I rilru timuangtu thluak thuruk GABA (gamma-aminobutyric acid) chungchang i zir dawn teh ang.

A châng chuan i rilru a buai a, i lungkham a, a nih loh leh hlauhna mai mai i nei em? A nih loh leh zanah mut theih lohna i tuar em? Heng thil hnung lamah hian kan thluaka chemical messenger te tak te a awm thei. Chu chu vawiinah kan sawi dawn a ni. GABA a ni. Kan thluaka ‘cool’ button ang maiin a che thin.

GABA (gamma-aminobutyric acid) hi eng nge ni?

A awlsam zawngin sawi ila, GABA hi kan thluaka nerve cell (neurons) inkara thuchah thawn chhuaktu chemical a ni. Kan taksaah postman fing tak ang mai a ni. Mahse a danglam bikna chu thluak thil tul lo tak takte chu a "calm down" ber a ni. Chu chu thluaka nerve cells te chu a tichak lutuk leh tihbuai lutuk loh nan a titawp tihna a ni. Scientist-te chuan heng chemical chi hrang hrangte hi neurotransmitter an ti a. GABA hi kan central nervous system speed control tu "brake" angin ngaihtuah la, chutah chuan kan thluak leh spinal cord te pawh a tel a ni. Kan phur lutuk loh leh hlauh lutuk lo tura min puitu a ni.

GABA hian engtin nge hna a thawh? Kan thluak chhungah eng thil nge thleng?

Tunah chuan he GABA hian kan thluak chhungah engtin nge hna a thawh tih hi han en teh. Mechanism mak tak a ni. Kan thluaka nerve cell maktaduai tam tak leh maktaduai tam tak kan nei a. Nerve cell pakhat atanga nerve cell dangah message kan thawn a ngai a ni. A nihna takah chuan heng nerve cell pahnih inkarah hian gap tlemte a awm a. Chu chu `(Synapse)` emaw, nerve junction emaw an ti a.

GABA ang chi `(Neurotransmitter)` chuan chu chu he junction kaltlangin thuchah chu a hruai a, a hnuaia nerve cell-a `(Receptors)` bikte nen a inzawm a ni. Lock chhunga chabi fit ang mai a ni. Key zawng zawng hian lock tin an hawng thei lo ang bawkin `(Neurotransmitter)` zawng zawng hi `(Receptor)` tin ah an inzawm thei lo. GABA hian a hre chiangtu `(Receptor)` bik pahnih a nei bawk – `(GABA-A)` leh `(GABA-B)`.

Chuvangin, GABA hian heng receptor te hi a kal a, a binding hian a hnuaia nerve cell te hian a chhan let theihna a ti tlem a ni. Chu chu, chu cell chuan a tul lo taka thuchah a siam emaw, mi dang hnena a thawn emaw theihna a tihtlem tihna a ni. Hei vang hian GABA hi "inhibitory" emaw calming neurotransmitter emaw an ti a ni.

GABA hian hriselna atana hlawkna eng nge a pek?

Chuti a nih chuan, hetianga thluak ti thlamuangtu GABA atang hian hriselna atana hlawkna eng nge kan hmuh? A nihna takah chuan an tam hle. Ngaihtuah teh, i ``stress'' hle a, chu chu stress nasa tak i tawh laiin, i rilru chu hmun khatah a awm lo va, i lungkham hle a, i rilru chu a na hle tih a hriat chuan. Chutiang hunah chuan i taksaa GABA level a dik chuan i rilru a ti thlamuang ang a, he stress hi a tihziaawm theih nan a pui ang che .

GABA hian lungkhamna thunun theihna mak tak a nei bawk . Thil tul lo taka hlauhna leh engkim ngaihtuahna tihziaawmna a ni.

Thil dang pakhat chu, mi thenkhat chu zanah an muhil thei lo. An mut dawnin an toss leh turn mai mai a, mahse an muhil lo niin a lang. Tuna zirchianna chuan GABA hian mut tha leh hahdam tak a pui bawk tih a tarlang .

GABA leh Glutamate: Thluak ‘On-Off’ Switch

GABA rual hian kan thluaka `(Neurotransmitter)` pawimawh tak dang a awm bawk. Chu chu `(Glutamate)` a ni. Heng pahnih hian pawisa lem sir pahnih ang maiin hna an thawk a, a nih loh leh ‘on’ leh ‘off’ switch pahnih angin hna an thawk bawk. Chu chu kawng hrang hranga inkalpawhna a ni.

• GABA: Thluak hnathawh ‘Turns off’ a, a ti reh (inhibitory).
• Glutamate: ‘A turn on’ a, thluak hnathawh a tichak (stimulant).

Chuvangin, kan thluak hian hrisel leh dik taka hna a thawh theih nan GABA calming power leh `(Glutamate) stimulating power inkarah hian balance nalh tak a awm a ngai a ni . Car accelerator leh brake ang bawkin. An pahnih hian an hnathawh dan dik leh a hun taka an thawh chauhvin tluang tak leh him takin kan zin thei ang. He balance hi a bo chuan harsatna chi hrang hrang a lo chhuak thin. Mak tak maiin he calming agent GABA an tih hi stimulant `(Glutamate) atanga siam a ni bawk. A chhungah hian `(enzyme)` bik a inrawlh a, chu chu enzyme (`glutamic acid decarboxylase`) a ni.

GABA hian neurotransmitter dang, serotonin nen pawh hna an thawk dun bawk. Dik tak chuan neurotransmitter tam tak hian kan taksa leh thluak hnathawh thatna turin neurotransmitter tam tak an thawk ho a, a chang chuan an dodal a ni.

GABA level hniam avanga lo awm thei natna

He GABA message exchange hi a thawk tha lo a nih chuan eng nge thleng ang tih han ngaihtuah teh, chu chu thluaka GABA level a hniam tihna a ni? Hei hian thluak lam leh rilru lam harsatna hrang hrang a thlen thei a ni. Research atanga a lan dan chuan GABA activity tlahniam hian hetiang dinhmun hi a thlen thei a ni:

• Lungkhamna leh rilru lam harsatna: Hlauhna, lungkham, hlimna hloh, leh ngaihtuahna seng thei lo anga inhriatna.
Schizophrenia : Rilru natna khirh tak, thil tak tak nena inzawmna hloh leh thil tak tak ni lo hmuh, hriat leh ngaihtuah te.
• Autism spectrum disorder: Hmasawnna lama harsatna, khawtlang inpawhna leh inbiakpawhna lama harsatna nei.
• Depression: Hun rei tak chhung lungngaihna, eng thil pawh ngaihven lo, nun bo tawh anga inhriatna.
• Epilepsy leh seizures: Thluaka nerve cells te chu rang taka, control theih loha hyperactivity avanga taksaa lo awm thin convulsions leh seizures ang chi natna.

Heng dinhmun lian tak takte bakah hian GABA imbalance nena inzawm nia ngaih natna dang engemaw zat a awm a:

• Pyridoxine tlakchhamna: 1.1.Hei hi natna hmuh tur awm lo tak a ni. Vitamin B6 (pyridoxine) tlakchham vang a ni a, hei hi GABA siamna atana pawimawh tak a ni. Hei hian naupang tê tête chu seizure a thlen fo ṭhin. Heng seizures te hi standard anti-epileptic drugs hmanga control a harsa a, mahse vitamin supplement hmanga tihdam theih a ni.
• Hepatic encephalopathy: Thin natna khirh tak, thluak hnathawh tichhe thei.
• Huntington’s disease: Natna rochun a ni a, thluak cell te a tichhe zauh zauh thin.
• Dystonia leh spasticity: Thil awm dan, taksa ruh a nghet lo leh a hrual (twitching) a awm.
• Hypersomnia: Nitin mutthilh lutuk emaw, mut tam lutuk emaw.

GABA level tihsan hian hriselna atan hlawkna a thlen em?

Researcher te chuan GABA level tihsan hian nghawng a neih dan an la zirchiang mek a ni. Evidence hi chiang taka la chiang lo mah se, GABA hian hriselna lama harsatna ṭhenkhat enkawlna emaw, venna emaw a pui thei em tih chhui mek a ni. Entir nan:

• Thisen sang a sang
• Mu thei lo
• Zunthlum

Hengte hi zirchian belh a ngai a ni.

GABA target thei damdawi chi hrang hrang

Hetianga GABA pawimawhna avang hian damdawi siamtute chuan GABA ``receptors'' target thei damdawi tam tak an siam chhuak ta a ni. Hengte hian GABA-in a natural calming effects a puih emaw, a tihpun emaw hmangin hna an thawk a ni. Hengte hi i hre tawh mai thei:

• Benzodiazepines: He damdawi chi hrang hrangah hian diazepam (Valium tia hriat bawk) leh alprazolam (Xanax tia hriat bawk) te a tel a, lungkhamna, mut theih lohna, seizure, leh zu in loh enkawlna atan hman a ni. Surgery neih laiin anesthesia atan an hmang bawk.
• Barbiturates: Hengte hi sedative chi khat a ni bawk a, mutthilh theihna a siam bawk. Mahse, tunah chuan an hman a tlem ta hle mai.
• Vigabatrin (Sabril®): Naupang tê tête seizure leh muscle spasm enkawlna atana hman ṭhin damdawi a ni.
• Flumazenil (Romazicon®): Benzodiazepine overdose enkawlna atan hman a ni. Tin, hepatic encephalopathy, thin natna avanga rilru dinhmun tihchangtlunna atan pawh hman a ni.
• Valproic acid: Hei hi mood-stabilizing drug a ni a, epileptic seizures a control thei a ni.
• Zolpidem (Ambien® emaw Edluar® tia hriat bawk): Hei hi mut theih lohna damdawi lian tak a ni.
• Propofol (Diprivan® tia hriat bawk): General anesthesia an tih laiin damlo tihreh leh muthilh tir nana hman thin damdawi a ni.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): Taksa taksa tichaktu a ni.

Hriat reng tur: Heng leh a ang chi damdawi dangte hi doctor enkawlna hnuaiah chauh hman tur a ni. Nangmah chauha hman emaw, i bula miin a tih vang mai mai emaw chuan chhiatna nasa tak a thlen thei a ni. Chuvangin fimkhur rawh.

GABA supplement hi a tangkai em?

Tunah chuan mi thenkhat chuan, ‘A nih leh engvangin nge supplement atan GABA hi kan lei theih loh?’ tiin an zawt mai thei. Ni e, GABA hi dietary supplement angin a awm a. Mahse hetah hian harsatna tlemte a awm. Oral-a kan ei GABA hi engzat nge kan thluaka a luh tak tak tih erawh a la chiang lo.

A chhan chu, kan thluak hi "blood-brain barrier" an tih, venhimna kawng bik takin a hual vel a ni. Hei hi gate ang a ni a, chemical zawng zawng chu awlsam taka thluaka luh phalsak lovin, thlan bikte chauh a luh phalsak a ni. Chuvangin, heng GABA supplement te hian thluak ah nghawng a nei tak tak em tih sawina tur scientific evidence nghet tak a la awm lo. Chuvangin hemi chungchangah hian mipui tam zawk hmanga zirchianna tam zawk neih a ngai a ni. Tuna kan dinhmun thlirin doctor nena inbiakna nei lova GABA supplement hman hi a finthlak lo.

GABA awmna ei tur a awm em?

GABA hi ei tur thenkhatah pawh a pianphungah a awm bawk. Entir nan:

• Chaw hmin: kimchi (Korea pickle), miso (Japanese soy paste), leh tempeh (Indonesia soy product) ang chi thil te.
• Tea chi hrang hrang: Green tea, black tea, leh oolong tea te hian GABA a pai bawk.
• Chaw dang: Ei tur, brown rice, soybean, peas, chestnuts (peanut chi khat), mushroom, tomato, spinach, broccoli, cabbage, cauliflower, Brussels sprouts (cabbage te chi khat), sprouted grains (e.g., green beans a lo chhuah chuan), leh sweet potato te hian GABA a pai emaw, taksain GABA a siam theih nan a pui bawk.

Mahse supplement chungchanga kan sawi tawh ang khan heng ei tur atanga GABA hian thluak a thlen tak tak dan hi sawifiahna chiang tak a la awm lo. Ei leh in hrisel takah telh a tha a, mahse heng ei tur te hi natna bik enkawlna bik atan chauh rinchhan hi a tha lo. Tin, hemi chungchangah hian doctor thurawn zawng bawk ang che.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Chuvangin, tuna kan sawi tak GABA (gamma-aminobutyric acid) hi kan thluak ti thlamuangtu neurotransmitter a ni tih i hrethiam tawh mai thei a, kan rilru hriselna, mut leh kan taksa hnathawh dan tlangpui atan a pawimawh hle.

Lungkhamna, lungkhamna leh mut theih lohna te a thunun thei a ni. GABA level hniam hian neurological leh psychiatric disorder hrang hrang a thlen thei a ni. Damdawi thenkhat chuan GABA system target-in hna an thawk thin.

GABA supplement leh GABA-containing foods te hlawkna chungchangah scientific research neih belh a ngai a ni. Chuvangin, GABA chungchangah harsatna, rinhlelhna, zawhna i neih chuan a tha ber leh him ber chu chhungkaw doctor hmu a, i dinhmun sawipui a, thurawn dik tak lak hi a ni.Guess emaw, thu hriat emaw atanga hnathawhna hmunah kal suh. I hriselna hi i tan a hlu a ni.

` GABA, gamma-aminobutyric acid, neurotransmitter, thluak, rilru hriselna, lungkhamna, mut