Parkinson natna chungchang hi i hre tawh em? A nih loh leh kea a chang chuan tuar theih loh khawpa lungawi lohna, chu chu Restless Legs Syndrome tihna a ni em? Vawiin hian damdawi chi khat, chutiang natna engemaw zat enkawlna atana hman thin chungchang kan sawi dawn a ni. Chungte chu Dopamine Agonists an ti a. A hming hi a buaithlak deuh a, mahse an hnathawh dan erawh a awlsam hle.
Dopamine agonists hi eng nge ni tak tak?
Hei hi hrethiam tur chuan kan thluak hi rei lo te han ngaihtuah ila. Kan thluaka nerve cell-te hian chemical bik hmangin an inbiak tawn a, a nih loh leh thuchah an inthleng a ni. Hengte hi neurotransmitter kan ti a . Kan thluak cell te hi lock inzawmkhawm angin ngaihtuah rawh. Heng neurotransmitter te hi chu special key ang mai an ni a, chu chuan chu lock chu a hawng thei a ni.
Dopamine hi chutiang "key" pawimawh tak chu a ni. He chemical hi thil kan zir lai te, hlimna leh lungawina kan neih lai te, kan taksa che vel kan thunun lai te hian a pawimawh hle.
A awlsam zawngin sawi ila, dopamine agonists hi damdawi dopamine ang maia thawk, mahse a takah chuan dopamine a ni lo. Dopamine an tih ‘key’ duplicate ang mai an ni. Kan thluak cell te hian an pahnih inthlauhna an hriat theih loh avangin dopamine agonist an dawn hian dopamine an dawng tak tak niin an ngai thin. Chuvangin, heng damdawi te hian dopamine level a hniam huna harsatna lo awm thin te chu hneh turin a pui thin.
He damdawi hi eng natna atan nge hman a nih?
Taksa chhunga dopamine level tlahniam hian damdawi lam harsatna hrang hrang a thlen thei a ni. A hnuaia tarlan te hi dopamine agonists hman tamna damdawi lam thil thenkhat tarlan a ni.
| Damdawi lam dinhmun | A sawifiahna awlsam tak |
|---|---|
| Parkinson natna leh a kaihhnawih movement disorder te | Taksa che vel control tu thluak hmun hrang hranga dopamine tlakchham vanga lo awm thin. |
| Restless Legs Syndrome a awm a, a rilru a hah hle | Ke chet duhna nasa tak, a bik takin zan lamah, leh nuam lo tihna. |
| Hyperprolactinemia vang a ni | Taksa chhunga hormone prolactin awm zat a sang. Hei hian thlasik hun mumal lo ang chi harsatna a thlen thei a ni. |
| Neuroleptic Malignant Syndrome natna a ni | Rilru natna enkawlna atana hman damdawi thenkhat avanga lo awm thei, harsatna awm lo mahse hlauhawm tak. |
| Type 2 Diabetes a ni | Dopamine agonists thenkhat chuan thisen sugar level control nan a pui bawk. |
Heng damdawi te hian eng hlawkna nge a neih?
Dopamine agonists an tih damdawi class hi damlo tan a pawimawh em em chhan hrang hrang a awm.
- Hlawhtlinna sang: Research atanga a lan dan chuan he damdawi chi hi damdawi lam harsatna tam tak enkawlnaah a tangkai hle a ni.
- Natna chi hrang hrangah hman theih a ni: A chunga kan sawi tawh ang khan hengte hi natna chi hrang hrang, thluak chetna lama harsatna atanga hormone lama harsatna thlengin hman a ni.
- Damdawi dang nena inkawp: Entirna tha tak chu Parkinson natna hi a ni. He natna atana hman damdawi ‘Levodopa’ nena dopamine agonist inkawp hian levodopa dose tlem zawk pawhin nghawng sang zawk a pe thei a ni. Levodopa tan hun tikhawtlai turin an pui bawk.
- Nunna chhanhimna: A châng chuan heng damdawi te hian nunna chhanhimna kawngah pawh a pui thei a ni. Entirnan, natna hlauhawm tak `Neuroleptic Malignant Syndrome` an tih chu an control thei a ni.
Risk leh side effect a awm lo em ni?
Damdawi dang ang bawkin, side effect awm thei a awm bawk. Mahse, hlau suh. A pawimawh ber chu hengte hi fimkhur hi a ni. A tlangpuiin, a dose a san chuan heng side effects te hi a awm theihna a sang zawk thin.
| Side effect awm fo thin | |
|---|---|
| - Ek khal | - Nausea leh luak chhuak |
| - Luak chhuak thei | - Lu na |
| - Chaw ei kawngah harsatna a awm | - Ding laia muhil (Orthostatic hypotension) . |
Impulse Control chungchang
Hei hi chipchiar zawka sawi a ngai a ni. Dopamine hi chemical a ni a, nuam tihna leh lungawina ang chi thil min hriatpuitu a ni. Chuvângin, heng damdawite hian chu thil kalphung chu a tichak a, mi ṭhenkhatin an rilru put hmang thunun theihna chu a nghawng thei bawk . Chu chu thil tih duhna chu an thunun thei lo tihna a ni. Entir nan:
- Gambling lama ruihhlo ngawlvei lutuk.
- Thil i mamawh lo a nih pawhin thunun theih loha thil lei.
- Mipat hmeichhiatna hmansual (hypersexuality).
- Thunun loh taka ei tam lutuk.
Hei hi a pawimawh hle. Nangmah emaw, i chhungte emaw chuan i nungchangah danglamna danglam tak i hmuh chuan zak suh la, i doctor nen inbia thuai rawh. Hemi chungchang hi doctor hriattir a pawimawh a, damdawi ei avanga side effect a nih theih avangin.
Damdawi i ei loh thut chuan eng nge thleng ang?
Hei pawh hi thil pawimawh tak a ni. Dopamine agonist damdawi hman i chawlhsan nghal emaw, damdawi lam thurawn tel lovin i tihtlem emaw chuan , mi thenkhat chuan harsatna hrang hrang an tawk thei. Hei hi Dopamine Agonist Withdrawal Syndrome (DAWS) kan ti a ni. Symptoms lo awm thei te chu:
- Lungkhamna leh hahdam lohna
- Thaw hah lutuk
- Chau
- Taksa natna
- Luhai
Chuvangin, hriat reng tur pawimawh tak chu he damdawi ei hi chawlhsan ngai lo tur a ni a, doctor thurawn tel lo chuan a dose hi thlak ngai lo tur a ni.
He damdawi ei hi a tha lo tihna dinhmun a awm em?
Ni e, mi thenkhat chu he damdawi chi hrang hrangah hian an tling lo. Hengte hi "contraindications" kan ti a ni.
- Nu naupai leh nau hnute pe mek:He damdawi hi heng hun chhung hian nau hnute pek a nghawng theih avangin a tha lo.
- Thisen sang nei te: Dopamine agonist thenkhat hian thisen sang a tisang lehzual thei.
- Kidney emaw liver natna nei te: A chhan chu heng natnate hian taksa atanga damdawi paih chhuah dan a nghawng vang a ni.
- Mite damdawi dang thenkhat ei: A bik takin MAOI damdawi i ei a nih chuan he damdawi hi i tan hmain kar hnih tal i ei tawh loh tur a ni.
- Psychosis nei tawhte: Heng damdawi te hian psychotic symptoms neih theihna a tipung thei a ni.
Heng natnate hi i neih chuan enkawl tan hmain doctor hnenah hrilh hmasa phawt ang che.
Dopamine leh dopamine agonists te hi eng nge an danglamna?
Hei hi mi tam takin zawhna an neih a ni. Dopamine a tlem chuan engvangin nge dopamine direct-a pek ai chuan dopamine agonists pek? A chhan hrang hrang a awm.
A chhan ber chu thisen leh thluak inkharkhip vang a ni . Kan thluak hi venhimna filter angin ngaihtuah rawh. Pawn lam atanga dopamine pek chuan he filter hi a paltlang thei lo va, thluaka a lut thei lo. Mahse, dopamine agonist damdawi hian he barrier hi a paltlang thei a, thluak chhungah direct-in a lut thei a ni. Chuvang chuan an hlawhtling zawk a ni.
Take-Home Thuchah a ni
- Dopamine agonist hi damdawi chi khat a ni a, thluak cell te chu chemical dopamine ang deuhin a tichak a, mahse dopamine ngei pawh a ni lo.
- Hengte hi natna tam tak enkawlna atan hman a ni a, chungte chu Parkinson natna leh Restless Legs Syndrome te hi a ni.
- Damdawi zawng zawng ang bawkin hengte hian side effect a nei thei a, a bik takin impulse control chungchangah.
- Nangmah emaw, i chhungte emaw chuan inthlak danglamna danglam tak i hriat chuan i doctor nen inbia nghal rawh.
- He damdawi hi ei nghal vat ngai suh la, damdawi lam thurawn tel lo pawhin a dose pawh thlak ngai suh.
- Doctor nen zalen tak leh rinawm taka inbiakna neih hi result hlawhtling ber neih theihna kawng tha ber a ni.
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