Na nɔmal tin fɔ mek ɛnibɔdi fred smɔl we i yɛri di wɔd brɔst kansa. Bɔt di impɔtant tin we wi fɔ no na dat nɔto ɔl di bɔdi kansa dɛn na di sem. Difrɛn kayn dɛn de. Tide wi go tɔk bɔt wan kayn we nɔ kin bɔku ɛn we nid spɛshal atɛnshɔn we dɛn de trit am. Wi kin kɔl dis ‘Triple-Negative Breast Cancer’ (TNBC fɔ shɔt). Fɔ yɛri dis nem kin tan lɛk se i nɔ izi fɔ yu, bɔt nɔ fred. Wi go tɔk bɔt dis rili simpul wan, di we we yu go ɔndastand.
Wetin mek dɛn kɔl dis ‘Triple-Negative’?
Okay, mek wi stat wit di minin of dis nem. Fɔ ɔndastand dis, wi nid fɔ gɛt smɔl aidia bɔt aw di nɔmal bɔdi kansa sɛl dɛn de wok.
Imajin se di sɛl dɛn na wi bɔdi tan lɛk domɔt. Dɛn domɔt dɛn de gɛt lɔk dɛn we de ol ki dɛn. Insay mεdikal, wi kin kכl dεn kihol dεm ya 'rεsεpכta'. we di ki dεm we de mach dεn rεsεpכta dεm ya kam εn kכnekt, dεn sεl dεm de gεt sכm mεsej dεm.
tri kayn rεsεpכta dεm de we mεntal implεnt fכ brεst kεnsar.
1. di εstrojen rεsεpכta dεm (ER): dεn wan ya de kכl di uman כmon εstrojen.
2. Progesterone Receptors (PR): Dɛn tin ya gɛt fɔ du wit ɔda uman ɔmon we dɛn kɔl progesterone.
3. HER2 rεsεpכta dεm: dis na rεsεpכta we de tay pan wan protin we dεn kכl HER2. dis protin de kכntro di growth fכ di brεst sεl dεm.
pan bכku kayn bכdi kεnsar, wan, tu, כ כl tri pan dεn rεsεpכta dεm ya de כva εksprεs. Dis min se dɛn ɔmon ɛn prɔtin ya de ɛp di kansa sɛl dɛn fɔ gro. I tan lɛk se yu de ad fiul to faya. So we dɔktɔ dɛn de trit dɛn kansa ya, dɛn kin tɔch dɛn riseptɔ dɛn ya ɛn gi dɛn mɛrɛsin we de blok dɛn (targeted therapy). Dɛn drɔgs ya kin lɔk dɛn ‘kihol’ dɛn de. Dɔn di kansa sɛl dɛn nɔ kin gɛt di mɛsej dɛn we dɛn nid fɔ gro.
Fɔ tɔk am simpul wan, ‘tripul-nɛgitiv’ min se dɛn kansa sɛl ya nɔ gɛt ɔl di tri risɛptɔ dɛn we wi bin dɔn tɔk bɔt (ɛstrojen, prɔjɛstɛron, ɛn HER2) . ‘Negativ’ min ‘nɔ’. I ‘triple-negative’ bikɔs i nɔ gɛt ɔl tri.
Naw yu go dɔn ɔndastand usay di prɔblɛm de? di usual dכg dεm we de tכk to di rεsεpכta dεm nכ de wok fכ dis kayn kεnsar. Bikɔs no risɛptɔ nɔ de fɔ tɔch. Dis na di men chalenj wit TNBC kansa. Bɔt dat nɔ min se dɛn nɔ go ebul fɔ trit am. Ɔda tritmɛnt dɛn de we go ɛp dis, ɛn wi go tɔk bɔt dat leta.
Wetin na di sayn dɛm fɔ dis kansa?
Di sayn dɛm fɔ triplɛ-nɛgitiv bɔdi kansa rili fiba di wan dɛm fɔ ɔda bɔdi kansa. If yu notis ɛnitin we nɔ kɔmɔn na yu bɔdi, i impɔtant fɔ pe atɛnshɔn.
If yu gɛt wan ɔ mɔ pan dɛn sik ya, duya nɔ panik ɛn go to dɔktɔ kwik kwik wan. If yu gɛt dɛn kayn sik ya, dat nɔ min se na kansa, bɔt i fayn fɔ mek dɛn chɛk yu.
| Di sayn we de sho se di sik de | Simpul ɛksplen |
|---|---|
| Nyu lump ɔ tik na di bɔdi | Somtin laik lump we neva de bifo, we dem kech fo han. |
| Brest ɔ nipple pen | Pen we kin de ɔltɛm, we pɔsin nɔ kin ɛksplen. |
| Brest skin kin chenj | Dipling, rɛd, tik, ɔ dray na di skin, we tan lɛk ɔrɛnj pil. |
| Nipple invashɔn | wan nipl we bin de nכmal bifo de sink insay. |
| Di wata we de kɔmɔt na di nipple | Blɔd ɔ ɔda wata we de lik frɔm di nipple we yu nɔto mama we de gi pikin in bɛlɛ. |
| Brest we de swel | di brεst de swεla, i kin swεla כl pat pan am. |
| Lumps na di armpit ɔ nia di kolabon | Lump dεm we de kכz bay we di limf no dεm de swel. |
Mɛmba se, we dɛn tek mammogram ɔltɛm, i kin no se kansa bifo ɛni sayn we de sho se i gɛt kansa. So, i rili impɔtant fɔ mek yu gɛt skrinin we fit yu ej di rayt tɛm.
Wetin na di tin dɛm wae kin mek yu gɛt dis kansa ɛn tin dɛm wae kin mek yu gɛt dis kansa?
Di wan dɛn we de stɔdi bɔt dis nɔ dɔn fɛn ɛni patikyula tin we kin mek pɔsin gɛt dis kansa yet, bɔt dɛn dɔn si se strɔng tin de bitwin am ɛn di jin dɛn.
in patikyula, strכng link de bitwin mכtεshכn dεm na di jin dεm BRCA1 εn BRCA2 εn TNBC. nכmal wan, dεn BRCA jin dεm ya de rispansabl fכ kכntro di growth fכ kεnsar na wi bכdi. Lɛk di brek sistem na motoka. We difεkt כ mכtεshכn de na dεn jin dεm ya, di ebul fכ kכntrכl kεnsar de lכs. Wi kin gɛt dɛn jin muteshon ya frɔm wi mama ɛn papa.
Apat frɔm dis, sɔm ɔda tin dɛn de we kin mek pɔsin gɛt TNBC kansa.
| Risk factor | Tɔk bɔt |
|---|---|
| Ej | I kin mɔs bi pan yɔŋ uman dɛn we nɔ rich 40 ia yet.(Bɔt i kin kam pan ɛni ej.) |
| BRCA jin mכtεshכn dεm | di risk de hכy spεshal if BRCA1 jin mכtεshכn de inhεrit. |
| Ras/etnik we dɛn kɔmɔt | Risach we dɛn dɔn du ɔlsay na di wɔl sho se dis kansa kin bɔku pan uman dɛn we kɔmɔt na Afrika ɔ Hispanik. |
Aw dɔktɔ kin no bɔt dis?
We yu go to dɔktɔ bɔt wan brɔst lump, i go fɔs chɛk yu bɔdi. Dɔn, dɛn go aks yu bɔt yu sik dɛn. Apat frɔm dat, dɛn go ɔda fɔ mek dɛn du bɔku tɛst fɔ no if pɔsin gɛt di sik.
- Mammogram: Na ɛkstrem raytin fɔ di bɔdi.
- Breast Ultrasound: na we dεn de yuz sawnd wev fכ tek imej fכ di tisu dεm we de insay di brεst.
- Breast MRI: Na wan we we dɛn kin yuz magnɛtik fil ɛn redio wev fɔ mek dɛn mek pikchɔ dɛn we klia ɛn we gɛt mɔ ditayli.
If dɛn skan ya sho se pɔsin gɛt kansa, di nɛks tɛst we impɔtant pas ɔl na fɔ tek bayɔpsi . Dis involv fɔ tek wan rili smɔl pat pan di tisu frɔm di suspicious lump yuz smɔl nidul ɛn chɛk am ɔnda maykroskɔp.
bayopsi na di onli we fכ 100% kכnfכm if dis na kεnsar כ nכ. כlso, di onli we fכ no fכ sכri if dis na TNBC na fכ egzamin dis pis tisu εn si if i gεt di tri rεsεpכta dεm we wi bin tכk bכt (ER, PR, HER2).
Apat frɔm dat, yu dɔktɔ kin rifer yu bak fɔ mek dɛn du yu jenɛtik tɛst fɔ chɛk fɔ si if yu gɛt chenj dɛn na yu jɛnɛtiks, lɛk BRCA. Dɛn kin yuz ɔl dis infɔmeshɔn fɔ no di stej we yu kansa gɛt ɛn fɔ mek di tritmɛnt plan we go fayn fɔ yu.
Wetin na di tritmɛnt dɛm fɔ dis?
Pan ɔl we prɔblɛm dɛn de fɔ trit TNBC kansa, bɔku tritmɛnt dɛn de naw we rili wok. Yu dɔktɔ we de mɛn yu kansa go tɛl yu fɔ du di bɛst tritmɛnt plan bay aw yu de fil.
Di men tritmɛnt na fɔ pul di kansa tumbu tru ɔpreshɔn. Apat frɔm dat, dɛn kin yuz wan ɔ mɔ pan dɛn tritmɛnt ya togɛda.
- Kimotɛrapi: Dis na wan pan di men ɛn di bɛst tritmɛnt fɔ TNBC. Dɛn kin gi kemotɛrapi bifo dɛn du di ɔpreshɔn fɔ mek di tumbu smɔl (neoadjuvant kemotɛrapi) ɛn afta dɛn du di ɔpreshɔn fɔ kil ɛni kansa sɛl we lɛf ɛn mek di sik nɔ kam bak (adjuvant kemotɛrapi).
- Radiation Therapy: Afta dɛn dɔn du ɔpreshɔn, dɛn kin put ay ɛnaji rayt na di say we di kansa bin fɔ dɔnawe wit ɛni kansa sɛl we lɛf.
- Immunotherapy: Dis na nyu tritmɛnt. I de wok bay we i de mek wi bɔdi in yon imyun sistɛm no ɛn atak di kansa sɛl dɛn. Fɔ sɔm TNBC pasɛnt dɛn, dɛn kin gi dis tritmɛnt togɛda wit kemotɛrapi fɔ mek dɛn gɛt rili gud rizɔlt.
- Targeted Therapy: Fכ TNBC pasεnshכn dεm we gεt BRCA jin mכtεshכn, dεn de yuz spεshal drog dεm lεk PARP inhibito dεm . Dɛn tin ya kin wok bay we dɛn kin ambɔg di we aw di kansa sɛl dɛn kin ebul fɔ mek dɛnsɛf fayn.
Naw, bɔku klinik trial de ɔlsay na di wɔl fɔ TNBC. Dɛn de fɛn nyu drɔgs ɛn nyu tritmɛnt dɛn ɔltɛm. So, wi kin gɛt gud op fɔ dis sik tumara bambay.
Tin dɛn we yu fɔ tink bɔt afta yu dɔn trit yu
Afta dɛn dɔn ɔpreshɔn ɔ ɔda tritmɛnt, sɔm tɛm dɛn kin gɛt prɔblɛm dɛn. Fɔ ɛgzampul, di wund we dɛn du di ɔpreshɔn kin gɛt infɛkshɔn ɔ blɔd kin klɔt. So, if yu gɛt ɛni wan pan dɛn sik ya, go to yu dɔktɔ wantɛm wantɛm.
| Ustɛm fɔ go to dɔktɔ wantɛm wantɛm | |
|---|---|
| Sayn dɛn we de sho se pɔsin gɛt infekshɔn |
|
| Di sayn dɛn we de sho se blɔd dɔn rɔtin | Wan leg kin swel wit pen, i nɔ kin izi fɔ blo. |
| Sɔm bad bad tin dɛn we kin apin to pɔsin | If di sayd ɛfɛkt dɛm fɔ tritmɛnt (e.g. vɔmit, dayarɛa) tu siriɔs fɔ bia. |
Tin dɛm wae yu kin du fɔ gɛt wɛl bɔdi wae yu de trit yu
Tritmɛnt fɔ kansa na tin we kin rili strɛs, pan bɔdi ɛn maynd. Sɔm tin dɛn de we kin ɛp yu fɔ fil fayn smɔl insay dis tɛm.
- Layt ɛksesaiz: Layt aktiviti dɛm lɛk fɔ waka ɛn yoga kin ɛp fɔ ridyus strɛs ɛn bak kin gi yu bɔdi gud trɛnk.
- Gud it: It it we gɛt fayn fayn tin dɛn we nɔ gɛt bɛtɛ prɔtin (fish, chukchuk), frut, vɛjitebul, ligɛm, ɛn ɔl gren (brawn rays, ɔtmil). Drink bɔku wata.
- Fɔ mek yu gɛt wɛl bɔdi: Risach dɔn sho se fɔ gɛt wɛl bɔdi we fit yu na gud sɔpɔt fɔ tritmɛnt.
- Saikɔlɔjik sɔpɔt:Tɔk to yu fambul ɛn yu tayt padi dɛn bɔt aw yu de fil, aw yu de fred, ɛn aw yu de wɔri. If nid de, go to pɔsin we de advays yu bɔt mental wɛlbɔdi biznɛs.
If di sayd ɛfɛkt dɛm we di tritmɛnt kin gɛt bad bad wan, nɔ shem fɔ tɔk to yu mɛdikal tim bɔt am. Dɛn dɔn mekɔp dɛn maynd fɔ sɔpɔt yu tru dis tranga tɛm.
Mɛsej we dɛn kin kɛr go na os
- tripl-nεgεtiv brεst kεnsar (TNBC) na wan spεsifi k tכp brεst kεnsar we nכ gεt כl di tri rεsεpכta dεm: εstrojen, projεstεron, εn HER2.
- So, kɔvɛnshɔnal ɔmon tɛrapi ɛn HER2-target tɛrapi nɔ kin wok fɔ dis.
- If yu notis ɛni chenj we nɔ kɔmɔn na yu brɔst (wan lump, pen, skin chenj), nɔ panik ɛn go to dɔktɔ wantɛm wantɛm. Di kwik we dɛn no am, na di mɔ di tritmɛnt go wok fayn.
- Bɔku fayn tritmɛnt dɛn de fɔ dis, lɛk kemotɛrapi, ɔpreshɔn, redyushɔn tɛrapi, ɛn di mɔdan tritmɛnt dɛn lɛk imyunotɛrapi.
- Pan ɔl we dis na sik we nɔ izi, we di mɛrɛsin dɛn we dɛn de yuz tide dɔn go bifo, dɛn de fɛn nyu tritmɛnt dɛn ɔltɛm. So nɔ giv ɔp fɔ gɛt op.
- Trɔst yu mɛdikal tim, ansa dɛn kwɛstyɔn dɛn ɔnɛs wan, ɛn aks dɛn bɔt di tin dɛn we de mɔna yu. Nɔto yu wan de na dis waka.
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