Otera okufuna alergy ng’olina amabala amamyufu n’okusiiwa omubiri gwonna? Kino kiyinza okuba nga kya Mastocytosis!

Otera okufuna ebizimba ebimyufu, okusiiwa, n’oluusi ebizimba eby’amaanyi ku mubiri gwo? Oba olina alergy ey’amaanyi n’ekintu ekitono ennyo okumala ennaku? Oyinza okulowooza nti, "Nnina alergy endala." Wabula oluusi emabega w’obubonero buno, wayinza okubaawo embeera etali ya bulijjo gye tutawuliddeko. Embeera emu ng’ezo ye `(Mastocytosis)`. Wadde erinnya lino liyinza okuwulikika ng’ekyewuunyisa katono, ka tukwogereko mu ngeri ennyangu.

Mastocytosis kye ki? Mu ngeri ennyangu...

Teebereza, munda mu mibiri gyaffe mulimu obutoffaali obulinga abakuumi abatono. Tuziyita ``mast cells.`` Zino ``mast cells`` kitundu kya ``immune system yaffe.`` Ziringa ebyokwerinda by'eggwanga lyaffe. Abalabe nga obuwuka, obuwuka, n'ebirungo ebikola alergy bwe biyingira mu mubiri, ``mast cells`` zino zijja mu maaso ne zilwana.

`(mast cells)` zino bwe ziddamu abalabe, zifulumya eddagala eriyitibwa `(histamine).` Kino `(histamine)` kye kireeta obubonero bwa alergy mu mubiri gwaffe (okugeza, okusiiwa, okumyuuka kw'olususu, okuzimba). Zino `(mast cells)` nazo ziyamba okukola asidi mu lubuto.

Mu budde obwabulijjo, zino `(mast cells)` zikola omulimu gwazo ne zifuga abalabe olwo ne ziddamu okusirika. Naye ekibaawo mu mubiri gw'omuntu alina `(Mastocytosis)` kwe kuba nti `(mast cells)` zino zeeyongera mu ngeri etaali ya bulijjo era nga tezifugibwa. Bwe zeeyongera bwe ziti, obutoffaali buno bufulumya `(histamine) mungi nnyo.` Awo w’ofuna alergy ennene ne ku kintu ekitono ennyo, oba bw’ofuna alergy, eba mbi okusinga mu muntu owa bulijjo, era ewangaala.

Ekisinga obukulu, buli muntu alina obulwadde bwa Mastocytosis ali mu bulabe obw’amaanyi obw’okulwala anaphylaxis , allergy ey’amangu, ey’amaanyi, era eyinza okutta omuntu . N’olwekyo, kikulu okumanya kino.

Wadde ng’abasawo tebasobola kuwonya ddala bulwadde bwa Mastocytosis, basobola okufuga obubonero n’okujjanjaba ebizibu byonna ebiyinza okuvaamu.

Bika ki ebikulu ebya Mastocytosis?

Obulwadde buno bulina ebika bibiri ebikulu:

1. Cutaneous Mastocytosis: Kino kitera okubaawo mu baana abawere n’abaana abato . Kyokka era kiyinza okubaawo mu bantu abakulu. Ekibaawo wano kiri nti ``mast cells`` ezitali za bulijjo zikuŋŋaanyizibwa mu lususu, ne zireeta ebizimba n'amabala ebisiiwa ebya langi emmyufu, emmyufu enzirugavu, kitaka, oba langi ezitabuliddwa. Kiringa omwana omuto omulundi gumu n’afuna amabala amamyufu mangi ku mubiri ne babikunya obutasalako.

2. Systemic Mastocytosis: Ekika kino kisinga kulabibwa mu bantu abakulu.Wano, ``mast cells`` ezitali za bulijjo zikuŋŋaanyizibwa mu bitundu by'omubiri eby'omunda nga obusigo bw'amagumba, amagumba, enkola yaffe ey'okugaaya emmere, n'amawuggwe. Teebereza, singa obutoffaali buno bukuŋŋaanyizibwa ekisukkiridde mu busimu bw’amagumba, kiyinza okukosa okutondebwa kw’obutoffaali bwaffe obw’omusaayi. Ekirala obutoffaali buno bwe bweyongera mu lubuto, busobola okukola asidi mu lubuto omungi ne buleeta amabwa mu lubuto.

Buno bulwadde bwa bulijjo?

Nedda, mu butuufu eno mbeera ya bbula nnyo. Okusinziira ku kunoonyereza, kigambibwa nti omuntu omu yekka ku buli mitwalo kkumi (10,000) oba omu ku buli mitwalo abiri (20,000) y’akwatibwa obulwadde buno. N’olwekyo, kya bulijjo nti si buli muntu nti akimanyi.

Bubonero ki obuyinza okuva mu bulwadde bwa Mastocytosis?

Nga ``mast cells`` zino zeeyongera mu ngeri etaali ya bulijjo, obubonero obw'enjawulo busobola okubaawo. Wadde ng’obubonero buno buyinza okuba obutono ennyo eri abantu abamu, ku balala buyinza okuba obw’amaanyi.

• Obulumi bw’amagumba: Owulira ng’amagumba gakuluma.
• Ekiddukano (okulumwa olubuto): Okubeera n’okugenda mu kinaabiro enfunda eziwera.
• Okuzirika (nga okuzirika): Amangu ago, amaaso gafuuka bbululu era olabika ng’ozirika.
• Embeera ey’okweraliikirira n’okutya buli kiseera: Okuwulira okweraliikirira awatali nsonga.
• Okufuukuuka: Olususu okumyuuka amangu mu mubiri gwonna.
• Ebizimba oba amabala agasiiwa ku lususu: Nga bwe twayogeddeko emabegako.
• Okulumwa omutwe: Omutwe ogutera okulumwa.
• Okuziyira okuva ku puleesa okukka: Okuwulira ng’oziyira ng’oyimiridde ng’oyimiridde.
• Obulumi mu binywa: Obulumi mu binywa.
• Amabala amamyufu oba aga kitaka ku lususu: Bino biyinza okusiiwa oba obutasiiwa.

Mastocytosis etandika ku myaka emeka?

Kyawukana okusinziira ku kika ky’obulwadde. Okutwaliza awamu:

• Cutaneous Mastocytosis: Kino kiyinza okukwata n’abalongo.
• Systemic Mastocytosis: Esinga kukwata bantu bakulu abasukka mu myaka 50.

Kiki ekivaako kino?

`(Mastocytosis)` si kintu kye tuzaalibwa nakyo. Kiva ku nkyukakyuka mu buzaale obuyitibwa `(KIT genes)`. Zino `(KIT genes)` ze genes eziyamba ebika by'obutoffaali ebimu, gamba ng'obutoffaali bwaffe obw'omusaayi, `(mast cells)`, okukula. Mu `(Mastocytosis), zino ezikyusiddwa `(KIT genes)` ziwa akabonero akakyamu eri `(mast cells)` "okukula ekisusse ne zikula mu ngeri etafugibwa."

Biki ebivaako obulwadde bwa mastocytosis?

Kino kiyinza okwawukana okusinziira ku muntu. Si buli muntu nti alina ebizibu bye bimu. Wabula waliwo ebintu ebimu ebiyinza okwongera ku bubonero okutwalira awamu:

• Okusiiga oba okusika olususu: Kino nakyo kiyinza okutuuka ku bantu abamu nga bambala engoye ezinywezeddwa zokka.
• Dduyiro n’okukola emirimu gy’omubiri ekisusse.
• Okulumwa oba okuluma ebiwuka:Naddala ebisolo ng’enseenene, enseenene, n’enjuki.
• Okunywa omwenge.
• Emmere ezimu: Naddala emmere erimu ebirungo, erimu ebirungo ebingi.
• Eddagala erimu: Okugeza, eddagala eriweweeza ku bulumi eriyitibwa ``NSAIDs`` (Nonsteroidal anti-inflammatory drugs), eddagala eriwummuza ebinywa, n'eddagala eribudamya ``(anesthesia)``.
• Enkyukakyuka ez’amangu mu bbugumu: Ng’okubuuka mu mazzi agannyogoga ennyo.
• Situleesi mu mubiri oba mu birowoozo: Kino kitera okukosa ennyo.

Bizibu ki ebiyinza okuva mu Mastocytosis?

Obulwadde buno buyinza okuleeta ebizibu ebirala mu bulamu omuli:

• Obulwadde bw’amagumba: Kino kireetera amagumba okunafuwa ne gamenya mangu.
• Obuzibu mu kibumba: Embeera ekibumba mwe kizimba ne kitakola bulungi.
• Cytopenia: Obutasobola kukola butoffaali bwa musaayi bumala.
• Okukwatibwa yinfekisoni enfunda eziwera.

Obulwadde bwa Mastocytosis buzuulibwa butya?

Omusawo ajja kukubuuza ku bubonero bwo era akebere olususu lwo. Okugatta ku ekyo, bayinza okukola ebigezo nga:

• Okukebera omusaayi: Kebera omuwendo gw'ekirungo ekiyitibwa ``tryptase`` mu musaayi gwo. Kino ``tryptase`` kintu ``mast cells`` kye zifulumya nga ziddamu abalabe.
• Sikaani y’amagumba: Okukebera oba amagumba gaayonoonese.
• Bone marrow biopsy: Sampuli y’obusimu bw’amagumba bagitwala ne bakeberebwa oba temuli obutoffaali obuyitibwa mast cells obutali bwa bulijjo.
• Okukebera obuzaale: Bw’oba ​​olina obulwadde bwa Systemic Mastocytosis, osobola okukeberebwa enkyukakyuka mu buzaale bwa KIT.

Bujjanjabi ki obw’obulwadde bwa Mastocytosis?

Enkola z’obujjanjabi zaawukana okusinziira ku kika ky’obulwadde n’obubonero bwo. Abasawo batera okukozesa eddagala n’obujjanjabi obulala okumalawo obubonero.

Ebika by’eddagala erikozesebwa ku Mastocytosis:

• Antacids (H2 blockers) ku bizibu by’olubuto: Ku bintu ng’okuzimba olubuto n’okuzimba olubuto.
• Antihistamines: Kikendeeza ku bubonero bw’olususu obuva ku alergy ng’okusiiwa n’okumyuuka.
• Ebirungo ebiyitibwa Bisphosphonates ku bulwadde bw’amagumba: Binyweza amagumba.
• Corticosteroids: Kikendeeza ku kuzimba.
• Antibodies eziyitibwa monoclonal antibodies: naddala eddagala nga omalizumab (Xolair®).
• Eddagala eriweweeza ku bulumi .

Enzijanjaba endala:

• Obujjanjabi bw’ekitangaala kya Ultraviolet (UV): Kikendeeza ku bifo ebiddugavu ku lususu.
• Obujjanjabi obugendereddwamu .
• Epinephrine eddagala eriweweeza ku bulwadde bw’okusannyalala:Obujjanjabi obw’amangu obw’okulwala alergy ey’amaanyi.
• Chemotherapy: Kino tekitera kubaawo nnyo era kiweebwa singa Mastocytosis efuuka kookolo.
• Okusimbuliza obutoffaali obusibuka mu magumba (bone marrow) transplantation: Kino era kirowoozebwako mu mbeera ez’amaanyi ennyo, enzibu ez’obulwadde bwa mastocytosis. Abantu abasinga kino tebeetaaga.

Waliwo ebizibu oba ebizibu ebiva mu bujjanjabi buno?

Yee, nga bwe kiri ku bujjanjabi bwonna, waliwo ebizibu ebimu ebiyinza okuva mu bujjanjabi bwa Mastocytosis. Ebimu biyinza okuba ebitonotono, ate ebirala biyinza okuba eby’amaanyi. Bw’oba ​​olina obulwadde bwa Mastocytosis, omusawo ajja kukunnyonnyola obujjanjabi bw’ofuna n’ebizibu ebiyinza okuvaamu.

Mastocytosis esobola okuwona ddala?

Okutwalira awamu, Mastocytosis etwalibwa ng’obulwadde obutawona ddala, naye nga busobola okuddukanyizibwa nga bufuga obubonero n’okujjanjaba ebizibu .

Obujjanjabi bwokka obuyinza okuwonya kino bwe ``allogeneic stem cell (bone marrow) transplantation'' eyayogeddwako emabegako. Kyokka, n’ekyo kirungi eri abalwadde bokka abalina embeera ezisinga okuba ez’amaanyi era enzibu.

Obulwadde bwa Mastocytosis bweyongera okusajjuka okumala ekiseera?

Singa tebujjanjabwa, obubonero buyinza okweyongera okumala ekiseera naddala mu muntu alina obulwadde bwa systemic mastocytosis , kubanga obutoffaali obuyitibwa mast cells obutali bwa bulijjo bweyongera okukosa obusigo bw’amagumba n’ebitundu by’omunda.

Obulwadde bwa Mastocytosis busobola okuziyizibwa?

Ebyembi, nedda. Okuva bwe kiri nti kiva ku nkyukakyuka mu buzaale bwa KIT, tewali ngeri yonna gye tuyinza kukiziyiza. Wabula bw’oba ​​olina obulwadde bwa Mastocytosis, osobola okufuga obubonero bwo ng’omanyi bulungi ekikuleetera okulwala alergy n’okwewala nga bwe kisoboka.

Okugeza bw’oba ​​olina ekikuviirako eddagala erimu, kirungi okwambala akakomo akalaga obusawo nga kaliwandiika. Kino kijja kuleetera abalala okumanya eddagala ly’otolina kumira singa wabaawo embeera ey’amangu.

Bw’oba ​​olina obulwadde bwa Systemic Mastocytosis, kyetaagisa bulijjo okutambula n’empiso eyeekuba empiso erimu epinephrine. Kino kiyinza okukozesebwa okujjanjaba alergy ey’amaanyi, eyinza okutta omuntu nga anaphylactic shock.

Nze nneerabirira ntya? (Mastocytosis) Nga babeera ne...

Okuva Mastocytosis bwe bulwadde obutawona ddala, oyinza okubeera nabwo okumala akaseera. Kiyinza okuba ekizibu. Kyokka bino bye bimu ku bintu ebiyinza okukuyamba:

• Manya bulungi ekikuleetera obubonero.Ebintu ebivaako buli muntu bya njawulo. Oyinza okwagala okukuuma diary n’owandiika obubonero bwo lwe buba bubi, by’olya n’ebyo bye wanywa, ne bye wakola mu kiseera ekyo.
• Situleesi esobola okwonoona obubonero buno. Bw’oba ​​weetaaga obuyambi mu kuddukanya situleesi, buuza omusawo wo ku nteekateeka z’okuziyiza situleesi. Ebintu ng’okufumiitiriza ne yoga biyinza okuyamba.
• Yambala akakomo akalaga obusawo. Lirina okuwandiika embeera yo ey’obujjanjabi n’eddagala lyonna ly’otolina kumira.
• Bulijjo tambula n’empiso ya epinephrine auto-injector. Kiyinza okutaasa obulamu singa wabaawo alergy ey’amaanyi.

Ddi lwe nnina okulaba omusawo wange?

Ojja kwekebejjebwa buli kiseera n’omusawo. Bajja kulondoola obubonero bwo n’okukyusa obujjanjabi bwo bwe kiba kyetaagisa. Bw’ofuna obubonero obupya, oba singa obubonero bwo bweyongera, tegeeza omusawo amangu ago.

Ngenda ddi mu kisenge ky’abalwadde ab’amangu?

Bw’oba ​​olina alergy ey’amaanyi ennyo nga tosobola kufugibwa ddagala, genda mu kisenge eky’amangu mu bwangu. Kwe kugamba, singa ofuna obubonero ng’okukaluubirirwa okussa, okunyiga emimiro, okuziyira ennyo, oba okubulwa amagezi.

Bibuuzo ki bye nnina okubuuza omusawo wange?

Bw’oba ​​olina obulwadde bwa Mastocytosis, kirungi okubuuza omusawo ebibuuzo nga bino:

• Nnina kika ki ekya Mastocytosis?
• Bujjanjabi ki obuliwo ku kika kye nnina?
• Obujjanjabi buno bunamalawo ddala obubonero bwange?
• Bubonero ki obulala obuyinza okulaga nti embeera yange yeeyongera okwonooneka?
• Nnaaba nnina okumira obujjanjabi emirembe gyonna?
• Bwemba nnina ffoomu esingako obuzibu, prognosis yange eri etya?
• Waliwo okugezesebwa kwonna okw’obujjanjabi kwe nsobola okwetabamu?

N’ekisembayo, by’olina okujjukira (Obubaka bw’okutwala awaka) .

Mastocytosis mbeera etali ya bulijjo ereeta okukula okutali kwa bulijjo, okutafugibwa kw’obutoffaali obuyitibwa mast cells mu mubiri. Kiyinza okukosa olususu n’ebitundu by’omunda. Abantu abasinga basobola okuddukanya obubonero bwabwe nga bazuula n’okwewala ebibaviirako n’okumira eddagala. Era kikulu okukuuma empiso ya epinephrine ng’eri mu ngalo okujjanjaba alergy ey’amaanyi.

Wadde buno bulwadde obutawona ddala, bw’ofuna amagezi amatuufu n’obujjanjabi bw’abasawo, osobola okugezaako okufuga obubonero n’obeera n’obulamu obwa bulijjo. Bw’oba ​​olina ekibuuzo ekirala kyonna ku nsonga eno, tolwawo kwogera na musawo wo. Bajja kukuyamba.

` Mastocytosis, mast cells, histamine, allergy, endwadde z’olususu, abaserikale b’omubiri, anaphylaxis