Cancer hriat dan thar: Liquid biopsy chungchang zawng zawng!

"Liquid biopsy " tih thumal hi i hre tawh em? I doctor-in a hrilh che emaw, khawi emaw laiah i chhiar tawh emaw pawh a ni thei. Hei hi cancer hmuhchhuah leh enkawlna atana test method pawimawh tak, thar tak a ni. Chuvangin, vawiinah hian awlsam tak leh chiang takin sawi ila. Hlauh tur a awm lo, i thianpain thil a hrilhfiah che ang mai a ni.

He liquid biopsy hi eng nge ni? A awlsam khawp mai!

A awlsam zawngin, liquid biopsy chu thisen tlemte lakna test a ni . Hei hian cancer natna a awm leh awm loh a hriat theih. Cancer natna hrik a lo lian chhoh zel chuan a hnah te te chu a inthen a, i thisenah a lut thei tih han ngaihtuah teh. Chu piece te chu he liquid biopsy hian a detect a ni.

He test hian thil pawimawh pahnih a zawng a:

• Circulating Tumor Cells (CTCs): Hengte hi cancer cells an ni a, tumor atanga inthen a, i thisen kaltlangin, spy te te ang maiin an kal a ni.
• Circulating tumor DNA (ctDNA): Hengte hi DNA chi hrang hrang, cancer cell atanga inthen darh a, thisen chhunga lut a ni. I hriat angin DNA hi lehkhabu ang a ni a, chutah chuan kan cell awm dan tur control tu genetic code a awm a. Chuvangin, heng ctDNA chi hrang hrangte hian cancer chungchang tam tak min hrilh thei a ni.

I thisenah heng `(CTCs)` emaw `(ctDNA)` te hi i taksaah khawi emaw laiah cancer natna a awm tih finfiahna a ni. Tin, heng piece te hian cancer chungchang `( genetic information)` a pe bawk avangin, i doctor tan eng enkawlna nge i tana tha ber tih relna kawngah tanpuina nasa tak a ni ang.

Liquid biopsy hi test thar tak a ni. Cancer enkawlna kawngah pawh danglamna lian tak thlen theihna a nei a ni. US Food and Drug Administration (FDA)-in a pawmpui hmanna tur eng emaw zat a awm tawh a ni. Hemi chungchangah hian zirchianna a la kal zel a ni.

Liquid biopsy leh regular biopsy kan hriat hi eng nge a danglamna?

Routine biopsy tih hi i hre tawh ngei ang. Chutah chuan doctor chuan cancer tumor atanga tissue te tak te chu direct-in a la a, lab-ah cancer cell a awm leh awm loh a enfiah thin.

Mahse, liquid biopsy-ah chuan tumor piece pakhat chu direct-in lak a ni lo . Chu ai chuan cancer awmna finfiahna zawng nan hman a ni a, chu chu cancer cell ``CTCs`` emaw cancer DNA ``ctDNA`` emaw kan sawi tawh kha thisenah a ni.

Tunah hian routine biopsy hi cancer a awm leh awm loh hriat theihna kawng tha ber nia ngaih a ni . "Gold standard" an ti bawk.

Liquid biopsy-ah chuan cancer i nei a nih pawhin thisen sample pakhatah a chhinchhiahna i hmu thei dawn tih hi 100% guarantee a awm lo. Mahse, liquid biopsy-a cancer hmuhchhuah a nih chuan cancer cell chungchanga thu hriat tur a pekte hi a hlu hle a, doctor-te tan pawh enkawl dan tur ruahmannaah a \angkai hle thei a ni.

Eng dinhmunah nge liquid biopsy hi tih a nih?

I doctor chuan a hnuaia thil awmte hi liquid biopsy neih a rawt thei ang:

• I taksa hmun dangah pawh metastatic cancer i vei a, tuna i enkawlna hi beisei angin a thawk lo a nih chuan. Metastatic cancer hi cancer natna nasa zawk, i taksa pum puia darh tawh a ni. Hetianga a darh chuan cancer chi hrang hrang a inthen a, i thisenah a lut mai thei.

Doctor chuan liquid biopsy a order thei a, chu chu hetiang hi a ni:

• Prognosis hriat chian: Liquid biopsies hian cancer chi hrang hrang tan circulating tumor cells (CTCs) a hmuchhuak thei a ni . Thisena cancer cell tlem chuan prognosis tha zawk a tilang a ni. Cancer cell tam lutuk hian prognosis a chhe zawk tih a tilang. Chuvangin, i doctor chuan he test hi a hun hunah a ti thei a, i dinhmun a enfiah thei a, a tul chuan i enkawlna pawh a siamrem thei bawk.
• Enkawlna chungchanga thutlukna siam: Cancer cell thenkhat chauh target (targeted therapy) enkawlna a awm. Chumi awmzia chu cancer cell pakhatin a DNA-ah tihsual (mutation) engemaw tak a neih chuan chu tihsual chu bei tura siam damdawi bik pek theih a ni tihna a ni. Liquid biopsy hmangin heng tihsualte hi a hmu thei a ni. Chumi hnuah chuan i doctor chuan chu tihsual chungchangah chuan a bik takin enkawlna a pe thei che a ni.

Tin, regular biopsy hmanga cancer hriat theih loh pawhin liquid biopsy i nei thei bawk. Hei hi a chhan chu regular biopsy hi liquid biopsy aiin invasive zawk a nih vang a ni. Biopsy tihsak tur chuan i hrisel tawk lo mai thei. A nih loh leh, tumor awmna hmun azirin, a bul hnaia taksa peng pawimawh tak takte tichhe lovin a ṭhen chu lak chhuah a harsa thei bawk.

Eng liquid biopsy test nge FDA-in a pawmpui?

U.S. Food and Drug Administration (FDA)-in a pawmpui test-te chu uluk taka zirchian tawh, a him leh dik loh finfiah tawhte an ni. Liquid biopsy test eng emaw zat chu research stage-ah a la awm a ni. Tunah hian FDA-in a pawmpui test lian pali a awm a, chungte chu:

1. Cell Search® Circulating Tumor Cell (CTC) Test: Hei hian CTC awm leh awm loh a test thin. Hnute, prostate tih teHei hi cancer vei, colon emaw rectum emaw-a darh tawhte hmalam hun tur hriatna atan hman a ni. Thisenah CTC a tlem a nih chuan chhinchhiahna tha tak a ni. CTC tam tak a awm a nih chuan chu chu a ṭha lo deuh.

2. cobas® EGFR Mutation Test v2: Hei hian ctDNA a test a. EGFR an tih gene-a mutation a hmuchhuak a, hei hi non-small cell lung cancer (NSCLC)-ah a tam hle. He information hian i doctor chu chu mutation target tur chuan eng treatment nge tha ber tih a rel thei a ni.

3. Guardant360® CDx: Hei hian ctDNA a zawng bawk. Cancer cell-a awm fo thin genetic defects te hriatchhuah nan hman a ni. Hei hian doctor chu enkawlna tha ber thlang turin a pui thin.

4. FoundationOne® Liquid CDx: Hei hian ctDNA a zawng bawk. Hei hian cancer chi hrang hranga genetic defects (mutations) hriatchhuahna kawngah a pui a ni. Hei hian doctor chu eng enkawlna nge a remchan ber tih a rel thei a ni.

Engtin nge liquid biopsy hi tih a nih? A na em?

Liquid biopsy hi thisen test awlsam tak a ni . Thisen test pangngai atan thisen sample i pek ang bawkin. Doctor emaw nurse emaw chuan i kut atanga thisen sample la in lab-ah test turin a thawn ang.

Lab-ah chuan machine hmangin i thisen chu cell part (solid part) leh plasma (liquid part) ah a then a. Tichuan, pathologist, tui leh tissue sample enfiah tura zirtir specialist chuan plasma part-ah natna chhinchhiahna a zawng a, chu chu CTC emaw ctDNA emaw an ti a ni.

Hei hian a ti na em? Ni lo, liquid biopsy hi thisen pek ang maiin a lang. I kut chhungah needle i dah chuan tingling sensation tlem i nei thei a, chu chu ant-in a seh ang mai a ni. Mahse chu hrehawmna chu a bo nghal vat thin.

Liquid biopsy thatna pakhat chu biopsy pangngai aiin a invasive lo zawk a, a hrehawm lo hle bawk .

He test result hian eng nge a sawi?

Test result hian i thisen sample- ah `(CTCs)` emaw `(ctDNA)` (`positive`) emaw awm lo (`negative`) emaw a awm leh awm loh a hriattir che a ni.

• A result chu ``positive`` a nih chuan thisenah hian thil tarlan te hi a awm tihna a ni. Tichuan, heng test te hian eng cancer chi nge i neih tih hriat theih nan a pui thei bawk. A bik takin, ``(ctDNA)`` zawnga test hian cancer chi thenkhat nena inzawm genetic defect awm fo te pawh a hmuchhuak thei bawk.

Results hmuh theih nan eng chen nge hun a duh? Liquid biopsy hi engtiang chiahin nge a dik?

Test result hi kar hnih atanga kar thum chhungin a awm tlangpui tur a ni .

Tunah chuan hei hi a dik leh dik loh i en ang u. FDA-in a pawmpui tawh liquid biopsy test te, eng atan nge an siam a, chutiang hna chu an thawk tak zet a ni.

• Doctor chuan i natna hmalam hun tur chu a hre thei a, `(CTC)` test hmangin i natna dinhmun a enfiah thei bawk.
• ``(ctDNA)`` test hian cancer cell DNA-a genetic defect a hriat theih avangin enkawlna chungchanga thutlukna siamnaah a pui a ni.

Mahse, liquid biopsy hmangin cancer hi 100% chiang taka hriat theih a ni lo . Cancer a awm leh awm loh finfiah nan standard biopsy neih a ngai a ni.

Tunah hian liquid biopsy test hi zirchianna leh hmasawnna nasa tak a ni. Thisen test awlsam tak hmanga cancer hriatchhuah leh enkawl theihna hi thil lian tak a ni. Cancer a lo awm hma pawha hriat theihna tur liquid biopsy test siam tumin zirchianna an nei mek a ni. Mahse, liquid biopsies hmanga thil tih theihna kimchang hriat chian nan zirchianna tam zawk neih a ngai a ni. Tunah hian cancer chi hrang hrang hriatchhuah leh case bik enkawlna chungchanga thutlukna siamna kawngah an pui tawh a ni. Nakinah chuan hlawkna nasa zawk an neih a rinawm.

A tawp berah chuan kan hriat reng tur thilte

Okay, chuvang chuan liquid biopsy chungchang hi kan sawi nasa hle. Thil engemaw zat hriat reng tur chu hetiang hi a ni:

• Liquid biopsy hi test thar a ni a , thisenah cancer marker awmte chu a zawng thin a ni .
• Hei hian `(CTCs)` (cancer cells) leh `(ctDNA)` (cancer DNA) te a hmuchhuak thei a ni.
• Biopsy pangngai angin harsatna lian tham leh natna lian tham a awm lo .
• Hei hian cancer hmalam hun tur hriat theihna leh enkawl dan tur thutlukna siamna kawngah a pui a ni .
• FDA-in a pawmpui test ṭhenkhat chu a awm tawh bawk.
• Mahse, cancer chu chiang taka finfiah nân, routine biopsy neih a ngai mai thei .
• Hei hi technology la thang zel a ni a, nakin lawkah pawh a tangkai hle thei a ni.

A pawimawh ber chu, he thil chungchanga zawhna emaw, ngaihtuahna emaw i neih chuan i doctor nen inbia ngei ang che. I tana tha ber tur zawngin engkim a hrilhfiah thei che a ni.

He thu hi i tan a tangkai ngei ka beisei! Hrisel takin awm rawh!

` Liquid Biopsy, Cancer, Cancer Detection, ctDNA, CTCs, Thisen Test, Cancer Enkawlna