Mi pakhat hnen atangin stem cell transplant i nei tawh em? He (Graft vs. Host Disease) hi i hrechiang ang u!

Stem cell transplant chungchang hi i hre tawh ngei ang. Natna thenkhat enkawlna pawimawh tak an ni. Mahse, vawiinah hian hetiang transplant hnua harsatna awm thei chungchang kan sawi dawn a ni. Hei hi `(Graft vs. Host Disease)` emaw, a tawi zawngin `(GvHD)` emaw an ti a. Ngaihtuah buai suh, he thu hi awlsam takin sawi ila.

`(Graft vs. Host Disease - GvHD)` tih hi eng nge ni? A awlsam zawngin sawi ila...

Mi dang, donor . Hei hi allogeneic transplant kan ti a. Heng stem cells te hi i taksa thisen siamna factory-a cell puitling lo ang mai an ni a, a nih loh leh hematopoietic stem cells ang an ni. Hengte hi a hnua i taksa mamawh thisen sen leh thisen var lo ni leh tur te an ni.

Tunah chuan engtikah nge hetiang donor atanga stem cell i mamawh ang? Cancer leukemia emaw lymphoma emaw, emaw, i ruhro hnathawh that lohna natna dang aplastic anemia ang chi i neih chuan he transplant chi hi i mamawh mai thei.

Okay, tunah chuan hei hi eng nge ni `(GvHD)`? `(GvHD)`-ah chuan thil thleng chu i dawn (graft) donor cell-te chuan i taksa (host) chhunga cell awmte chu thil mak, hriat loh angin an hmu a ni. I taksa hi an tan hmun thar a nih ang mai a ni. Chuvangin, heng donor cell te hian i taksa cell te chu an rawn bei tan ta a ni. Chuvangin `(Graft vs. Host Disease)` tih a ni a, chu chu "graft against host" tihna a ni. I hrethiam em?

GvHD chi hrang hrangte chu engte nge ni?

GvHD hi chi hnih a awm a. Tun hma chuan doctor-te chuan symptoms intan hun chhung a zirin an classified thin. Mahse tunah chuan a chi dik tak hriat tumin symptoms leh test result an en thin.

1. Acute GvHD (aGvHD) hmanga siam a ni.

Hei hi i stem cell transplant hnu lawkah a thleng tlangpui a, a tam zawk chu ni 100 hmasa berah a thleng thin . Mahse, a chang chuan symptoms hi a hnuah a intan thei. Acute GvHD hian i vun, digestive system (GI tract), emaw i thin emaw a nghawng tam ber.

2. GvHD rei tak (cGvHD) .

Chronic GvHD hi allogeneic transplant hnuah engtik lai pawhin a awm thei. Mahse, a tam ber chu kum hnih chhungin a intan thin . Chronic GvHD hian i vun, i hmui, i thin, i lung, i GI tract, i taksa ruh, i ruh, emaw, i serh emaw a nghawng thei a ni.

Pawimawh: Heng GvHD chi hrang hrang zinga pakhat, pahnih emaw, pakhat mah emaw i nei thei lo. Mi tin a inang lo.

`(GvHD)` natna lan chhuah dan chu engte nge ni? Hengte hi fimkhur rawh!

GvHD symptoms hi mi hrang hrangah a inang lo. Mi thenkhat chuan symptoms na lo tak tak an nei thei a , thenkhat chuan symptoms moderate an nei thei bawk , thenkhat chuan symptoms na tak tak an nei thei bawk.A na hle thei (nunna atana hlauhawm pawh a ni).

Acute `(GvHD)` natna lan chhuah dan

Acute GvHD hian vun, GI tract leh liver a nghawng tam ber tih kan sawi tawh a.

• Vun (aGvHD): A lan chhuah dan tlangpui chu vun rawng emaw, sen emaw (ni zung ang chi) a ni. Natna leh hrisel lohna a awm thei bawk. A natna hi a tlangpuiin kawr, kekawrte, beng, kutphah leh kephah atanga lo chhuak a ni. Chumi hnuah taksa peng dangah a darh thei a ni.
• Gastrointestinal (GI) tract (aGvHD): A lan chhuah dan tlangpui chu luak chhuak, luak chhuak, leh luak chhuak (bloating) te hi a ni. Heng symptoms te hi a na lo thei hle a, a nasat em avangin damdawi ina dah a ngai thei bawk.

Acute GvHD natna lan chhuah dan tlangpui chu:

• Vun rawng leh/ emaw, vun natna.
• Kawthalo.
• Nausea leh luak chhuak.
• Pum na, limping.
• Jaundice (vun leh/ emaw mit sen).

Chronic GvHD natna lan chhuah dan

Chronic GvHD hian i vun, i thin, GI tract leh i lung a nghawng tam ber. Mahse, i taksa peng eng pawh a nghawng thei a ni.

A lan chhuah dan chu:

• Vun rawng leh/ emaw, vun natna.
• Vun tightening leh swelling.
• Lu leh taksaah sam tlakchham.
• Kawng a vawt.
• Kawngkhar natna.
• Gum natna.
• Mit hring, a chhungah chuan sand chi khat a inkhung ang maia hriat.
• Mit hmuhna lama inthlak danglamna.
• Kawthalo.
• Nausea leh luak chhuak.
• Vun leh/ emaw mit sen (jaundice).
• Thâwk harsa (dyspnea).
• Dry, khuh chhunzawm zel.
• Chau.
• Muscle chak lohna, limping emaw, natna emaw.
• Joint bend leh extend tha thei lo.
• Hmeichhia hian inpawl laiin vaginal dryness, itching, na emaw an nei thei.
• Mipa hian penis emaw testicles emaw a na thei a, inpawl laiin na a nei thei bawk.

Engvangin nge hetiang `(GvHD)` hi a lo awm? A chhan chu eng nge ni?

A awlsam zawngin, GvHD hi i transplant dawngtu donor atanga stem cells te chuan nangmah ngeiin i taksa cell te chu "ram dang" anga an hmuh a, an rawn beih tan hian a lo awm thin.

Hei hi thil thleng tlangpui chu a ni: I immune system cell (i thisena cell) te hian natna lakah an venghim che a ni. Ram dang thil, virus leh bacteria te an do thin. Mahse, heng cell te hian nangmah cell te hi an bei lo. Hei hi i cell-te hian protein bik ``Human Leukocyte Antigens'', emaw ``HLA'' tih an neih vang a ni. Hei hi hming ziakna tag ang a ni. He ``HLA'' hian i immune cells te hnenah, "Hey, hei hi kan ta a ni," tiin a hrilh thin.

A pawimawh ber chu, identical twins tih loh chu, mi zawng zawng `(HLA)` hi a danglam vek a ni.

Midang hnen atanga stem cell transplant i dawn hnuah i taksaa thisen cell tharte hian i `(HLA)` an nei lo va, a petu `(HLA)` an nei zawk a ni Chuvangin, he thisen petu `(HLA)` hi i taksaa `(HLA)` nen a danglam hle a nih chuan , chu thisen cell tharte chuan i taksa cell te chu an rawn bei tan ta a ni. Chutah chuan `(GvHD)` a lo awm ta a ni.

Hei vang hian doctor-te chuan stem cell transplant an tih hmain donor-te HLA chu uluk takin an enfiah hmasa a, i HLA hnaih thei ang bera a awm leh awm loh an enfiah thin. Chutiang match hmuh chuan GvHD vei theihna a ti tlem a ni. Mahse, identical twin atanga cell i dawn loh chuan GvHD i neih theihna chance a la awm a, engzat pawh match i tum pawhin GvHD i neih theihna chance a la awm tho.

GvHD vei theihna hlauhawm ber chu tute nge ni?

Risk factor pawimawh ber chu i donor HLA leh i HLA nena a inmil em em hi a ni. GvHD vei theihna i nei sang zawk a, chu chu:

• I chhungte hnen atangin stem cells i dawng a, mahse HLA match dik tak erawh a ni lo .
• I chhungte ni lo, mahse `(HLA)` match mi pakhat hnen atangin stem cells i dawng a ni .

Risk factor dangte chu:

• Donor chu a hmaa naupai tawh hmeichhia a ni tur a ni.
• Donor emaw nangmah emaw kum tihpun.
• Donor leh nangmah inkara gender incompatibility (e.g. mipa donor atanga hmeichhia hnena cell dawng, emaw hmeichhe donor atanga mipa hnena cell dawng).
• Donor-te stem cells chu bone marrow (thisen siamna hmun) atanga lak ni lovin thisen kalna (thisen) atanga lak a nih chuan.

Acute `(aGvHD)` i neih tawh chuan chronic `(cGvHD)` vei theihna i nei sang zawk.

Engtin nge GvHD hi hmuhchhuah a nih?

I doctor chuan GvHD hi a enfiah thei che a, i natna lan chhuah dan a en a, lab test leh biopsy result a en thei bawk. Biopsy tih hian i tissue emaw cell emaw sample tlemte lak a, lab-ah test turin thawn a ngai a ni.

Chronic GvHD (cGvHD) ah chuan a lan chhuah dan thenkhat chu natna dang nen a inang thei. Chuvangin, doctor chuan cGvHD a awm tih chiang taka a hriat hmain a chhan dang zawng zawng a paih vek ang.

GvHD enkawlna tur engte nge ni?

Stem cell transplant i dawn hnuah, donor cell-te’n i tissue an beih theihna tihtlem nan prophylactic measure atan immunosuppressive damdawi pek i ni ang.

Heng damdawi te hian GvHD lo awm tur a titawp lo a nih chuan i doctor chuan i natna nasat dan leh GvHD chi hrang hrang a zirin enkawlna a pe ang che.

Acute GvHD enkawl dan

Doctor-te chuan acute GvHD vei te chu immune system titawp thei damdawi dose tihpun hmangin hlawhtling takin an enkawl fo thin. Hengte hi damdawi chi khat, corticosteroids an tih zingah an tel a ni. Kawngpuiah emaw, thisenah emaw, a chungah emaw pek theih a ni. Steroids hian hna a thawk lo a nih chuan i doctor chuan Ruxolitinib (Jakafi®) ang damdawi a pe thei ang. Damdawi thar test-na clinical trial-ah pawh tel theihna hun i nei thei bawk.

GvHD natna khirh tak enkawlna

Chronic GvHD hi hun rei tak chhunga immunosuppressive damdawi hmanga enkawl a ni tlangpui. Heng damdawi te hian a puih loh chuan i doctor chuan hetiang damdawi te hi a pe thei ang:

• `Ruxolitinib (Jakafi®) tih a ni
• `Belumosudil (RezurockTM)` tih a ni
• `Ibrutinib (Imbruvica®)` tih a ni
• Photopheresis (Hei hi enkawlna bik a ni) .

``Clinical trials'' atan pawh i tling thei bawk.Chu chu doctor chuan a hrilh ang che.

Enkawlna avanga harsatna/side effects awmte chu engte nge ni?

Heng immunosuppressive damdawi te hian i immune system a tichak lo a, fungal, bacterial, leh viral infection i vei tam zawk a ni . Chuvangin, i doctor chuan heng natna hlauhawm tak tak laka inven nan damdawi dang engemaw zat a pe ang che.

GvHD hi ven theih a ni em?

Tissue typing lab te hian DNA-based test thar, dik zawk an siam chhuak zel a, an hmang reng bawk. Hei hian i medical team te chuan i tan HLA match nei tam ber donor an thlang thei a ni. Match a tha poh leh GvHD venna chance a tha zawk.

Tin, i doctor chuan i stem cell transplant hnuah GvHD venna tur immunosuppressants a pe bawk ang.

GvHD hi a dam kim thei ang em?

A tam zawkah chuan doctor-te chuan hlawhtling takin an enkawl thei a ni (GvHD). Chu chu, natna lan chhuah dan an thunun thei a, nun pangngaia i awm theih nan an pui thei che tihna a ni.

Hetihlai hian zirchiangtute chuan clinical trial hmangin GvHD ven dan thar an zirchiang mek a ni. Entirnan, immunosuppressive damdawi chi hrang hrang leh prophylaxis damdawi thar an chhui mek a ni.

GvHD hi nunna atana hlauhawm a ni thei ang em?

Ni e, GvHD hi a chang chuan nunna atana hlauhawm tak a ni thei. Chronic GvHD hi allogeneic stem cell transplant dawngtu zingah chuan an natna bulpui ber tih loh chu thihna thlentu lian ber a ni.

Chuvangin, eng enkawlna pawh i neih hmain – stem cell transplant pawh nise – i doctor nen a hlauhawm dan sawiho a pawimawh hle. Ani chuan a hlauhawmnate chu a hrilhfiah thei che a, enkawlna ṭhatna leh ṭhat lohna tehna atan a pui thei bawk che a ni.

`(GvHD)` hian a chang chuan advantage a nei em?

Mak ti suh, GvHD hian i nunphungah nghawng tha lo tak nei thei mahse, hlawkna engemaw zat a nei bawk. I cell pangngai beitu immune response ang bawk hian i taksaa cancer cell awm thei zawng zawng chu a zawng chhuak a, a tichhia bawk. Hei hi graft-versus-tumor effect an ti a. GvHD vei te chu an natna bulpui (a bik takin cancer) lo kir lehna an nei tlem zawk tih hmuhchhuah a ni.

Engtin nge ka in enkawl ang? Heng tips te hi zawm rawh!

I doctor chuan i stem cell transplant hnua i in enkawl dan tur a hrilhfiah ang che. Entirnan, eng symptom nge fimkhur tur tih leh eng symptom nge i neih chuan i medical team ko nghal tur tih te. GvHD vei theihna hlauhawma i awm chuan enkawl dan tur dang pawh an pe thei bawk. Heng thupekte hi a hnuaia mi ang hian a ni:

• Ni laka i vun venghim rawh. Kawr kawr sei leh pants sei ha la. SPF 50 tal nei sunscreen hmang rawh.(Ni chhuahna hian GvHD a ti na zual thei a, a tichhuak thei bawk.)
• Kawng hriselna tha tak vawng reng rawh. Hei hian ha natna vei theihna a ti tlem ang.
• I pum ti na thei leh hmui ulcer thlen thei ei tur spicy ei loh tur.
• Hriselna laka inven nan hma la rawh. (Hemi chungchang hi i doctor in a hrilh belh ang che.)

Engtikah nge Doctor ka hmuh ang?

Taksa lama inthlak danglamna i neih chuan doctor hriattir nghal a pawimawh a, a bik takin natna hrik kai leh khawsik (100.4 Fahrenheit / 38 Celsius aia sang) i neih chuan i doctor hriattir nghal a pawimawh. Immunosuppressant i ei hian nunna atana hlauhawm thei natna hrik i vei theihna a sang hle.

Allogeneic stem cell transplant hnuah i doctor chuan Graft vs. Host Disease (GvHD) ang chi complication awm leh awm loh uluk takin a enfiah ang che. Acute emaw chronic GvHD symptoms i neih chuan i doctor chuan i damdawi a thlak thei a, damdawi thar a pe thei bawk. Damdawi zawng zawng hi a pek ang chiah chiah ei tur a ni. Mahni in enkawl dan tur, a bik takin natna hrik laka inven dan tur chungchangah doctor thupek zawm rawh.

A tawi zawngin hriat reng tur pawimawh ber berte chu!

Okay, chuvangin Graft vs. Host Disease, a nih loh leh GvHD hi midang atanga stem cell transplant an dawn hnua lo awm thei complication a ni. A awlsam zawngin, donor cell-te’n nangmah ngeiin i cell an beih hian a ni.

GvHD enkawlna tur a awm tih hre reng la, a natna pawh hi enkawl theih a ni. A pawimawh ber chu i medical team-te thupek uluk taka zawm a, symptom thar a awm chuan a rang thei ang bera hriattir hi a ni.

Hemi chungchanga zawhna dang i neih chuan i doctor zawh hreh suh. Anni hian an pui thei ber che a ni.

` GvHD, stem cell thlak, allogeneic transplant, immune system, HLA, donor cells, symptoms te