Kan taksa hian thisen thar a siam chhuak reng em tih i ngaihtuah ngai em? Ni e, a dik a ni. Damdawi lamah chuan hei hi hematopoiesis kan tih chu a ni. A awlsam zawngin, hei hi kan taksain thisen cell, a nih loh leh thisen cell a siam chhuah dan mak tak chu a ni. Car hlui chhuahsan a, a thar lei ang bawkin, kan taksa hian thisen cell hlui te chu a paih chhuak reng a, a aiah thisen cell thar, thar a siam chhuak zel a ni. Hei hi kan taksain thisen supply a neih reng dan a ni. Mak a ni lo’m ni? Hetiang kalphung hi kan pian hma pawhin a intan a, kan dam chhung zawngin a kal zel a ni.
Hematopoiesis tih hi eng nge ni? A awlsam zawngin...
Okay, he thumal Hematopoiesis hi eng nge a awmzia kan en ang. Thumal mak tak angin lang mah se, a awmzia chu a awlsam hle. He thumal hi Greek tawng atanga lo chhuak thumal pahnih inzawmkhawm atanga lo chhuak a ni.
- ‘Haîma’ (Haima): Hei hi ‘thisen’ emaw ‘ thisen ’ emaw tihna a ni.
- Poesis (poesis): Hei hi ‘thil siam’ emaw, ‘producing’ emaw tihna a ni.
Tichuan heng thumal pahnih hi kan dah khawm chuan
‘thisen siam’ emaw
‘thisen siam chhuah’ emaw ngaihtuahna a lo chhuak ta a ni. Hriatthiam a awl em em a ni lawm ni? A châng chuan he
hematopoiesis an tih hi hemopoiesis, hematogenesis emaw hemogenesis emaw an ti bawk. Heng thumal zawng zawng hian awmzia a inang vek a ni.
Hematopoiesis hian eng ang thisen cell nge siam chhuah?
Kan thisen hi cell chi khat atanga siam a ni lo. Chaw eiah hian ei tur chi hrang hrang, buhfai, lentils, leh sangha te a awm ang bawkin kan thisenah hian cell chi hrang hrang a awm bawk. Heng thisen cell chi hrang hrang zawng zawng hi
hematopoiesis process hmanga siam chhuah a ni . Eng nge an nih i en ang u.
Thisen sen (Erythrocytes) te hi 1.1.
Hengte hi kan thisena cell chi hrang hrang tam ber an ni. Thisen sen (red blood cells) hnathawh ber chu
taksa pum huapa taksa peng leh tissue dang zawng zawngah kan thawk chhuah hian lung chhunga oxygen lut chu a phur chhuak tih i hria em. Heng cell te hian oxygen tank angin hna an thawk a. Tin, heng thisen sen (red blood cells) te hian kan taksaa carbon dioxide siam chhuah duh loh chu lungah a hruai kir leh a, kan thawk chhuah hunah a chhuah tir bawk. Thisen sen siam chhuah dan hi
erythropoiesis an ti a .
Thisen var (Leukocytes) te hi a awm a.
Thisen var (white blood cells) hi kan taksaa security guard awm ang mai a ni. Ram venghimtu sipai ang maiin heng cell-te
hian kan taksaa lut natna hrik, bacteria leh virus te doin natna lakah min venghim a ni. Chu mai ni lovin, heng thisen var te hian kan taksa chhunga cell pangngai lo thang lian, cancer cell ang chi te chu a tichhia bawk. Thisen var siam chhuah dan chu an ti a
Leukopoiesis natna (Leukopoiesis) a awm. Thisen var chi khat chauh a awm lo va, chi hrang hrang a awm a: Chûng zîngah chuan neutrophils, basophils, leh eosinophils te hian hna an thawk inang hle a, chuvângin, an vaiin granulocytes tiin an sawi a ni. Platelets (a nih loh leh Thrombocytes) te hi .
Platelets hi kan taksaa doctor te te ang mai a ni. Hliam te tak te i neih a, thisen a chhuah tan chuan heng platelet te hian thisen chhuah tihtawp nan a pui thin. Chungte chu sticky, cell fragment te tak te an ni. Hliam awmna hmunah an inkhawm a, clot an siam a, hliam chu an seal thin. Plaster bun ang mai a ni. Hei vang hian a tul lovah kan taksa atangin thisen a chhuak lo. Platelet siam chhuah dan hi thrombopoiesis an ti a . He thisen siamna hi khawiah nge a awm?
Zawhna pawimawh tak a ni! He thil mak tak, hematopoiesis an tih hi kan ruh chhunga spongy part-ah a thleng ber a ni. Hei hi ruhro (bone marrow) kan ti a. Vawk i ei laiin ruh chhunga a sen lai kha i hmu tawh em? Chutiang chu he ruhro hi a ni. Hetianga ruhro chhunga thisen lo awm hi medullary hematopoiesis an ti a . Chutianga thisen cell siamte chu kan taksa pum puiah kan thisen kalna kawngah an kal kual a ni. Mahse, a châng chuan, a bîk takin natna ṭhenkhatah chuan, ruhro bâkah kan taksa pêng dangah thisen a chhuak thei a, entîr nân, liver leh spleen ang chi taksa peng hrang hrangah Hetianga ruhro pawn lama thisen lo awm hi extramedullary hematopoiesis an ti a . He thisen siamna hmunah hian kan pian hma leh kan pian hnuah pawh inthlak danglamna tlem a awm a. Pian hma
He thisen hi kan nu pum chhunga kan la awm laiin, chu chu embryo angin a lo piang tan a ni.- Pakhatnaah chuan naupai kar 3 hmasa berah chuan thisen sen chi khat chu embryo chhehvela structure pakhat , yolk sac tiin a lo piang tan a. Hengte hi puitling kan nih laia thisen sen kan siam chhuah aiin a lo thang tlem zawk a ni.
- Tichuan, naupai atanga thla 2-3 vel ah chuan thisen sen leh platelet te chu liver leh spleen ah a lo awm tan thin. Thisen var (white blood cells) hi liver, spleen leh thymus gland-ah te a lo piang a.
- Naupai thla nga-naah chuan thisen siam chhuah tam zawk hi ruhroah a thleng thin. Mahse, thisen var chi thenkhat chu thymus gland, spleen leh lymph tissue dangteah pawh a lo piang chhuak bawk.
Pian hnuah
Kan pian hnu, nausen atanga puitling thlengin kan thisen siam chhuah tam zawk hi ruhroah a thleng thin. Mahse, kan thymus gland-ah hian thisen var chi khat bik lymphocytes an tih pawh a lo piang chhuak bawk. Mahse, natna dinhmun thenkhatah, entirnan, ruhro hian thisen cell a siam tha thei lo a nih chuan kan taksa hian pian hmaa thisen siamna hmun, thin, spleen, lymph node-ah te thisen siam leh a tum thin. Hei hi emergency-a hman tur strategy ang mai a ni. Engtin nge hematopoiesis kalphung hi a lo awm?
Hei hi thil buaithlak tak a ni a, mahse a kalphung mumal tak a ni. Stem cell pakhat atanga thisen cell chi hrang hrang engzat nge siam theih tih hi han ngaihtuah teh! Heng thisen cell chi hrang hrangte hian cell inang, bul tanna cell an nei vek a. Hei hi hematopoietic stem cell (HSC) kan ti a ni. Hei hi "master cell" ang mai a ni. He HSC cell hi a hmasa berin precursor cell emaw "blast" cell emaw ah a lo thang lian thin . He precursor cell hi thisen cell bik ni tura kal mek, mahse a la thang kim lo. Chumi hnuah chuan he precursor cell hian cell inthen darhna engemaw zat a tawk leh a, chu chu thisen cell puitling, hnathawk thei a nih hmain a inthlak leh thin. Hematopoiesis hi a bulpui ber pathum a awm a, chu chu a hmaa kan sawi tawh thisen cell chi thumte siam dan atanga chhut a ni:- Erythropoiesis: Thisen sen (red blood cells) siam chhuah.
- Leukopoiesis: Thisen var siam chhuahna.
- Thrombopoiesis: Platelet siam chhuah.
Heng inthlak danglamna zawng zawng nen hian chu original stem cell (HSC) chu a specialized zual sauh sauh a ni. Chu chu stem cell mizia a hloh a, thisen sen, thisen var emaw, platelet emaw mizia a nei tihna a ni. Erythropoiesis (Thisen sen siam chhuahna) .
Kan ruhroah hian thisen sen (red blood cells) siam a ni. Primary blood cell (HSC) chu a hmasa berah chuan erythroblast an tih chu precursor cell a lo ni ta a ni. Chu erythroblast chu thisen sen puitling lo tak a lo ni ta a , chu chu reticulocyte an ti a ni . A tawpah chuan he reticulocyte hi thisen sen (red blood cell) lo puitling tawh, hnathawk thei tak a lo ni ta a ni. Thisen var siam dan (Leukopoiesis) .
Thisen var zawng zawng hi a siam dan inang vek a ni lo. A hmaa kan sawi tawh granulocyte - chu chu basophils, eosinophils, leh neutrophils te hi monocyte leh lymphocyte te aiin a danglam deuh deuhin an siam a ni. Granulocyte siam dan
Granulocyte chi thum hi ruhroah siam chhuah vek a ni. Primary blood cell (HSC)-in a siam chhunzawm zel chuan myeloid cell line an tih kawngpuiah a lo thang lian a ni. "Myeloid" tih thumal hi "bone marrow nena inzawm" tihna a ni. Chuvangin, heng cell te hi ruhro (bone marrow) atanga siam an nih avangin an hming an vuah a ni. Granulocyte siam tur chuan HSC cell chu a hmasa berin precursor cell myeloblast an tih a lo ni ta a ni. Chu myeloblast chu myelocyte , a tawpah chuan basophil, eosinophil, emaw neutrophil-ah a inthlak danglam ta a ni. Mononuclear cell siam dan
Monocytes hi ruhro (bone marrow) ah a lo piang chhuak thin. Lymphocytes - chu chu B-cells, T-cells leh natural killer cells te hi ruhro leh lymphoid tissue dang, thymus gland-ah te siam chhuah a ni. Entirnan, ruhroah hian lymphocyte te hi kum naupang takah an lo piang a, chutah chuan thymus gland-ah an insawn a, chutah chuan T-cell-ah an puitling ta a ni.- Monocytes hi myeloid cell line kaltlangin an lo piang chhuak : Ruhroah pawh an lo piang a, a hmasain precursor cell monoblast an tih ah an lo thang lian a, chuta tang chauh chuan monocytes lo piang chhuak kim vek an ni ta a ni.
- Lymphocyte te hi lymphoid cell line zawhin an lo thang lian a: a chhan chu lymphoid tissue, ruhro leh thymus gland-a siam an nih vang a ni. Chuvangin, HSC cells lymphocytes lo ni ta te chu precursor cells lymphoblasts an tih ah an lo thang lian ta a ni. Hengte hi a tawpah chuan T-cells, B-cells emaw natural killer cells-ah an inthlau ta a ni.
Platelet siam chhuah (Thrombopoiesis) .
Platelet siamchhuahna pawh hi ruhroah a awm bawk. Hetah hian primary blood cell (HSC) chu a hmasa berin precursor cell megakaryoblast an ti a ni. He megakaryoblast hi chu cell lian takah a lo thang lian a , chu chu megakaryocyte an ti a ni . A tawp berah chuan he megakaryocyte hmun thenkhat a chhiat chuan platelet a lo piang ta a ni. Mak a ni lo maw? Hetiang hematopoiesis kalphung hian eng chen nge a daih?
Dik tak chuan thisen cell siam chhuah chak dan hi i taksa mamawh danah a innghat a ni. Entirnan, i damloh chuan i taksain natna hrik do turin thisen var (white blood cells) a siam tam zawk thin. A tlangpuiin hematopoiesis kalphung hi a thleng chhunzawm zel a, a chhan chu thisen cell te hian dam chhung hun engemaw chen an nei bawk. Thisen cell pakhat a thih chuan taksa hrisel chuan a thlaktu tur thar a siam thin. Thisen cell dam rei zawng chu hetiang hi a ni:- Thisen sen: Ni 120 vel a dam.
- Thisen var: Darkar tlemte atanga ni engemaw zat thleng a nung.
- Platelets: Ni 5 leh ni 9 inkar a dam.
Chuvangin, kan taksa hian heng cell hlui te hi a paih chhuak zel a, a thar a siam chhunzawm zel a ni.
Hematopoiesis process-ah harsatna a awm a nih chuan engtin nge ni ang?
Kan taksa hian heng thisen cell siamchhuahna hi a control thiam hle a, chu chu thisen cell zat dik tak kan nei tihna a ni. Mahse, damdawi lam thil thenkhat chuan he hematopoiesis kalphung hi a tibuai thei a ni. Hei hian thisen cell tlem lutuk emaw, tam lutuk emaw a thlen thei a ni. Hetianga thisen cell zat hi a pangngai lo taka a inthlak chuan symptom hrang hrang leh damdawi lam dinhmun hrang hrang a awm thei a ni.- Thisen sen (red blood cells) chungchanga harsatna awmte:
- I thisen zam (red blood cells) a tlahniam chuan anemia an ti a ni. I taksa tissue-in oxygen a hmuh tlem avangin i chau a, i chak lo thei bawk.
- Thisen sen tamna chu erythrocytosis an ti a . Mild case-ah chuan hei hian symptoms nuam lo thenkhat a thlen thei. Amaherawhchu, natna khirh takah chuan thisen sen (red blood cells) a pun chuan thisen a ti thim thei a, heart attack emaw stroke emaw a thlen theihna a tipung thei a ni.
- Thisen var nena inzawm harsatna: 1.1.
- I thisen var zat a tlahniam chuan leukopenia an ti a ni. Hei hian natna hrik i vei theihna a tipung a ni.
- Thisen var tamna chu leukocytosis an ti a . Hei hi infection chhinchhiahna a ni tlangpui. Mahse, a chang chuan thisen var (white blood cell count) sang lutuk hi thisen natna emaw cancer emaw chhinchhiahna a ni thei.
- Platelet nena inzawm harsatna: 1.1.
- Platelet count hniam chu thrombocytopenia an ti a . Hetiang dinhmun hian thisen a chhuah awlsam zawk a, hliam awlsam zawk a thlen thei bawk.
- Platelet count a san chuan thrombocytosis an ti a ni. Hei hian thisen zam na tak a thlen theihna a tipung a ni.
Hematopoiesis kalphung tibuaitu dinhmunte chu engte nge ni?
Hematopoiesis kalphung tibuaitu thil engemaw zat a awm a. Chûng zînga ṭhenkhat chuan nghawng na lo tak a nei thei a, ṭhenkhat erawh chu a na thei hle thung. Entirnan, kan upat deuh deuh hian kan ruhroah thau a lo pungkhawm thei a, chu chuan thisen siam theihna a ti tlem a ni. Thisen kaihhnawih natna leh thisen cancer , leukemia, lymphoma, leh myeloma te pawhin thisen cell siam chhuahna a tibuai thei bawk. Heng natnate hian thisen cell pangngai lo, natna nei te chu a tipung lutuk a ni. Thil dang pakhat chu damdawi thenkhat hian hematopoiesis kalphung a tibuai thei a, chu chuan thisen cell a ti tlem thei a ni. Entirnan, cancer cell tihchhiatna atana hman thin chemotherapy hian thisen var (white blood cells) a ti tlem thei a ni. Hei hi neutropenia an ti a . Chuvangin, damdawi thenkhat hian side effect angin thisen cell a tihhniam thei bawk. He thawnthu atang hian kan in lama kan hruai duh ber (Take-Home Message) .
Okay, chuti a nih chuan tunah chuan he hematopoiesis, vawiin a kan sawi tawh thisen siam dan hi thil thleng reng reng, kan hrisel taka kan awmna leh kan dam khawchhuahna atana thil pawimawh tak a ni tih i hrethiam ta. Hetiang thisen supply mumal tak hi kan taksa tissue-a oxygen supply-na atan leh natna laka min humhimna atan a pawimawh hle. Hetiang thil hi kan ruhro chhungah a thleng tam ber tih hre reng ang che. Kan hriselna tichhe thei thil tam tak hian he thisen siam theihna hi a nghawng thei bawk.
Chuvangin, ei leh in inthlau tak ei te, exercise lak te, leh damdawi lam thurawn zawm te hmanga kan hriselna zawng zawng vawn nun hian he hematopoiesis kalphung mak tak hi a kal tluang thei ang. Hemi chungchanga zawhna dang i neih chuan doctor biak pawh hlau ngai suh.
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