Nangmah emaw, i hmangaih tak emaw chuan Cystic Fibrosis (CF) i vei a nih chuan, chu natna nena nunpui harsatna chu i hre chiang hle mai thei. Mahse thu lawmawm tak chu medical science hmasawnna avang hian tunah hian he natna hi i hmachhawn thei tur damdawi thar a lo awm ta a ni. Vawiin hian chutiang damdawi pakhat chu kan sawi dawn a ni. Ivacaftor tih a ni. Brand name Kalydeco hmangin i hre mai thei. He damdawi hi han thlir thuai teh ang.
He damdawi hi eng nge thleng tak tak?
A awlsam zawngin sawi ila, Ivacaftor hi Cystic Fibrosis (CF) enkawlna atana hman thin damdawi a ni. Mahse, CF vei zawng zawng tan a tha lo. He damdawi hian CF thlentu genes-a mutations bik nei te tan chauh hna a thawk a ni. I doctor chuan he damdawi hi i tan a tha em tih hriat nan a tul angin test a ti ang.
Cystic Fibrosis hi kan taksaa protein pakhat hnathawh tichhe thei genetic disease a ni. Hei hian lung leh pancreas ang chi taksa peng hrang hrangah secretion thick, sticky tak tak a awm khawm a, harsatna hrang hrang a thlen thin. Damdawi Ivacaftor hian protein chhia chu eng emaw chen chu a thawk tha leh a, a secretion te chu a ti thim a, taksa atanga awlsam taka lakchhuah theihna a siam a ni.
Damdawi ei tan hmaa doctor hnena i hrilh tur thilte
He damdawi hi i hman hmain i doctor hnenah i hriselna zawng zawng chiang taka hriattir a pawimawh hle . A bik takin heng thilte hi hrilh ngei ang che:
- Thin natna: Thin natna i neih chuan doctor hrilh a pawimawh. Hei hi a chhan chu he damdawi hi liver hian a metabolize ber a ni. Liver lama harsatna i neih chuan i doctor chuan i dose a siam danglam a ngai mai thei.
- Kal natna: Chutiang bawkin kal lama harsatna i neih chuan chu chu min hrilh bawk ang che.
- Allergy: Ivacaftor emaw damdawi dang emaw, ei tur emaw, dye dang emaw allergy i neih chuan doctor hnenah hrilh rawh.
- Naupai emaw, nau neih tum emaw: Naupai emaw, nau pai tum emaw i nih chuan doctor hnenah hrilh rawh.
- Nu hnute petu i nih chuan: Nau hnute i pek chuan hei hi sawi tel ngei ang che.
He thu hi thup lova doctor hnena hrilh chu nangmah himna tur a ni. Chuvangin thil tenawm tak pawh nise hrilh theihnghilh suh ang che.
Engtin chiah nge he damdawi hi ka hman ang?
Damdawi pakhat atanga hlawkna tam ber hmu tur chuan a hman dik a pawimawh hle.
Damdawi ei dan tur
He damdawi hiChau thau awmna chaw nen ei tur a ni ngei ang. Entirnan, he pill hi egg, cheese toast, peanut butter nena siam chhangphut slice emaw, butter hmanga siam omelet emaw ang chi thil nen i ei chuan damdawi chu taksain a hip lut tha zawk ang. Pum ruak ah ei loh tur.
A pawimawh ber: He damdawi hi grapefruit tui nen hian eng vangin pawh ei loh tur a ni. Seville orange pawh a tha lo. Chungte chuan damdawi hman tangkai dan a nghawng thei a ni.
Dose pek zat chauh ei la, i doctor-in a pek hunah. A tam zawk ei loh tur. Doctor thurawn tel lo chuan damdawi ei kha bansan nghal suh.
Naupangte hnena i pek chuan
He damdawi hi a chang chuan naupang kum 6 chunglam tan pek thin a ni a, mahse, i naupang enkawltu doctor nen uluk takin sawipui la, a thupek zawm rawh.
Damdawi dose tihpun a nih chuan (Overdose) .
Damdawi i ei tam lutuk nia i hriat chuan Emergency Treatment Unit (ETU) hnai ber pan nghal rawh . A nih loh leh Colombo National Hospital-a National Poisons Information Center-ah thurawn dil turin phone la.
Damdawi dose khat i ei loh chuan
Dose i miss a nih chuan i hriatreng veleh ei nghal rawh. Mahse, i dose leh tur thleng darkar 6 aia rei lo a nih chuan missed dose kha skip la, i dose leh tur chu a hun ruatah ei rawh. Double dose ei ngai suh.
Ivacaftor nena inzawm thei damdawi dang
Damdawi i ei zawng zawng, vitamin leh herbal products te pawh doctor hnenah hrilh vek a pawimawh hle. Damdawi thenkhat chu Ivacaftor nen an inzawm thei. He table hi en rawh.
| Damdawi/thil chi hrang hrang | Level ngaihtuah tur a awm |
|---|---|
| Seizure natna atana hman damdawi thenkhat (e.g. carbamazepine, phenobarbital, phenytoin) . | Ivacaftor hman tangkai dan a ti tlem. |
| Grapefruit tui leh Seville orange te a awm bawk | A tul lovah damdawi concentration a tipung. |
| Rifampin, Rifabutin (TB natna damdawi) . | Ivacaftor hman tangkai dan nasa takin a ti tlem. |
| St. John’s Wort (herbal atanga siam) a ni. | Ivacaftor hman tangkai dan a ti tlem. |
| Antifungals (e.g. ketoconazole, itraconazole, fluconazole) te hi a tha hle a, a hmanna tur a awm lo. | Ivacaftor concentration a tisang thei bawk. |
| Antibiotics thenkhat (e.g. clarithromycin, erythromycin) te hi a tha hle. | Ivacaftor concentration a tisang thei bawk. |
| Cyclosporine, Tacrolimus, Digoxin te a awm bawk | Ivacaftor hian heng damdawi te hi a thatna a tichhe thei a ni. |
He list hi a kim lo a, chuvangin i ei zawng zawng doctor hnenah hrilh vek a tha ber.
Damdawi ei avanga side effect awm thei
Damdawi dang ang bawkin Ivacaftor hian mi thenkhatah side effect a nei thei a ni. Chûng zînga ṭhenkhat chu a pawi hle a, ṭhenkhat erawh chu a nêm hle thung.
| Heng symptoms te hi i neih chuan doctor hnenah hrilh nghal rawh. | |
|---|---|
| Allergy natna lan chhuah dan | Vun vun rawng, hnim hring, hmai, hmui emaw lei emaw a hring. |
| Liver-a nghawng a neih dan | Zun dum, bawlhhlawh rawng hring, mit emaw vun emaw a sen, pum dinglam chunglam na, chaw ei chak lohna. |
| Vision a danglam thin | Blurred vision emaw thil dang dang emaw a awm thei. |
| Thildang | Chau lutuk anga inhria, khawsik nei ang maia inhria. |
| Hengte hi a pawi lo tlangpui a, mahse a awm reng chuan doctor hnenah hrilh rawh. | |
| Chaw ei dan (digestive system) a ni | Indigestion, luak chhuak, luak chhuak. |
| Thildang | Lu na , luak chhuak , ruh natna. |
He damdawi i ei lai hian i doctor hian i mit hmuh dan leh i thisena liver enzyme awm zat a enfiah fo a ngai mai thei. Hei hi thil pangngai a ni.
Damdawi hi engtin nge him taka kan vawn theih ang?
- Naupang lakah inthiarfihlim rawh.
- Room temperature (15-30 degree Celsius inkar) ah dah tur a ni.
- Damdawi expire tawh chu hmang lovin paih mai rawh.
He damdawi hi i tan chauh pek a ni. Eng vangin pawh midang hnenah share suh.
Take-Home Thuchah a ni
- Ivacaftor hi damdawi bik a ni a, cystic fibrosis chi hrang hrang enkawlna atana pek thin a ni.
- He damdawi hi thau awmna chaw ei rualin ei fo tur a ni.La rawh. Grape tui nen ei ngai suh.
- Damdawi dang i ei zawng zawng leh i natna dang zawng zawngte chu i doctor hnenah hrilh rawh.
- Side effect na tak tak, mit sen, zun dum, vun vun rawng i neih chuan doctor hnenah hrilh nghal rawh.
- He damdawi hi i tan chauh a ni. Midang hnenah pe suh. Zawhna i neih chuan doctor nen inbia fo ang che.
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