Kya bulijjo omuntu yenna okuwulira okutya okunene n'okuwuniikirira ng'awulira ebigambo "kookolo w'omumwa gwa nnabaana". Kyokka olw’enkulaakulana eriwo mu by’obusawo leero, waliwo obujjanjabi bungi obupya era obutuuse ku buwanguzi obusobola okutuyamba okugumira endwadde ng’ezo. Leero, tugenda kwogera ku nkola ya "targeted therapy" eyawukana ku chemotherapy ey'ekinnansi era nga naddala etunuulira n'okulumba obutoffaali bwa kookolo.
Mu ngeri ennyangu, zino Monoclonal Antibodies ze ziruwa?
Kino nga tetunnakitegeera, katutunuulire enkola ey’okwekuuma eyeewuunyisa emibiri gyaffe gye girina. Obuwuka, gamba nga obuwuka oba akawuka, bwe buyingira mu mibiri gyaffe, abaserikale baffe abaserikale bakola obutoffaali obw’enjawulo obusobola okutegeera ebirungo bino, ne bibyekwatako, n’okubisaanyaawo. Bino tubiyita "bodyguards," oba antibodies okubeera entuufu.
Kati, zino ``Monoclonal Antibodies`` kika kya antibodies ez'obutonde ezikolebwa mu laabu nga bakozesa tekinologiya ow'enjawulo. Bino bikolebwa okulumba ekigendererwa kimu kyokka ekigere. Okusobola okubeera omutuufu, zikoleddwa okutegeera puloteyina entongole ku ngulu w’akatoffaali ka kookolo, okugikwatako, n’okusaanyaawo akatoffaali ako aka kookolo .
Kino kiringa komando omutendeke mu ngeri ey’enjawulo asobola okusanga omulabe mu kifo ekijjudde abantu n’alumba omulabe oyo yekka nga tafunye bulabe ku muntu mulala yenna. N’olwekyo, mu kifo ky’okwonoona obutoffaali obulungi mu mubiri ng’obujjanjabi obwa bulijjo, enkola eno ey’obujjanjabi eyinza okusuubirwa okuba n’ebizibu ebitono kubanga esinga kuba ya njawulo.
Eddagala erikomya okukula kw’emisuwa mu kookolo (Angiogenesis Inhibitors) .
Kookolo si kintu ekimala okukula. Kiba ng’ekimera. Kyetaaga ebiriisa okusobola okubeerawo, okukula n’okukula. Okusobola okufuna ekiriisa kino, obutoffaali bwa kookolo bukuza emisuwa emipya egy’omusaayi okwetooloola. Enkola eno tugiyita ``angiogenesis.`` Kale, singa tuyimiriza emisuwa egigabira bino "emmere n'ebyokunywa" eri kookolo, tusobola okuyimiriza okukula kwa kookolo, nedda? Ekyo kye tuyita kiraasi y’eddagala erikola ekyo.
Eno y’engeri Bevacizumab (Avastin) gy’ekola:
Bevacizumab (erinnya ly’ekika: Avastin) ddagala ddene mu kiraasi eno. Obutoffaali bwa kookolo buweereza akabonero akabugamba nti "bazimba emisuwa." Akabonero kano kayitibwa vascular endothelial growth factor oba VEGF. Avastin ky’ekola kwe kuziyiza siginiini eyo okutuuka mu kifo ky’egenderera. Mu ngeri ennyangu, ekwata "ebbaluwa okuzimba emisuwa" eyasindikibwa kookolo n'agisaanyawo.
Kino kikomya kookolo okukola emisuwa emipya, ekikendeeza ku kukula kwa kookolo. Eddagala lino likkirizibwa ku kookolo w’olubuto olunene eyasaasaana (metastasized) mu bitundu by’omubiri ebirala. Wadde nga tesobola kuwonya kookolo mu bujjuvu, okunoonyereza kuzudde nti Avastin bw’eweebwa n’eddagala eriweweeza ku bulwadde, esobola okwongera ku bulamu bw’abalwadde emyezi nga 5 .
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, ne `ziv-aflibercept (Zaltrap)` lye limu ku ddagala eppya eritunuulidde ne `VEGF`.
Avastin aweebwa atya? Biki ebivaamu?
Avastin mpiso ya misuwa (IV). Butera kuweebwa buli luvannyuma lwa wiiki bbiri oba ssatu wamu n’obujjanjabi bw’eddagala.
Kikulu nnyo okumanya ebizibu ebiyinza okuva mu ddagala lino.
| Ekika ky’ebizibu ebivaako | Okunnyonnyola |
|---|---|
| Ebizibu ebitera okuvaamu |
|
| Ebizibu eby’amaanyi ebivaamu |
|
Eddagala erikwata butereevu ku kukula kw’obutoffaali bwa kookolo
Cetuximab (Erbitux) ne panitumumab (Vectibix) bika birala bibiri eby’obutoffaali obuziyiza endwadde obuyitibwa monoclonal antibodies. Bino bikola mu ngeri ya njawulo. Zitunuulira puloteyina eyitibwa epidermal growth factor receptor (EGFR) ku ngulu w’obutoffaali bwa kookolo.
Lowooza ku `EGFR` eno nga switch ya `On` egamba akatoffaali ka kookolo `okwekutula amangu n'okukula ennyo.` Eddagala `Erbitux` ne `Vectibix` kye likola kwe kutuula ku switch eno ne `zizibira`. Olwo, akabonero ak’obutonde akagamba akatoffaali okukula tekasobola kukoleeza switch. Mu ngeri eno, okukula kw’obutoffaali bwa kookolo kufugibwa.
Eddagala lino liweebwa ani?
Erbitux ne Vectibix zombi zikkiriziddwa okujjanjaba kookolo w’olubuto olunene asaasaanidde mu bitundu by’omubiri ebirala.
Eddagala lya Erbitux liweebwa omulundi gumu mu wiiki, oba lyokka oba n’eddagala eriweweeza ku bulwadde bwa irinotecan (Camptosar). Eddagala lya Vectibix liweebwa buli luvannyuma lwa wiiki bbiri nga ligatta wamu n’eddagala eddala erijjanjaba eddagala.
Kikulu nnyo nga tonnaba kuwa ddagala lino, okukeberebwa okw’enjawulo okw’enkyukakyuka mu buzaale ku butoffaali bwo obwa kookolo okulaba oba eddagala lino linaakolera kookolo oyo. Zino tezisaanira kookolo yenna. N’olwekyo, okugezesebwa kuno mazima ddala kukolebwa.
Biki ebiva mu Erbitux ne Vectibix?
Eddagala lino era lirina ebizibu ebitongole.
| Ebizibu ebitera okuva mu Erbitux ne Vectibix | |
|---|---|
| Ebizibu by’olususu | Ebizimba ebiringa embalabe, ebizimba ku lususu, n’olususu olukalu. Naye ekyewuunyisa, oluusi enkola zino ez’olususu zitegeeza nti eddagala lino likola bulungi ku kookolo. |
| Ebizibu ebirala ebivaamu |
|
Obubaka Obutwala Awaka
- Monoclonal Antibodies bujjanjabi bwa mulembe obugenderera mu ngeri ey’enjawulo n’okulumba obutoffaali bwa kookolo. Za njawulo ku bujjanjabi obwa bulijjo obw’eddagala eriweweeza ku bulwadde bwa ddagala.
- Eddagala erimu lisalako omusaayi ogugenda mu kookolo, ate eddala liziyiza enkola y’obubonero obuvuga obutoffaali bwa kookolo okukula.
- Eddagala lino lyonna lirina ebizibu byalyo. Yogerako n’omusawo wo ku bino nga tonnatandika kujjanjaba.
- Enzijanjaba zino tezisaanira buli muntu. Omusawo wo ajja kusalawo obujjanjabi ki obusinga okukuyamba okusinziira ku kika kya kookolo gw’olina, we yasaasaanidde, n’ebyava mu kukeberebwa kw’obuzaale okw’enjawulo.
- Bw’oba ggwe oba omuntu mu maka go alina kookolo, tosattira. Yogerako n’omusawo wo ow’obulwadde bwa kkansa ku bujjanjabi bwonna obuliwo, ebirungi n’ebibi byabwo, era ofune obuvumu okwolekagana n’obujjanjabi obwo.
💬 Comments (0)
Tewali bigambo biwandiikiddwa n'okutuusa kati. Yongera wano comment yo omulundi ogusoose.
Yongera ku comment yo