Obulwadde bwa Evans Syndrome kye ki? Ka twogere ku nsonga eno!

Oluusi owulira ng’okooye? Oba olina obuzibu okukomya omusaayi ne bwe guva mu bintu ebitonotono? Mpozzi kiva ku kuba nti abaserikale b’omubiri gwo bakukolako. Leero tugenda kwogera ku mbeera bwetyo etali ya bulijjo naye nga nkulu nnyo okumanya. Oyo ye Evans Syndrome . Teweeraliikiriranga, buli kimu tujja kwogera mu bigambo ebyangu.

Kale, obulwadde bwa Evans Syndrome kye ki?

Mu ngeri ennyangu, Evans Syndrome bulwadde obuva ku busimu obuziyiza endwadde . Ekibaawo abaserikale abalina okukuuma omubiri gwaffe, abaserikale b’omubiri, mu nsobi batandika okusaanyaawo obumu ku butoffaali bwaffe obw’omusaayi. Kiringa eggye lyaffe lyenyini okulumba abantu baffe. N’ekyavaamu, omubiri gwaffe gufiirwa obutoffaali bw’omusaayi obwetaagisa. Okukendeera kuno okutali kwa bulijjo mu butoffaali bw’omusaayi kye tuyita cytopenia mu ddagala.

Abantu abasinga obungi abalina obulwadde bwa Evans Syndrome basooka kukwatibwa obutoffaali obumyufu obutono (embeera eyitibwa anemia ) n’obutoffaali obuyitibwa platelets (embeera eyitibwa thrombocytopenia ). Ng’oggyeeko byombi, abantu abamu bayinza n’okuba n’omuwendo omutono ogw’ekika ky’obutoffaali obweru obuyitibwa neutrophils (embeera eyitibwa neutropenia ).

Ebika by’obutoffaali buno bwe biba bitono, ebintu bingi ebikulu mu mubiri gwaffe, gamba ng’okufuna omukka gwa oxygen, okuzimba omusaayi, n’okulwanyisa endwadde, bikosebwa. Eno y’ensonga lwaki tuwulira nga tunafuye, nga tukooye, tutandika okuvaamu omusaayi amangu, era tutera okulwala .

Embeera eno esobola okukwata abantu abamu mu ngeri etali ya maanyi nnyo, ate abalala eyinza okuba ey’amaanyi ennyo. Era ebivaamu tebiwangaala mu ngeri y’emu mu bulamu bwonna. Ekisinga obulungi kiri nti wadde nga tewali ddagala eriwonya, obujjanjabi busobola okuyamba okufuga obubonero n’okukendeeza ku buzibu obuvaamu .

Bubonero ki obulaga obulwadde bwa Evans Syndrome?

Obubonero bw’obulwadde bwa Evans Syndrome busobola okwawukana ennyo. Kisinziira ku kika kya cytopenia ky’olina n’engeri gye kiri eky’amaanyi. Ebiseera ebisinga, okukendeera kw’omusaayi oba okukendeera kw’obutoffaali obukola omusaayi (thrombocytopenia) kusooka kubaawo, ate ebirala ne birabika oluvannyuma.

Obubonero obusooka obw’obutaba na butoffaali obumyufu ( anemia ):

Okooye ne bw’oba ​​otambudde akabanga katono? Owulira ng’okooye era nga tosobola kukola bintu bye wali okola? Mpozzi ffeesi yo eringa eyaka katono. Buno bwe bumu ku bubonero obusooka obw'okubulwa omusaayi :

• Just okuwulira obukoowu obuyitiridde .
• Olususu olumyufu (olumyufu) .
• Okuziyira oba okuziyira .
• Obuzibu mu kussa (okusannyalala) .
• Omutima okukuba amangu (tachycardia) .
• Okuwulira oba okuwulira ng’omutima gwo gukuba mu ngeri etaali ya bulijjo (omutima okukuba) .

Obubonero obusooka obw’obutaba na buwuka obuleeta omusaayi (thrombocytopenia):

Okirabye nti oluusi obutundutundu obutono obumyufu bulabika ku lususu lwo? Oba omala kufuna biwundu ku mubiri gwo gwonna? Owulira ng’ennyindo zo zivaamu omusaayi okusinga bulijjo ng’osenya amannyo? Buno bwe bubonero obuyinza okulabika ng’olina obulwadde bwa platelets obutono:

• Obutundutundu obutono obumyufu obuvaamu omusaayi (petechiae) wansi w’olususu.
• Amabala aga kakobe ku lususu (purpura) .
• Okunyiga (ecchymosis) okubaawo awatali nsonga.
• Okuvaamu omusaayi omungi okuva mu nnyindo oba mu nnyindo.
• Okuvaamu omusaayi omungi nga bagenda mu nsonga mu bakyala.
• Okuvaamu omusaayi n’omusulo oba omusulo.

Obubonero bw’okukendeera kw’obusimu obuyitibwa neutropenia (buno buyinza okubaawo oba obutabaawo oluvannyuma):

Kya bulijjo okufuna omusujja oba bbiri omwezi. Naye otera okulwala omusujja? Ofuna amabwa mu kamwa buli kiseera? Kirabika zitwala ekiseera kiwanvu okuwona? Bino bye bimu ku bintu ebiyinza okubaawo nga neutrophils zo ziri wansi:

• Omusujja.
• Amabwa mu kamwa .
• Omusujja, omusujja n’okulumwa olubuto emirundi mingi.
• Obulwadde bw’amatu obuddirira.
• Obulwadde bwa ffene obumala ebbanga eddene.
• Obulwadde bw’omusulo (UTIs) .

Obubonero obulala obw’obulwadde bwa Evans Syndrome (buno buyinza okulabika oluusi n’oluusi):

• Ensigo ezizimba mu bulago.
• Ensigo ezigaziye .
• Ekibumba ekigaziye .
• Obulwadde bwa Jaundice .

Lwaki obulwadde bwa Evans Syndrome bubaawo?

Nga bwe twagambye emabegako, Evans Syndrome bulwadde obuva ku busimu obuziyiza endwadde . Kino kitegeeza nti abaserikale b'omubiri gwaffe mu bukyamu bategeera obumu ku butoffaali bwaffe obw'omusaayi nga "omulabe" ne batandika okubulumba.

Omulimu guno gukolebwa obutoffaali bwa B, ekika ky’obutoffaali obw’enjawulo mu baserikale baffe abaserikale b’omubiri. Obutoffaali buno obwa B bukola ekintu ekiyitibwa antibodies . Obuziyiza buno bugenda ne bukwata obutoffaali obwo obutaliiko musango ne bubusaanyawo. Ebiseera ebisinga, batandika okusooka okulumba ekika ky’obutoffaali bw’omusaayi ekimu, oluvannyuma ne batandika okulumba ebika by’obutoffaali ebirala.

Enkola eno y’esembayo okukuleetera obutaba na bika bya butoffaali bwa musaayi ebitakka wansi wa bibiri (cytopenia), n’oluusi byonna ebisatu. Obutabaawo mu byonna ebisatu buyitibwa pancytopenia . Embeera essatu enkulu obutoffaali buno mwe buba obutono ze zino:

• Okukendeera kw’omusaayi mu mubiri (AIHA) .: Kino obutoffaali obumyufu bwe bukendeera. Kwe kugamba, zisaanawo mangu okusinga omubiri bwe gusobola okuzikola.
• Immune thrombocytopenia (ITP) : Eno mbeera mwe wabaawo okukendeera kw’obutoffaali obukola omusaayi. Abaserikale b’omubiri balumba ne baggyawo obuwuka obuyitibwa platelets mu musaayi.
• Autoimmune neutropenia (AIN) : Eno mbeera omuwendo gwa neutrophils, ekika ky’obutoffaali obweru bwe gukendeera. Abaserikale b’omubiri balumba ne basaanyaawo obuwuka obuyitibwa neutrophils.

Lowooza ku kino, wayinza okubaawo ensonga nnyingi eziviirako obutoffaali bw’omusaayi okubeera obutono (cytopenia). Oluusi kiyinza okuba nga kiva ku busimu bw’amagumba obutakola butoffaali bumala. Kyokka mu autoimmune cytopenia, abaserikale b’omubiri basaanyaawo obutoffaali bwabwe obw’omusaayi.

Biki ebivaako obulwadde bwa Evans Syndrome?

Bannasayansi n’okutuusa kati tebamanyi bulungi lwaki endwadde zino ez’obusimu obuziyiza endwadde zikula. Naye bakirabye nti endwadde zino zitera okutandika oluvannyuma lw’obulwadde obw’amaanyi oba ekintu ekiteeka situleesi ennene ku baserikale b’omubiri. Bino biyitibwa ebiziyiza ( triggers ) .

Ate era, bw’oba ​​olina obulwadde bumu obuva ku busimu obuziyiza endwadde, mu bibalo otera okukwatibwa obulala. Kiringa obuzibu buno obw’abaserikale b’omubiri obusaasaana okuva mu kitundu ky’omubiri ekimu okudda mu kirala.

Evans syndrome esobola okubaawo ku bwayo (kino kiyitibwa primary Evans syndrome ), oba kiyinza okubaawo ng’embeera ey’okubiri ekwatagana n’embeera endala (kino kiyitibwa secondary Evans syndrome) . Ezimu ku mbeera eziyinza okukwatagana mu ngeri eno ze zino:

• Obulwadde bwa lupus erythematosus obw’omubiri (lupus) .
• Obutaba na busimu obuziyiza endwadde obukyukakyuka obumanyiddwa
• Obutabeera na IgA mu ngeri erongooseddwa
• Obulwadde bwa Sjögren
• Obulwadde bwa lymphoma obutali bwa Hodgkin
• Obulwadde bwa lymphocytic leukemia obutawona
• Obulwadde bw’ekibumba obutawona C
• Obulwadde bwa siriimu obutawona

Bw’oba ​​olina obulwadde bwa Evans syndrome obusookerwako, buyinza okuba nga bwakula oluvannyuma lw’okulwala okumala akaseera, oba oyinza obutaba na kizibu kitegeerekeka. Bannasayansi bassa obulwadde bwa Evans syndrome mu kibinja ky’obulwadde bwa idiopathic . Kino kitegeeza nti tewali kivaako butereevu kizuuliddwa.

Bizibu ki ebiyinza okuva mu bulwadde bwa Evans Syndrome?

Si buli muntu alina obulwadde bwa Evans Syndrome nti ajja kufuna ebizibu. Abantu abamu baba n’obubonero obutono ennyo. Kyokka mu mbeera ez’amaanyi, obutaba na butoffaali buno obw’omusaayi (cytopenias) buyinza okutta obulamu. Okugeza nga:

• Bwe waba tewabaawo butoffaali bumyufu bumala okutwala omukka gwa oxygen mu mubiri, mu musaayi tewabaawo oxygen emala (hypoxemia) . Kino kikaluba nnyo omutima era kiyinza okuvaako omutima okulwala n’omutima okulemererwa.
• Bw’oba ​​tolina platelets zimala , eziyamba omusaayi gwo okuzimba, omusaayi gwo teguzimba bulungi. Kino kiyinza okukuleetera okuvaamu omusaayi amangu ate mu bwangu. Kino kiyinza okuvaako amangu okukendeeza ku musaayi ogw’amaanyi.
• Omubiri gwo bwe gufiirwa obuwuka obuyitibwa neutrophils , obuyamba okulwanyisa yinfekisoni, otera okufuna yinfekisoni, era buyinza okufuuka obw’amaanyi ne busaasaana mu mubiri gwo gwonna. Kino kiyinza okuvaako embeera ey'akabi eyitibwa sepsis .

Abasawo bazuula batya obulwadde bwa Evans Syndrome?

Obulwadde bwa Evans Syndrome buzuulibwa nga bayita mu kukeberebwa omusaayi . Kiyinza okuzuulibwa singa ofuna obubonero bw’okukendeera kw’obutoffaali, oba mu kiseera ky’okubala obutoffaali bw’omusaayi okukolebwa mu kukebera obulamu okwa bulijjo.

Singa Complete Blood Count (CBC) yo eraga nti olina obutoffaali obumyufu, platelets oba neutrophils obutono, ttiimu yo ey’abasawo ejja kukola okukebera okusingawo. Okugeza, bajja kukebera omusaayi gwo oba teguliimu buwuka obuziyiza endwadde obukwatagana n’obulwadde bwa Evans Syndrome. Era bajja kukebera oba waliwo embeera endala eziyinza okuvaako cytopenia, gamba nga yinfekisoni ezimu oba kookolo.

Abasawo bakakasa obulwadde bwa Evans Syndrome nga bagaana ebirala byonna ebivaako obulwadde buno. Oluusi, era bayinza okwetaaga okukola CT scan (computed tomography scan) oba bone marrow biopsy okusobola okugaana embeera endala.

Waliwo eddagala erijjuvu eriwonya obulwadde bwa Evans Syndrome? Kijjanjabwa kitya?

Mu butuufu, tewali ddagala lyonna eriwonya Evans Syndrome, oba obulwadde obulala bwonna obuva ku busimu obuziyiza endwadde. Abasawo bajjanjaba endwadde zino ez’abaserikale b’omubiri nga bakuwa eddagala erikendeeza ku mirimu gy’abaserikale b’omubiri.

Okugatta ku ekyo, obubonero bwo buyinza okujjanjabibwa mu ngeri ey’enjawulo. Ng’ekyokulabirako, singa obutoffaali bwo buba butono nnyo, omusawo ayinza okutereeza kino ng’ateekebwamu omusaayi oluusi n’oluusi .

Okufaananako endwadde nnyingi ezimala ebbanga eddene ezikwata ku busimu obuziyiza endwadde, Evans Syndrome esobola okweyongera okutereera oluvannyuma lw’ekiseera. Oluusi obubonero buyinza okulabika ng’obugenda (buyitibwa okusonyiyibwa) , naye oluvannyuma buyinza okuddamu oba okweyongera (obuyitibwa okuddamu okugwa ).

Oyinza okwetaaga okugezaako obujjanjabi obw’enjawulo mu bulamu bwo bwonna, kubanga obuwanguzi bwabwo buyinza okwawukana okumala ekiseera. Omusawo wo ajja kufuba okukukuuma okuva ku bizibu ebisinga okuba eby’amaanyi eby’obulwadde bwa Evans Syndrome.

Obujjanjabi bwe buruwa?

Obujjanjabi obutuufu obw’obulwadde bwa Evans Syndrome bwe ddagala eriziyiza obusimu obuziyiza endwadde era bwe kiba kyetaagisa okuteekebwamu omusaayi. Eddagala lino eriziyiza abaserikale b’omubiri likola nga likendeeza ku kulumba okukyamu okukolebwa abaserikale b’omubiri bo.

Ebika by’eddagala ebikulu ebiweebwa:

• Eddagala eriyitibwa corticosteroids , nga prednisone . Ebiseera ebisinga buno bwe bujjanjabi obusooka okuweebwa.
• Obujjanjabi bwa immunoglobulin mu misuwa (IVIg) buzingiramu okuwa eddagala eririmu obutoffaali obuziyiza endwadde z’omuntu okuyita mu musuwa. Antibodies zino empya zisobola okwesiba ku autoimmune antibodies ezitali nnungi ne zizilemesa.

Bw’oba ​​toddamu bulungi bujjanjabi obwa bulijjo, omusawo ayinza okugezaako obujjanjabi obulala. Mu bino mulimu:

• Obulwadde obuziyiza endwadde obuyitibwa monoclonal antibodies , nga rituximab . Zino zibeera antibodies ezikolebwa mu laabu. Oluusi bino bisobola okuyimiriza okuddamu kw’abaserikale b’omubiri. Omusawo ayinza okukuwa amagezi ku bino singa eddagala eddala terikola.
• Okuggyibwako omusulo . Mu mbeera enzibu, omusawo ayinza okukuwa amagezi okulongoosebwa okuggyamu enseke. Ensigo yo mwe muggyibwamu obutoffaali obukadde obw’omusaayi. Kale enseke bwe ziggyibwamu, enkola eno ekendeera katono.

Waliwo ebizibu oba ebizibu ebiva mu bujjanjabi buno?

Bw’omira eddagala eriweweeza ku busimu bw’omubiri, abaserikale b’omubiri bo bwe baddamu obulwadde bwo obw’abaserikale b’omubiri bukendeera. Kyokka n’obuziyiza bwo eri yinfekisoni bukendeera . N’olwekyo ojja kwetaaga okwegendereza okw’enjawulo okwewala okulwala.

Omusawo ayinza okukuwa amagezi okukozesa eddagala eddala erigema ng’oggyeeko eryo lye wafuna edda. Abaserikale b’omubiri bwo bwe banafuwa (immunocompromised), oyinza okukwatibwa ennyo endwadde z’otoyinza kufuna mu budde obwa bulijjo.

Okubeera n’obulwadde bwa Evans Syndrome kikosa obulamu?

Obulwadde bwa Evans Syndrome tekitegeeza nti bukwata ku bulamu bwo. Abantu abamu baba n’obubonero obutono ennyo, oluusi n’oluusi. Kyokka ebizibu ebimu, gamba ng’okuvaamu omusaayi, endwadde z’omutima, n’okukwatibwa yinfekisoni, biyinza okutta omuntu.

Bw’oba ​​olina obulwadde bwa Evans syndrome obw’okubiri, ekitegeeza nti olina n’embeera endala etali ya bulijjo, nayo eyinza okukosa obulamu bwo. Oyinza okuba n‟ebizibu ebiyinza okutta obulamu bwo ebijja n‟embeera yo endala.

Endowooza etya eri omuntu alina obulwadde bwa Evans Syndrome?

Ebintu abantu abalina obulwadde bwa Evans Syndrome bye bayitamu byawukana nnyo. Obubonero buyinza okuba obutono oba obw’amaanyi. Abantu abamu bawulira ng’obubonero bwabwe bugenda ddala (okusonyiyibwa). Abalala baddamu okuzifuna oluvannyuma (okuddamu okuzifuna).

Abantu bangi beetaaga obujjanjabi obw’engeri emu oba endala n’okukeberebwa abasawo buli kiseera. Obujjanjabi butera okukola obulungi, naye si bulijjo. Oluusi, obulungi bw’obujjanjabi buyinza okulabika ng’obukendeera okumala ekiseera. Oyinza okwetaaga okugezaako obujjanjabi obulala.

Nkola ntya okwerabirira nga mbeera n’obulwadde bwa Evans Syndrome?

Bw’oba ​​olina obulwadde bwa Evans Syndrome, kikulu okusigala ng’ogenda mu maaso n’okukeberebwa kw’abasawo buli kiseera . Ne bw’oba ​​owulira bulungi, omusawo ajja kwagala okulondoola embeera yo n’agikwata nga bukyali singa yeeyongera okusajjuka.

Ekirala, bulijjo olina okwefaako n’okutunuulira obubonero bwonna obupya. Bw’oba ​​olina omusujja ogutawona, oba ng’ovaamu omusaayi ogutayinza kufugibwa, kuba essimu y’omusawo amangu ago .

Bibuuzo ki bye nnina okubuuza omusawo wange?

Oyinza okwagala okubuuza omusawo ebibuuzo nga bino:

• Butoffaali bwa bika ki bwe mbulwa?
• Zikendedde kimeka?
• Bubonero ki oba bubonero ki obulabula bwe nnina okwegendereza?
• Ntegeera ntya oba obujjanjabi bukola oba nedda?
• Kiki ekibaawo singa obujjanjabi tebukola?
• Ddi lwe nnina okuteeka essaawa y’omusawo eddako?

Evans Syndrome mbeera etali ya bulijjo gy’oyinza okuba nga towulirangako. Obubonero buno buyinza okuba obw’ekyewuunyo era nga butaataaganya. Okutegeera ekigenda mu maaso ne kye kitegeeza kiyinza okuba ekizibu ekitono.

Wadde ng’obulwadde bwa Evans Syndrome bulwadde bwa bulamu bwonna, si bulijjo nti y’emu. Kuuma essuubi nti ojja kuwulira bulungi, waakiri oluusi. Ne bw’owulira otya, ttiimu yo ey’abasawo ejja kubaawo okukuwa obujjanjabi bw’olina.

Obubaka Obusembayo Okutwala Awaka

Okay, kale ka tukujjukize ebimu ku bintu ebikulu bye twogeddeko.

• Obulwadde bwa Evans Syndrome kye ki?Obulwadde obutatera kulabika ng’abaserikale b’omubiri bo bennyini balumba obutoffaali bwo.
• Kino kiyinza okuvaako obutoffaali obumyufu ( anemia ), platelets (thrombocytopenia), era oboolyawo neutrophils (neutropenia) okukendeera.
• Obubonero ng’okukoowa ennyo, okufuuka omuddugavu, okunyiga amangu, okuvaamu omusaayi ennyo, n’okukwatibwa yinfekisoni enfunda eziwera .
• Wadde nga tewali ddagala lyonna eriwonya kino, obubonero busobola okufugibwa n’obujjanjabi .
• Kikulu nnyo okugoberera amagezi g’abasawo buli kiseera n’okufaayo ku bubonero.
• Toli wekka. Abasawo bo n’abaagalwa bo bajja kukuyamba. Era kikulu nnyo okusigala ng’olina endowooza ennungi.

Nsuubira nti amawulire gano gakuyamba. Bw’oba ​​olina ekibuuzo kyonna, tolwawo kwogera na musawo wo.

Evans syndrome, obulwadde bw’abaserikale b’omubiri, okukendeeza ku busimu obuyitibwa cytopenia, okukendeeza ku musaayi, okukendeeza ku busimu obuyitibwa thrombocytopenia, neutropenia, obuzibu mu musaayi