Glucagonoma tih hi eng nge ni? He dinhmun rare tak hi han sawi ila!

Pancreas hi i taksa peng te tak te, mahse pawimawh tak a ni. Kan taksa mamawh hormone engemaw zat a siam chhuak thin. Chuvangin, a chang chuan cancer chi khat hmuh tur awm lo tak, pancreas-a lo awm hian harsatna a thlen thei a ni. Chu chu he natna hi Glucagonoma an tih chu a ni. Zunthlum i vei thut a ni mai thei, a nih loh leh i vunah hnah mak tak tak ang chi i nei a ni mai thei, hei hi hriat a pawimawh hle.

Glucagonoma tih hi eng nge ni? A awlsam zawngin...

Glucagonoma hi cancer natna hlauhawm tak a ni a, i pancreas-ah a lo awm thin. He tumor hian hormone glucagon an tih chu a siam tam lutuk a. Tunah chuan he glucagon hi eng nge a nih i ngaihtuah mai thei.

Glucagon hi hormone pawimawh tak a ni a, kan taksa sugar level, chu chu thisen glucose level control turin a pui a ni. Alpha cells siam a ni a, chu chu i pancreas-a cell chi khat bik a ni. Hun engemaw chen i ei loh chuan, exercise i tih nasat tak tak chuan emaw, protein tamna chaw i ei chuan i thisen sugar level a tlahniam thei tih han ngaihtuah teh, a dik em? Chutah chuan he glucagon hi a rawn lut a, i liver-a sugar dahkhawm, chu chu glycogen , chu a chhuah tir a, thisen sugar level chu a ti sang leh ta a ni. Kan taksaa sugar balance awm reng tura puitu ang mai a ni.

Mahse, glucagonoma a awm chuan he glucagon hormone hi a tam lutuk a siam chhuak thin. Tichuan kan taksain a tuar thei lo. Hei vang hian symptoms lo awm zawng zawng inzawmkhawm chu Glucagonoma Syndrome an ti a ni. Hei hian harsatna tam tak a thlen thei a, chu chu vun lama harsatna leh zunthlum te a ni.

He cancer chi hi glucagonoma tia koh hi pancreatic neuroendocrine tumors , a nih loh leh islet cell tumors category-ah a tel a ni. A tam zawkah chuan hengte hi pancreas tail emaw middle part emaw-ah an lo chhuak thin.

Hei hi cancer tak tak a ni em?

Ni e, a tam zawkah chuan glucagonoma hi cancer a ni . Thil lungchhiatthlak tak chu, a hmuhchhuah a nih pawhin, 50% vel, chu chu pahnih zinga pakhat velin, he cancer hi taksa peng dang, a bik takin liver-ah a darh (metastasized) a ni thei

Hetiang dinhmun hi engtiang chiahin nge a awm?

Glucagonoma hi a takah chuan natna hlauhawm tak a ni. Kum tin hri kai thar maktaduai khat zinga pakhat aia tlem lo hmuhchhuah a ni. Kum 50 leh 70 inkar te a nghawng tam ber .

Hei hi eng symptoms nge ni?

Glucagonomas hi a lo thang zawi zawi fo thin . Chuvangin, i taksain harsatna thlen thei khawpa glucagon a siam chhuah loh chuan symptoms i nei lo mai thei.

Mahse, glucagonoma hian glucagon a siam tam lutuk a, taksain a tuar thei lo a nih chuan a hmaa kan sawi tawh angin glucagonoma syndrome hi a lo awm ta a ni.A thleng thin. Tichuan, symptom chiang tak i hmu ang. Heng symptoms te hi i neih chuan a rang thei ang bera Doctor pan a pawimawh hle.

Vun natna (Necrolytic Migratory Erythema - NME) tih hi a awm lo.

Hei hi glucagonoma syndrome chhinchhiahna ber leh langsar ber a ni. He syndrome vei zinga 90% vel chuan he vun lama harsatna hi an nei thin. A hming chu necrolytic migratory erythema (NME) an ti a ni.

Ngaihtuah teh, i vun, a bik takin mimal taksa peng hrang hrang, hnute leh ke hnuai lam te chu a sen tan a, a hring a, a chang chuan a na bawk. Chûngte chu a hnuah chuan blister-ah an chang a, an crack a, an crust over bawk. An dam hnuah pawh brown spot a awm thei. Hei hi hmun khatah a lo piang thei a, a dam thei a, hmun dangah a lo lang leh thei bawk. Hmun khat atanga hmun danga kal kual vel ang mai a ni.

NME-a thil dangte chu:

• Hei hi a lo kal thei a, a kal thei bawk a, taksaah pawh a kal kual thei bawk .
• A tir lamah chuan a itchy hle thei a, a na thei bawk .
• Rash chu a sen a, chutah chuan blisters a awm a, crust a siam ta a ni. A dam hnuah pawh brown spot a awm thei.
• Hei hian lei natna (glossitis ), hmui natna, hmui chhe, leh angular cheilitis ang chi thil a thlen thei a ni.
• Mitmeng hring ( blepharitis ), sam tlakchham, leh nail lama harsatna te pawh a awm thei bawk.

Zunthlum natna lan chhuah dan

He syndrome hian thisen sugar level sang ( hyperglycemia ) a thlen a, chu chuan zunthlum a thlen thei a ni. Zunthlum natna lan chhuah dan chu:

• Chhan awm lova thinrim .
• Tuihal tam lutuk (Polydipsia) .
• Zun tam ( polyuria ), a bik takin zan lamah.
• riltam lutuk ( Polyphagia ).

(glucagonoma syndrome) natna lan chhuah dan dangte .

Symptom dang engemaw zat a awm bawk:

• Chronic diarrhea a awm thin .
• Thisenah hemoglobin a tlahniam (anemia ). Hei hian hahna leh luak chhuak a thlen thei a ni.
• Thisen zam, a bik takin ke ruh thuk takah ( Deep Vein Thrombosis (DVT) ).

Rilru leh nervous system nena inzawm symptoms

A châng chuan, rilru leh nervous system nena inzawm symptoms i hmu thei bawk a, chu chu:

• Lungngaihna
• Dementia natna (dementia) a awm
• Agitation tih hi a ni
• Hyperreflexia (taksa chhanna chak zawk) .
• Kal dan mak tak (ataxia ) .
• Rilru lama harsatna ( Psychosis) .) .
• Hlauhna leh rinhlelhna dik lo ( Paranoid Delusions ) .

Eng thilin nge glucagonoma hi a thlen?

A tam zawkah chuan doctor-te hian glucagonoma hi a chhan dik tak an hre lo . Mahse, 10% velin he cancer hi Multiple Endocrine Neoplasia type 1 (MEN type 1) tih hming pu genetic condition nen a inzawm a ni.

Mahse, MEN type 1 vei zawng zawng hian glucagonoma an vei vek lo. Chu pawh chu percentage tlemte chauh a ni.

Engtin nge hei hi i hriat chian?

A hmaa kan sawi tawh ang khan vun natna necrolytic migratory erythema (NME) i neih chuan doctor chuan glucagonoma a ringhlel mai thei. Chumi hnuah chuan test an ti thei a, chungte chu:

• Fasting Blood Sugar Test: Sugar level a san chuan glucagonoma rinhlelh theih a ni a, a kaihhnawih zunthlum a awm tih finfiah theih a ni bawk.
• Fasting Glucagon Blood Test: Glucagon level hi glucagonoma-ah hian a sang lo hle – a tlangpuiin milliliter khatah picogram 500 (pg/mL) aia tam a ni. Fasting-a glucagon level pangngai chu 150 pg/mL aia tlem a ni.
• Amino Acid Thisen Test: Glucagonoma hian thisenah amino acid a ti hniam tlangpui ( hypoaminoacidemia ).
• Complete Blood Count (CBC): Hei hian thisen tlakchhamna a enfiah thin , glucagonoma nen hian thisen tlakchhamna a awm thei a ni.

Heng ang imaging test te hian lump a awm leh awm loh finfiah nan a pui thei a ni:

• CT Scan hmanga tih a ni
• MRI Scan a ni
• Endoscopic Ultrasound hmanga tih a ni

Engtin nge enkawl a nih?

Glucagonoma enkawl dan hi a tam zawk chu cancer hi pancreas-ah chauh a awm (localized) emaw, taksa hmun dangah a darh (metastasized) emaw a ni .

Symptoms control dan hmasa ber

A hmasa ber chu glucagon tam lutuk avanga natna lanchhuahna leh harsatna awm thei te control a ni. Hei hi hetiang hian enkawl a ni:

• Glucagon tam lutuk control nana damdawi: Octreotide leh Lanreotide tia koh injection hian glucagon tam lutuk nghawng a tihziaawm bakah glucagon siamchhuah a titawp thei bawk. Heng damdawi te hian tumor te pawh a ti hniam thei a ni. NME, zunthlum, ril\am, leh nervous system lama harsatna te pawh a\angin chhanchhuahna an pe bawk.
• Diabetes management: I thisen sugar level dik tak a awm theih nan oral diabetes damdawi emaw insulin injection emaw i mamawh mai thei.
• Ei leh in lama tanpuina:Total Parenteral Nutrition (TPN) , amino acid leh zinc supplement te pek theih a ni a, hei hian ei leh in tha lo avanga nghawng a neih tihziaawmna tur a ni.
• NME vun natna enkawl dan: Antibiotics leh corticosteroids hian NME a ti tha thei a.
• Anticoagulant Therapy: Heparin ang chi thisen tithianghlimtu hian deep vein thrombosis (DVT) a veng thei a ni.

Pancreas-ah chauh a awm a nih chuan...

Cancer hi pancreas-ah chauh a awm chuan operation hi a enkawlna ber a ni . Surgeon chuan tumor chu a paih chhuak vek thei a nih chuan natna chu a dam fo thin . Glucagonoma tihbo hnuah i glucagon level chu a normal leh tur a ni. I symptoms te pawh a bo tur a ni.

Hmun dangah a darh tawh a nih chuan (metastasized)...

A theih phawt chuan doctor-te chuan tumor te chu surgery hmanga lakchhuah an rawt thin. Hei hian pancreas, a bul hnaia lymph node leh liver-a tumor awmte lakchhuah a huam thei.

Mahse, surgeon chuan a hnah pakhat emaw, a pum emaw a la chhuak thei lo a nih chuan, i medical team chuan heng enkawlna pakhat emaw, a aia tam emaw chu an rawt thei ang:

• Chemotherapy: He enkawlna hian cancer cell te a tichhia a, a thang lian lo turin a veng a ni.
• Radiofrequency Ablation: Hei hian radio wave atanga lumna hmangin cancer cell te a that thin.
• Cryosurgical Ablation: Hei hian chemical lum tak tak, liquid nitrogen ang chi hmangin cancer cells a tichhia a ni.
• Chemoembolization: He enkawlna hian cancer tumor-a thisen kalna tur a block avangin hna a thawk a ni.

Hetiang dinhmun atanga dam lehna tur prognosis chu eng nge ni?

Glucagonoma vei tan chuan thil engemaw zat a innghat a:

• I kum leh i hriselna zawng zawng .
• Cancer tumor lian tham tak chu .
• Cancer a darh tawh emaw a darh lo emaw .

Cancer hi pancreas-ah chauh a awm a nih chuan, a hmalam hun chu a tha tlangpui . Tumor lakchhuahna tur operation hi tihdamna a ni fo a, mahse glucagonoma vei zinga 20% vel chauh tan chuan hetiang hi a ni.

Glucagonoma hi a tlem em em avangin, eng chen nge i dam theih ang tih leh cancer a darh chuan eng nge a chhuah dawn tih chiang taka sawi theihna tur data a awm lo. I medical team chuan i dinhmun bik a zirin thu belhchian dawl zawk an pe thei ang.

Hei hi ven theih a ni em?

Scientist-te chuan glucagonoma vei tam zawk chhan an hriat loh avangin, a venna tur engmah i tih theih a awm lo tak zet a ni .

Mahse, i chhungte first-degree (biological parents leh siblings) zinga pakhatin MEN (Multiple Endocrine Neoplasia) a vei tih hmuhchhuah a nih chuan i doctor nen genetic testing chungchang sawipui rawh. MEN pawh i neih chuan genetic testing hian cancer hi a tir lamah a hriat theih nan a pui thei a ni.

Cancer vei nia hriat a nih hi thil lungchhiatthlak tak a ni. Glucagonoma ang chi thil tlemte a nih chuan a harsa zawk. Mahse, i medical team te chu i zawhna chhang tur leh thlawp turin an awm reng tih hre reng ang che. Glucagonoma natna vei hian rilru leh rilru lamah mahni chauha awm i nih chuan i doctor hnenah i tanpui thei tur program leh service hrang hrang zawt rawh.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Chuvangin, glucagonoma hi thil awm lo tak ni mahse, hriat a pawimawh hle. A bik takin zunthlum ang chi symptoms i neih ruala vun rawng mak tak (NME) i neih thut chuan, kan sawi tawh ang khan doctor pan hmasa phawt ang che. Hriat hmasak a nih chuan enkawl theih a ni. Hei hi a tlem hle nachungin, enkawlna a awm.

Lungngai suh, nangmah chauh i ni lo. He zinkawngah hian i doctor leh medical team te chuan an pui ang che. Chak takin awm la, an thurawn pek che chu zawm rawh.

` Glucagonoma, pancreatic cancer, glucagon, zunthlum, vun natna, hormone, cancer hmuh tur awm lo