Omusaayi gwo guzimba awatali nsonga? Ka tuyige ebisingawo ku Factor V Leiden Thrombophilia!

Emibiri gyaffe gyonna si gye gimu, nedda? Oluusi tuyinza okuba n’enjawulo entonotono mu mibiri gyaffe nga tetumanyi na. Leero tugenda kwogera ku mbeera emu ng’eyo ey’obusika, ereetera omusaayi gwaffe okuzimba ennyo katono, ekitegeeza nti gutera okuzimba nga tekyetaagisa. Kino kiyitibwa Factor V Leiden Thrombophilia .

Kale Factor V Leiden kye ki?

Mu ngeri ennyangu, buno buzibu bwa kusikira omusaayi . Kwe kugamba, ozaalibwa n’enkyukakyuka mu buzaale bwo. Enkyukakyuka eno ereetera omusaayi gwo okuzimba okusinga ogwa bulijjo. Kino kikuteeka mu bulabe obw’amaanyi obw’okufuna embeera nga:

• Obulwadde bwa Deep Vein Thrombosis (DVT): Kino we wabaawo ebizimba by’omusaayi mu misuwa emiwanvu egy’omubiri gwo naddala mu magulu oba mu mikono gyo. Kyokka oluusi zisobola okutondebwa mu misuwa mu bifo ng’ekibumba, ensigo, obwongo n’amaaso.
• Pulmonary Embolism (PE) : Kino kya bulabe katono. Ekibaawo wano, ekimu ku bikuta by’omusaayi ebyogeddwako waggulu, oba omusaayi ogukoleddwa awalala, ne gusumululwa, ne gutambula mu musaayi, ne gusibira mu limu ku mawuggwe go.

Naye wuuno ekintu, just because you have this condition tekitegeeza nti definitely ojja kufuna DVT oba PE . Mu butuufu, abantu nga mwenda ku buli kkumi abalina embeera eno tebajja kufuna kuzimba musaayi mu ngeri etaali ya bulijjo mu bulamu bwabwe. Wabula kikulu okukitegeera nti oli mu bulabe katono okusinga abalala.

Obuzibu bw'embeera eno eya `Factor V Leiden` bwawukana mu mawanga ag'enjawulo. Okutwalira awamu bulabibwa nnyo mu bazungu mu Amerika ne Bulaaya.

• Abantu nga 5 ku buli 100 abava mu Bulaaya.
• Abantu nga 2 ku buli 100 abasibuka mu Hispanic.
• Abantu nga 1 ku buli 100 nga muddugavu oba Native American.
• Mu bantu abava mu Asiya, tekiwera 1 ku buli 100.

Wabula abantu nga omu ku buli bataano abalina okuzimba omusaayi mu misuwa gyabwe azuuliddwa ng’alina enkyukakyuka y’obuzaale eya `Factor V Leiden`. Kino kiyitibwa ``Factor V Leiden.'' Ennukuta V eyimiridde ku namba y'Oluruumi ku ttaano.

Bubonero ki obulaga embeera eno?

Wano waliwo ekintu ky’olina okujjukira: Enkyukakyuka eno ey’obuzaale yokka tereeta bubonero bwonna . Osobola okukifuna obulamu bwo bwonna nga tokimanyi. Kyokka nga bwe kyayogeddwako emabegako, obubonero bulabika singa wabaawo ekizimba ky’omusaayi.

Ekikulu: Bw’oba ​​olowooza nti olina obubonero bwa `DVT` oba `PE`, kuba 911 oba ennamba yo ey’amangu mu kitundu kyo mu bwangu . Bwe kitaba ekyo, genda mu kitongole ky’abalwadde ab’amangu mu ddwaaliro ekikuli okumpi amangu ddala nga bwe kisoboka n’omuntu. Kino si kintu kya kuggyawo.

Obubonero bw’okuzimba emisuwa emiwanvu (DVT) buyinza okuli:

• Okuzimba ekigere oba omukono, okuwulira ng’olina ebbugumu ng’okwatako, n’okukyuka mu langi y’olususu (oboolyawo okufuuka emmyufu oba bbululu).
• Okuwulira obulumi ng’okwata ku kigere oba omukono ogwo, obulumi ng’onyiga .
• Emisuwa wansi w'olususu eminene okusinga ku gya bulijjo era nga girabika kungulu .
• Singa omusaayi guzimba mu misuwa egiri munda mu lubuto, oyinza okulumwa olubuto oba okulumwa mu lubuto .
• Singa omusaayi guzimba mu bwongo, guyinza okuvaako okulumwa omutwe okw’amangu, okw’amaanyi ne/oba okukonziba .

Obubonero bw’okuzimba amawuggwe (PE) buyinza okuli:

• Okukaluubirirwa okussa mu bwangu .
• Obulumi obw’amaanyi mu kifuba ng’ossa omukka omungi, ng’osesema oba ng’osesema.
• Okusesema, oluusi n’omusaayi omutono ogufuluma wamu n’omusulo .
• Eddoboozi ery’okuwunya ng’ossa.
• Omutima okukuba amangu ennyo (tachycardia) .
• Okuwulira nga weeraliikirira era nga towummudde .
• Okuwulira ng’oziyira, okuwulira ng’ogenda okuggwaamu amaanyi (tekitera kubaawo, oyinza n’okubulwa ekizibu) .

Kiki ekivaako Factor V Leiden?

Ensonga enkulu lwaki kino kibaawo ye nkyukakyuka y'obuzaale . Waliwo protein mu mubiri gwaffe eyamba omusaayi okuzimba, eyitibwa `Coagulation factor V` . Okubeera omutuufu, kiyamba okulekera awo okuvaamu omusaayi nga waliwo obuvune. Kale, omubiri gwaffe gulagirwa okukola puloteyina eno okuva mu ggiini eyitibwa `F5` .

Mu budde obwabulijjo, ffenna tusikira kkopi bbiri eza bulijjo ez’obuzaale buno obwa `F5`. Naye singa osikira kkopi emu oba eziwera ezitali za bulijjo ez’obuzaale buno, kigambibwa nti olina enkyukakyuka ya `Factor V Leiden` (oluusi eyitibwa `mutation`). Erinnya `Leiden` liva mu kibuga Leiden mu Budaaki abanoonyereza gye baazudde enkyukakyuka eno ey’obuzaale.

Enkyukakyuka eno ey’obuzaale eya `Factor V Leiden` ereeta enkyukakyuka entono mu nsengekera mu puloteyina ya `factor V` ekolebwa mu mubiri gwaffe. Olw’enkyukakyuka eno, puloteyina eno eyakyusiddwa eya `factor V` egumira ekikolwa kya puloteyina endala bbiri enkulu ezifuga okuzimba omusaayi , Protein C (`Protein C`) ne Protein S (`Protein S`) . Mu ngeri ennyangu, obutoffaali obwo obufuga tebusobola kukikomya. Olwo, puloteyina ya `factor V` ekola nnyo okusinga bwe yandibadde, era omusaayi ne gutandika okuzimba mu ngeri eteetaagisa, ne bwe kiba nga tekikyetaagisa.

Kino kintu ekiyita mu maka okudda mu mulala?

Yee, ddala. Embeera eno osobola okugisikira okuva ku maama wo oba kitaawo, oba byombi. Ensonga V Leiden esikira mu nkola y’obusika efugira mu autosomal.Ekyo kitegeeza nti ne bw’oba ​​ofuna enkyukakyuka eno ey’obuzaale etali ya bulijjo okuva ku omu ku bazadde bo yekka, okyayinza okusikira embeera eno.

Abantu abasinga obungi (abalina Factor V Leiden) basikira kkopi emu yokka etali ya bulijjo ey’obuzaale. Kino kiyitibwa heterozygous . Si bulijjo nnyo, osobola okusikira kkopi zombi ezitali za bulijjo ez’obuzaale okuva ku maama wo ne taata wo. Kino kiyitibwa homozygous .

Biki ebirala ebyongera ku bulabe bw’okuzimba omusaayi?

Omuntu alina Factor V Leiden ayinza okulwala omusaayi singa:

• Bw’oba ​​osikira kkopi zombi ez’obuzaale bwa `F5` obutali bwa bulijjo nga bwe kyayogeddwako emabegako (bw’oba ​​oli `homozygous`) .
• Singa ab’eŋŋanda zo ez’omusaayi (nga maama, taata, baganda bo) baba n’ebyafaayo bya DVT oba PE .
• Bwoba olina embeera endala ezikwata omusaayi .
• Bw’oba ​​olongoosebwa (naddala ng’omaze okulongoosebwa ennyo, kuba ojja kuba mu kifo kimu okumala ebbanga ddene).
• Bw’oba ​​oli lubuto (mu kiseera kino, enkyukakyuka mu busimu n’omwana asobola okuleeta puleesa ku misuwa).
• Bw’oba ​​omira ebika by’empeke ezimu eziziyiza okuzaala (ezirimu estrogen) oba eddagala erikyusa obusimu (obusimu obukyusa obusimu) .

Bw’oba ​​olina ekimu ku bintu bino eby’obulabe, kikulu nnyo okwogera n’omusawo wo n’omanya akabi akali mu kuzimba omusaayi n’okwegendereza kw’oyinza okukola.

Bizibu ki ebiyinza okubaawo olw’embeera eno?

Bw’oba ​​olina obulwadde bwa Factor V Leiden Thrombophilia, oyinza okufuna bino wammanga:

• Okukola `DVT` oba `PE` nga tonnaweza myaka 50 .
• Emirundi egisukka mu gumu, ekitegeeza emirundi mingi egya `DVT` oba `PE`.
• Okuzimba omusaayi kutondebwa mu misuwa egitera okukola omusaayi omutono , okugeza mu misuwa gy’ekibumba, obwongo n’ensigo.
• DVT oba PE nga oli lubuto oba nga omaze okuzaala .
• DVT oba PE eyinza okubaawo mu bbanga ttono oluvannyuma lw'okutandika empeke eziziyiza okuzaala .

Abasawo bazuula batya embeera eno?

Abasawo basobola okuzuula oba olina embeera eno nga bayita mu kukeberebwa omusaayi . Kino kiyinza n'okuzingiramu okukebera obuzaale . Omusawo ayinza okukuwa amagezi okukebera embeera eno naddala:

• If you have had a DVT or PE before , naddala nga kyaliwo ku myaka emito okusinga bwe kyali kisuubirwa.
• Singa omu oba abasingawo ku b'oluganda lwo abalina ebyafaayo by'okuzimba omusaayi .

Factor V Leiden ajjanjabwa atya?

Factor V Leiden mbeera ya bulamu bwonna. Ekyo kitegeeza nti mu kiseera kino tewali bujjanjabi oba ddagala lya njawulo ku nkyukakyuka eno ey’obuzaale. Mu kifo ky’ekyo, obujjanjabi bukola okusaanuusa ebizimba ebiriwo n’okukendeeza ku bulabe bw’okuzimba omusaayi mu biseera eby’omu maaso . Omusawo ayinza okukuwa amagezi ku bujjanjabi nga:

• Eddagala eriziyiza okuzimba omusaayi (era erimanyiddwa nga blood thinners) : Lino liyamba okusaanuusa ebizimba ebiriwo n’okuziyiza ebizimba ebipya okutondebwawo.
• Sitokisi ezinyigiriza : Zino sitokisi ez’enjawulo ezinywezeddwa nga zambalibwa ku magulu okulongoosa entambula y’omusaayi n’okukendeeza ku bulabe bw’okuzimba omusaayi.
• Vena cava filter placement : Kino kyuma kitono ekiteekebwa mu musuwa omunene okuziyiza omusaayi okutambula okutuuka mu mawuggwe. Si buli muntu nti akyetaaga.
• Okulongoosa okuggyamu ebizimba by’omusaayi : Mu mbeera ezimu, kiyinza okwetaagisa okulongoosa okuggyamu ebizimba ebinene.

Ebbanga ly’olina okumira eddagala erikendeeza omusaayi kisinziira ku bulabe bw’okufuna okuzimba omusaayi omulala. Abantu abamu beetaaga okumira eddagala lino okumala emyezi mitono gyokka. Abalala kiyinza okwetaagisa okukimira okumala ebbanga eddene, ne bwe kiba nti obulamu bwabwe bwonna. Omusawo ajja kukunnyonnyola enteekateeka y’obujjanjabi ekusinga obulungi.

Ddi lw’osaanidde okulaba omusawo?

Bw’oba ​​okimanyi nti olina embeera eno, kikulu okubeera ng’okwatagana n’omusawo buli kiseera.

• Genda okwekebejjebwa abasawo bonna waakiri omulundi gumu mu mwaka .
• Bw’oba ​​olina DVT oba PE era ng’ofuna obujjanjabi, ojja kwetaaga okulaba omusawo wo okugenda okugoberera buli kiseera okulaba obujjanjabi bwe butambula.
• Bw’oba ​​omira eddagala erikendeeza omusaayi nga Warfarin , olina okwekebeza omusaayi (Prothrombin time test - PT/INR test) buli luvannyuma lwa kiseera okukebera oba eddagala likola bulungi ate nga n’omuwendo gutuufu.

Ate era, kyetaagisa okwogera n’omusawo mu mbeera nga zino:

• Nga tonnaba kukozesa ddagala lya kuzaala (naddala eryo eririmu estrogen).
• Nga tonnatandika bujjanjabi bwa kukyusa busimu .
• Bw’oba ​​oteekateeka okufuna olubuto, nga ekyo tekinnatuuka .

Kino kyogera ki ku bulamu obusuubirwa?

Ku bantu abasinga obungi, okubeera ne Factor V Leiden tekikosa bulamu bwabwe obwa bulijjo . Ne bw’ofuna okuzimba omusaayi, singa ofuna obujjanjabi obw’amangu era obutuufu, osobola okuziyiza ebizibu eby’amaanyi ebiyinza okuvaamu . Bw’oba ​​olina ekikweraliikiriza ku bulamu bwo oba ebizibu ebiyinza okubaawo mu biseera eby’omu maaso, yogerako n’omusawo wo ku byo.

Kiki kye tusaanidde okwewala singa tulina Factor V Leiden?

Omusawo ajja kukuwa amagezi okusinziira ku mbeera yo ssekinnoomu, naye okutwalira awamu, kirungi okwewala ebintu bino:

• Okunywa sigala, okunywa taaba, n’okukozesa ebintu ebirala ebikolebwa mu taaba .
• Okutuula mu kifo kye kimu okumala ebbanga eddene (e.g., okukola mu ofiisi, okulinnya bbaasi oba eggaali y’omukka empanvu, oba okubuuka ennyonyi okumala essaawa). Bwe kiba kisoboka, situka otambule waakiri omulundi gumu mu ssaawa.
• Weewale okunywa omwenge omungi , naddala ku nnyonyi empanvu.
• Empeke eziziyiza okuzaala n’obujjanjabi obukyusa obusimu obulimu estrogen (mazima ddala olina okwogera n’omusawo wo nga tonnaba kukozesa bino).

Obutabeera na Factor V ne Factor V Leiden kintu kimu?

Yee, tobuzaabuza byombi. Zino mbeera bbiri ez'obuzaale ez'enjawulo ddala . Naye embeera zino zombi zikwatagana n’enjawulo mu ggiini ya `F5`.

Mu Factor V Leiden Thrombophilia, enkyukakyuka mu buzaale ereetera omusaayi gwo okuzimba amangu.

Wabula mu mbeera eyitibwa `Factor V deficiency` , enkyukakyuka mu buzaale eremesa omusaayi gwo okuzimba obulungi nga kyetaagisa. Kino kitegeeza nti oli mu bulabe bw’okuvaamu omusaayi. `Factor V deficiency` bulwadde bwa kuvaamu omusaayi obutatera kulabika nnyo (nga kimu ku bukadde). Kiyinza okuvaako ebintu ng’okuvaamu omusaayi ennyo mu nnyindo, okuvaamu omusaayi omungi ng’oli mu nsonga, n’okuvaamu omusaayi obutasalako oluvannyuma lw’okulongoosebwa.

N’ekisembayo, ebintu by’olina okujjukira

Kale, bw’okizuula nti ggwe oba omuntu gw’omanyi alina obulwadde bwa Factor V Leiden Thrombophilia, tosattira mangu. Jjukira nti abantu abasinga obungi abalina embeera eno basobola okubeera mu bulamu obulungi nga tebalina kuzimba musaayi gwonna .

Kyokka, bw’ofuna okuzimba omusaayi, waliwo obujjanjabi obulungi . Ekisinga obukulu kwe kugoberera ebiragiro by’omusawo wo n’obwegendereza, okufuna okukeberebwa n’obujjanjabi bwe weetaaga, n’okubeera n’obulamu obwa bulijjo, obw’essanyu n’embeera eno, ng’ogiddukanya bulungi nga tennafuuka kizibu.

` Factor V Leiden, Thrombophilia, okuzimba omusaayi, DVT, PE, obulwadde bw’obuzaale, okuzimba omusaayi, obuzibu mu buzaale