Cancer i vei tih hriat a nih chuan hlauhna, mangang leh rinhlelhna i neih hi thil pangngai a ni. "Tunah hian eng thil nge thleng dawn?" leh "Eng ang enkawlna nge ka mamawh ang?" i rilruah an awm ngei ang. Mahse, cancer chi khat, hnute cancer ang chi pawh hi mi tin a danglam thei tih i hria em? Kan kutziak ang bawkin cancer tin hian ‘genetic signature’ danglam bik an nei vek a. Chu signature chu chhiarin, tunah chuan medical science chuan i cancer enkawlna tha ber, hlawk ber a thlang thei ta a ni. Vawiin hian chu revolutionary method chu kan sawi dawn a, chu chu genomic testing a ni.
A awlsam zawngin, genomic testing chu eng nge ni?
Hei hi thumal buaithlak tak angin a lang thei a, mahse a concept erawh a awlsam hle. Ngaihtuah teh, kan taksa hi cell maktaduai tam tak atanga siam a ni. Cell tin hi genes hmangin thupek pek an ni. Cancer cell hi cell chi khat a ni a, he instruction system hi a buai a, thunun theih lohvin a inthen darh thin.
Genomic testing hian i cancer cell-a gene awmte chu ngun takin a enfiah thin. Chumi hnuah chuan chu gene-a inthlâk danglamna, a nih loh leh inthlâk danglamna chiang tak chu a hmu thei a ni. A awlsam zawngin, cancer tihpun leh darh zel tura puitu secret code a pholang a ni.
Mahse hei hi cancer vei zawng zawng mamawh test a ni lo. Entirnan, cancer, a lo thang chak lo hle a, standard treatment hmanga awlsam taka tihdam theih chu chutiang in-depth test chu a ngai lo mai thei. A tam zawkah chuan hengte hi cancer hmuh tur awm lo tan emaw, standard treatment dawng lo cancer tan emaw hman a ni. Hetiang thutlukna siamtu tur hian i doctor hi a tha ber a ni.
Heng test-te hian hlawkna lian ber berte chu engte nge ni?
Engvangin nge doctor chuan he test hi a rawt ang? Hei hi chhan hrang hrang a awm a. He test hi cancer enkawlna tur ruahmanna siamna atana hmanraw pawimawh tak a ni thei.
| Hmantlakna | A awlsam zawngin... |
|---|---|
| I duh ang enkawlna thlan (Targeted Therapy) . | Tun hma chuan cancer hi ‘one-size-fits-all’ hmanga enkawl a ni. Chu chu lung cancer vei zawng zawng tan damdawi inang vek tihna a ni. Chutiang chu a ni tawh lo. Genetic testing hian cancer ‘mutation’ chu a hmuchhuak a, chu mutation chauh bei thei damdawi a pe (Targeted Therapy). Entirnan, lung cancer vei thenkhat chuan gene mutation (EGFR) an nei a. Chu gene target thei damdawi pek an ni. Tin, (BRCA) gene mutation nei hnute, ovarian leh prostate cancer te tan damdawi bik, (PARP inhibitors) te pawh a awm bawk. |
| Enkawlna tuar thiamna hriatthiamna | A chang chuan cancer cell te hi an fing hle thin. Hun a kal zel a, damdawi an pekte chu an do thei ta a ni. Genetic test hmangin i cancer hian enkawlna bik a do theih leh theih loh a hriat lawk thei a ni. Chutiang a nih chuan i doctor chuan a tir a\angin enkawlna dang, \angkai zawk a tan thei ang. |
| Enkawlna dang a ngai em tih hriat chian | Cancer natna hrik paih chhuah tumin operation i nei tawh ang tih han ngaihtuah teh. Cancer hi a lo let leh theihna tur a awm em? Genetic test hian cancer natna nasatna a teh thei a, a hlauhawmna a chhut thei bawk. A hlauhawmna a san chuan cancer a lo let leh tawh loh nan enkawlna dang (e.g. chemotherapy) a ngai mai thei. |
| Side effects tih tlem | Traditional treatment chemotherapy leh radiation te hian cancer cell chauh ni lovin cell hrisel te pawh a that thei a ni. Chuvangin sam tlakchham leh luak ang chi side effect a awm thin. Mahse targeted therapy, genetic testing hmanga hmuh chhuah chu missile ang mai a ni a, target chu a kap chiang hle. Cancer cell-ah a kal nghal a, anmahni chauh a hit a ni. Chuvangin cell hrisel tak takte tihchhiatna leh side effects a tlem hle. |
| Enkawlna thar zawn (Clinical Trial) . | A châng chuan, tuna enkawlna pawm tawh aiin a thawk ṭha zawk thei, experimental drugs a awm ṭhin. Hei hi ‘Clinical Trials’ kan tih chu a ni. Khawvel hmun dangah i cancer-a genetic mutation nena inmil zirchianna thar a awm a nih chuan he test hian a inzawm tir thei bawk che a ni. |
Engtin nge he test hi ka duh leh duh loh ka tih ang?
Hei hi zawhna pawimawh ber a ni. Hei hi nangmah chauhva thutlukna siam tur a ni lo tih hre reng ang che. Hei hi i oncologist nen in thutlukna siam tur a ni .
I doctor chuan he test hi a rawt hmain thil engemaw zat a ngaihtuah ang:
- I cancer chi leh a stage.
- Tun hmaa eng enkawlna nge i lo dawng tawh a, engtin nge i lo dawnsawn dan.
- I hriselna zawng zawng.
- He test atanga information kan hmuh dan atang hian targeted therapies i pek theih tur a awm em tih hi a ni.
Hemi chungchang hi doctor nen inhawng takin sawipui hlau suh. Zawhna zawt la, "Doctor, he genetic test hi ka cancer tan a inhmeh em?", "He test hian ka tan eng hlawkna nge a neih?", "He test result atang hian ka treatment plan hi a danglam dawn em?" I doctor mawhphurhna a ni a, engkim hi i hriatthiam theih ang anga sawifiah hi a ni.
He technology hian cancer enkawlna kawngah thutiam ropui tak a thlen a ni. Tunah chuan one-size-fits-all treatment hunlai chu tihtawp theihna kan nei ta a, damlo tinte chu an cancer genetic makeup nena inmil, personalized treatment kan pe thei ta a ni. Chu chu thil lian tak a ni tak zet a ni.
Take-Home Thuchah a ni
- Cancer hi natna pakhat chauh a ni lo. Cancer tin hian anmahni genetic signature danglam bik an nei vek a.
- Genomic testing hmang hian cancer cell-a genetic changes (mutations) bikte hriatchhuah a ni.
- He information hmang hian targeted therapy tha zawk leh side effect tlem zawk nei tur thlan theih a ni.
- He test hi damlo zawng zawng tan a tul lo va, thutlukna tha ber chu i doctor nen inrawnkhawmin siam a ni.
- He technology thar chungchang hi i oncologist zawt hreh suh. Hriatchhuah hi i damna zinkawngah chuan thil pawimawh tak a ni.
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