I doctor-in cancer i vei thu a hrilh che chuan i rilruah zawhna tam tak a awm a ni lawm ni? ‘Chemo’ leh ‘radiation’ chungchang kan hre tawh a, mahse i doctor hian damdawi class thar ‘Angiogenesis Inhibitors’ tih a sawi mai thei. He damdawi mak tak hi eng nge an tih? Eng nge a tih tak tak? Ngaihtuah buai suh, awlsam takin sawi ila.
A hmasain, heng angiogenesis inhibitor te hi engte nge ni?
A awlsam zawngin sawi ila, hei hi thisen kalna kawng thar, tumor supply tu thisen kalna kawng tipungtu damdawi chi khat a ni. Hei hi a hming dangte chu anti-angiogenics, anti-angiogenic agents, leh anti-angiogenic therapy te an ni.
Ngaihtuah teh, eng thil pawh a lo thang lian tur chuan ei tur, ei leh in a mamawh a ni lawm ni? Cancer cells te hi chutiang chiah chu an ni. Tin, an lo thang lian tur leh an darh zel theih nan thisen tha tak tak, nutrients khata khat thisen supply chhunzawm zel an mamawh bawk. Cancer cell chu a te a nih chuan a chhehvela tissue hrisel tak tak atanga thisen engemaw zat a hip a, a dam khawchhuak thin. Mahse cell chu millimeter 1-2 vel a lo seilian chuan a thisen kalna kawng thar a siam a ngai a ni. Chutiang a nih loh chuan a lian zawk thei lo.
Hetah hian damdawi Angiogenesis Inhibitors an tih te hi a lo lut a, heng damdawi te hian cancer cell te thisen kalna kawng thar an tihpun dan tur a tikhawlo a ni. Thingkung tui pekna tur titawp ang mai a ni. Hei hian cancer thanna a ti hniam a, a chang chuan tumor hi a tlem thei hle. He enkawlna hian cancer chu a tidam kim lo mai thei a, mahse tumor thanna a control thei a, i hmangaih te nen rei vak lo i awm thei bawk.
He damdawi hian taksa chhungah engtin nge hna a thawh?
Heng damdawi te hian angiogenesis an tih process a tibuai a ni . Hei hi a takah chuan kan taksaa thil awm dan pangngai a ni. I kut i tan chuan thisen kalna kawng thar a lo thang lian a ngai tih han ngaihtuah teh, chu chuan hliam chu a tidam a, chu lai hmunah chuan thisen a thlen a ni. Chu chu angiogenesis an ti a. Hliam tuar cell te chuan signal an thawn chhuak a, "Min pui rawh!" He signal hian thisen kalna kawng thar a tipung a.
Mahse buaina chu cancer cell te pawhin he process ang chiah hi an hlawkna atan an hmang thin. Cancer cell te pawhin signal ang chi hi an thawn chhuak a, anmahni tan thisen kalna kawng thar an tipung bawk. Heng thisen kalna kawngte hian tumor hian a mamawh ei tur a pe a, chu chuan a lo thang lian thei a, taksa peng dangah pawh a darh thei a ni.
Angiogenesis Inhibitor te hian cancer atanga he signaling system hi tibuaitu hna an thawk thin. Heng damdawi tam zawk hian protein pakhat vascular endothelial growth factor (VEGF) tih chu block-in hna a thawk a ni. VEGF hi cancer cell-in "help" signal a tihchhuah ber angin han ngaihtuah teh. He VEGF signal hian cancer cell-a VEGF receptor-te a binding chuan thisen kalna kawng thar a lo piang tan thin.
Tunah chuan he damdawi hian engtin nge he signal hi a tihtawp tih kan en ang.
- VEGF signal chu receptor nena inzawmna nei lo tura block: Damdawi thenkhat (entir nan, Bevacizumab (Avastin®) ang chi monoclonal antibodies te chu VEGF protein ah direct in an kal a, an inzawm khawm thin. Tichuan chu receptor ah chuan a kal thei lo va, a inzawm thei lo. Letter pakhat chu a dawngtu tur a thlen hmaa intercept ang mai a ni.
- VEGF receptor atanga signal lo lut blocking: Damdawi dang thenkhat (entir nan, tyrosine kinase inhibitor sorafenib (Nexavar®) leh sunitinib (Sutent®)) te hian receptor chu message thawn let leh turin a block a, signal dawng mahse.
- Signaling system dang block: Damdawi dang thenkhat (entir nan, immunomodulators thalidomide leh lenalidomide (Revlimid®)) te hian he thila inrawlh signaling system dangte a tibuai thin.
He damdawi hi eng cancer chi hrang hrangah nge hman a nih?
Doctor-te chuan cancer zual emaw, cancer lo awm leh emaw tan heng angiogenesis inhibitor te hi an pe fo thin. He enkawlna atana hman tur cancer chi thenkhat chu:
- Thluak cancer a ni
- Hnute cancer a ni
- Cervical cancer a ni
- Colon cancer a ni
- Fallopian tube cancer a ni
- Kidney cancer a ni
- Liver cancer a ni
- Lung cancer a ni
- Lymphoma natna (Lymphoma) a ni
- Multiple myeloma a awm thei
- Pancreatic cancer natna a ni
- Peritoneal cancer a ni
- Pum cancer a ni
- Thyroid cancer a ni
- Nausen pum/endometrial cancer a ni
Tin, heng damdawi (VEGF inhibitors) te hi mit natna thenkhat, mit chhunga thisen kalna kawng pangngai lo thang lian te enkawlna atan pawh hman a ni.
Enkawl lai hian eng nge thleng?
Doctor-te hian heng damdawi ringawt hi an pe tlangpui lo. Cancer enkawlna dang, immunotherapy leh chemotherapy te nen an pe fo thin .
Indona ang maiin han ngaihtuah teh. Angiogenesis Inhibitor hian hmelma (cancer)-in ei leh in leh ralthuam (thisen) a hmuh chu a titawp thin. Enkawlna dang (chemotherapy ang chi) chu hmêlma (cancer cell) hnenah a kal nghal a, a bei nghal a ni. Heng kawng pahnih hi a thawh dun chuan a rah chhuah chu a hlawhtling zawk thei a ni.
Damdawi pek i nih dan azirin ni khatah vawi khat emaw vawi hnih emaw pill angin i ei a ngai mai thei a, a nih loh leh IV (like saline ) angin vein-ah schedule mumal takin i luh a ngai thei bawk.
He enkawlna hian eng chen nge a daih?
I enkawlna hun chhung hi thil tam takah a innghat a, chu chu damdawi chi hrang hrang i pek leh cancer chi hrang hrangah a innghat a ni. Mi tam zawk chuan heng damdawi te hi an hnathawh chhung chuan an ei chhunzawm zel a ni. A châng chuan, a side effects chu tuar theih loh khawpa tam a nih chuan enkawlna chu tihtawp theih a ni. I doctor chuan enkawlna a thatna leh a side effect te chu a sawipui ang che a, thutlukna tha ber a siam ang.
A side effect leh risk te chu engte nge ni?
Damdawi dang ang bawkin heng enkawlnate hian side effect leh risk a nei thei a ni. Chung zinga a tam zawk chu thisen chhuah (thisen chhuak) leh thisen zam chungchangah harsatna a ni. A tlem berah chuan heng side effects te hi nunna atana hlauhawm tak a ni thei. Chuvangin hengte hi fimkhur a pawimawh hle.
Heng hlauhawmnate tihziaawmna turin i doctor chuan i hriselna a enfiah fo ang.
| Side effect/risk awm thei | Hrilhfiahna awlsam tak |
|---|---|
| Thisen sang a sang | Thisen sang a sang. Hei hi enfiah leh control reng tur a ni. |
| In chhungril lama thisen chhuak | Taksa chhunga thisen chhuak. |
| Hliam dam zawi zawiin | Thisen kalna kawng thar siam a tihbuai avangin hliam damna hun a tipung thei a ni. |
| Gastrointestinal perforation a awm thin | A tlem hle a, pum emaw, intestines emaw perforation a awm thei. |
| Thyroid hnathawh a tlahniam | Taksa hormone control tu thyroid gland slow down. |
| Liver a chhiat phah | A chang chuan liver function a nghawng thei bawk. |
| Thisen a chhuak thin | Thisen kalna kawngah thisen zam hlauhawm tak a lo awm theihna a awm. Hengte hian heart attack emaw stroke emaw ang chi dinhmun a thlen thei a ni. |
I tih theih pawimawh ber chu enkawlna i tan hmain heng side effect leh risk te hi hriatthiam hmasak phawt hi a ni. Beisei tur i hriat chuan i taksaa inthlak danglamna chu i hre chiang thei zawk a ni. Thil danglam tak i hmuh chuan i doctor hnenah hriattir nghal rawh. Chumi hnuah chuan a side effects enkawl dan tur emaw, i damdawi hman dan tur siam dan tur emaw a zirtir thei ang che.
Hetiang thil hi a pianphung anga titawp thei thil a awm em?
Hei hi mi tam takin an zawh thin a ni. Chaw thenkhatah chuan angiogenesis kalpui danah signal thenkhat inrawlh tikhawlotu compound a awm a. Heng ei tur tam tak hi Mediterranean diet-ah hian a awm a. Entir nan:
- Asparagus a ni
- Dandelion zung a ni
- Green tea a ni
- Olive hriak a ni
- Peanuts a ni
- Red wine a ni
- Grape sen a ni
Medical zirchiangtute chuan heng compound te hmang hian damdawi thar siam an tum a, mahse chu zirchianna chu a la hmasa ber a la ni.
Mahse hetah hian hriat reng tur pawimawh tak chu heng ei tur te hi cancer damdawi aiah an ni ngai lovang. Phên dangin sawi ila, grape sen tam tak ei leh green tea in hian cancer lo awm chu a titawp lo vang. Chu chu ngaihdan dik lo tak a ni.
Amaherawhchu, i taksa chakna tur chuan chaw tha tak ei hi a pawimawh hle. Cancer enkawl lai leh enkawl hnua taksa tana ei leh in tha pek hi a pawimawh hle.
Engtikah nge doctor nen inbiakna neih a ngaih?
Inenkawl laia rin loh takin natna lanchhuahna i neih chuan doctor rawn nghal tur a ni.
A bik takin nunna atana hlauhawm, heart attack emaw stroke emaw chhinchhiahna i hmuh chuan Emergency Department (ETU) ah kal nghal rawh.
Angiogenesis inhibitor hi damdawi pawimawh tak a ni a, cancer cell-in kan taksa a tihdamna a hijack theihna a tikhawlo a ni. Cancer hi an tidam kim lo mai thei a, mahse a darh zel dan tur control-na atan an pui thei a, nunna hun tam zawk an pe thei bawk. I doctor-in he damdawi hi a rawt a nih chuan, i enkawlna ruahmanna pum puia a chanvo chungchang chu i doctor nen sawipui ngei ang che.
Take-Home Thuchah a ni
- Angiogenesis Inhibitors hi cancer cell-te thisen supply tu thisen kalna kawng thar siamna titawptu damdawi chi khat a ni. Hei hian cancer cell te hian an mamawh ei tur an hmuh loh nan a veng a, an thanlenna a control bawk.
- Hei hian cancer hi a tidam kim lo nachungin, natna darh zel tur a thunun thei a, dam rei theihna a ti rei thei bawk.
- He enkawlna hi enkawlna dang, chemotherapy ang chi te nen hian pek dun a ni fo thin.
- Thisen sang, thisen zam, leh hliam dam tlai te ang chi side effects te hriat a pawimawh a, thil dik lo i neih chuan doctor hriattir a pawimawh bawk.
- Natural food thenkhatah hian he thil tih tibuaitu compound awm mahse, damdawi hmanga enkawlna aiah hman ngai lo tur a ni.
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