Ka tuyige ku kookolo wa Parathyroid. Totya, twogere!

Ffenna tufuna enkyukakyuka entonotono n’obutabeera bulungi mu mibiri gyaffe oluusi n’oluusi, nedda? Mpozzi nga kizimba kitono mu bulago, oba kiyinza okuba ekintu ng’okuwulira ng’okooye awatali nsonga, oba okuwulira ennyonta buli kiseera. Wadde ng’ebintu bino ebisinga si kintu kya kweraliikirira, mu mbeera ezitatera kubaawo, biyinza okuba obubonero obukulu obw’embeera y’obujjanjabi. Leero tugenda kwogera ku kika kya kookolo ekitali kya bulijjo, naye nga kikulu nnyo ffenna okukimanya. Oyo ye kookolo akula mu nseke za parathyroid, mu by’obujjanjabi ayitibwa kookolo wa parathyroid , oba `(Parathyroid Carcinoma)`.

Kookolo wa Parathyroid kye ki?

Mu ngeri ennyangu, kookolo wa parathyroid kika kya kookolo ekitali kya bulijjo nnyo era akula mu bitundu by’endwadde zo eza parathyroid. Endwadde zo eza parathyroid zitera okubeera emabega w’endwadde ya thyroid eringa ekiwujjo mu maaso g’ensingo yo.

Kookolo wa parathyroid tagabanyizibwa mu mitendera ena (``enkola y'okutuuma amannya ey'emitendera ena``) nga ebika bya kookolo ebirala. Mu kifo ky’ekyo, abasawo kookolo ono bamugabanyaamu ebika bisatu ebikulu:

• Localized: Kino kitegeeza nti kookolo ali mu parathyroid gland yo yokka. Oluusi kiyinza okuba nga kyasaasaana katono mu bitundu ebikyetoolodde. Kino kitegeeza nti kookolo akyali mu kitundu kimu.
• Metastatic: Kino kookolo bw’aba asaasaanidde mu bitundu by’omubiri gwo ebirala, gamba ng’ennywanto, ekibumba, amawuggwe, amagumba oba olubuto. Abantu abali wakati wa 10% ne 30% abalina kookolo wa parathyroid balina kookolo asaasaana (metastatic) mu kiseera we bazuulibwa. Ebifo ebisinga okubeera amawuggwe, amagumba oba ekibumba.
• Okuddamu: Kino kookolo w’akomawo oluvannyuma lw’okusooka okujjanjabwa – ebiseera ebisinga ng’endwadde ya kookolo emaze okulongoosebwa. Abantu abasoba mu kitundu abalina kookolo wa parathyroid bajja kuba ne kookolo ow’ekika kino. Kookolo atera okudda mu myaka ebiri oba etaano bukya alongoosebwa okusooka. Kyokka, oluusi kiyinza okudda nga kikeeredde emyaka 20.

Endwadde zino eziyitibwa parathyroid glands ze ziruwa?

Abasinga obungi ku ffe tulina endwadde nnya eziyitibwa parathyroid glands eziringa entangawuuzi. Nga bwe kyayogeddwako emabegako, bino bibeera emabega w’endwadde ya thyroid. Okufaananako n’endwadde ya thyroid, endwadde za parathyroid kitundu ku nkola yo ey’endwadde z’omu lubuto. Oluusi, endwadde zino eza parathyroid zisobola okubeera ku mabbali g’omumwa gwo oba ne mu kifuba kyo. Kino kiyitibwa ectopic.Endwadde za parathyroid ziyitibwa parathyroid glands ekitegeeza nti tezisangibwa we zirina okubeera mu budde obwa bulijjo.

Omulimu omukulu ogw’endwadde zo eza parathyroid kwe kufuga obungi bwa calcium mu musaayi gwo nga zikola obusimu obuyitibwa parathyroid hormone (PTH) . Oluusi, endwadde zo emu oba eziwera ku parathyroid glands zitandika okukola ekisusse ku busimu buno obuyitibwa parathyroid hormone (PTH). Embeera eno eyitibwa Primary Hyperparathyroidism (pHPT) . PTH bw’ekola ennyo, omuwendo gwa calcium mu musaayi gwo gweyongera. Embeera eno eyitibwa hypercalcemia .

Njawulo ki eri wakati wa kookolo wa parathyroid ne parathyroid adenoma?

Parathyroid adenoma kwe kukula okutali kwa kookolo, okutali kwa kookolo mu nnywanto ya parathyroid. Wabula kookolo wa parathyroid kwe kukula kw’obutoffaali obubi, obutali bwa kookolo mu bitundu byo eby’omubiri ebiyitibwa parathyroid. Ku ndwadde ezikwatagana n’endwadde za parathyroid, parathyroid adenoma etera nnyo okusinga kookolo wa parathyroid.

Naye kino kye kikulu: Mu mbeera zino zombi, kookolo wa parathyroid ne parathyroid adenoma, endwadde yo eya parathyroid esobola okukola ennyo n’ekola obusimu bwa parathyroid obuyitiridde (PTH). Olwo nga bwe kyayogeddwako emabegako, hypercalcemia ebaawo. Obulwadde buno obwa hypercalcemia buyinza okuba obw’obulabe eri omubiri gwo n’obulamu bwo. N’olwekyo, obujjanjabi obusinga okukozesebwa ku kookolo wa parathyroid, awamu ne parathyroid adenomas, kwe kulongoosa okuggyawo endwadde ya parathyroid ekola ekisusse.

Ne ku basawo, kiyinza okuba ekizibu okumanya amangu ddala oba parathyroid adenoma oba parathyroid carcinoma. Olw’okuba obutoffaali bwa byombi busobola okufaanana, oluvannyuma lw’okulongoosebwa enseke ya parathyroid ekola ennyo, kyetaagisa okwongera okukeberebwa okukakasa oba ya adenoma oba carcinoma.

Obulwadde bwa hypercalcemia kye ki? Kikwatagana kitya ne kookolo wa parathyroid?

Hypercalcemia bwe buba nga calcium mu musaayi gwo asinga ku ya bulijjo. Abantu abalina kookolo wa parathyroid batera okufuna obulwadde bwa hypercalcemia. Kino kiri bwe kityo kubanga kookolo aleetera endwadde yo eya parathyroid okukola ennyo n’ekola obusimu obuyitibwa parathyroid hormone (PTH) obuyitiridde. Obusimu obuyitibwa Parathyroid hormone (PTH) butereeza obungi bwa calcium mu musaayi gwo. Kale, bw’oba ​​n’obusimu obuyitibwa parathyroid hormone (PTH) bungi, omuwendo gwa calcium mu musaayi gwo gujja kweyongera.

Hypercalcemia kiyinza okuba eky’obulabe eri obulamu bwo n’omubiri gwo. N’olwekyo kikulu nnyo okujjanjaba obulwadde bwa hypercalcemia obuva ku kookolo wa parathyroid awamu ne kookolo yennyini.

Waliwo ebika bya kookolo wa parathyroid eby’enjawulo?

Yee, waliwo ebika bibiri ebikulu ebya kookolo wa parathyroid.

1. Ekika ekisinga okumanyibwa: Mu mbeera eno, obutoffaali bwa kookolo buleetera endwadde yo eya parathyroid okukola obusimu obuyitibwa parathyroid hormone (PTH) obuyitiridde ne bubufulumya mu musaayi. Kino kireetera omuwendo gwa calcium mu musaayi gwo okulinnya.

2. Kookolo wa parathyroid atakola: Kino era kiyitibwa ``non-secreting parathyroid carcinoma''. Kino kyawukana ku bika ebirala. Kubanga, abantu abalina kookolo ow’ekika kino tebalina busimu bwa parathyroid hormone (PTH) oba calcium mu musaayi gwabwe. Ekika kino tekitera kubaawo nnyo, kibeerawo mu balwadde ba kookolo wa parathyroid abatakka wansi wa 10% .

Kookolo wa parathyroid bw’amala okuzuulibwa, wabaawo okukeberebwa okulala okuzuula oba ali mu kitundu , agenda mu bitundu ebirala , oba azzeemu . Nga bwe kyayogeddwako emabegako, ensengeka y’emitendera ena ekozesebwa ku kookolo omulala tekozesebwa ku kino.

Ani asinga okulwala kookolo wa parathyroid?

Kookolo ono akwata abakyala n’abasajja kyenkanyi. Butera okulabibwa mu bantu abasukka mu myaka 30 .

Obulwadde buno butera kwenkana wa?

Kookolo wa parathyroid bulwadde obutatera kulabika nnyo. Just think, ekola ebitundu 0.005% byokka ku kookolo yenna. Era, kookolo wa parathyroid akola wakati wa 0.5% ne 1% ku ndwadde zonna ezikwatagana n’endwadde za parathyroid. Kale, kino ddala tekitera kubaawo.

Biki ebivaako kookolo wa Parathyroid?

Mu butuufu, tewali kivaako kookolo wa parathyroid n’okutuusa kati kizuuliddwa.

Naye, embeera zino wammanga ez’obuzaale ezitatera kulabika (i.e., ezisikira okuva mu maka) zitwalibwa ng’ensonga ez’obulabe eri kookolo ono:

• Obulwadde bwa multiple endocrine neoplasia ekika kya I (MEN1) .
• Obulwadde bwa hyperparathyroidism obwawuddwamu mu maka (FIHP) .
• Obulwadde bwa hyperparathyroidism-obulwadde bw’ekizimba ky’akawanga

Okugatta ku ekyo, bw’oba ​​wali ofunye obujjanjabi bw’amasannyalaze ku mutwe oba mu bulago mu biseera eby’emabega, era kiyinza okwongera ku bulabe bw’okufuna kookolo wa parathyroid.

Bubonero ki obulaga kookolo wa Parathyroid?

Ebiseera ebisinga, obubonero bwa kookolo wa parathyroid bwe bubonero bwa hypercalcemia obuvaamu. Obubonero n’obubonero bw’obulwadde bwa hypercalcemia buyinza okuli:

• Okwetaaga okufulumya omusulo emirundi mingi okusinga bulijjo (okufuka ennyo) .
• Okuwulira ennyonta okusinga bulijjo
• Okuziyira n’okusiiyibwa
• Nga bulijjoObutawulira njala
• Obuteeyabya
• Okuwulira nga okooye nnyo
• Okuwulira ng’olina ekiwuubaalo
• Okwerabira oba okubulwa okujjukira
• Obulumi mu binywa, obunafu, ne/oba okulemagana

Obubonero obulala obuyinza okuva mu kookolo wa parathyroid:

• Okubeera n’ekizimba mu bulago
• Eddoboozi likyuka oba okuwuuma
• Okukaluubirirwa okumira emmere

Bw’oba ​​olina obubonero buno bumu oba obusingawo, totya kulowooza nti ddala kookolo wa parathyroid. Obubonero buno era busobola okulabibwa mu mbeera endala nnyingi. Wabula ekintu nga kino bwe kisigala, kirungi okugenda ew’omusawo akuwe amagezi.

Kookolo wa Parathyroid azuulibwa atya?

Okuzuula kookolo wa parathyroid oluusi kiyinza okukusoomooza katono. Ensonga emu eri nti obutoffaali bwa kookolo wa parathyroid atali kookolo n’obw’obulwadde bwa kookolo wa parathyroid busobola okulabika kye kimu.

Kookolo wa parathyroid atera okuzuulibwa oluvannyuma lw’okulongoosebwa kw’endwadde yo eya parathyroid etali ya bulijjo, ekola ennyo (a `parathyroidectomy`), era ebitundu by’omubiri ne byongera okwekebejjebwa. Oluusi, omusawo alongoosa asobola okuzuula kookolo wa parathyroid ng’alongoosebwa.

Bikebere ki ebikolebwa okuzuula obulwadde?

Nga bwe kyayogeddwako emabegako, kookolo wa parathyroid atera okuzuulibwa ng’omaze okuzuulibwa nti olina primary hyperparathyroidism , era endwadde ya parathyroid etali ya bulijjo era ekola ennyo n’elongoosebwa. Oluusi, omusawo alongoosa asobola okuzuula kookolo wa parathyroid ng’alongoosebwa.

Nga tonnalongoosebwa okuggyako endwadde yo eya parathyroid ekola ennyo, oyinza okukeberebwa nga bino:

• Okukebera calcium mu musaayi
• Okukebera PTH mu musaayi
• Parathyroid scan - Kino kitera okuba nga kya radioactive sestamibi scan ne/oba CT scan.

Bw’ozuulibwa nti olina kookolo wa parathyroid, omusawo ayinza okulagira okukeberebwa ebifaananyi nga bino okulaba oba kookolo asaasaanidde (metastasized) mu bitundu by’omubiri gwo ebirala:

• CT scan (computerized tomography scan): CT scan ekozesa X-ray ne kompyuta okukola ebifaananyi bingi eby’omubiri gwo eby’ebitundu bisatu (3D).
• MRI scan (MRI - okukuba ebifaananyi mu ngeri ya magineeti):MRI scan ekozesa magineeti ennene, amayengo ga leediyo, ne kompyuta okukola ebifaananyi ebikwata ku mubiri gwo mu bujjuvu. Tekozesa X-ray (radiation).

Bujjanjabi ki obuweebwa kookolo wa parathyroid?

Enkola enkulu ey’obujjanjabi eri kookolo wa parathyroid kwe kulongoosa okuggyawo kookolo w’endwadde ya parathyroid (`en bloc resection`). Singa kookolo wa parathyroid asaasaana (metastasized), omusawo akulongoosa era ayinza okwetaaga okuggya ebitundu ebyetoolodde enseke yo eya parathyroid oba ebitundu bya kookolo okuva mu bitundu by’omubiri gwo ebirala.

Obukodyo buno obw’okulongoosa busobola okukozesebwa ku kookolo wa parathyroid:

• En bloc resection: Mu nkola eno, omusawo alongoosa aggyawo enseke yo yonna eya parathyroid n’akapiira akagyetoolodde. Oluusi, era ziyinza okuggyawo ekitundu ky’endwadde ya thyroid ku ludda lwe lumu n’ennywanto ya kookolo eya parathyroid, awamu n’ebitundu ebibyetoolodde, ebinywa n’obusimu.
• Tumor debulking: Mu nkola eno, omusawo alongoosa aggyamu ekizimba ekinene nga bwe kisoboka. Ebizimba ebimu biyinza obutaggyibwawo ddala.
• Metastasectomy: Mu kino, omusawo alongoosa aggyawo kookolo yenna eyasaasaana (metastasized) mu bitundu ebirala ne/oba ebitundu by’omubiri gwo, okugeza, amawuggwe.

Nnafuna obujjanjabi bwa ddagala oba obujjanjabi obw’amasannyalaze?

Chemotherapy ne radiation therapy tezitera kukozesebwa kujjanjaba kookolo wa parathyroid. Omusawo wo ajja kusalawo oba obujjanjabi bw’eddagala n’/oba obujjanjabi obw’amasannyalaze (radiation therapy) birungi gy’oli.

Waliwo eddagala eriwonya kookolo wa parathyroid?

Mu kiseera kino, tewali ddagala ddene erijjanjaba kookolo wa parathyroid. Abantu bangi abalina kookolo wa parathyroid bafuna obubonero bw’obulwadde bwa hypercalcemia. Olw’okuba obulwadde bwa hypercalcemia buyinza okuba obw’obulabe, omusawo ayinza okukuwa eddagala erimu oba okusingawo ku ddagala lino wammanga erya hypercalcemia:

• Ekirungo kya Cinacalcet (Cinacalcet - Sensipar®) .
• Ebirungo ebiyitibwa Bisphosphonates
• Denosumab (Eddagala lya Denosumab - XGEVA®) .

Bw’oba ​​olina obubonero obw’amaanyi obw’obulwadde bwa ‘hypercalcemia’, omusawo ayinza okukuwa amagezi okuweebwa ekitanda mu ddwaaliro mu bwangu n’otandika okukozesa amazzi mu misuwa (IV) n’obujjanjabi obulala.

Kookolo wange ow’ekirungo kya parathyroid asobola okuddamu?

Yee, abantu abasukka mu kitundu abazuuliddwa nga balina kookolo wa parathyroid basobola okuddamu okufuna kookolo.Kookolo atera okudda mu myaka mitono – ebiseera ebisinga wakati w’emyaka ebiri n’etaano. Naye mu mbeera ezimu, kiyinza okubaawo emyaka mingi (emyaka 20 oba okusingawo) oluvannyuma lw’okusooka okuzuulibwa n’okujjanjabibwa.

Kookolo ono asobola okusaasaana (okusaasaana) mu bitundu by’omubiri ebirala?

Yee, kookolo wa parathyroid asobola okusaasaana (okusaasaana) mu bitundu by’omubiri gwo ebirala. Wakati wa 10% ne 30% ku bantu abalina kookolo wa parathyroid kookolo ono yasaasaana dda (metastatic) mu kiseera we bazuuliddwa. Mu mbeera zino, kookolo asinga kusaasaana mu mawuggwe, amagumba oba ekibumba. Wabula era kiyinza okusaasaana mu nnywanto zo oba mu pancreas.

Kiki ekitegeeza kookolo wa parathyroid?

Enteebereza ya kookolo wa parathyroid esinziira ku ngeri okulongoosa okuggyawo enseke z’ekibumba gye kujjuvu ng’osoose okuzuulibwa, kubanga obujjanjabi obw’okubiri ng’obujjanjabi obw’amasannyalaze n’obujjanjabi butono.

Ku bantu abalina kookolo wa parathyroid abakoleddwako en bloc resection era nga balina negative margins, omuwendo gw’abawona guli waggulu nga 90% nga wayise emyaka etaano bukya balongoosebwa mu kusooka. Omuwendo gw’abawona nagwo guli waggulu nga 67% oluvannyuma lw’emyaka kkumi oluvannyuma lw’okulongoosebwa okwasooka.

Abantu abasoba mu kitundu abazuuliddwa nga balina kookolo wa parathyroid ne balongoosebwa okuggyamu endwadde eno bajja kuddamu okufuna kookolo. Mu mbeera zino, kookolo atera okudda mu myaka ebiri oba etaano okuva lwe yasooka okulongoosebwa. Kyokka, kiyinza okuddayo oluvannyuma lw’emyaka mingi.

Kookolo wa Parathyroid asobola okuziyizibwa?

Ebyembi, tewali ngeri emanyiddwa ey’okuziyiza kookolo wa parathyroid. Ate era, tewali ngeri yonna gye tuyinza kukendeeza ku bulabe bw’okukwatibwa obulwadde buno. Singa omuntu yenna mu maka go abadde n’obulwadde bwa parathyroid gland, kirungi okwogera n’omusawo wo.

Bibuuzo ki bye nnina okubuuza omusawo wange?

Bw’oba ​​olina kookolo wa parathyroid, oyinza okubuuza omusawo ebibuuzo nga bino:

• Kookolo asaasaanidde okusukka enseke yange eya parathyroid?
• Bujjanjabi ki obusinga obulungi ku kookolo wa parathyroid?
• Obulabe ki n’ebizibu ebiva mu bujjanjabi buno?
• Famire yange eri mu bulabe bw’okukwatibwa kookolo wa parathyroid?
• Nsobola okuddamu okufuna kookolo wa parathyroid?
• Ndi mu bulabe bw’okufuna ebika bya kookolo ebirala?
• Obulabirizi ki obw‟okugoberera bwe nja okwetaaga oluvannyuma lw‟okujjanjabwa?
• Nsaanidde okumanya obubonero bw’ebizibu?

N’ekisembayo, ebintu by’olina okujjukira

Okuzuulibwa nti olina kookolo kiyinza okuba ekintu ekitiisa. Naye jjukira nti .Ttiimu yo ey’abasawo eri wano okukuyamba n’okukulaga obujjanjabi obusinga obulungi. Wadde nga mu kiseera kino okulongoosa kwe kujjanjaba kookolo wa parathyroid, okunoonyereza n’obujjanjabi bwa kookolo buli kiseera bigenda bitereera. Wayinza n’okubaawo okugezesebwa okw’obujjanjabi kw’osobola okwetabamu.N’olwekyo, totya kubuuza musawo wo bibuuzo ku kookolo wo ow’ekirungo kya parathyroid. Kakasa nti buli kimu kinnyonnyolwa mu ngeri gy’otegeera.

` Kookolo wa Parathyroid, Endwadde za Parathyroid, Hypercalcemia, Parathyroid Hormone, PTH, Obubonero bwa kookolo, Obujjanjabi bwa kookolo, Okulongoosa