Mas cells zino ze ziruwa? Kino kye kikuviirako alergy?

Naawe otandika okusesema ng’okwata ku katundu k’enfuufu? Oba ensekere oba ensiri bw’ekuluma, ekitundu ekyo kimyufu, kizimba, ne kisiiwa mu ngeri etagumiikiriza? Bangi ku ffe tubadde n’ebyo ebifaananako bwe bityo. Kale, leero tugenda kwogera ku muzannyi omukulu avunaanyizibwa ku reaction eno ebeerawo munda mu mubiri gwaffe mu biseera nga bino. Oyo ye "Mast Cells ".

Mu ngeri ennyangu, obutoffaali buno obuyitibwa mast cells be baani?

Mast cells bajaasi ba njawulo mu baserikale b’omubiri gwo. Nga ensi yaffe bwerina eggye erigikuuma, n’omubiri gwaffe gulina n’abaserikale b’omubiri okugikuuma. Obutoffaali buno obuyitibwa mast cells bwe bukuuma mu nkola eyo, bulijjo nga bulindaala.

Obutoffaali buno bukolebwa mu busimu bwaffe obw’amagumba. Olwo zitambula mu musaayi ne zisenga mu bitundu by’omubiri gwaffe eby’enjawulo. Awo omulimu gwabwe we gutandikira. Omulimu gwabwe omukulu kwe kutukuuma okuva ku bitiisa eby’enjawulo eri omubiri.

Naye oluusi obutoffaali buno obuyitibwa mast cells bufuuka bwa maanyi nnyo. Awo ebizibu we bitandikira. Ziyinza okuleeta enkola ennene ennyo n’ebintu ebitali bya bulabe ng’enfuufu oba emmere. Embeera zino tuziyita ‘allergies’ oba ‘allergic asthma’. Mu mbeera ezimu ez’amaanyi, emirimu gy’obutoffaali buno obuyitibwa mast cells giyinza okuleeta alergy ey’amaanyi eyitibwa anaphylaxis, ekiyinza okuteeka obulamu mu matigga.

Obutoffaali buno obuyitibwa mast cells bukola butya? Katutegeere 'enkola ya alamu' eno!

Omubiri gwo gulowoozeeko ng’ekigo ekinene. Mast cells ziringa enkola ey’okulabula essiddwa buli wamu ku bbugwe w’ekigo ekyo. Enkola eno eya alamu bulijjo yeetegefu okukuuma omubiri okuva ku balabe ab’ebweru, kwe kugamba, obuwuka obuleeta endwadde nga akawuka ne bakitiriya, n’obutwa ng’obutwa bw’omusota n’obutwa bw’enseenene.

Ka tulabe engeri enkola eno gy’egenda mu maaso mu bujjuvu katono:

1. Okuzuula omulabe: Ekisooka, obuwuka obupya oba alergen bwe buyingira mu mubiri gwo, ekitundu ky’abaserikale b’omubiri ekiyitibwa B-cells kikitegeera.

2. Okukola ebyokulwanyisa eby’enjawulo: Oluvannyuma lw’okutegeera omulabe, obutoffaali bwa B butandika okukola ekika ky’ekirungo ekiziyiza endwadde ekikwata ku mulabe oyo. Obuziyiza buno buyitibwa immunoglobulin E (IgE) .

3. Okuwa abakuumi ebyokulwanyisa:Antibodies zino eza IgE ezikoleddwa zigenda ne zinywerera ku ngulu w’obutoffaali obuyitibwa mast cells, abazira b’emboozi yaffe. Kiba ng’okuwa omukuumi ekyokulwanyisa.

4. Alaamu evuga: Kati mast cells ziri ku high alert n’ebyokulwanyisa byabwe ebya IgE. Omulundi oguddako omulabe y’omu (i.e. obuwuka oba allergen y’emu) bw’anaddamu okuyingira mu mubiri, ajja kukwatibwa IgE eyeegasse ku mast cells. Awo we wava obutoffaali obuyitibwa mast cells bwe ``bukola''.

5. Obulumbaganyi bwa histamine: Obutoffaali obuyitibwa mast cells bwe bukola, bufulumya eddagala lingi eriterekeddwa mu zo omulundi gumu. Eddagala lino erisinga obukulu ye histamine .

Ka tulabe ebibaawo mu mibiri gyaffe nga eddagala eriyitibwa histamine lifulumye.

Kati otegedde ekituuka ku mubiri nga tulina allergy, nedda? Wadde bino byonna bikolebwa okutukuuma, oluusi okuddamu kuno kufuuka kwa maanyi nnyo.

Wa mu mubiri obutoffaali buno obuyitibwa mast cells obusinga obungi?

Abakuumi bano basinga kusimba ku miryango emikulu obuwuka n’ebirungo ebiva ebweru mwe bituyingira. Ekyo kili:

• Enkola y’okussa n’amawuggwe: Weekuume ku bintu ebijja n’empewo gye tussa.
• Enkola y’okugaaya emmere (GI tract): Weekuume ku buwuka obujja n’ebintu bye tulya n’okunywa.
• Olususu: Weekuume ebintu ebiyingira nga biyita mu lususu.
• Obutoffaali buno era busangibwa okwetoloola emisuwa n'obusimu .

Endwadde ki eziyinza okukwatagana n’obutoffaali obuyitibwa mast cells?

Obutoffaali obuyitibwa mast cells bwe butakola bulungi, endwadde ez’enjawulo ziyinza okubaawo. Ebimu ku byo bya bulijjo era bimanyiddwa nnyo.

Bubonero buno bumanye.

Obubonero bw’obulwadde bwa mast cell buyinza okuli:

• Olususu okumyuuka, okusiiwa, okuwulira ebbugumu.
• Okuzimba (edema) mu bitundu by’omubiri eby’enjawulo.
• Okukaluubirirwa okussa.
• Allergy ey’amaanyi (anaphylaxis).

Bw’otera okulaba obubonero buno, kikulu nnyo okugenda ew’omusawo akuwe amagezi okusinga okwejjanjaba.

Omusawo azuula atya embeera zino? Obujjanjabi bwe buruwa?

Singa omusawo ateebereza nti olina obulwadde bw’obutoffaali obuyitibwa mast cell okusinziira ku bubonero bwo, ayinza okulagira okukeberebwa mu ngeri ez’enjawulo.

• Okukebera omusaayi
• Okukebera omusulo
• Okukebera olususu lwa allergy
• Oluusi balongoosebwa omubiri okutwala akatundu akatono ak’obusimu bw’amagumba oba olususu.

Enkola z’obujjanjabi zaawukana okusinziira ku mulwadde era okusinziira ku ngeri y’embeera. Obujjanjabi obumanyiddwa ennyo buyinza okuli:

• Okwewala ebivaako alergy: Okuzuula by’olina alergy n’okubyewala.
• Eddagala: Eddagala eriweebwa okufuga obubonero. Eby’okulabirako mulimu eddagala eriweweeza ku bulwadde bwa histamine ne montelukast.
• Mast cell stabilizers: Eddagala lino likola nga liyimiriza okufulumya eddagala nga histamine okuva mu mast cells.
• Eddagala ery’amangu: Eddagala nga epinephrine eriwonya obulwadde bw’okusannyalala obw’amaanyi.

N’ekisembayo, obutoffaali obuyitibwa mast cells birungi oba bubi?

Abantu abasinga bawulira ku mast cells nga balina embeera ezibu nga allergy, kale bayinza okulowooza nti kintu kibi. Naye mu butuufu, obutoffaali obuyitibwa mast cells kitundu kikulu nnyo era kikulu nnyo mu nkola y’omubiri gwaffe ogw’okwekuuma.

Ebiseera ebisinga, zitukuuma obutakwatibwa ndwadde n’obuwuka. Bwe bafuna obunyiikivu obusukkiridde katono ne tufuna allergy. Ng’ekibinja ky’abakuumi abanyiikivu ennyo abaakuma ekyalo kyonna omuliro okukwata akabbi akatono.

Kale, omulundi oguddako bw’omala okusesema oba okwekunya, weebaze obusimu buno obutono obuyitibwa mast cells okwebaza okuva ku mutima. Kubanga bakola nnyo okukukuuma!