Omanyi kookolo atatera kulabika ayitibwa Sarcomatoid Carcinoma? Ka twogere mu bujjuvu!

Kookolo atutiisa ffenna katono, nedda? Naye kookolo yenna si y’emu. Leero tugenda kwogera ku kika kya kookolo ekitali kya bulijjo era ekizibu. Kiyitibwa Sarcomotoid Carcinoma. Erinnya lino liyinza okukuwulikika ng’ekyewuunyisa, naye ka tugezeeko okulinnyonnyola mu ngeri ennyangu. Abasawo kino bakiyita ekika kya kookolo ekikula amangu ennyo, eky’obukambwe .

Sarcomatoid Carcinoma kye ki?

Mu ngeri ennyangu, Sarcomatoid Carcinoma ye bika bya kookolo bibiri nga bigattiddwa wamu. Kwe kugamba nti erina engeri za kookolo ne sarcoma. Kati ka tulabe carcinoma ne sarcoma kye ki.

• Carcinoma: Kino kye kika kya kookolo ekisinga okubeerawo. Kitandikira mu bitundu ebibikka kungulu ku bitundu byaffe oba olususu. Ebitundu bino tubiyita epithelial tissue kubanga bikolebwa obutoffaali obuyitibwa epithelial cells.
• Sarcoma: Kino tekitera kubaawo okusinga kookolo. Sarcomas zitandika mu bifo ng’amagumba, ebitundu ebiyunga (e.g., eggumba, emisuwa), n’ebitundu ebigonvu (e.g., ebinywa, amasavu, obusimu). Zikolebwa ekika ky’obutoffaali obuyitibwa mesenchymal cells.

Kale, mu mbeera ya sarcomatoid carcinoma, ekizimba ekirimu obutoffaali n’ebitundu ebikwatagana ne carcinoma ne sarcoma byombi bitondebwa. Ebizimba bino bikula mangu nnyo era bisobola okusaasaana (okusaasaana) mu bitundu by’omubiri eby’enjawulo. Kino bwe kisaasaana, ebitundu ebiramu mu mubiri byonoonebwa.

Kino kisinga kubeera wa ku mubiri?

Bw’owulira erinnya sarcomatoid carcinoma, osinga kulikwataganya n’amawuggwe go . Wabula kookolo ow’ekika kino alina engeri za kookolo ne sarcoma, asobola n’okubeera mu bitundu by’omubiri ebirala. Okugeza nga:

• Omubiri
• Eggumba
• Omumwa
• Ensigo ya thyroid
• Amabeere
• Olubuto
• Ekyenda ekitono
• Ekibumba
• Olubuto oluyitibwa pancreas
• Nnabaana
• Enseke z’enseke
• Ekibumba
• Ensigo
• Ekifo ekiri wakati mu kifuba (kino kiyitibwa ``Mediastinum''. Ebintu ng'omutima, omukka, n'endwadde ya thymus biri wano)

Sarcomatoid carcinoma, atandikira mu mawuggwe, kigambibwa nti asaasaana mangu nnyo. Mu ngeri eno, esobola okusaasaana mu bifo ebiwerako omulundi gumu, gamba ng’endwadde z’ekibumba, obwongo, amagumba, ekibumba, ensigo, olubuto, olubuto, olususu n’omutima.

Kino nakyo waliwo ebika eby’enjawulo?

Yee, ekitongole ky'ebyobulamu mu nsi yonna (WHO) kyagabanya kookolo wa sarcomatoid mu bika bitaano ebikulu mu 2015. Buli kimu ku bika bino kiyitibwa "poorly differentiated non-small cell lung carcinoma." "Okwawukana obubi" kitegeeza nti obutoffaali bwawukana mu ngeri etaali ya bulijjo ne kiba nti kizibu okwogera ddala ekika ki. Kookolo w’amawuggwe atali wa butoffaali butono kika kya kookolo w’amawuggwe atera okukula n’okusaasaana amangu.

Ebika bino ebitaano bye bino:

• Pleomorphic carcinomas: Zino zisinga kuba na bifaananyi bya kookolo. Wabula waakiri ebitundu 10% ku bo bitera okuba n’ebifaananyi bya sarcoma. Kino kye kika kya kookolo wa sarcomatoid ekisinga okubeerawo.
• Spindle-cell carcinoma: Kookolo ow’ekika kino erinnya lye yafuna okuva ku ngeri obutoffaali bwe gye bulabika mu microscope. Ziwanvu, zigonvu era zifaananako ebiwujjo bya nnamuziga ewunyiriza.
• Giant cell carcinoma: Kino kirina obutoffaali obunene obusengekeddwa mu ngeri efaananako ne sarcomas. Bino bitera okukolebwa mu kitundu eky’okungulu eky’amawuggwe.
• Carcinosarcoma: Kuno kw’ogatta ebitundu ebiva mu bika bya kookolo ebimu, gamba nga adenocarcinoma ne squamous cell carcinoma. Era kizingiramu ebitundu bya sarcoma ebitali bya bulijjo, ebitakula bulungi.
• Pulmonary blastoma: Kino kika kya adenocarcinoma ekiringa ebitundu by’amawuggwe g’omwana ali mu lubuto. Obutoffaali bwa mesenchymal (nga sarcomas) nabwo busobola okulabibwa.

Ani asinga okukulaakulanya kino?

Sarcomatoid Carcinoma asinga kubeera mu basajja . Kitera nnyo naddala mu bantu abakozesa ebintu bya taaba mu kiseera kino oba ababikozesezza emabegako . Emyaka gya bulijjo egy’okuzuulibwa obulwadde buno giri nga 65.

Kino kya bulijjo kitya?

Kino kika kya kookolo ekitali kya bulijjo nnyo . Sarcomatoid Carcinoma ekola ekitundu kitono nnyo ku kookolo w’amawuggwe yenna, wakati wa 0.1% ne 0.4%.

Bubonero ki obulaga kino?

Obubonero bw’olaba businziira ku kookolo w’asaasaanidde mu mubiri gwo. Bw’oba ​​olina kookolo w’amawuggwe ow’ekika kya sarcomatoid, oyinza okufuna obubonero nga:

• Okusesema (okutaggwaawo) .
• Obuzibu mu kussa (okusannyalala) .
• Obulumi mu kifuba
• Okuvaamu omusaayi n’omusulo
• Okugejja awatali nsonga yonna

Lwaki ekintu nga kino kibaawo?

Abasawo balowooza nti ekisinga okuvaako kookolo wa sarcomatoid y'enkola eyitibwa "Epithelial-Mesenchymal Transition (EMT)." Mu ngeri ennyangu, wano we wava obutoffaali bwa kookolo obuyitibwa epithelial cells mu non-small cell lung carcinoma bwe bukyuka, era obumu ku bwo bwe bukyuka ne bufuuka obutoffaali bwa mesenchymal. Obutoffaali bwa kookolo obukyuse mu ngeri eno busaasaana mangu nnyo mu mubiri gwonna.

Enkyukakyuka zino ez'obutoffaali n'okukula amangu bitera okukwatagana n'enkyukakyuka mu buzaale mu butoffaali . Omanyi obuzaale bwaffe bye biragiro ebibuulira obutoffaali engeri y’okweyisaamu. Enkyukakyuka mu buzaale y’enkyukakyuka oba ensobi mu biragiro ebyo. Bannasayansi bazudde enkyukakyuka z’obuzaale eziwerako ezikwatagana ne kookolo wa sarcomatoid.

Biki ebiyinza okukosa kino?

Ekintu eky’obulabe kye kintu ekyongera emikisa gy’okufuna obulwadde. Mu mbeera ya kookolo wa sarcomatoid, okunywa sigala kye kisinga era ekisinga okumanyibwa nti kiyinza okuvaako akabi. Kinajjukirwa nti abantu wakati wa 80% ne 90% abafuna kookolo w’amawuggwe ono be banywa sigala mu kiseera kino oba abaali banywa sigala.

Tewerabira nti okulekera awo okunywa sigala kiyinza okukukuuma endwadde z’amawuggwe nnyingi omuli ne kookolo nga ono.

Omusawo kino akitegeera atya?

Omusawo ajja kusooka kukukebera era bwe kiba kyetaagisa akole ebimu ku bifaananyi. Wabula okukakasa nti ono kookolo wa sarcomatoid, kyetaagisa okukebera obutoffaali bwa kookolo.

• Okukuba ebifaananyi: Omusawo ayinza okukola CT scan okulaba kookolo gy’ali. Okusobola okulaba obulungi munda mu mubiri, CT/PET scan oba F-fluorodeoxyglucose (FDG)-PET scan eyinza okukolebwa. Sikaani ya CT/PET egatta ebigezo bibiri (CT ne PET) mu kiseera kye kimu. Fluorodeoxyglucose ddagala erifukibwa mu mubiri nga bakola PET scan. Kikung’aanya okwetooloola obutoffaali bwa kookolo, ne bulabika obulungi ku sikaani.

• Histopathology: Histopathology kwe kukebera mu microscopic sample y’ebitundu bya kookolo ebiggiddwa mu biopsy. Endabika y’obutoffaali esobola okuyamba omusawo okuzuula oba kookolo wa sarcomatoid era bwe kiba bwe kityo, kika ki ekitono (e.g., pleomorphic carcinoma, spindle cell carcinoma).

• Enkola y’obusimu obuziyiza endwadde:Okukebera kuno kunoonya ebintu ebiyitibwa antigens ebikwatagana n’ebika by’obutoffaali ebimu. Antigens ezimu zisobola okuzuula akatoffaali nga akatali ka bulijjo oba nga kabi.

Kijjanjabwa kitya?

Obujjanjabi obusinga okukola obulungi ku kookolo ono kwe kulongoosa okuggyamu ekizimba kyonna. Chemotherapy esobola okuyamba okutta obutoffaali bwa kookolo bwonna obusigaddewo oluvannyuma lw’okulongoosebwa. Kyokka ebiseera ebisinga, kookolo w’azuulibwa ng’asaasaana, n’olwekyo okulongoosebwa kuyinza obutasoboka. Singa wabaawo ebizibu ng’obulumi, okuvaamu omusaayi oba okukaluubirirwa okussa, n’obujjanjabi obw’amasannyalaze buyinza okuweebwa.

Mu mbeera ya kookolo wa sarcomatoid, okugezesebwa mu malwaliro kuyinza okuba obujjanjabi obusinga obulungi. Okugezesebwa mu malwaliro kwe kunoonyereza okugezesa obukuumi n’obulungi bw’obujjanjabi obupya. Mu kiseera kino bannassaayansi bali mu kunoonyereza ku bujjanjabi obuyinza okuyamba okwongera ku budde bw’osobola okubeera ne kookolo ono. Ebibiri ku byo bye bino:

• Obujjanjabi obugendereddwamu: Kino kizingiramu okutunuulira engeri entongole ezireetera obutoffaali bwa kookolo okweyongera mu ngeri etafugibwa.
• Obujjanjabi bw’abaserikale b’omubiri: Kino kisitula abaserikale b’omubiri gwo, ne kibayamba okuzuula n’okusaanyaawo obutoffaali bwa kookolo.

Kiki kye tuyinza okukola okukendeeza ku bulabe?

Bw’osalawo obutakozesa bikozesebwa mu taaba, osobola okukendeeza ku bulabe bw’okufuna kookolo wa sarcomatoid carcinoma, awamu ne kookolo w’amawuggwe amalala mangi. Lino lye ddaala erisinga obukulu ly’oyinza okukwata.

Kino kisobola okuwona ddala?

Mu butuufu, kookolo wa sarcomatoid kika kya kookolo ekitera okuba ekizibu okuwona ddala. Kyokka, bannassaayansi bwe beeyongera okumanya ebikwata ku butoffaali bw’ebizimba bino, gamba ng’enkyukakyuka mu buzaale, basobola okukola obujjanjabi obupya obubigenderera. Singa ozuulibwa nti olina obulwadde buno, oyinza okuba n’ebisaanyizo okwetaba mu kugezesebwa okw’obujjanjabi okukebera obujjanjabi obupya. Buuza omusawo wo ku nsonga eno.

Olina okumala bbanga ki n’obulwadde buno?

Kizibu okwogera ebbanga ly’onoomala mu mbeera eno, naye kikulu okukimanya. Ku kigero, omuwendo gw’abantu abawangaala wakati gubeera gwa myezi nga 10. Omuwendo gw’abantu abawangaala mu myaka etaano guli nga 15%. Wabula ebibalo bino tebikwata ku buli muntu kye kimu. Waliwo ebintu bingi ebiyinza okukosa embeera yo:

• Ekika ky’obutoffaali ekigere mu kookolo.
• Nkyukakyuka ki ez’obuzaale ezibaddewo?
• Ebanga lye kyatwala okuva obubonero lwe bwatandika okutuuka ku kuzuula obulwadde buno.
• Kookolo gy’akula n’okusaanyaawo ebitundu ebiramu.
• Kookolo ono asaasaanidde wa.
• Oba omusawo asobola okuggyawo ddala ekizimba kya kookolo.

N’olwekyo, kikulu nnyo okwogera mu lwatu ku bino byonna n’omusawo wo okufuna okutegeera okutuufu ku mbeera yo.

Bibuuzo ki ebikulu by’olina okubuuza omusawo?

Bw’okizuula nti olina kookolo wa sarcomatoid, oyinza okuwulira nga weeraliikirira nnyo era ng’osobeddwa kubanga kookolo ono wa njawulo nnyo era nga muzibu nnyo. Kikulu okwogera mu lwatu n’omusawo wo ku ngeri gy’oyinza okukozesaamu obujjanjabi n’engeri obulwadde buno gye bunaakwatamu mu biseera eby’omu maaso. Omusawo asobola okukunnyonnyola ky’osuubira okusinziira ku mpisa z’obutoffaali bwa kookolo n’ekifo kookolo w’ali mu mubiri gwo.

Bino bye bimu ku bibuuzo by’oyinza okubuuza omusawo wo:

• Kookolo wange asasaanye?
• Kookolo wange wa maanyi atya?
• Bujjanjabi bwa ngeri ki gy’oteesa?
• Biki ebiyinza okusuubirwa okuva mu bujjanjabi?
• Olowooza kyandibadde kirungi nnyo okufuna endowooza y’omusawo eyookubiri?
• Nkole n’abakugu mu kujjanjaba obulwadde bw’okukkakkanya obulumi?
• Nnina ebisaanyizo okwetaba mu kugezesebwa okw’obujjanjabi?

Omusawo asobola okukuwa amawulire ge weetaaga, okukusindika mu kugezesebwa mu malwaliro bw’oba ​​olina ebisaanyizo, n’okukuyamba okufuna obujjanjabi obukkakkanya obulumi.

Ebintu bye tulina okujjukira

Okay, kale, okusinziira ku bye twogeddeko ku Sarcomatoid Carcinoma, bino bye bintu ebikulu by’olina okujjukira:

• Kino kika kya kookolo ekitatera kulabika, kya bukambwe era asaasaana mangu nnyo.
• Kino kiraga ebifaananyi bya kookolo ne sarcoma byombi.
• Okunywa sigala kye kisinga okuleeta akabi ku kino.
• Obubonero businziira ku kifo kookolo w’ali. Mu mawuggwe, obubonero buyinza okuli okusesema n’okukaluubirirwa okussa.
• Okukebera okw’enjawulo (biopsy, imaging) kwetaagibwa okuzuula obulwadde.
• Enkola z’obujjanjabi nzibu nnyo. Ng’oggyeeko okulongoosa, eddagala, n’obujjanjabi obw’amasannyalaze, n’obujjanjabi obupya (obujjanjabi obugendereddwamu, obusimu obuziyiza endwadde) nabwo bulowoozebwako.
• Wadde ng’emikisa gy’okuwona ddala mitono, okunoonyereza okupya kuwa essuubi.
• Kikulu nnyo okwogera mu lwatu n’omusawo wo ku mbeera gy’olimu era buli kimu okimanye bulungi.

Nsuubira nti amawulire gano gakuyamba. Bw’oba ​​olina ekibuuzo ekirala kyonna ekikwata ku nsonga eno, wulira nga oli waddembe okwebuuza ku musawo.

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