Thâwk harsa i nei em, asthma ang chi i nei em? I hman thin inhaler hming kha i en tawh em? I doctor chuan "beta-agonist" tih damdawi a pe che a ni mai thei. Hei hian eng nge a awmzia tak tak? A hming hi a buaithlak deuhin a lang thei a, mahse lungngai suh. Vawiin hian i hriatthiam theih tur khawpa awlsam takin kan sawi dawn a ni.
A awlsam zawngin, he beta-agonist hi eng nge ni?
Beta-agonists hi damdawi chi khat a ni a, lung natna enkawlna atana hman ber a ni. An hnathawh dan hrethiam tur chuan kan taksa chhunga "switch" te te te hi i hriatthiam a ngai a ni. Hengte hi beta-receptor kan ti a ni. Kan cell chhunga kawngkhar te tak te angin ngaihtuah rawh. Beta-agonist hi heng kawngkharte hawnsaktu key a ni.
He damdawi (chabi) hi a kal a, chu receptor (kawngkhar) nen chuan a inzawm chuan chu cell chuan thil tih tur "signal" a dawng a ni. He signal hian kan lung leh thinlung ang chi taksa peng hrang hranga ruh (muscles) te chu a ti hahdam tir thin. Lung chhunga ruhte a hahdam chuan thawkna kawng a zim chu a zau a, chu chuan thawk a ti awlsam hle. Tin, beta-agonists chi thenkhat hian kan heart rate a tisang thei a, heart efficiency a ti sang thei bawk.
Beta-agonists chi hrang hrangte chu engte nge ni?
Kan taksaah hian beta-receptor chi thum a awm a, chungte chu beta-1, beta-2, leh beta-3 te an ni. Chuvangin heng damdawi te hi chu receptor te chu target turin an siam a ni.
Beta-1 agonists a ni
Hengte hian kan thinlunga beta-1 receptor te hi an target ber a ni . Heng damdawi te hi pek a nih chuan thinlung chu a na zual tan a, chakna nasa zawkin thisen a pump tan thin. Hengte hi damdawi ina doctor-te chuan heart attack ang chi emergency-ah an hmang tlangpui.
Beta-2 agonists a ni
Hei hi beta-agonist chi hman tlanglawn ber a ni. Asthma inhaler i hman hi heng damdawi chi hrang hrang zinga mi a ni ngei ang. Hengte hian lung chhunga beta-2 receptor te chu an target a ni . Heng damdawi te hi inhaler hmanga kan inhnim hian lung chhunga thawkna kawng vel a thau te chu a ti hahdam a, chu chuan a tizau zawk a ni. Chuvangin bronchodilators an ti bawk.
Hetiang beta-2 agonist chi hi group hnih ah then a ni bawk:
- Short-acting beta-agonists (SABA): Hengte hi i "rescue inhalers"-a i neihte chu an ni. Asthma natna i nei nghal a, thawk i hahdam lo tih han ngaihtuah teh. He inhaler hi i vuak hian i thawkna kawng a tizau nghal vat a, minute tlemte chhungin thawk a awlsam phah bawk.
- Hun rei tak chhunga thawk thei beta-agonists (LABA):Hengte hi nitin symptoms control nan an hmang thin. Doctor-te chuan hengte hi COPD (Chronic Obstructive Pulmonary Disease) ang chi natna nei emaw, asthma attack nei fo tan emaw an rawt a ni. Chungte nghawng chu darkar tam tak chhung a daih a ni.
Beta-3 agonists a ni
Hetiang damdawi chi hi a thar deuh hlek a ni. Beta-3 agonists awmsa te hi bladder muscle te tih hahdam nan an hmang thin . Hei hi "overactive bladder" tih natna enkawl nan a ni a, chu chu zun chhuah fo a ngaih hun a ni. Bladder theihna an tipung a, zun chhuah duhna an control bawk.
Beta-agonists hmanna tur condition lian ber ber
Kan sawi tawh ang khan beta-agonists hman dan tur hi beta-agonist chi hrang hrang a zirin a inang lo.
- Thluak lam natna: Beta-2 agonists (a bik takin inhalers) hi asthma leh COPD ang chi natna enkawlna atan hman a ni tlangpui.
- Medical emergency: Beta-1 agonists hi damdawi inah hman a ni a, hei hian allergy na tak (anaphylaxis) leh cardiogenic shock ang chi te chu heart function siam that nan a hmang thin.
- Lung natna: Hengte hi thinlung lam natna thenkhat enkawl nan pawh hman theih a ni.
- Bladder harsatna: Beta-3 agonists hi overactive bladder enkawlna atan hman a ni.
- Thisenah potassium level sang (Hyperkalemia): A then phei chuan beta-2 agonist hmangin thisenah potassium level sang hlauhawm tak control nan an hmang bawk.
A pawimawh ber chu heng damdawi te hi doctor thurawn tel lova hman loh tur a ni. I doctor chauhvin i tan damdawi dik tak, a hman dan tur leh a hman dan tur dik tak chu a ruat thei ang.
| Beta-agonist chi khat a ni | Entirna (damdawi hming) . | A hman ber |
|---|---|---|
| Hun rei lote chhunga thawk thei beta-2 agonist (SABA) . | Albuterol, Salbutamol, Levalbuterol te a awm bawk | Asthma emaw COPD emaw avanga thawk harsatna nghal mai tan. |
| Hun rei tak chhunga thawk thei beta-2 agonist (LABA) . | Formoterol, Salmeterol, Indacaterol te pawh a awm bawk | Nitin asthma leh COPD symptoms enkawl dan tur. |
| Beta-1 agonist a ni | Dobutamine, Norepinephrine (Noradrenaline) te hi a tha hle a, a man hi a to hle bawk. | Heart attack ang chi emergency-a heart function tihpun nan. |
| Beta-1 leh beta-2 agonists te an ni | A rilru a buai em em a, a rilru a hah em em bawk a. Isoproterenol | Allergy na tak (anaphylaxis) ang chi emergency-ah te. |
| Beta-3 agonist a ni | Mirabegron a ni | Bladder a thawk nasa lutuk. |
He damdawi hian taksa chhungah engtin nge hna a thawh?
Hei hi hriatthiam a awl hle mai. Kan taksa hian "autonomic nervous system" tih hming pu thil a nei a. Hei hian kan thunun theih loh thil (thawk, heart rate ang chi) control tu chu a ni. Chumi zinga a then chu "sympathetic nervous system" an ti a. Hei hi kan taksa "fight-or-flight" response tichhuaktu a ni.
Kawngpuiah i kal a, rang takin ui pakhatin a rawn um che ang tih han ngaihtuah teh. I taksa hian inthlak danglamna lian tak a tawk nghal a ni lawm ni?
- Thinlung chu a na hle mai.
- Thâwk a chak chho zel a.
- Taksa hian chakna nasa tak a nei tih a hria.
Chu chu "sympathetic nervous system" hian a ti a ni. Beta-agonist damdawi hian he system hmun thenkhat hi artificial takin a tichak a, chutiang dinhmun hlauhawm tak thlen theihna tur a awm lo.
- Lung tan: Thlawhna kawng a tizau a, taksain oxygen tam zawk a hmuh theih nan a pui thin.
- Thinlung tan: Heart rate a tisang a, oxygen tamna thisen chu taksa peng hrang hrangah rang zawkin a thawn chhuak thin.
- Bladder tan chuan:Bladder a ti hahdam a, zun tam zawk a vawng thei a ni.
Hei hi a kalh zawng tak ti thin damdawi class pakhat chu "beta-blockers" an ti a. Kan sawi tawh beta-receptor (gate) te kha an block thin. Tichuan beta-agonists te hian an stimulate thei lo.
Heng damdawi te hian eng side effect nge a neih theih?
Damdawi dang ang bawkin beta-agonists hian mi thenkhatah side effect a thlen thei a ni. Mahse, inhaler atana hman a nih chuan damdawi hi lungah a kal nghal a, chuvangin side effect a awm theihna a tlem tlangpui. Mahse, mi ṭhenkhat chuan hetiang hi an tawng thei a ni:
- Lung chakna sang (Tachycardia) .
- Thinlung thawk mumal lo (Arrhythmia) .
- Thisen sang (Hypertension) 1.1.
- Khua leh ke ruhte a nghing
- Restlessness emaw, lungkhamna emaw
- Thawmhnaw hak
- Lu na
- Muscle a ti na hle
Heng side effects zinga pakhat tal i neih chuan, emaw, i damdawi ei hian hna a thawk lo ang tih a hriat chuan, i doctor nen inbia nghal rawh . I dose chu a siamrem thei a, damdawi dang a pe thei bawk.
Engtikah nge Doctor ka hmuh ang?
Beta-agonist i hman chuan heng dinhmunah hian doctor hmu ngei ang che.
- Beisei loh emaw, side effect na tak emaw i neih chuan.
- I enkawlna hian hna a thawk tawh lo nia i hriat chuan. Entirnan, hmanlai khan i inhaler puff vawi khat chauh i hmang thei a, mahse tunah chuan puff pahnih emaw pathum emaw i hman a ngai a nih chuan.
- I symptoms te chu nitin a na zual zel a nih chuan.
Thâwk harsatna nasa tak, rilru na, hmui dum i neih chuan damdawi in hnai ber emergency room (ETU)-ah kal nghal rawh. Chungte chu natna khirh tak chhinchhiahna a ni thei.
Take-Home Thuchah a ni
- Beta-agonists hi damdawi chi khat a ni a, thawkna lam natna, asthma leh COPD te a enkawl ber a ni.
- Hengte hian lung chhunga thawkna kawng a zau a, thawk a ti awlsam bawk.
- A chi hnih a awm a, chungte chu short-acting (SABA) leh long-acting (LABA) te an ni. SABA hi emergency-ah hman a ni.
- He damdawi hi doctor rawtna ang chauha hman tur a ni a, a zat tur pawh a ni.
- Side effects, kut nghing leh heartbeat chak tak ang chi te hi a awm thei a, a nasat chuan emaw, a enkawlnain a thawk tha lo nia i hriat chuan doctor thurawn zawng nghal rawh.
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