Yu gɛt Ankylosing Spondylitis? Lɛ wi tɔk bɔt TNF Inhibitors

Yu kin bigin yu de bak wit stiff bak ɛn pen we yu wek na mɔnin? Yu taya wit di pen wae de kam na yu joyn wae yu de waka ɔr de muv? Dɛn tin ya kin bi sayn dɛm fɔ ankylosing spondylitis , ɔ AS fɔ shɔt. Dis na wan sik we de mek yu fil fɔ lɔng tɛm we kin apin na di spayna ɛn ɔda jɔyn dɛn. So if yu gɛt dis sik, yu dɔktɔ go dɔn tɔk bɔt wan spɛshal kayn mɛrɛsin we dɛn kɔl TNF Inhibitors. Lɛ wi tɔk bɔt dis simpul ɛn klia wan tide.

Wetin mek di jɔyn dɛn kin at na AS? Wetin na TNF?

Okay, mek wi put dis simpul wan. Wi ɔl gɛt wan imyun sistɛm na wi bɔdi. Na wetin de protɛkt wi bay we wi de fɛt di jem dɛm we de mek wi gɛt sik. Bɔt insay kɔndishɔn dɛn lɛk AS, dis imyun sistɛm kin bi ɔva aktiv. I tan lɛk gad we de wach ɔltɛm.

We dis apin, wi bɔdi kin bigin fɔ mek mɔ wan spɛshal prɔtin we dɛn kɔl Tumor Necrosis Factor, ɔ TNF . dis TNF protin na in de mek wi joyn dεm inflameshn , we min se wi de inflameshn, swεla, rεd, εn pen. Dis na di rizin we mek jɔyn dɛn lɛk yu bak ɛn yu hip kin stif, swel, ɛn yu kin fil pen.

So wetin na dɛn TNF Inhibitors ya?

Fɔ tɔk am simpul wan, TNF inhibito na wan kayn mɛrɛsin we de ‘blɔk’ di TNF protin we wi bin dɔn tɔk bɔt bifo tɛm, we de mek pɔsin inflamɛns. Dɛn tin ya nɔ tan lɛk di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pen ɔltɛm. Di mɛrɛsin dɛn we de mek pɔsin fil pen kin jɔs stɔp di pen fɔ sɔm tɛm. Bɔt TNF Inhibitors de wok dip pas dat.

Dɔktɔ dɛn kin kɔl dɛn mɛrɛsin ya bak ‘TNF blɔk’, ‘bayolojikal’, ɔ ‘anti-TNF drɔgs’. difrεn kayn TNF inhibito dεm de we dεn apruv fכ AS:

• Adalimumab we dɛn kɔl Adalimumab
• Certolizumab we dɛn kɔl pegol
• Etanercept we dɛn kɔl Etanercept
• Golimumab we dɛn kɔl golimumab
• Infliximab we gɛt di sik

Yu dɔktɔ go ɔltɛm tink bɔt dis tritmɛnt we yu nɔr de kɔntrol yu sik dɛn wit pen kil (NSAID). Nɔto ɔl di TNF inhibito dɛn de wok fɔ ɔlman. Wan drɔg kin wok fayn fɔ sɔm pipul dɛn, bɔt nɔto fɔ ɔda pipul dɛn. So yu dɔktɔ kin tray difrɛn mɛrɛsin dɛn te dɛn fɛn di wan we go wok fɔ yu.

Aw dɛn kin yuz dɛn mɛrɛsin ya?

Tu men we dɛn de fɔ gi dis mɛrɛsin , we go difrɛn difrɛn wan bay di kayn mɛrɛsin we dɛn gi yu.

1. As injεkshכn כnda di skin (Injection) .

Sɔm mɛrɛsin dɛn kin kam as injɛkshɔn. Di bɛst pat na dat yu kin gi dɛn na os. Yu dɔktɔ ɔ nɔs we tren go sho yu aw fɔ gi dɛn kɔrɛkt wan. Dɛn kin gi dɛn na di skin na yu bɛlɛ ɔ yu shɔl. Di impɔtant tin na fɔ rɔta di say we di injɛkshɔn de, nɔto di sem wan ɛvri tɛm.

2. Lεk salin sכlushכn we dεn gi insay wan vein (Intravenous Infusion) .

Dɛn kin gi mɛrɛsin lɛk Golimumab ɛn Infliximab as salin sɔlvushɔn insay wan vein. Dis kin mek yu go na ɔspitul ɔ say usay dɛn kin put infushɔn. Dis tritmɛnt kin tek sɔm awa. Bɔku tɛm, di dɔktɔ go gi yu di mɛrɛsin fɔ lɛk tu awa so ɛn afta dat i go de wach yu fɔ tu awa mɔ fɔ si if yu gɛt siriɔs alɛji. Yu kin nid fɔ tek dis tritmɛnt ɛvri tu wiks fɔs, bɔt dis tɛm kin ridyus as tɛm de go.

Wetin na di bɛnifit dɛn we TNF Inhibitors gɛt?

Stɔdi dɔn sho se pipul dɛm wae gɛt AS kin gɛt bɔrku bɛnifit frɔm dis tritmɛnt.

• Di pen kin ridyus bad bad wan.
• di joyn fכnshכn εn fכ fleksibul impruv.
• Di sayn dɛm lɛk fɔ mek yu jɔyn dɛn stif na mɔnin ɛn fɔ swel kin go dɔŋ.
• I de ridyus di inflamɛns we de rawnd di spayna ɛn ɔda jɔyn dɛn.
• I de slo fɔ pwɛl di jɔyn dɛn we go de sote go as tɛm de go.

Bɔku pipul dɛn kin bigin fɔ notis difrɛns afta dɛn jɔs dɔn tek di mɛrɛsin tu ɔ tri dos. Bɔt sɔntɛnde, i kin tek tri mɔnt fɔ si di ful ifɛkt we dis mɛrɛsin gɛt. So, i impɔtant fɔ peshɛnt wit di tritmɛnt.

Wi no bak bɔt di bad tin dɛn we kin apin to wi.

Lɛk ɛni mɛrɛsin, dis wan kin gɛt sayd ɛfɛkt. Bɔt bɔku pipul dɛn kin jɔs gɛt smɔl smɔl sayd ɛfɛkt dɛn. Di tin we impɔtant pas ɔl na fɔ no bɔt dis ɛn tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni prɔblɛm.

Bikɔs dɛn mɛrɛsin ya de mek wi nɔ ebul fɔ fɛt di sik dɛn we de ambɔg wi bɔdi, dat kin mek wi nɔ ebul fɔ fɛt di jem dɛn smɔl. Dis kin mek di risk fɔ gɛt infɛkshɔn smɔl smɔl .

Risk de fɔ mek TB (TB) kam bak. Nɔ wɔri, yu dɔktɔ go tɛst yu fɔ TB ɛn ɔda infɛkshɔn bifo yu bigin dis mɛrɛsin.

Dis dɔŋ ya na sɔm kɔmɔn sayd ɛfɛkt dɛm we kin apin.

Sɔntɛnde, dis mɛrɛsin kin mek yu gɛt kansa na yu skin smɔl (nɔto melanoma skin kansa), so yu dɔktɔ go no bɔt dat bak.

Udat nɔ fɔ yuz dis mɛrɛsin?

TNF Inhibitors nɔ fayn fɔ ɔlman. Yu dɔktɔ nɔ go gi yu dɛn if yu gɛt ɛni wan pan dɛn tin ya:

• If yu na mama we de gi pikin in bɛlɛ .
• Naw yu gɛt wan aktif infɛkshɔn.If wan aktif infεkshכn de.
• If yu gɛt histri bɔt sik dɛn lɛk lupus ɔ multiple sclerosis .
• If yu gɛt kansa ɔ prɛkansa sɛl (dis kin difrɛn difrɛn wan bay di dɔktɔ in disayd fɔ kes dɛm we gɛt kansa we dɔn pas 10 ia ɛn we dɛn dɔn trit ɛn mɛn).
• If yu gɛt histri fɔ gɛt siriɔs at sik .

Yu tink se dɛn kin yuz dɛn tin ya we uman gɛt bɛlɛ?

Dis na impɔtant kwɛstyɔn fɔ bɔku pipul dɛn. Stɔdi dɔn sho se bɔku pan dɛn mɛrɛsin ya nɔ bad fɔ yuz we uman gɛt bɛlɛ. כltu, sכm mεdikal dεm, spεshal wan insay di sεkכn כ tכd trimεst we di bεlε de kכros, kin kכros di plasεnta to di pikin.

So if yu de op fɔ bɔn pikin, fɔ tru, tɔk to yu dɔktɔ we de mɛn yu rεumatɔlɔji bɔt dis. I kin ebul fɔ tɛl yu wan mɛrɛsin we bɛtɛ fɔ yu, lɛk Certolizumab, we nɔ de krɔs di plasnta.