Ekizimba ekitaliimu makulu mu mubiri? Ka twogere ku kino (Undifferentiated Pleomorphic Sarcoma - UPS)!

Wali owuliddeko ekintu ng’ekizimba ekikula ne kyeyongera obunene awalala ku mubiri gwo? Oluusi, awatali nsonga, oyinza okuzimba oba okuziyira mu mukono oba okugulu. Wadde ng’ebiseera ebisinga tetufaayo nnyo ku bintu bino, wayinza okubaawo ekintu eky’amaanyi ekikwese emabega wabyo. Leero, tugenda kwogera ku kika kya kookolo eky’enjawulo abantu bangi kye batatera kuwulira, naye nga kikulu nnyo ffenna okukimanya. Totya, kino ka tukitegeere mu ngeri ennyangu.

``Undifferentiated Pleomorphic Sarcoma - UPS'' kye ki?

Mu ngeri ennyangu, ``Undifferentiated Pleomorphic Sarcoma'' oba ``UPS'' nga bwe tugiyita mu bufunze, kika kya kookolo ekiyitibwa soft tissue sarcoma . Wano obutoffaali bwa kookolo bwe butondebwa mu bitundu ebigonvu eby’omubiri gwaffe, gamba ng’ebinywa, amasavu, n’emisuwa.

Ebiseera ebisinga, kino `(UPS)` kitandikira mu bitundu ebigonvu eby'emikono oba amagulu go . Oluusi era kiyinza okubaawo mu kitundu ekizito eky’emabega w’olubuto, ekiyitibwa `retroperitoneum` . Tekitera nnyo, kino `(UPS)` kikosa amagumba. Eky’ennaku kiri nti, kino kitera okuba kika kya kookolo ekizibu ennyo . N’olwekyo kitera okusaasaana mu bitundu by’omubiri ebirala naddala mu mawuggwe oba mu bitundu by’omubiri ebiyitibwa lymph nodes .

Edda, kino `(UPS)` kyayitibwanga `malignant fibrous histiocytoma` . Ensonga lwaki kino kiri bwe kityo eri nti abanoonyereza baali balowooza nti kookolo ono ava mu butoffaali obw’enjawulo obw’abaserikale b’omubiri obuyitibwa `histiocytes` . Wabula oluvannyuma okunoonyereza kwazuula nti kisinga kutandikira mu butoffaali obuyitibwa `mesenchymal cells`, obukola ebitundu ebiyunga mu mubiri gwaffe.

Kati katutunuulire amakulu g’ebigambo ebibiri ebiri mu linnya lino.

"Undifferentiated" kitegeeza nti obutoffaali buno bwa kookolo bufuna endabika ey'akavuyo ennyo, etali ntegeke . Ng’eby’okuzannyisa ebibunye nga tebirina kiragiro kyonna. Zifuuse za njawulo nnyo era nga tezikuze ne kiba nti tekisoboka kumanya bulungi butoffaali bulamu bwe zaatandikira oba omulimu gwe zaali zigendereddwamu okukola.

Ekigambo "pleomorphic" kitegeeza nti obutoffaali buno bwa njawulo mu nkula, obunene, oba nucleus, ekifo ekifuga obutoffaali . Kilowoozeeko ng’ekintu ekitali kikoleddwa mu kibumbe kimu, buli kimu kya njawulo mu nkula n’obunene. Obutoffaali obumu butono, obumu bunene. Ebimu byetooloovu, ebirala biwanvu. Ne nucleus, erimu chromosomes munda mu butoffaali, ya njawulo mu buli katoffaali. Eno y’ensonga lwaki obutoffaali buno obwa kookolo bukula mu ngeri etaali ya bulijjo nnyo era mu bwangu nga tebulina kye bufuga.

UPS mu butuufu kika kya kookolo ekitali kya bulijjo nnyo . Ng’ekyokulabirako, mu Amerika, obulwadde buno bukwata abantu abatakka wansi wa 5,000 omwaka. Kyokka mu bika bya sarcomas z’ebitundu ebigonvu, .Ng’oggyeeko liposarcoma (kookolo akula mu bitundu by’amasavu) ne leiomyosarcoma (kookolo akula mu binywa ebiseeneekerevu), (UPS) kye kika eky’okusatu ekisinga okubeera mu bitundu ebigonvu ebiyitibwa sarcoma .

Bubonero ki obwa `(UPS)`?

Obubonero bwa `Undifferentiated Pleomorphic Sarcoma (UPS)` busobola okwawukana okusinziira ku muntu. Abantu abamu bayinza obutafuna bubonero bwonna. Kyokka waliwo obubonero obumu obutera okulabika:

• Ekizimba oba ekizimba ekikula mpolampola: Kano ke kabonero akakulu. Kiyinza okuwulira ng’ekizimba wonna ku mubiri naddala mu mukono, ekigere oba mu lubuto.
• Ekizimba ekitaliimu bulumi ekiyinza okutambula oba obutatambula nga kikutte: Ebiseera ebisinga, ebizimba bino tebireeta bulumi mu ntandikwa. N’olwekyo, abantu abamu bayinza obutabafaako nnyo.
• Okuzirika oba okwokya olw’ekizimba okunyigiriza ku busimu: Oluusi, ekizimba kino bwe kikula, kiyinza okunyigiriza ku busimu obuli okumpi. Kino kiyinza okuvaako emikono oba ebigere okuziyira, okuwunya oba okwokya.
• Okuzimba mu mukono oba okugulu: Singa omukono oba ekigere kizimba awatali nsonga, ekyo nakyo kisaana okulowoozebwako.

Ekikulu, UPS tetera kulaga bubonero obweyoleka. Zitera obutalumwa , era tewali nkyukakyuka mu lususu ku kizimba (nga okukyusa langi oba amabwa). Ate era obubonero obutera okulabika ng’omusujja, okugejja, n’obutabeera bulungi tebutera kulabibwa.

Biki ebivaako `(UPS)`?

Abakugu n’okutuusa kati tebamanyi bulungi kiki ekivaako UPS. Kye bamanyi nti kiva ku nkyukakyuka (enkyukakyuka) mu DNA (molekyulu erimu amawulire gaffe ag’obuzaale) y’obutoffaali obulamu. Kyokka, ekivaako enkyukakyuka ezo mu DNA tekinnategeerekeka bulungi.

Ensonga z’akabi Ezongera Obulabe bw’okukulaakulanya UPS

Ensonga ey’akabi kye kintu ekyongera emikisa gy’okufuna obulwadde. Waliwo ensonga eziwerako ez'akabi ezizuuliddwa ku `(UPS)`. Naye jjukira, si buli muntu alina ensonga zino ez’akabi nti ajja kufuna `(UPS)`, era tekiyinza kwogerwa nti abantu abatalina kintu kyonna ku bintu bino eby’akabi tebajja kukulaakulanya `(UPS)`.

Ebintu eby’obulabe ebizuuliddwa mu kiseera kino bye bino:

• Okuba abasajja: Abasajja batera okukwatibwa obulwadde buno okusinga abakyala, ng’obulabe buno buba bungi nnyo mu basajja abazungu.
• Emyaka egisukka mu 50: Obulwadde buno bweyongera n’emyaka.
• Embeera z’obujjanjabi ezimu: Okugeza, abantu abalina endwadde nga neurofibromatosis (embeera ereetera ebizimba okukola mu busimu) oba obulwadde bwa Paget obw’amagumba (obulwadde obuleeta okukula kw’amagumba mu ngeri etaali ya bulijjo) bali mu bulabe obw’okukwatibwa (UPS).
• Embeera ezimu ez’obuzaale:Abantu abalina embeera z’obuzaale ezitatera kulabika nga Li-Fraumeni syndrome bali mu bulabe obw’okufuna ebika bya kookolo eby’enjawulo omuli (UPS).
• Okukwatibwa eddagala erimu: Okumala ebbanga eddene ng’olina eddagala erimu, gamba nga arsenic oba vinyl chloride, nakyo kiyinza okuba eky’obulabe.
• Obujjanjabi bw’amasannyalaze mu kitundu ekikoseddwa emabegako: Bw’oba ​​ofunye obujjanjabi bw’amasannyalaze mu kitundu ekimu olw’obulwadde obulala, waliwo akabi akatono ak’okukwatibwa obulwadde bwa sarcoma (UPS) mu kitundu ekyo oluvannyuma.
• Okukwatibwa obusannyalazo ku mulimu: Bw’oba ​​olina okubeera n’obusannyalazo mu mirimu egimu, ekyo nakyo kiyinza okuba eky’akabi.

Kyewunyisa nti abantu bangi abafuna UPS tebalina kintu kyonna ku bino ebiyinza okuleeta akabi . Kale bw'olaba ekintu ekifaanana ng'ekizimba ekitali kya bulijjo ku mubiri gwo, tokibuusa maaso ng'olowooza nti, "Sirina n'emu ku nsonga zino ez'akabi."

Abasawo bazuula batya `(UPS)`?

Bw’olaba omusawo alina ekizimba nga kino, ajja kusooka kukubuuza ku bulamu bwo, oba waliwo omuntu yenna mu maka go abadde n’endwadde nga kookolo (family history), n’ebirala Olwo ajja kukubuuza ku bubonero bwo. Ekizimba kino kimaze bbanga ki? Kigenda kyeyongera obunene? Kiruma? Okugatta ku ekyo, ajja kukola ebigezo bino wammanga:

1. Okukebera omubiri: Omusawo ajja kwekenneenya ekifo ekizimba we kiri, obunene bwakyo, n’engeri gye kiwuliramu nga kikutteko (ekikalu oba ekigonvu).

2. Okukebera ebifaananyi: Okukebera kuno kuyamba okulaba ekizimba bwe kifaanana munda n’obuwanvu bwe kibunye. Ebiseera ebisinga, okukebera okumu oba okusingawo, gamba nga X-ray, ultrasound scans, ne/oba MRI scans, kuyinza okukolebwa.

3. Biopsy: Kino kye kigezo ekisinga obukulu okuzuula obulwadde buno mu ngeri enkakafu . Kino kizingiramu okuggya akatundu akatono mu kizimba (oboolyawo n’akatono akalinga empiso) n’okukeberebwa mu microscope omusawo w’endwadde (omusawo mukugu mu kuzuula endwadde). Olwo lwe tusobola okugamba mu bukakafu oba UPS oba embeera endala.

Bujjanjabi ki obwa `(UPS)`?

Obujjanjabi bwa UPS businziira ku bintu nga obunene bw’ekizimba n’okumanya oba kookolo asaasaanidde. Obujjanjabi obukulu eri UPS mu kiseera ekisookerwako kwe kulongoosa okuggyamu ekizimba . Kino kitera okukolebwa nga kigatta wamu n'obujjanjabi obw'amasannyalaze . Kyokka, oluusi kiyinza okwetaagisa obujjanjabi obulala obwa kookolo.

Okuloongoosa

Ekigendererwa ekikulu eky’okulongoosa UPS kwe kuggyawo ddala ekizimba kya kookolo.. Abasawo bagezaako okuggyako kookolo yekka, wabula n'obutundutundu obutono obulamu obumwetoolodde (kino kiyitibwa "margin") . Nga bwe tuggyawo omuddo mu lusuku, tetuggyawo kimera kyokka, wabula n’ettaka ettono erikyetoolodde. Olwo wadde akatundu akatono ak’ekikolo ky’omuddo tekasigalawo. Mu ngeri y’emu, abasawo bwe baggyawo kookolo ono, bamuggyako wamu n’akatundu akatono akalamu akamwetoolodde. Olwo lwe tusobola okukakasa nti obutoffaali bwa kookolo bwonna buggyibwawo nga tebusigaddewo. Singa wabaawo obutoffaali bwa kookolo ku mabbali g’ekizimba ekiggiddwamu, kitegeeza nti mu mubiri muyinza okubaawo obutoffaali bwa kookolo obusingawo.

Singa ekizimba kiba mu mukono oba ku kigere kyo, omusawo akulongoosa ajja kugezaako okuggyawo kookolo n’okukuuma emirimu mingi nga bwe kisoboka mu mukono oba okugulu okwo. Kyokka, mu mbeera ezimu ez’amaanyi, kiyinza okwetaagisa okusalako ebitundu by’omubiri . N’olwekyo, kikulu okwogera n’omusawo wo omukugu mu by’obulwadde bwa kkansa okusalawo obujjanjabi ki obusinga ku mbeera gy’olimu.

Obujjanjabi Obulala obwa Kookolo

Abakugu mu by’obulwadde bwa kkansa nabo bayinza okukozesa obujjanjabi obulala nga tebannalongoosebwa oba nga bamaze okulongoosebwa. Wadde obujjanjabi buno butera obutakendeeza kizimba, busobola okuyamba okukifuula ekitali kya bulabe eri okulongoosebwa okuggyamu ekizimba, oba okutta obutoffaali bwa kookolo bwonna obuyinza okusigalawo oluvannyuma lw’okulongoosebwa.

Obujjanjabi buno obw’enjawulo bwe buno:

• Chemotherapy: Okuwa eddagala eritta obutoffaali bwa kookolo.
• Obujjanjabi bw’abaserikale b’omubiri: Okusitula abaserikale b’omubiri gwennyini okulwanyisa obutoffaali bwa kookolo.
• Obujjanjabi bw’amasannyalaze: Okusaanyaawo obutoffaali bwa kookolo nga tukozesa emisinde egy’amaanyi amangi.

Enteekateeka yo ey’obujjanjabi ya njawulo gy’oli. Kiyinza okuba eky’enjawulo ku ky’omuntu omulala. Kale yogerako n’omusawo wo ow’obulwadde bwa kkansa ku ngeri gy’oyinza okukolamu. Ojja kutera okujjanjabibwa ttiimu ekola emirimu egy'enjawulo . Ttiimu eno eyinza okubaamu omusawo alongoosa, omusawo akola ku bulwadde bwa kkansa obuyitibwa radiation oncologist, n’omusawo akola ku bulwadde bwa kookolo. Wadde nga buli musawo mukugu alina omulimu gwa njawulo, bonna bakolera wamu okukujjanjaba. Zijja kukuyamba okusalawo ekisinga obulungi mu mbeera gy’olimu.

Ddi lwe nnina okulaba omusawo?

Bw’olaba ekizimba oba okukula wonna ku mubiri gwo ekikula mpola , naddala nga kiwerekerwako obubonero ng’obulumi, okuzimba, oba obutasobola kutambuza bulungi kitundu kyo , olina okulaba omusawo amangu ddala .

Bwoba nga wazuula dda nti olina `(UPS)`, ggweBw’ofuna obubonero obupya, oba singa obubonero bwo bweyongera, tegeeza omusawo wo ow’obulwadde bwa kkansa amangu ago .

Ebintu bya ngeri ki omuntu alina `(UPS)` by'ayinza okusuubira?

Obulamu obusuubirwa bwawukana okusinziira ku muntu. Kisinziira ku bunene bwa sarcoma n'omutendera gw'obulwadde . Okutwaliza awamu, omuwendo gw’abantu abawangaala mu myaka etaano eri aba ddaala erya waggulu (UPS) guli nga 60% . Kino kitegeeza nti abantu nga 60% abazuuliddwa n’obulwadde buno bakyali balamu oluvannyuma lw’emyaka etaano. Omuwendo gw’abantu abawangaala mu myaka 10 guli nga 48% .

Naye jjukira nti emiwendo gino egy’okuwonawo kuteebereza kwa bulijjo kwokka . Tebakubuulira ddala bbanga ki ly’onoowangaala oba obujjanjabi bwe bunaasinga okukukolera. Okumanya ebisingawo ku miwendo gy’abawona n’engeri gye gikukwatako, kirungi okwogera ne ttiimu yo ey’abasawo ba kkansa.

`(UPS)` esobola okuwona ddala?

(UPS) ewonyezebwa ddala naddala singa ezuulibwa nga bukyali . Ne mu mbeera ng’obulwadde buno busaasaanidde, waliwo obujjanjabi obuyinza okuyamba okutumbula omutindo gw’obulamu bwo n’okuwangaaza obulamu bwo. Nga bwe kiri ku kika kya kookolo kyonna, okuzuula amangu n’okujjanjaba (UPS) y’engeri esinga obulungi ey’okutuuka ku buwanguzi .

Ebintu by’olina okulowoozaako

Bw’ozuulibwa nti olina kookolo, asobola okukosa buli kimu mu bulamu bwo. Bw’eba kookolo atatera kulabika nga Undifferentiated Pleomorphic Sarcoma (UPS), oyinza okuwulira ng’oli wekka nnyo era nga tewali akutegeera. Mu biseera nga bino, kiyinza okuyamba okwegatta ku kibiina ekiwagira abantu nga waliwo abalala abayita mu mbeera ze zimu nga ggwe . Okwogera nabo kiyinza okukuyamba okutegeera enneewulira zo n’okuziddukanya.

Ate era, ttiimu yo ey’abasawo bulijjo ebeerawo okukuyamba . Basobola okwogera naawe ku bujjanjabi bwo, okukuwagira, n’okukuwa amawulire n’ebikozesebwa by’olina okusalawo ku by’obulamu mu ngeri entuufu. Totya kubabuuza kibuuzo kyonna ky'olina . Bulijjo jjukira nti toli wekka.

` Undifferentiated Pleomorphic Sarcoma, UPS, sarcoma, kookolo w’ebitundu ebigonvu, kookolo, ekizimba, obubonero bwa kookolo, obujjanjabi bwa kookolo