ dis kכndyushכn na di jεnεtik inflכεns, we min se na sכmtin we de pas frכm jεnereshכn to jεnereshכn.

Di Kɔz dɛn we dɛn kin gɛt frɔm dɛn mama ɛn papa

wan jin de na wi bכdi we de sho wi fכ mek wan protin we dεn kכl Protein C. dεn kכl am di PROC jin . if mכtεshכn de na dis jin, i kin bi se dεn nכ mek di Protein C fayn, כ ivin if dεn mek am, i nכ kin wok fayn.

• Tayp I Dεfisiεns: Dis kin kכz fכ di dכn we di Protein C lεvεl dεm de dכn.
• Tayp II Dεfisiεns: dis kin apin we di protin C lεvεl dεm nכmal, bכt di protin nכ de wok fayn fayn wan.

Imajin se wan pan di mama ɛn papa gɛt dis PROC jin we dɔn chenj. Dɔn 50% chans de fɔ mek di pikin we dɛn gɛt go gɛt da mutated jin de. If dat apin, di pikin go gɛt wan kayn we we nɔ kin gɛt dis sik.

Naw imajin se dɛn mama ɛn papa dɛn ɔl tu gɛt dis jin we dɔn chenj. afta dat 25% chans de fכ mek pikin gεt כl tu dεn mutated jin dεm. Da pikin de go gɛt di bad bad sik we de sho di sayn dɛn we dɛn bɔn am.

Di Kɔz dɛn we dɛn dɔn gɛt

Dis nɔ kin apin ɔltɛm we pɔsin gɛt frɔm in mama ɛn papa. Sɔm mɛrɛsin ɔ ɔda tin dɛn kin mek bak di Protɛin C nɔ bɔku.

• Vitamin K we nɔ de
• Yuz di blɔd thinner Warfarin (wi go tɔk bɔt dis leta)
• Siriɔs sik na di liva
• Wan sik we dɛn kɔl Disseminated Intravascular Coagulation (DIC) .
• Siriɔs baktriyal infɛkshɔn (Sepsis) .

Aw fɔ no bɔt dis sik?

If yu dɔktɔ sɔprayz se yu gɛt dis sik, dɛn go tɛst sɔm tin dɛn fɔ no if yu gɛt dis sik.

• Yu pasɔnal mɛdikal istri: If yu bin dɔn gɛt prɔblɛm wit blɔd we de klɔt bifo.
• Yu famili mɛdikal histri: Ɛnibɔdi na yu famili gɛt dɛn kayn prɔblɛm ya we de mek yu blɔd klɔt?
• Blɔd tɛst: Dis na di tin we impɔtant pas ɔl. Dɛn kin mɛzhɔ yu Protein C aktiviti ɛn Protein C lɛvɛl na yu blɔd.
• jεnεtik tεst: dεn kin du jεnεtik tεst fכ chεk fכ mכtεshכn na di PROC jin. Bɔt dis nɔ nid fɔ bi fɔ kɔnfirm di sik.

Aw dɛn kin trit am?

Di tritmɛnt dipen pan us kayn Protein C Deficiency yu gɛt ɛn aw yu sik dɛn kin tranga.

Tritmɛnt fɔ mild fɔm

• Bɔrku pipul nɔr nid tritmɛnt: Bɔrku pipul nɔr nid ɛni tritmɛnt. Bɔt dɛn kin nid spɛshal atɛnshɔn ɛn sɔntɛm tritmɛnt we dɛn de du ɔpreshɔn, we dɛn gɛt bɛlɛ, if dɛn gɛt big aksidɛnt (e.g., motoka aksidɛnt), ɔ di tɛm we dɛn nɔ de du tin wit dɛn bɔdi (e.g., if dɛn de na bed).
• Anticoagulants: If yu dɔn ɔlrɛdi gɛt thrombotic event, yu dɔktɔ go gi yu anticoagulants.

Tritmɛnt fɔ siriɔs fɔm

fכ dis siriכs kכndyushכn na nyu bכbi dεm, dεn kin gi spεshal tritmεnt we dεn kכl Protein C concentrate (Ceprotin®) כ fresh frozen plasma.

Us prɔblɛm dɛn dis kin mek?

Bɔrku big big prɔblɛm dɛn de wae kin kam wit dis sik.

• Prɔblɛm dɛn we gɛt fɔ du wit di skin we gɛt fɔ du wit wɔfarin: Afta dɛn dɔn bigin fɔ yuz warfarin, sɔm pipul dɛn kin gɛt pen, rɛd ɔ pepul. Dɛn tin ya kin apin mɔ na di ɔp pat na di bɔdi, an ɔ leg. If dɛn nɔ trit dis fayn, dis kin mek di skin ɛn di tisu we de ɔnda di bɔdi day.
• Pulmonary Embolism: Na bכdi we de fכm na di leg dεm (dip vein thrombus) kin brok, travul tru di bכdi, εn lod insay wan vein na di lכng. Dis na tin we kin mek pɔsin in layf de pan denja.
• Purpura Fulminans: Na prɔblɛm we de mek blɔd klɔt ɔlsay na di nyu bɔbɔ in bɔdi. If dɛn nɔ trit am, i kin kil pɔsin.
• di kכmplikεshכn dεm we de fכ fresh plasma tεrapi: we dεn kכntinyu fכ gi pikin dεm dis tritmεnt, kכmplikεshכn kin apin bikoz di wata we de na di bכdi de inkrεs (fluid ovalod).

Wetin yu kin ɛkspɛkt afta dɛn dɔn no se yu gɛt dis sik?

Di tin wae kin kam wit dis kin difrɛn bad bad wan fɔ di kayn sik wae de kam pan pɔrsin.

di prכgnosis fכ bebi dεm we gεt siriכs Protein C Dεfisiεns nכ gud. Dɛn kin ivin day jɔs afta dɛn bɔn dɛn. Nɔr infɔmeshɔn nɔr de yet fɔ tɔk bɔt wetin na de lɔng tɛm layf fɔ di wan dɛm wae gɛt dis siriɔs sik.

If yu gɛt mild fɔm, yu de pan risk fɔ gɛt rikɔrɛkt venɔs tromboɛmbolizm. Risk de bak fɔ mek di klot dɛn go travul go na di lɔng dɛn. Fɔ mek yu gɛt di bɛst rizɔlt, i impɔtant fɔ kip yu dɔktɔ in apɔntinmɛnt fɔ fala yu. Dis go mek i ebul fɔ wach yu sik gud gud wan ɛn ajɔst yu tritmɛnt as nid de.

Yu tink se dɛn go ebul fɔ stɔp dis?

Bikɔs di Protein C Deficiency na tin we dɛn kin gɛt frɔm dɛn mama ɛn papa, dɛn nɔ kin ebul fɔ stɔp am. Bɔt mama ɛn papa ɛn pikin dɛn kin go to dɔktɔ we de mɛn blɔd fɔ no mɔ bɔt am ɛn fɔ mek dɛn du di tɛst dɛn we dɛn nid.

Dɔn bak, sɔmtɛm dɛn kin avɔyd di Protein C Deficiency we ɔda mɛrɛsin kin kam wit. Fɔ ɛgzampul,

• Di ɛstrojen ɔmon we de insay sɔm bɔn kɔntrol pils dɛn we uman dɛn kin tek kin mek di blɔd klɔt mɔ.
• Dis risk kin go ɔp mɔ bikɔs ɔf tin dɛn lɛk fɔ smok, fɔ fat pasmak, fɔ gɛt bɛlɛ, ɛn fɔ nɔ de du tin wit in bɔdi.

Sɔntɛnde, yu dɔktɔ kin gi yu di mɛrɛsin dɛn we de mek yu nɔ gɛt blɔd fɔ mek yu nɔ gɛt dis prɔblɛm. So, e fayn fɔ tɔk to yu dɔktɔ opin wan bɔt di tin dɛn we kin mek yu gɛt dis sik.