Estrogen leh cancer hi eng inzawmna nge ni? Estrogen-Dependent Cancers chungchang hi awlsam takin i zir dawn teh ang!

Chibai! Hormone estrogen tih hi i hre tawh ngei ang. Hmeichhe hriselna nena inzawm hian he hming hi kan hre fo thin. Mahse estrogen hian cancer chi hrang hrang lo awm dan pawh a nghawng thei tih i hre lo mai thei. Chu chu vawiinah hian kan sawi dawn a ni, a awlsam zawngin, i hriatthiam theih tur angin.

Estrogen chu eng nge ni? I hrethiam phawt ang u!

A awlsam zawngin sawi ila, estrogen hi kan taksain a siam chhuah natural chemical a ni. Hormone kan ti bawk. He estrogen hormone hian kan thisen kaltlangin kan taksa pum puia cell leh tissue hrang hrangah a kal a.

Mi tam tak chuan estrogen hi hmeichhiate tan chauh a awm niin an ngai. Dik tak chuan hmeichhe reproductive system-a tel ovary-te hian estrogen hormone an siam tam ber a ni. Mahse mak tak maiin mi zawng zawng hian, mipa leh hmeichhia thliar lovin, an taksaah estrogen engemaw zat an siam chhuak a, chutah chuan hnute tissue leh thau cell te pawh a tel.

Hmeichhiaah chuan puitlin hun hi estrogen leh sex hormone dang, progesterone inkawp vang a ni. Hei hian hnute thanna leh pubic hair growth ang chi thil a kawk a ni. Tin, thla tin thlasik hun chhung control tu hormone estrogen a ni bawk.

Mahse, hormone estrogen hian mipaah ​​pawh hmun pawimawh tak a chang a ni. Thluak thanlenna te, mipat hmeichhiatna hman dan hrisel te, leh libido te a nghawng a ni.

Chuti a nih chuan, estrogen-a innghat cancer te hi eng nge ni?

Tunah chuan heng estrogen-a innghat cancer te hi eng nge an nih kan en ang. A châng chuan estrogen receptor-positive , hormone-dependent , hormone-positive , hormone receptor-positive , a nih loh leh hormone-sensitive tia koh i hre thei bawk. Engti kawng pawhin, an sawi tum chu a inang reng a ni.

A awlsam zawngin, hei hian hormone estrogen hian cancer cell te chu a tipung a, chu chu a lo thang lian a, a darh zel tihna a ni. Thlai pakhatin tui a mamawh ang bawkin, heng cancer chi hrang hrang tan hian hormone estrogen hi a pawimawh hle.

Cancer chi hrang hrang a awm a, chungte chu estrogen-a innghat ber a ni. A bulpui berte chu:

• Hnute cancer a ni
• Ovarian cancer a ni
• Uterine cancer – Hei hi endometrial cancer an ti bawk.

Estrogen hian cancer a thlen tak tak em? Hei hi a buaithlak deuh a ni lawm ni?

Hei hi a takah chuan thawnthu buaithlak deuh a ni. Hormone estrogen hi a chang chuan carcinogen an ti bawk. Chu chu cancer thlen theihna engemaw chen a nei tihna a ni. Mahse chu chu engtin nge a lo awm tih hi kan hriatthiam a ngai a ni.

Kan taksaa cell zawng zawng deuhthaw hian protein chi khat, hormone receptor an tih chu an nei vek a. Kan thisena estrogen awm chu a lo kal a, heng receptor te hi a binding a ni. Hei hi a tlangpuiin kan taksa hnathawh tam tak atan a pawimawh hle. Cell hrisel takah chuan estrogen hian cell te chu a thawk dan pangngaiin a pui a, hrisel takin a thang lian thin.

Mahse, chhan engemaw avangin thil engemaw a inzawm khawm chuan cell hrisel tak takte chu cancer cell-ah an chang thei a ni. Chutiang a nih chuan estrogen hian meialh ang maiin hna a thawk tan thin. Chu chu, estrogen hian cancer cell lo piang tawhte chu rang taka inthen darh, pung leh taksa hmun khat atanga hmun danga darh zel turin a pui a ni.

Chuvangin, estrogen chauh hian cancer a thlen tih sawi ai chuan , estrogen hi cancer lo awm tawhna thlentu thil dangte nen a inzawm chuan cancer awm tawh chu a lo thang lian thei a ni tih hi a dik zawk

Eng thil nge hetiang ang estrogen-dependent cancer vei theihna tipung?

Estrogen-dependent cancer vei theihna hi eng emaw chen tipungtu thil engemaw zat a awm. Eng nge an nih hi han thlir ila:

• Taksaah estrogen level pangngai aia sang neih: Mi thenkhat chuan an pianphungah estrogen level sang tak an nei thin.
• Taking Hormone Replacement Therapy (HRT): Hei hi menopause hnua taksa lama harsatna (e.g. hot flashes, night sweats) awm thin enkawlna atana pek fo thin a ni. I nu emaw, i pi emaw chu doctor-in a naupai hnua a natna lan chhuahna a neih avangin hormone damdawi a pe niin han ngaihtuah teh. Chu chu HRT chu a ni.
• Thau lutuk: Taksa thau a pun chuan estrogen siamchhuah pawh a pung thei bawk.
• Polycystic Ovary Syndrome (PCOS) tih natna nei: Hei hi hormone inthlauhna nen pawh a inzawm a ni.
• Diethylstilbestrol (DES) hman dan: Hei hi synthetic estrogen a ni a, kum 1938 atanga 1971 thleng khan naupai te hnenah nau pai lo tura pek a ni a, he hun chhung hian nuin DES a hmang a, a nih loh leh nuin naupai laiin DES a tawk a, nau a hrin a nih chuan naupang chu a naupan laiin he cancer chi hi a vei theihna a hlauhawm hle.

Estrogen leh hnute cancer hi eng inzawmna nge ni?

Hnute cancer chungchang sawi dawn chuan, hnute cancer sawm zinga pariat vel chu hormone receptor-positive an ni . A awlsam zawngin, heng cancer te hi an lo thanglian theih nan estrogen, progesterone, a nih loh leh heng hormone pahnih hi an mamawh a ni.

Estrogen concentration sang taka rei tak a awm chuan hnute cancer vei theihna a sang chho zel a ni. Hei hi a chhan ber chu:

• Menopause tan hormone replacement therapy (HRT) hmanga enkawl a ni.
• Taksaah hian naturally high levels of estrogen neih.
• Klinefelter syndrome hi mipa (genetic condition) a ni a, mipa (he natna nei mipa hian estrogen level a sang hle).

Tun hma chuan mipa thenkhat chu prostate cancer enkawlna atan hormone estrogen an pe thin a. Mahse tunah chuan doctor-te chuan chu enkawlna chu an rawt tlem hle a, a chhan chu mipaah ​​pawh hnute cancer vei theihna a tipung bawk.

Estrogen leh ovarian cancer hi eng nge inzawmna?

Nun chhung zawnga estrogen ei hian ovarian cancer vei theihna a tipung thei a ni. Risk factors te chu:

• Kum 12 tlin hmaa thlasik tan (puberty hma tihna).
• Naupai ngai lo.
• Kum 55 hnu lama menopause (hun rei zawk period neih tihna) tawn.
• Menopause hnua combination hormone therapy (hormone therapy) ei, estrogen leh progesterone pahnih a awm.

Estrogen leh uterine cancer hi eng inzawmna nge ni?

Uterine cancer, a nih loh leh kan sawi tawh ang khan endometrial cancer hi i uterus lining-ah a lo awm a ni . Hmeichhia hian menopause hnuah he cancer hi an vei tam zawk.

Estrogen nena inzawm risk hi thil hrang hrang avang hian a pung thei a ni:

• Estrogen replacement therapy: Estrogen hian menopause avanga harsatna awm thei te, hot flashes, zan lama thawk hah, leh vaginal dryness te a tiziaawm thei a ni. Mahse, estrogen-only therapy ei hian uterine cancer vei theihna a tipung a ni. Hei hi a chhan chu estrogen hian nausen pum chhunga lining lian tham tak a tichak a ni. Chuvangin estrogen hi progesterone (combination hormone therapy) tih hormone nen pek a ni fo thin. Hei hian uterine cancer vei theihna a ti tlem a ni. Amaherawhchu hysterectomy i neih tawh chuan nausen pum i neih loh avangin he cancer hi i nei lovang.
• Tamoxifen hman dan: Tamoxifen hi hnute cancer enkawlna atana hman tur leh cancer lo let leh tur venna atana hman tur damdawi pawimawh tak a ni. Selective Estrogen Receptor Modulator (SERM) angin hna a thawk a, hnute tissue-a estrogen-in nghawng a neih dan a titawp bawk. Mahse, postmenopausal hmeichhiaah chuan tamoxifen hian nausen pum chhungah estrogen angin hna a thawk a ni. Hei hian nausen pum chhunga lining a tipung a, chu chuan endometrial cancer vei theihna a tipung a, eng emaw chen chu a tipung a ni. Mahse lungngai suh, tamoxifen avanga endometrial cancer vei theihna hi kum khatah 1% aia tlem a ni tlangpui. Tin, uterine sarcoma, cancer chi khat, nausen taksa ruh emaw, taksa peng dang emawa lo awm hi a tlem hle bawk.

Engtin nge estrogen-a innghat cancer hi an hriat chhuah? Engtin nge doctor-te hian hei hi an hriat chhuah?

Cancer i vei nia i rinhlelh chuan i doctor-in a tih hmasak ber tur chu tumor atanga tissue te tak te (hei hi tumor biopsy kan ti a) la in lab-ah a thawn ang. Chutah chuan test bik hmangin chu cell-te chuan hormone receptor an nei em tih an enfiah ang.

Test result chu hormone receptor positive (HR+) anga a lo lang leh a nih chuan estrogen, progesterone, emaw heng hormone pahnih hian i cancer chu a tipung a, chu chu a chawm tihna a ni.

Hetiang ang estrogen-a innghat cancer hi engtin nge enkawl an nih?

Doctor-te tan chuan cancer pakhat hormone receptor dinhmun hriat a pawimawh a, enkawlna thenkhat chu hormone-positive cancer tan chauh a hlawk avangin. Heng cancer chi hrang hrang enkawlna atana hmanraw pawimawh thenkhat chu:

• Aromatase inhibitors: Heng damdawi te hian taksain hormone androgens chu estrogen-ah a chantir loh nan hna a thawk a ni. He enkawlna hi hmeichhia menopause paltlang tawh (i.e., an ovary-in estrogen a siam chhuah tawh loh) te tan chauh a tangkai hle.
• Hormone therapies dang: Hengte hian taksain estrogen a siam chhuah a ti tlem emaw, a titawp emaw a ni.
• Tamoxifen leh SERM damdawi dangte: Kan sawi tawh ang khan hengte hian hormone receptor te estrogen nena inzawmna nei lo turin hna an thawk a ni.
• Oophorectomy: A then phei chuan estrogen siamtu taksa peng lian ber ovary te chu operation hmangin an la chhuak thin. Hei hian taksaa estrogen level nasa takin a tihniam thei a ni.

Birth control pill hian he cancer vei theihna hi a ti tlem tak tak thei ang em?

Chumi chhanna chu ‘ni’ leh ‘ni lo’ tih pawh a ni thei. Engtin nge chu chu?

Zirna thenkhatah chuan hmeichhia hormonal birth control method, pill ang chi hmang te hian hnute cancer vei theihna a sang hle (7% vel) a ni thei tih a tarlang

Mahse, a lehlamah chuan naupai venna damdawi ei hian a hnuaia cancer chi hrang hrangte hi a vei theihna a ti tlem thei bawk:

• Cervical cancer a ni
• Colorectal cancer a ni
• Ovarian cancer a ni
• Uterine cancer a ni

Chuvangin, in hmuh angin hei hi a buaithlak deuh a ni. Chuvangin, i doctor nen inbia a, eng birth control method nge i tan a tha ber, eng nge him ber tih i rel a tha ber fo.

Estrogen-a innghat cancer lo awm tur ven nan eng nge kan tih theih ang?

Cancer tam zawk hi chhan hriat lohvin an lo awm thin. Chumi awmzia chu eng ang pawhin fimkhur mah ila, a chang chuan cancer hi a lo awm thei tihna a ni. Mahse, cancer vei theihna hi eng emaw chen tihtlem nan thil awlsam tak tak kan tih theih a awm.

• A theih chuan fate hnute pe rawh. Nu hnute pek hian hnute cancer vei theihna a ti tlem tih hmuhchhuah a ni.
• A theih ang anga zu in tlem la, zu in loh vek tur a ni. Hengte hi cancer tam tak thlentu thil a ni.
• Ei leh in hrisel ei tum ang che. Thlai leh thei ei tam zawk rawh. Tin, nitin exercise la la, taksa chak takin awm bawk ang che.
• I thau lutuk, chu chu i thau lutuk a nih chuan, i taksa rihna tihtlem tum ang che.
• I tana naupai venna kawng him ber chungchang chu i doctor nen sawiho rawh.
• Menopause avanga harsatna awmte enkawl i duh chuan combination hormone therapy emaw nonhormonal treatment emaw chungchangah doctor thurawn la rawh.

Doctor ka zawh tur zawhna pawimawh ber berte chu engte nge ni?

Hetiang dinhmun chungchangah hian ngaihtuahna i neih chuan, emaw, estrogen nena inzawm cancer hlauhawmna i neih chuan, i doctor zawt hreh ngai suh. I rinhlelhna te tihfai a pawimawh. Zawhna i zawh theih ṭhenkhat chu hetiang hi a ni:

• Cancer ka neih/ka neih hi estrogen-a innghat nge hormone-receptor-positive?
• Tunah hian he cancer chi hrang hrang enkawlna tha ber berte chu engte nge ni?
• Heng enkawlnate hian eng nge a hlauhawmna leh a nghawng tha lo?
• Ka hriselna humhim tur leh cancer vei theihna tur tihtlem nan ka nunphungah eng inthlak danglamna nge ka siam theih ang?
• Tuna ka hman mek birth control method hi ka thlak tur em ni? Eng method nge ka tan a tha ber?
• Hormone therapy ka ei hi a remchang em? Ka tan risk a awm em?

A tawp berah chuan hriat reng tur (Take-Home Message) .

A tam zawkah chuan hormone estrogen hian kan taksaah hna \ha tak a thawk a, hrisel taka a thawh theih nan a pui \hin. Mahse, estrogen-a innghat cancer erawh chu chutiang tho chu a ni. Heng cancer bikteah hian estrogen hian cancer chu a tipung tak zet a, chu chu cancer chu a chawm tihna a ni.

Cancer i vei tih hmuhchhuah a nih a, i doctor-in hormone-sensitive a nih a rinhlelh chuan estrogen nen a inzawm em tih hriat nan test tul tak tak an ti ngei ang. Chu thu hriat a\ang chuan i doctor chuan i tana enkawlna \ha ber leh \ha ber a thlang thei ang.

Chuvangin, hlauhna leh engmah tihkhawtlai lovin, i zawhna leh rinhlelhna zawng zawng chu i doctor nen zalen takin sawipui rawh. I hriselna atan leh i rilru hriselna atan a pawimawh hle.

` Estrogen, cancer, hormone, hnute cancer, ovarian cancer, uterine cancer, hmeichhe hriselna