Nang emaw i fa emaw hian Beta Thalassemia i vei a nih chuan nun hi a harsatzia kan hria. Thisen pek fo ngai leh a kaihhnawih harsatnate nena nunpui chu thil awlsam a ni lo. Mahse vawiinah hian damdawi lam thiamna a lo thang chho zel a, he natna hi a tidam kim thei tur enkawl dan tur kan sawi dawn a ni. Chu chu stem cell transplant emaw, mi tam takin an hriat angin ``Stem Cell Transplant'' emaw a ni.
A awlsam zawngin, stem cell transplant tih hi eng nge ni?
Hei hi awlsam takin i hrethiam ang u. Kan taksa hian thisen siamna factory a nei niin han ngaihtuah teh. Hei hi bone marrow kan ti a . Hei hi kan ruh lian tak tak chhunga spongy part chu a ni. Thalassemia-ah chuan thil thleng chu he factory-a machine (cell) thenkhat, chu chu ruhroah hian a thawk tha lo a ni. Chuvangin, thisen sen tha, hrisel tak tak siam chhuah a ni tawk lo.
Stem cell transplant-ah chuan i taksa ruhro (bone marrow cell) tha lo tak takte chu lakchhuah a ni a, mi hrisel atanga thisen stem cell (Hematopoietic Stem Cells) hmanga thlak a ni. Heng cell thar te hi factory thar ang mai an ni. I ruhroah an kal a, thisen sen hrisel tak tak an siam tan thin.
Chu chu, machine hlui, hnathawk lote paih chhuah a, machine thar tak tak thenkhat dah a, factory start leh ang mai a ni.
Engtin nge he transplant process hi a lo awm?
Hei hi step engemaw zatah a thleng thin.
Transplant hmain
A hmasain, i taksaa ruhro (bone marrow cell) hlui, thawk tha lo tak takte chu i tihchhiat a ngai a ni. Chu chu chemotherapy hi a ni. "Chemo" tih thumal hian mi thenkhat a ti hlauhawm thei a, mahse hetah hian ruhroah hian cell thar, hrisel tak tak lo lut a, an awm theihna tur hmun siam nan hman a ni. Thlai hlui zawng zawng tihfai vek a, phun hmaa lei buatsaih ang mai a ni.
Transplantation neih chhung hian
Hei hi i ngaihtuah angin surgery lian tak a ni lo. Thisen pek ang mai a ni. Donor atanga stem cells te chu plastic tube (catheter) hmangin i taksaah inject a ni a, chu chu i rilruah dah a ni. Heng cell te hian i thisen kal tlangin an kal a, ruhroah an hmun an zawng a, chutah chuan an awm ta a ni. Chutah chauh chuan thisen cell hrisel tak tak an siam tan ta a ni.
Khawi atanga nge heng cell te hi kan lak chhuah?
Hei hi he enkawlna atana pawimawh leh harsa ber a ni. Tu atang chauh pawhin cell kan la thei lo. Donor leh recipient inkara genetic match hi a sang hle tur a ni.
- Match tha ber:Hemi atana thilpek petu tha ber chu damlo unaupa emaw, unaunu emaw a ni. Genetic match tha ber an nei tam zawk.
- Thil dang: Mahse, i unau nena inmil unau i hmu lo tih beiseina chu bansan suh. International donor registry kaltlangin genetic match hmuh theihna hun remchang a awm a, i inzawm lo a nih pawhin. Hei hi hun rei tak daih a ni thei.
He enkawlna hian eng hlauhawmna nge a neih?
Enkawlna lian dang ang bawkin, hlauhawmna engemaw zat a awm. Hengte hi doctor nen zalen taka sawipui a pawimawh.
| Tum chhin | Hrilhfiahna awlsam tak |
|---|---|
| Organ tihchhiat a ni | Thisen pek fo vanga taksaa iron awm zat a pung a, thinlung leh thin ang chi taksa peng hrang hrang a chhiat chuan a thlak hnuah pawh a hlauhawmna a sang lehzual thei a ni. Chuvangin transplant hmain chelation therapy dik taka tih a pawimawh hle. |
| Graft leh Host natna (GVHD) inkara natna (GVHD) . | Hetiang dinhmunah hian thil thleng chu, donor cell, taksa chhunga lut tharte chuan damlo taksa chu ‘hmêlma’ a nihzia an hre chiang a, an bei a ni. Hei hi control turin damdawi a awm. |
| Infection awm thei te | GVHD control nana damdawi hman te, a thlak hmaa chemotherapy pek te hian taksa invenna a ti tlem a ni. Hei hian bacteria infection i neih theihna a tipung a ni. Amaherawhchu, hemi hun chhung hian doctor ten antibiotics ang chi damdawi an pe dawn a ni. |
Pawimawh tak chu he enkawlna hi naupang zawkah a hlawhtling zawk a, a bik takin naupang kum 14 hnuai lam tan pawh a hlawhtling zawk a , chubakah taksa peng hrang hrang tihchhiat a tlem poh leh taksa peng hrang hrang tihchhiat a tlem poh leh a rah a tha zawk.
Enkawlna hnua side effect awm thei
Transplant hnuah hian hun rei lote leh hun rei tak chhunga side effect engemaw zat a awm thei.
A pawimawh ber chu fa neih theihna a nghawng dan (Infertility) . Transplant hmaa high-dose chemotherapy pek hian hmeichhe ovary a tichhe thei a, mipa sperm siamchhuahna a tichhe thei bawk. Mahse tunah chuan hei pawh hi solution a awm ta. Mipain an sperm an humhalh thei a, hmeichhiain an egg (sperm/egg freezing) chu enkawl hmain an humhalh thei bawk. Hemi chungchang hi doctor nen inbiakna neih hmasak a pawimawh a, thurawn lak a pawimawh hle.
Chu bakah, a hnuaia thilte hi transplant hnu lawkah a thleng thei bawk:
- Kawng emaw, kawr emaw a na
- Nausea leh luak chhuak
- Thisen chhuah emaw, hliam emaw
- Lung a hring (swelling) a awm
Heng stem cells te hi ruhro (bone marrow)-a kal a, hna an thawh tan a, i thisena cell awm zat chu a pangngaia an awm leh theih nan kar 2 atanga kar 6 vel a ngai a ni. Hemi chhung hian medical team te chuan uluk takin an lo vil reng ang che. Chuvangin ngaihtuahawm tur a awm lo.
Take-Home Thuchah a ni
- Stem cell transplant hi beta thalassemia tidam kim thei damdawi a ni a, mahse mi zawng zawng tan a tha lo.
- Hei hian ruhro (bone marrow cells) natna vei te chu donor hrisel tak hnen atanga stem cells hmuh hmanga thlak a huam a ni.
- Donor tling ber chu damlo unaupa emaw, unaunu emaw a ni a, mahse donor dang pawh hmuh theih a ni.
- Risk leh side effect a awm avangin he damdawi hi i rel hmain i doctor nen a lam zawng zawng ngun taka sawiho hmasak a pawimawh hle.
- Heng enkawlnate hi a tha chho zel a, chuvangin nakin hun atan beiseina nei reng ang che.
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