Ka tuyige ku bulwadde bwa Lynch Syndrome, obwongera obulabe bw’okufuna kookolo.

Wali owuliddeko ku kigambo ``Lynch Syndrome''? Kino kiyinza okuba ekigambo ekipya gy’oli. Naye kikulu ffenna okumanya. Mu ngeri ennyangu, Lynch Syndrome mbeera eyongera ku bulabe bw’okufuna kookolo olw’enkyukakyuka ezimu mu buzaale bwaffe. Okusingira ddala, kyongera obulabe bw’okukwatibwa kookolo nga tonnaweza myaka 50. Kale, ka twogere ku nsonga eno mu bujjuvu katono, tunaakola?

Ddala Lynch Syndrome kye ki? Ani agifuna?

Lynch syndrome mbeera ya buzaale esikira . Kwe kugamba, kiva ku nkyukakyuka mu buzaale mu buzaale bwe tusikira okuva ku maama oba taata waffe. Teebereza nti obutoffaali bwaffe bwe bwawukana, oluusi ensobi entonotono ziyinza okubaawo. Emibiri gyaffe girina obuzaale obw’enjawulo obuzuula n’okutereeza ensobi zino. Zino ziyitibwa ‘Mismatch Repair genes’ (obuzaale bwa MMR). Omuntu alina obulwadde bwa Lynch syndrome alina ekikyamu mu kimu oba ebisingawo ku buzaale buno obwa ‘MMR’. Olwo, ensobi endala teziyinza kulongoosebwa ng’obutoffaali obwo bwawuddwamu. Obutoffaali buno obwonooneddwa bukuŋŋaanyizibwa ne bufuuka kookolo .

Kino kiyinza okutuuka ku muntu yenna. Kubanga kya buzaale. Oluusi, ne bwe kiba nti tewali muntu yenna mu maka abadde n’embeera eno emabegako, omuntu asobola okubufuna olw’enkyukakyuka y’obuzaale ey’ekifuulannenge. Kino kitegeeza nti olw’okuba tewali byafaayo by’amaka, tekitegeeza nti tekijja kubaawo.

Okusinziira ku bibalo ebiri mu Amerika, abantu nga omu ku buli bantu 279 ayinza okuba n’obulwadde bwa Lynch syndrome. Kigambibwa nti abantu nga 4,000 abakwatibwa kookolo w’olubuto n’omumwa gwa nnabaana nga 1,800 be bava ku bulwadde bwa Lynch syndrome. Kikulu nnyo okumanya embeera eno mu Sri Lanka nayo.

Bubonero ki obulaga obulwadde bwa Lynch syndrome?

Obubonero buno buyinza okwawukana okusinziira ku buzibu bw’embeera eno n’ekika kya kookolo agireeta. Obubonero obusinga okulabika ku kookolo w’olubuto n’omumwa gwa nnabaana mulimu:

• Omusaayi mu musulo gwo.
• Obuteeyabya .
• Obulumi mu lubuto oba okuzimba.
• Ekiddukano oba omusulo omutono okusinga ogwa bulijjo.
• Okuwulira ennyo obukoowu obuyitiridde (`Fatigue`).
• Okuwulira ng’ojjudde oba ng’ozimba.
• Okuziyira oba okusiiyibwa.

Ekikulu abantu abamu bayinza obutalaga bubonero bwonna okutuusa nga kookolo akuze nnyo. N’olwekyo, bw’oba ​​olina obubonero buno bwonna, olina okugenda ew’omusawo mu bwangu .

Bika ki ebya kookolo ebiyinza okuva ku bulwadde bwa Lynch syndrome?

Kino mu butuufu kiyinza okukosa ebitundu by’omubiri bingi. Bino bye bika bya kookolo ebiyinza okuva ku bulwadde bwa Lynch syndrome:

• Kookolo w’obwongo
• Kookolo w’olubuto n’omumwa gwa nnabaana - Ono y’asinga.
• Kookolo w’ekibumba
• Kookolo w’ekibumba
• Kookolo w’enkwaso
• Kookolo w’olubuto
• Kookolo w’enseke
• Kookolo w’olususu
• Kookolo w’ekyenda ekitono
• Kookolo w’olubuto
• Kookolo w’omusulo ogwa waggulu
• Kookolo wa nnabaana (endometrial) - Kika kya kookolo ekirala ekitera okukwata abakyala.

Enkyukakyuka y’obuzaale (`gene`) mw’eri y’esalawo ekitundu ki ekiri mu bulabe obw’amaanyi obwa kookolo. Waliwo obuzaale butaano obukulu obukwatagana n’obulwadde bwa Lynch syndrome. Zino ze zino: `MLH1`, `MSH2`, `MSH6`, `PMS2` ne `EPCAM`.

Kookolo w’olubuto olunene aleetebwa obulwadde bwa Lynch syndrome asobola okukula amangu (mu myaka 1-2) okusinga mu bantu bonna. Ebiseera ebisinga kitwala emyaka nga 10 kookolo w’olubuto olunene okukula. Ate era, omuntu abadde ne kookolo w’olubuto olunene alina emikisa mingi okuddamu okukwatibwa kookolo . Waliwo akabi nga 15% mu myaka 10 oluvannyuma lw’okulongoosebwa kookolo asooka, akabi nga 40% mu myaka 20, n’akabi nga 60% oluvannyuma lw’emyaka 30.

Kiki ekivaako obulwadde bwa Lynch syndrome?

Nga bwe kyayogeddwako emabegako, ekisinga okuvaako kino kwe kukyusa obuzaale mu buzaale obumu oba okusingawo ku buzaale obutaano obutereeza ensobi mu DNA yaffe (``obuzaale obuddaabiriza obutakwatagana`` oba ``obuzaale bwa MMR``). Ensengekera z’obuzaale ezo ettaano ze zino:

• `MLH1`
• `MSH2`
• `MSH6`
• `PMS2`
• `EPCAM`

Bw’oba ​​olina obulwadde bwa Lynch syndrome, obuzaale bwo obwa `MMR` tebufuna biragiro bye byetaaga okugoba obutoffaali obwonooneddwa. Olwo obutoffaali obwo obwonooneddwa ne bukuŋŋaanyizibwa mu bitundu by’omubiri ne buleeta kookolo.

Kino kiva kitya okuva ku mulembe okudda ku mulala?

Lynch syndrome mbeera ya ``autosomal dominant``. Mu ngeri ennyangu, ne bwe kiba nti omuzadde omu yekka y’alina obuzaale obukyusiddwa, omwana asobola okubusikira . Kino kitegeeza nti waliwo emikisa 50% nti omwana naye ajja kuba n’embeera eno.

Bw’oba ​​ozuuliddwa ng’olina obulwadde bwa Lynch syndrome, kikulu okutegeeza ab’omu maka go n’okubakubiriza okunoonya okubudaabudibwa ku buzaale . Okubuulirira ku buzaale kuyinza okukuyamba ggwe n’ab’omu maka go okutegeera embeera eno n’akabi akali mu mwana wo okugisikira. Okukebera obuzaale nakyo kisobola okukolebwa okulaba oba olina enkyukakyuka mu buzaale bw’obulwadde bwa Lynch syndrome.

Obulwadde bwa Lynch syndrome buzuulibwa butya?

Omusawo asobola okuzuula obulwadde bwa Lynch syndrome ng’ayita mu kukeberebwa nga tonnazaala n’okukebera obuzaale. Okukebera obuzaale nakyo osobola okukikola ng’omwana amaze okuzaalibwa.

Okukebera obuzaale kuzingiramu okutwala omusaayi oba okukebera mu buccal swab okukebera enkyukakyuka mu buzaale obwogeddwako emabegako `MLH1`, `MSH2`, `MSH6`, `PMS2` oba `EPCAM`. Singa okukebera obuzaale kukakasa nti waliwo enkyukakyuka ng’eyo, omusawo ajja kuzuula obulwadde bwa Lynch syndrome.

Bikebere ki ebikozesebwa okuzuula kookolo akwatagana n’obulwadde bwa Lynch syndrome?

Singa ozuulibwa nti olina obulwadde bwa Lynch syndrome, omusawo ajja kutera okukuwa amagezi okukeberebwa emirundi egiwerako okukebera kookolo. Ebigezo ebisinga okukozesebwa bye bino:

• Colonoscopy: Kino kizingiramu okuyingiza ekyuma ekiyitibwa tube (scope) nga kiriko camera eyungiddwaako okuyita mu nseke okwekenneenya munda mu kyenda ekinene n’omumwa gwa nnabaana. Kino kitera okukolebwa omulundi gumu mu mwaka oba buli luvannyuma lwa myaka ebiri.
• Transvaginal ultrasound: Ekintu ekitono (probe) kiyingizibwa nga kiyita mu bukyala okwekenneenya enkwaso ne nnabaana. Kino nakyo kirungi omulundi gumu oba ebiri mu mwaka.
• Okwekenenya omusulo: Sampuli y’omusulo gwo bagitwala okukebera ebintu ng’ebizimba mu kibumba. Kino kitera okukolebwa omulundi gumu mu mwaka.
• Tumor biopsy: Singa omusawo ateebereza nti olina ekizimba awalala mu mubiri gwo, ajja kukitwala akatundu akatono n’akikebera mu laabu okulaba oba kirimu obutoffaali bwa kookolo.
• Upper endoscopy oba capsule endoscopy: Enkola ekozesa akapiira akatono akagonvu (scope) oba microscopic camera (akapiira akatono akagonvu akamira ng’empeke) okunoonya kookolo mu lubuto n’ekyenda ekitono. Kino oyinza okusabibwa okukikola buli luvannyuma lwa myaka esatu oba etaano.

Obulwadde bwa Lynch syndrome bujjanjabwa butya?

Ekikulu mu kujjanjaba obulwadde bwa Lynch syndrome kwe kuzuula ebizimba amangu n'okulongoosa okubiggyawo . Kino kitegeeza okwekebejjebwa buli kiseera n’okukwata kookolo nga bukyali, bw’aba abeerawo.

Kino ani akijjanjaba?

Kirungi okunoonya obujjanjabi okuva mu ttiimu y’abasawo abakugu ku mbeera nga eno.Olw’okuba obulwadde bwa Lynch syndrome buyinza okukosa enkola z’ebitundu by’omubiri ebingi, ttiimu y’abajjanjabi eyinza okubaamu abakugu ab’enjawulo, omuli abakugu mu by’omu lubuto, abalongoosa, abakugu mu by’obulwadde bwa kookolo, abakugu mu by’ensusu, abasawo b’ensusu, abakyala, abasawo abasookerwako, abakugu mu by’obuzaale, ababuulirira ku buzaale, n’abakugu mu by’obulwadde bwa kkansa.

Kookolo asobola okuddamu oluvannyuma lw’okujjanjabibwa?

Yee, ne bwe kiba nti kookolo alongooseddwa, waliwo omukisa nti kookolo ajja kuddamu . Eno y’ensonga lwaki kikulu okugenda mu maaso n’okugezesa.

Abantu abamu abalina obulwadde bwa Lynch syndrome, olw’okuba bali mu bulabe bwa maanyi okukwatibwa kookolo, basalawo okulongoosebwa okuggyamu nnabaana (hysterectomy), enkwaso (oophorectomy), oba ekitundu ky’ekyenda (colectomy oba bowel resection surgery) nga bukyali. Kino okusinga kisalawo kya muntu ku bubwe, era kisaana okukolebwa ku magezi g’omusawo.

Obulwadde bwa Lynch syndrome busobola okuziyizibwa?

Ebyembi, obulwadde bwa Lynch obulwadde bwa buzaale, n’olwekyo tebusobola kuziyizibwa ddala . Kyokka, abantu abalina obulwadde bwa Lynch syndrome basobola okwekebejjebwa kookolo obulamu bwabwe bwonna, okutandika nga bakuze, kookolo asobole okuzuulibwa nga bukyali singa akula .

Kiki ekibaawo singa oba olina obulwadde bwa Lynch syndrome? Kiki ky’oyinza okusuubira?

Mu kiseera kino tewali ddagala liwonya bulwadde bwa Lynch syndrome. Wabula ebisinga obulungi bifunibwa singa kookolo azuulibwa n’aggyibwawo nga bukyali, nga tannasaasaana mu bitundu by’omubiri ebirala . N’olwekyo, kikulu nnyo abantu abalina obulwadde bwa Lynch syndrome okwekebejjebwa buli mwaka, gamba ng’okukebera ekyenda ekinene.

Obulwadde bwa Lynch syndrome bunaaleeta ebizimba mu kyenda kyange?

Abantu abalina obulwadde bwa Lynch syndrome bayinza okufuna ‘adenomas’ eziwerako, ekika ky’okukula okutali kwa kookolo mu kyenda oba mu nseke zaabwe. Singa ‘polyps’ zino tezizuulibwa ne ziggyibwawo, zisobola okufuuka kookolo. Eno y’ensonga lwaki kikulu okukebera colonoscopies buli kiseera okukebera bino n’okubiggyamu singa bibaawo.

Ddi lwe nnina okulaba omusawo?

Bw’oba ​​olina obulwadde bwa Lynch syndrome, kikulu okwekebejjebwa n’okukeberebwa buli mwaka ku nteekateeka eya bulijjo .

Bw’olaba ebizimba byonna, ebipya ebikula, oba enkyukakyuka mu lususu wonna ku mubiri gwo, laba omusawo mangu , kubanga buno buyinza okuba obubonero bwa kookolo.

Bibuuzo ki bye nnina okubuuza omusawo wange?

• Mirundi emeka gye nnina okwekebeza kookolo?
• Ekizimba kino kiri ku kookolo w’olususu lwange?
• Nkyukakyuka ki ey’obuzaale bwe nnina?
• Nsobola okwekebeza obuzaale nga sinnateekateeka kufuna lubuto?

Lynch Syndrome ne HNPCC kintu kimu?

Lynch syndrome ne ``Hereditary Non-Polyposis Colorectal Cancer`` (``HNPCC``) oluusi zikozesebwa nga zikyusibwakyusibwa okutegeeza embeera y'emu. Kyokka waliwo enjawulo entono wakati w’ebintu bino byombi mu ngeri gye biyisibwamu okuyita mu milembe.

Obulwadde bwa Lynch syndrome buva ku nkyukakyuka mu ggiini ya `MMR`. Enkyukakyuka y’emu ey’obuzaale era ekosa abantu abalina `HNPCC`. Naye erinnya `HNPCC` liweebwa ng'embeera eno ebaddewo n'ebyafaayo by'amaka . Ekyo kitegeeza nti `HNPCC` bulijjo esikira okuva ku mulembe okudda ku mulala. Obulwadde bwa Lynch oluusi busobola okubaawo nga tewali muntu yenna mu maka abulina, era busobola n’okubaawo olw’enkyukakyuka y’obuzaale ey’ekifuulannenge. Eno y’ensonga lwaki kati erinnya Lynch syndrome likozesebwa nnyo.

N’ekisembayo, ebintu by’olina okujjukira (Obubaka bw’okutwala awaka) .

Tewali ayagala kuwulira bigambo nti, "Olina kookolo." Bw’okizuula nti olina obulwadde bwa Lynch syndrome, oyinza okuba ng’olina okuwulira ebigambo ebyo okuva eri omusawo wo. Naye tekiteekwa kuba kintu kibi.

Bw’omala okuzuulibwa nti olina obulwadde bwa Lynch syndrome, omusawo wo ajja kukolagana naawe okuteekawo enteekateeka y’okukeberebwa buli kiseera okuyamba okuzuula kookolo nga bukyali. Okuzuula amangu n'okujjanjaba y'engeri esinga okutumbula emikisa gyo egy'okuwona . Olwo osobola okubeera n’obulamu obw’essanyu era obw’obulamu obulungi.

N’olwekyo, mu kifo ky’okutya amawulire gano, beera mwegendereza, funa amagezi g’abasawo bwe kiba kyetaagisa, era fuba okubeera n’obulamu obulungi . Singa omuntu yenna mu maka go alina embeera eno, kikulu nnyo okumutegeeza ku nsonga eno nayo.

` Lynch syndrome, HNPCC, kookolo, enkyukakyuka mu buzaale, endwadde ez’obuzaale, kookolo w’olubuto olunene, kookolo wa nnabaana