Kan thisen sang control tu secret regulator: Renin chungchang zawng zawng!

Kan taksa chhungah thil mak engzat nge thleng tih i ngaihtuah ngai em? A châng chuan kan hriat loh pawhin kan taksa hrisel taka awmtirtu mechanism mak tak tak a awm a. Entirnan, kan thisen sang control-na puitu chu Renin an ti a. Vawiin hian Renin hi eng nge a nih, a hnathawh dan leh kan hriselna atana a pawimawh zia kan sawi dawn nia.

Renin chu eng nge ni? A awlsam zawngin...

Okay, tunah chuan he renin hi eng nge a nih kan en ang. A awlsam zawngin sawi ila, renin hi i kal chhunga cell bikte siam enzyme a ni. Enzyme hi hlau suh, kan taksaa chemical process hrang hrang ti chak theitu protein a ni.

He tlangval renin an tih hi amah chauhin hna a thawk lo. Amah hi renin-angiotensin-aldosterone system (RAAS) tih mechanism lian zawka tel a ni. Chain reaction ang mai a ni. He system pumpui hian a tum ber chu i thisen sang control-na tur a ni. A bik takin renin hian hormone aldosterone an tih chu a control a, chu chu kan adrenal glands (kidney chunga awm gland te tak te) atanga siam a ni.

Chuti a nih chuan, engtin nge he Renin hian hna a thawh?

Tunah chuan hetah hian a pawimawh ber. Renin hna ber chu thisen sang control hi a ni. Hei hi hormone pawimawh dang pahnih angiotensin leh aldosterone te nen a thawk dun a ni. Heng pathumte hi an inzawm khawm chuan i taksaa sodium (salt) leh potassium level te chu a control theih nan a pui thin.

Hetiang thil thleng hi han mitthla teh:

1. Pakhatnaah chuan renin hian i liver siam angiotensinogen (angiotensin hmahruaitu) chu angiotensin I ( angiotensin, i thisen kalna kawng tizautu hormone) ah a chantir a.

2. Tichuan, he angiotensin I hi angiotensin II ah a chang ta a ni.

3. Tunah chuan he angiotensin II hi workhorse tak tak a ni ta. I thisen kalna kawng a ti tawi a, hormone aldosterone pawh a chhuah tir bawk.

4. A tawp berah chuan he aldosterone hian i kal (kidney) te chu i taksaah tui leh chi (sodium) a vawng reng thei a ni. Hei hian i taksaa tui awm zat a tipung a ni. Hei hian i thisen sang a tisang a ni.

A awlsam zawngin, thisen sang a tlahniam chuan renin an tih tlangval pakhat a rawn lut a, mi tlemte a la lut leh a, thisen kalna kawng thenkhat a tikhawlo a, taksaah tui engemaw zat a vawng reng a, thisen sang chu a normal leh ta a ni.

Engtin nge renin hi a chhuah chhuah? Engtik hunah nge?

Okay, tunah chuan zawhna i nei ta: he renin hi taksaah siam mai mai a ni em, a nih loh leh hun bik takah a chhuak em? Renin hi i thisen sang a tlahniam lutuk a, emaw, i taksa atanga sodium (salt) i hloh tlem chuan i thisenah a chhuak thin.

A bik takin, a hnuaia thilte hian renin secretion a nghawng a ni:

• I thisen kalna kawng chhunga baroreceptors (hengte hi pressure-sensitive receptor an ni) te hian thisen sang tlahniam an hre thin.
• I kal (kidney)-in i taksaah chi (sodium) a tlem tih a hriat chuan.
• Beta 1 adrenergic receptor, i heart rate control tu hian i sympathetic nervous system-a activity a hre thei (hei hi kan lungkham emaw, kan hlauhthawn emaw hian a thleng thin).

Renin chauh hian thisen sang a tisang em?

Ni lo, a dik chiah lo. Renin ringawt hian i thisen sang a nghawng lo. Chu ai chuan a sawi tawh ang khan angiotensin leh aldosterone te nen a thawk dun a ni. Angiotensin hian i thisen kalna kawng a ti tawi a, aldosterone hian i kal (kidney)-ah tui leh chi a vawng reng thei bawk. Hei hian i taksain tui a vawng tam a, i thisen sang a tisang a ni.

Khawiah nge renin hi siam chhuah?

Tunah chuan hei hi i hre tawh ngei ang. Renin hi i kal (kidney) ah a lo chhuak thin. I systolic blood pressure (thisen sang tehna atana number sang ber) a tlahniam emaw, i kal (kidney)-in i taksaah tui a tlem tih a hriat chuan i thisenah renin a chhuah tir thin.

Renin hi eng atanga siam nge ni? (Hei hi scientific deuh a ni a, mahse hriat hlawh tak a ni.)

Hei hi thupui thuk deuh a ni a, mahse a awlsam zawngin sawi ila, renin hian amino acid residue 340 vel a nei a ni. Amino acids hi proteins building block te te ang mai a ni. Chungte chu an inzawm khawm a, enzyme renin an siam ta a ni. Brick tam tak inzawmkhawma bang siam ang mai a ni.

Eng damdawi lam dinhmun nge renin siam chhuahna nena inzawm thei?

A chang chuan taksaah renin level a sang thei. Hetiang thil hian a thlen thei a ni:

• Thisen sang hniam (Hypotension) .
• Thisen tam tak i hloh a nih chuan (e.g. accident atanga).
• I kal (kidney) a thisen kal a tlahniam a nih chuan .
• Volume tlahniam (e.g., luak chhuak emaw, pum natna avanga tui tlakchhamna).
• Sympathetic nervous system hnathawh tihpun (Sympathetic nerve activation) (hetiang a nih chuan heart rate, thawk chakna, thisen sang a sang a, mit chhunga black circle te chu a lian zawk a ni).

Renin level enfiah nan test a awm em?

Ni e, a dik tak zet. I doctor hian renin activity test leh aldosterone level test a ti thei bawk. Hei hian i adrenal glands te hian aldosterone engzat nge an siam tih a hriattir ang.

Thisen sang i neih chuan, a bik takin i damdawi hman thin hmanga thunun loh chuan i doctor chuan he test hi a ti thei ang.Primary aldosteronism (PA) ( Conn’s syndrome an ti bawk) tih natna i nei thei bawk . Hetiang dinhmunah hian aldosterone tam lutuk a siam chhuak a, chu chuan thisen sang a thlen thin. Renin test hian PA hi i thisen sang chhan a nih leh nih loh hriat theih nan a pui thei a ni.

Engtin nge renin hi teh a nih?

Renin hi plasma renin activity (PRA) tih thil hmanga teh a ni fo thin. Hei hian renin hian angiotensin I (angiotensin II hmahruaitu) a siam that dan a teh a ni. Direct renin angin pawh teh theih a ni.

I renin level a san chuan eng nge a awmzia?

I renin level a sang a nih chuan:

• Addison natna (i adrenal glands-in hormone a siam chhuah tlemna hmun) - a bik takin taksa tui a tlahniam chuan.
• Dehydration (taksa chhunga tui tlakchhamna).
• Thisenah potassium level hniam (hypokalemia) .
• Hemorrhage (organ chhung emaw pawnah emaw thisen tam tak luang chhuak).
• Renin siamtu kidney tumor .
• Renal hypertension (thisen sang, kal lam panna thisen kalna kawng a zim avanga thisen sang).
• Malignant hypertension (hei hi thisen sang, rang taka lo thleng, hriattirna awm lovin a ni ).
• Primary hypertension (hei hi thisen sang, damdawi lam thil dang avanga lo awm lo a ni).
• Heart failure emaw cirrhosis of the liver (heng dinhmunte nen hian taksa hnathawh thisen volume a tlahniam chuan).

Renin level a hniam chuan engtin nge ni ang?

Renin level a hniam theih chhan pawh a awm. Entir nan:

• Primary aldosteronism (PA) tih hi a awm lo.
• Taksa chhunga chi (salt retention) thlentu steroid damdawi i hman chuan.
• Salt-sensitive hypertension (mi thenkhat chuan chi tlem an ei tam lutuk pawhin thisen sang an nei a , chu chu condition a ni).

Engtin nge ka renin level hi ka hrisel theih ang?

I renin level chu a tlangpuiin a sang emaw a hniam emaw a nih chuan i doctor chuan a chhan bulpui chu a hre chhuak ang a, enkawlna tur ruahmanna a siam ang. I renin tihhniam emaw, tihsan emaw nan damdawi an pe mai dawn lo.

Entirnan, renin level sang leh thisen sang i neih chuan i doctor chuan thisen sang tihhniamna damdawi, beta-blockers leh clonidine te chu a pe thei che a ni.

A tawp berah chuan hriat reng tur (Take-Home Message) .

Chuvangin, renin hi enzyme mai a ni lo. Renin-angiotensin-aldosterone system (RAAS)-a thil pawimawh tak a ni. I thisen sang control-na kawngah hmun pawimawh tak a chang a ni.

I renin level a dik lo chhan hrang hrang a awm thei. Chuvangin rinhlelhna i neih chuan a tha ber chu Doctor hmuh a, a chhan dik tak hriatchhuah a, a tul anga enkawlna dawng hi a ni. I gut feeling nen chauh kal suh, a chhan chu heng thilte hi a buaithlak deuh a ni.

I doctor chuan chiang takin a pui thei che a ni. Hrisel takin awm rawh!

` Renin, Thisen sang, Kal, Aldosterone, Angiotensin, Thisen sang, Thisen hniam, Renin, Thisen sang, kal, Aldosterone, Angiotensin, RAAS