I thisen kal tlanga thisen luang chu a châng chuan a ṭul lovah a hnim thei tih i hria em? Chutiang thisen zam chu thluaka a kal chuan stroke a thlen thei a, thinlungah a kal chuan heart attack a thlen thei bawk. Chuvangin vawiinah hian heng dinhmun hlauhawm tak takte laka invenna atana doctor-te hman thin damdawi chi khat bik kan sawi dawn a ni. Chungte chu Direct Thrombin Inhibitors an ti a.
A awlsam zawngin, heng Direct Thrombin Inhibitor te hi engte nge ni?
Hengte hi thisen zam vengtu damdawi chi khat an ni. "Thisen tithianghlimtu" kan tih tlangpui thin an ni. Mahse an hnathawh dan erawh a danglam deuh. Heng damdawi siamna tur ngaihtuahna hi leeches chi hrang hranga protein awm atanga siam a ni. Tun hma pawhin leeches hi damdawi atan an hmang thin tih i hre tawh mai thei.
Khawvela mi tam zawk hi lung natna vangin an thi thin. Chumi chhan ber chu thisen zam (blood clots) a ni. Chuvangin doctor-te chuan he hlauhawmna atanga mi chhanchhuah nan hetiang damdawi hi an pe thin.
He damdawi hi eng condition atan nge hman a nih?
He damdawi chi hrang hrang, direct thrombin inhibitors tia koh hi damdawi lam harsatna hrang hrang avanga thisen zam venna emaw enkawl nan emaw hman a ni fo thin. Eng nge an nih i han thlir teh ang.
| Natna dinhmun | A sawifiahna awlsam tak |
|---|---|
| Acute coronary syndrome (thinlung lama thisen kal that lohna) . | Thinlung a thisen pe chhuaktu veins block emaw thisen kal slow emaw. |
| Heparin vanga thisen zam (thrombocytopenia) (HIT) . | Thisen tithianghlimtu dang heparin an tih avanga harsatna awm. |
| Venous thromboembolism (VTE) natna hi a awm thei lo. | Taksa vein pakhata thisen zam. |
| Atrial Fibrillation (Afib) a awm thei lo. | Heartbeat mumal lo avanga thisen zam leh stroke hlauhawmna. |
| Hip thlak surgery hnuah | Operation hnua thisen zam awm theihna tihziaawm. |
| Ke ruh thuk takah thisen zam (Deep vein thrombosis - DVT) . | Thisen zam, a bik takin ke ruh thûk takah. |
| Lung chhunga thisen zam (Pulmonary embolism) . | Taksa hmun danga thisen zam lo awm chu lungah a kal a, a lo awm ta a ni. |
Tin, angioplasty ang chi enkawlnaah he damdawi hi pek i ni thei bawk a, chu chuan i thinlunga thisen kalna kawng a hawng thei bawk.
Eng damdawi nge he category-a tel?
Tunah hian Sri Lanka leh khawvelah hian direct thrombin inhibitor damdawi chi hrang hrang hman a ni.
- Argatroban (hei hi IV injection anga pek a ni) .
- Bivalirudin (hei hi thisen kal tlanga injection - IV injection angin pek a ni bawk) .
- Dabigatran (hei hi pill atana i ei tur a ni) .
He damdawi hian taksa chhungah engtin nge hna a thawh?
A awlsam hle mai. A hming ang bawkin he damdawi hian Thrombin an tih enzyme pakhatah a kal nghal a, a inactivate bawk.
Tunah chuan he Thrombin hi eng nge a nih i zawt mai thei. A awlsam zawngin sawi ila, Thrombin hi kan taksaa thisen zam chhuahna atana thil pawimawh tak a ni. Main chef-in chaw a buatsaih ang mai a ni. He damdawi hian a tih chu chu chef chu a dah bo vek a ni. Tichuan thisen zam (blood clotting process) chu a thleng dik lo. Chuvangin a tul lo taka thisen zam siam chu a tawp ta a ni. I hrethiam em?
Mahse a chang chuan he damdawi hian thisen a tipung thei a ni. Injection bik a awm a, chu chuan pill Dabigatran a nghawng chu a tidanglam thei a ni. `Idarucizumab` tih a ni. Mahse, thisen kalna damdawi hi damdawi bik a awm lo. Mahse, damdawi chu tihtawp a nih chuan a nghawng chu rei vak lo hnuah a reh mai ang.
He damdawi hi eng chen nge ka ei a ngaih?
Mi tin a inang lo. Mi thenkhat chuan hun rei lote chhung chauh an ei a ngai a, hip replacement surgery an neih atanga thla khat hnuah pawh an ei a ngai a ni. Mahse thisen zam hlauhawmna sang zawk nei mi pakhat chuan an dam chhung zawng he damdawi hi an ei a ngai mai thei . I doctor chuan i tih tur dik tak chu a rel ang.
Hetiang damdawi chi hi eng nge a thatna?
He damdawi class thar hian damdawi hlui aiin thatna engemaw zat a nei a ni.
- A result chu a inang vek: Hengte hian Thrombin chauh direct-in a nghawng avangin, a vawi khatnaah pawh dose inang atang hian result inang chiah i beisei thei a ni.
- Platelets tlahniam lo: Damdawi hlui thenkhat ang lo takin hengte hian platelet level a tihhniam lo va, thisen zam a pui thin.
- I thisen test nawn fo a ngai lo: Damdawi thenkhat, Warfarin ang chi te hian i thisen a zang chak zia enfiah nan thisen test mumal a ngai thin. Mahse he damdawi hian chutiang chu a mamawh lo.
- Side effects tlem zawk: Dabigatran hi pill anga ei a ni a, Warfarin nena khaikhin chuan thisen chhuah leh damdawi dang nena inzawmna a nei tlem zawk.
- Hman awlsam: Ni khatah vawi khat emaw vawi hnih emaw chauh pill ei tur a nih avangin hman a awlsam hle.
- Thil dang: Hengte hi Heparin ang damdawi hmang thei lo tan chuan duhthlan tur tha tak a ni.
He damdawi hi engtiang chiahin nge a thawh? Tin, a hlauhawmnate chu engte nge ni?
Research atanga a lan dan chuan he damdawi hi Warfarin emaw Heparin emaw ang bawkin a him a, a hlawk bawk. Mahse, heart valve natna thenkhat nei tan chuan an tha tawk lo.
Mahse hetah hian a pawimawh ber chu he damdawi taksaa a awm chhung hi a tlem phah a ni. Entirnan, Warfarin dose khat i ei hian a 50% vel chu darkar 20-60 chhung taksaah a awm thei. Mahse Dabigatran i ei chuan darkar 12-14 chhungin taksa atangin 50% a chhuak thin.
Hei hian eng nge a awmzia? He damdawi ei hi ni khat pawh i tlai thei lo. Ni khat pawh i ei loh chuan thisen zam (blood clot) i neih theihna chu nasa takin a pung a ni.
Side effect awm thei te
Damdawi dang ang bawkin hei hian side effect a thlen thei a, a then chu pawi tak a ni thei bawk.
| Side effect a awm thei | Hrilhfiahna |
|---|---|
| Thisen chhuah tam lutuk | Gums atanga thisen chhuak, hnar thisen chhuak emaw, hliam emaw, thisen chhuah tawp lo. |
| Chaw ei tha lo (Dyspepsia) . | Pum na, nuam lo. |
| Zun rawng a inthlak danglam | Zun chu brown emaw pink emaw a lo ni. |
| Lu na, luak chhuak | Lu na tlangpui emaw, luak chhuak emaw. |
| Chhung na, thawk harsa | Hengte hi symptom na tak tak a ni thei. |
| Khawsik, natna hrik (Sepsis) . | Infection avanga natna khirh tak tak. |
Engtikah nge Doctor ka hmuh ang?
He damdawi i hman lai hian side effect i neih chuan doctor hnenah hriattir nghal rawh.
A bik takin, thisen chhuak tam lutuk (entir nan, hliam atanga thisen chhuak i chawlhsan thei lo a nih chuan, i ek chhungah thisen a awm a nih chuan, hnar thisen chhuak a awm a, chu chuan concussion a neih phah a nih chuan) emaw, natna lanchhuahna na tak dang (ril na na tak, thawk harsa tak tak) i neih chuan, tihkhawtlai ngai lovin damdawi in hnai ber Emergency Department (ETU) ah kal hmasa phawt ang che.
A tawp berah chuan thisen zam (blood clot) lo awm hi hlauh a ngai lo. Tunlai damdawi direct thrombin inhibitor ang chi hian chu hlauhawmna chu nasa takin a control thei a ni. Mahse i doctor chuan eng damdawi nge i tana tha ber tur leh eng chen nge i ei tur tih a rel ang. Chuvangin i doctor thurawn zawm fo ang che.
Take-Home Thuchah a ni
- Direct Thrombin Inhibitors hi thisen zam tur venna damdawi class thar a ni.
- Chûngte chuan thisen zam chhuahna kawnga enzyme pawimawh tak thrombin chu direct-a inactivate-in hna an thawk a ni.
- He damdawi hi i hman chuanDamdawi dose khat pawh skip ngai suh. Chutianga tih nghal chuan thisen zam a tipung a ni.
- Thisen chhuah tam lutuk emaw, natna dang danglam tak emaw i hmuh chuan doctor rawn nghal rawh.
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