Yu skin kin tɔn rɛd wantɛm wantɛm, blista, ɛn pul? Lɛ wi lan bɔt dis denja Stivins-Jɔnsin Sindrom (SJS)?

Yu dɔn ɛva si, ɔ i dɔn apin to yu, wan rash wantɛm wantɛm na yu bɔdi we tɔn rɛd, tan lɛk rash, dɔn blista dɛn kin kɔmɔt ɛn di skin kin kɔmɔt? Dɛn lɛsin ya kin apin bak insay di mɔt, na di yay, ɛn na di say we di uman in bɛlɛ de. Dis nɔto simpul tin, ɛn kin bi siriɔs tin we kin mek pɔsin go na ɔspitul wantɛm wantɛm . Tide, wi go tɔk bɔt dis sik we dɛn kɔl Stevens-Johnson Syndrome (SJS).

Wetin na Stivins-Jɔnsin Sindrom (SJS)?

Fɔ tɔk am simpul wan, Stevens-Johnson Syndrome (SJS) ɛn Toxic Epidermal Necrolysis (TEN) na tu rili siriɔs tin dɛn we kin apin na di skin. Wetin kin apin na dat yu skin kin bigin fɔ gɛt rɛd bɔmp dɛn we kin it wantɛm wantɛm, we kin blista ɛn pul kɔmɔt. I kin afɛkt yu yay, yu bɔdi, ɛn di mukɔs mɛmbran dɛn we de insay yu mɔt bak. If yu gɛt dɛn kayn tin ya, yu go mɔs nid fɔ go na ɔspitul fɔ gɛt tritmɛnt.

Sɔm dɔktɔ dɛn kin tek SJS ɛn TEN as tu difrɛn sik dɛn, ɔda wan dɛn kin se na difrɛn stej dɛn fɔ di sem sik. SJS na wan kayn sik wae nɔr kin pasmak pas TEN. fכ egzampl, insay SJS, lεs dan 10% pan di skin na di כl bכdi kin lכs. insay TEN, pas 30% pan di skin kin lכs. Bɔt i impɔtant fɔ mɛmba se dɛn tu tin ya kin mek pɔsin in layf de pan denja .

Us ɔda nem dɛn SJS gɛt?

Yɛs, i gɛt sɔm ɔda nem dɛn. Fɔ ɛgzampul:

• Di sik we dɛn kɔl Lyell in Syndrome
• Stevens-Johnson sεndrכm/tכxik εpidamal nεkrכlaysis
• Stevens-Johnson sεndrכm tכxik εpidamal nεkrכlaysis spεktrum

Sɔntɛnde, di nem kin chenj dipen pan di tin we mek i apin. if na wan patikyula dכg kכz am, dεn kin kכl am ``drug-induced Stevens-Johnson syndrome'', εn if na infεkshכn we dεn kכl ``Mycoplasma'', dεn kin kכl am ``mycoplasma-induced Stevens-Johnson syndrome''.

Udat kin gɛt mɔ chans fɔ gɛt SJS?

Dɛn kin si SJS mɔ pan yɔŋ pipul dɛn we nɔ rich 30 ia yet ɛn pan yɔŋ pikin dɛn. Bɔt i kin apin to pipul dɛn we gɛt ɛni ej, mɔ di wan dɛn we dɔn ol. Uman dɛn kin gɛt SJS pas man dɛn.

Imajin, if yɔŋ pikin gɛt infɛkshɔn lɛk nyumonia ɛn afta dat i gɛt prɔblɛm wit in skin lɛk dis... i kin bi SJS. Di men tin we kin mek pikin dɛn gɛt SJS na infɛkshɔn lɛk nyumonia. Bɔt pan big pipul, SJS/TEN kin kam mɔ pan di mɛrɛsin dɛn we dɛn kin tek.

Wetin na di risk factor dɛm fɔ divɛlɔp SJS?

Nɔto wan tin de we kin mek pɔsin gɛt dis sik, bɔt na tin dɛn we kin kam togɛda. Di impɔtant tin pan dɛn tin ya na di we aw pɔsin kin gɛt jɛnɛtiks. Dat min se yu jin dɛn kin gɛt sɔm pawa. Sɔm tin dɛn we de na di envayrɔmɛnt kin mek dɛn jin dɛn de wok bak. wan pan dεn jεnεtik fכs tin ya na di spεshal pat dεm na wi bכdi we dεn kכl `(Human Leukocyte Antigens - HLAs). Pipul dεm we gεt sכm vεryכnt dεm fכ dεn `(HLA)` dεm de pan hכy risk fכ divεlכp SJS כ TEN pas כda wan dεm.

Wetin na di sayn dɛm fɔ SJS?

Bɔku sayn dɛn de we kin apin pan SJS. I impɔtant fɔ no bɔt dɛn tin ya:

• Bɔrku pen na di skin: Fɔs, di skin kin bigin fɔ at.
• Fiva: Yu gɛt fiva.
• Bɔdi pen: I kin fil lɛk se yu wan ol bɔdi de at.
• Rɛd spat ɔ pat na di skin: Rɛd spat ɔ pat de apia na di skin.
• Kɔf.
• Blista ɛn sos: Nɔto jɔs blista ɛn sos kin apin na di skin, bɔt i kin apin bak na di myukɔs mɛmbran dɛn na say dɛn lɛk di mɔt, trot, yay, di bɔdi we de na di bɔdi, ɛn di rɛktum. Imajin, sɔri we de insay di mɔt nɔ de jɔs mek i nɔ izi fɔ it, bɔt i nɔ kin izi fɔ tɔk bak.
• Fɔ pul di skin: Di skin kin kɔmɔt na di blista dɛn.
• Drooling: Bikɔs ɔf di mɔt sos, saliva kin kɔmɔt we yu nɔ ebul fɔ kip yu mɔt lɔk.
• Aylid swel: Blista ɛn swel na di yay kin mek di yay swel sote i nɔ kin ebul fɔ opin.
• Pen we yu de pis: Blisters na di mucous membranes kin mek yu fil bad bad wan we yu de pis.

Imajin se yu bigin fɔ tek nyu mɛrɛsin, ɛn insay sɔm dez yu nɔ de fil fayn, yu gɛt fiva, ɛn yu de pen, dɔn wantɛm wantɛm rɛd spat dɛn de na yu skin ɛn blista dɛn de apia... Na da tɛm de yu fɔ bigin fɔ sɔprayz se dis na SJS.

Wetin kin mek pɔsin gɛt SJS?

Bɔku men tin dɛn de we kin mek pɔsin gɛt SJS:

• Alɛji riakshɔn to wan drɔg: Dis na di men tin we kin mek bɔku pan di SJS ɛn ɔl di TEN kes dɛm. Dis kin apin if yu mis wan doz fɔ wan mɛrɛsin we yu de tek.
• Infɛkshɔn: Fɔ ɛgzampul, infɛkshɔn lɛk Mycoplasma pneumonia, Herpes virus, ɛn Hepatitis A.
• Graft-versus-host disease: Dis na kכndyushכn we kin apin, spεshal wan afta dεn transplant bon mכro.
• Nɔr kɔz nɔr de: Sɔmtɛm SJS kin divɛlɔp witout ɛni klia kɔz.

If yu gɛt SJS bikɔs ɔf wan mɛrɛsin, di sayn dɛm kin bigin fɔ sho insay wan, tu, ɔr tri wiks afta yu bigin fɔ tek di mɛrɛsin. Yu kin bigin wit fiva, kɔf, ɛn ed we de at, dɔn yu kin gɛt rash na yu skin ɛn yu kin pul yu bɔdi. Na sɔm pipul dɛm wae gɛt TEN, dɛn ia ɛn nel kin ivin fɔdɔm. Na smɔl tɛm nɔmɔ, dɛn dɔn ripɔt se na wan vaksin we dɛn jɔs dɔn gi SJS.

Us mɛrɛsin dɛn we kin mek pɔsin gɛt SJS?

Sɔm mɛrɛsin dɛn de we gɛt ay risk fɔ mek yu gɛt SJS. Dɛn tin ya na:

• Antibacterial sulfa drɔgs dɛn we dɛn kin yuz.
• Di mɛrɛsin dɛn we de mek pɔsin nɔ gɛt ɛpilepshɔn: Sɔm ɛgzampul dɛn na Fɛnitɔyn (Dilantin®), Kabamazɛpin (Tegretol®), Lamotrijin (Lamictal®), ɛn Fɛnobarbital (Luminal®).
• `(Allopurinol (Aloprim®, Zyloprim®))`: Dis na mɛrɛsin we dɛn kin yuz fɔ gaut ɛn kidni ston.
• Nɔn-stɛroyd anti-inflammatory drɔgs (NSAID): Ɛgzampul dɛn na Piroxicam (Feldene®), Nevirapine (Viramune®), ɛn Diclofenac (Cambia®, Flector®).
• Ɔda antibayɔtik dɛn.

Impɔtant: Dis nɔ min se ɔlman we de tek dɛn mɛrɛsin ya go gɛt SJS. Bɔt dɛn dɔn si se dɛn mɛrɛsin ya gɛt fɔ du wit di risk we de go ɔp fɔ gɛt SJS.

Ɔda tin dɛn de we kin mek pɔsin gɛt SJS?

Yes, sɔm ɔda tin dɛn de we kin mek pɔsin gɛt SJS. Dɛn na:

• Bikɔs dɛn bin dɔn transplant dɛn bon mɛrɔ.
• fכ gεt כtoimyun sik dεm lεk `(Systemic lupus erythematosus - SLE)`.
• Human immunodeficiency virus (HIV) infεkshכn.
• Ɔda sik dɛn we nɔ de mɛn na di jɔyn ɛn di kɔnektiv tisu.
• Kansa.
• Fɔ gɛt di imyun sistɛm we wik.
• If sɔmbɔdi na yu famili dɔn gɛt SJS (family history).
• fכ gεt wan vεryכnt fכ wan spεsifi k jin we dεn kכl ``Human Leukocyte Antigen-B - HLA-B''.

Aw dɔktɔ dɛn kin no dis SJS kɔndishɔn?

Dɔktɔ dɛn kin no se dɛn gɛt SJS ɛn TEN bay we dɛn tink bɔt dɛn tin ya:

• egzamin di skin we afekt εn di mכkus mεmbran dεm: כltεm at le tu mכkus mεmbran dεm de afekt.
• Dipen pan di lɛvɛl wae yu de fil pen.
• Dipen pan aw kwik yu skin bin afɛkt.
• Dipen pan aw yu skin de afɛkt.
• Skin biopsy: Sɔntɛnde, dɛn kin tek smɔl sampul pan di skin ɛn chɛk am ɔnda maykroskɔp fɔ kɔnfirm di diagnosis.

Aw dɛn kin trit SJS?

SJS na wan sik wae nid fɔ go na ɔspitul kwik kwik wan ɛn trit am. If yu tray fɔ trit am na os, dat kin mek di sik wɔs. Dis na sɔm pan di tritmɛnt dɛm:

• Wantɛm wantɛm, stɔp fɔ tek di mɛrɛsin we dɛn tink se de mek yu gɛt di prɔblɛm: Dis na di fɔs tin we yu fɔ du.
• di wata we dεn kin put insay di bכdi (IV) fכ mek di εlektrolayt dεm kam bak: dεn kin du dis fכ kכntrכl di wata we de kכmכt na di bכdi we di skin de kכl.
• Fɔ put dresin we nɔ de adhesive pan di skin we di sik dɔn afɛkt.
• Fɔ gi it dɛn we gɛt bɔku kalori fɔ mek yu wɛl kwik: Sɔntɛnde, i kin nid fɔ gi yu tyub.
• Fɔ gi antibayɔtik if nid de fɔ mek yu nɔ gɛt di sik.
• Fɔ gi mɛrɛsin fɔ mek pɔsin fil pen.
• Tritmɛnt na ɔspitul, sɔntɛm na Intɛnsiv Keya Yunit (ICU) ɔ Bɔn Yunit.
• Fɔ fɛn ɛp frɔm spɛshal tim dɛm lɛk Dɛmatɔlɔji ɛn Ɔftalɔji (if di yay dɛn afɛkt).
• Sɔntɛnde, dɛn kin gi spɛshal tritmɛnt dɛn lɛk IV immunoglobulin, sayklosporin, IV stɛroyd, ɔ amniotic membrane grafts (fɔ di yay).

Wetin na di pɔsibul kɔmplikeshɔn dɛm fɔ SJS?

Bikɔs SJS ɛn TEN na siriɔs kɔndishɔn, di prɔblɛm dɛn kin rili bad.

• Day: Dis na di prɔblɛm we rili siriɔs. Na lɛk 10% pan di wan dɛn we gɛt SJS ɛn lɛk 50% pan di wan dɛn we gɛt TEN kin day.
• Nyumonia.
• Sepsis: Dis na bad bad baktriyal infεkshכn, we fiba blכd pכyzin.
• Shok stet `(Shok)`.
• Bɔku ɔgan dɛn we nɔ de wok fayn.

Na bikɔs ɔf dɛn siriɔs kɔmplikeshɔn ya we SJS/TEN kɔndishɔn dɛn kin nid fɔ go na ɔspitul wantɛm wantɛm.

Yu tink se dɛn kin ebul fɔ stɔp SJS?

Infakt, bɔku tɛm, dɛn nɔ kin ebul fɔ stɔp SJS. Bikɔs bɔku tɛm na bikɔs pɔsin nɔ bin de tink se i go biev we i tek wan mɛrɛsin, no we nɔ de fɔ no if dis go apin bifo yu tek wan mɛrɛsin.

Bɔt if dɛn no se yu gɛt wan sik we pɔsin kin gɛt we i de tek drɔgs, di tin we impɔtant pas ɔl na fɔ nɔ ɛva yuz da mɛrɛsin de ɔ ɔda kayn drɔgs igen. I rili impɔtant fɔ tɛl yu dɔktɔ bɔt dis ɛn rayt am na yu mɛdikal rɛkɔd.

Wetin na di lukin-grɔn fɔ pɔsin we gɛt SJS? (Autluk) .

Nɔto ɔlman wae gɛt SJS kin gɛt di sem kayn sik. Sɔm pipul dɛn kin wɛl insay sɔm wiks. Bɔt if di sik bad bad wan, i kin tek sɔm mɔnt fɔ mek i wɛl ɔltogɛda. Sɔm pipul dɛn kin gɛt prɔblɛm dɛn we go de fɔ lɔng tɛm. Fɔ ɛgzampul:

• Skin: Dray skin, it, skin de chenj in kɔlɔ.
• Ay: I kin swel ɛn/ɔ dray bɔku tɛm, di yay kin inflamɛns bɔku tɛm, i nɔ kin si fayn, i kin fil lɛk layt (fotophobia).
• We pɔsin de swet pasmak.
• di lכng dεm we de pwεl: Kכndishכn dεm lεk krεse sik (COPD), asma.
• Nɛl dɛn we de fɔdɔm ɔ we nɔ fayn.
• Di ia we de lɔs (Alopecia).
• di dray we di mכkus mεmbran dεm: Dis kin mek tin dεm lεk i at fכ pis.
• Sindrom we de mek pɔsin taya we nɔ de dɔn.
• Di chenj dɛn we de apin na di teist.

Impɔtant tin na dat, di sik kin kam bak if di pɔsin gɛt di mɛrɛsin bak we bin mek i gɛt di SJS fɔs. If dat apin, de sik kin mɔna di sɛkɔn tɛm.

Na lɛk 10% pan di SJS pasɛnt dɛn ɛn 30% pan di TEN pasɛnt dɛn kin day, mɔ bikɔs ɔf sɛpsis, akyu respiratory distress syndrome (ARDS), ɛn bɔku ɔgan dɛn we nɔ de wok fayn.

Na sɔm tin dɛn we yu fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt (Take-Home Message):

Okay, so wi don tok plenti boht dis dangerous kondishon we dem kol SJS. Na sɔm tin dɛn we yu fɔ mɛmba:

• Stevens-Johnson Syndrome (SJS) ɛn Toxic Epidermal Necrolysis (TEN) na tin dɛn we rili siriɔs, ivin we kin mek pɔsin in layf de pan denja.
• If yu gɛt sɔm sayn dɛn lɛk pen na yu skin, rɛd spat, blista, skin we de pul, ɔ yu mɔt ɔ yay sos afta yu dɔn bigin fɔ tek nyu mɛrɛsin, mɔ insay wan ɔ tu wiks, go to dɔktɔ wantɛm wantɛm. I kin bi SJS.
• Ɔltɛm tɛl yu dɔktɔ if yu dɔn gɛt alɛji ɔ bad bad riakshɔn to wan mɛrɛsin bifo.
• Nɔ ɛva yuz drɔg ɔ ɔda kayn mɛrɛsin we dɛn dɔn no se de mek pɔsin gɛt SJS igen.**
• If yu saspek dis kɔndishɔn, nɔr de na os, go na ɔspitul kwik kwik wan. Kwik tritmɛnt kin sev yu layf.

A op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!

` Stevens-Johnson Syndrome, SJS, Toxic Epidermal Necrolysis, TEN, Skin sik, Alɛji, Drug sayd ɛfɛkt, Blista, Skin rash, Dɛmatɔlɔjik sik