Pum na, bawlhhlawh chhunga thisen? Juvenile Polyposis Syndrome (JPS) a ni thei bawk.

Nang emaw, i chhungkuaa mi emaw, a bik takin naupang emaw hian pum na hi i nei fo em? I ek chhungah thisen tlem i hmu ngai em? A nih loh leh i chau a, i chau hle em? Heng chhinchhiahnate hi pum natna awlsam tak emaw, ei tur tuar theih lohna emaw angin kan hnawl fo thin. Mahse, a châng chuan heng symptoms te hi kan hriat tam loh, mahse kan hriat chian a ngai, condition avanga lo awm thei a ni. Vawiin hian chutiang dinhmun pakhat, Juvenile Polyposis Syndrome (JPS) chungchang kan sawi dawn a ni.

JPS hi eng nge ni tak tak?

A awlsam zawngin sawi ila, Juvenile Polyposis Syndrome (JPS) hi kan chaw ei dan (gastrointestinal - GI tract) chhungril bang (gastrointestinal - GI tract)-ah hian thil danglam tak tak, a lo piang chhuak thin, genetic condition a ni. Medical lamah chuan heng growths te hi polyps kan ti thin . Kan rilru chhunga grape ang chi hnah te tak te, hnah pakhata innghat chu han mitthla teh. Chutiang chuan heng polyps te hi an lo piang ta a ni.

Heng polyp te hi kan digestive system khawi hmunah pawh a lo awm thei a ni.

• Pumpui
• Intestine te tak te ah
• Intestine lian (colon) ah chuan .
• Rectum (Rectum) atanga lo chhuak

Mahse, intestine lian leh rectum-ah an awm tam ber. JPS vei chuan heng polyp tlemte atanga za tam tak thlengin a nei thei.

Tunah chuan "juvenile" tih thumal a neih avangin hei hi naupang tê tê chauh natna a ni tih i ngaihtuah mai thei. A tak tak lo. Heta "juvenile" tih hian natna lo awm kum a kawk lo. Polyp lak a, microscope hmanga enfiah a nih chuan cell awm dan a kawk a ni. Mahse, a tam zawkah chuan he natna lan chhuah dan hi naupan lai emaw, tleirawl lai emaw atang hian a lang tan thin a, a tlangpuiin kum 20 an tlin hmain a lang thin.

JPS chi hrang hrang lian ber ber a awm em?

Ni e, JPS hi chi thum ah then theih a ni. Heng classification te hi polyp lo piang lian leh te leh an awmna hmun a zirin an siam thin.

He natna hi tuin nge vei? Hrilhfiahna a ni em?

JPS hi genetic mutation avanga lo awm a nih avangin tu pawhin an nei thei a ni. Condition hmuh tur awm lo tak a ni. Khawvel pumah, a vei hi mi sâng za zînga pakhat vêl a ni .

Ni e, he natna hi rochun theih a ni . JPS hi damdawi lama kan sawi thin ``autosomal dominant`` condition a ni. Hei hian a awmzia chu naupangin he natna atana mutated gene copy khat chu nu emaw pa emaw hnen atangin a rochun pawhin naupang tan he natna hi a vei theih nan a tawk tihna mai a ni.

• JPS vei zinga 75% vel chuan an nu leh pate hnen atangin he natna hi an rochun thin.
• A bak 25% ah chuan naupang taksaa spontaneous mutation vangin natna hi a lo awm thei a, nu leh pate hian he gene mutation hi nei lo mahse.

JPS natna lan chhuah dan chu engte nge ni?

He natna lanchhuahna ber chu a hmaa kan sawi tawh ang khan intestine-ah polyps a lo awm hi a ni. Chûngte chu taksa chhûnga siam a nih avângin pâwn lam a\angin kan hmu thei lo. A tam zawkah chuan polyp hi a lian deuh emaw, a tam emaw hma loh chuan symptom a lang lo thei. Mahse symptoms a lo lan tan chuan hetiang hian a lang thei.

Pian tirh atanga hmuh theih mizia dang

JPS vei zinga 15% vel chuan intestinal polyp bakah hian an pian tirh lamah taksa lama harsatna dang an nei bawk.

• Hmuh leh hmui a inthen
• Kut zungtang emaw ke ruh emaw extra neih (Polydactyly) .
• Thluak, thinlung emaw, zun kawng emawa hmasawnna dik lo
• Intestines a inthlak danglam (Malrotation) .

JPS leh cancer hlauhawmna inzawmna a awm em?

Hei hi he natna chungchanga hriat tur pawimawh ber a ni. JPS avanga polyp lo awmte hi a tir lamah chuan cancer (benign) an ni lo. Tumor pangngai an ni. Mahse, hun kal zelah heng polyp te hi cancer-a an chan theihna chance a sang hle .

Chuvangin JPS vei tu emaw chuan a hnuaia cancer chi hrang hrangte hi a vei theihna a sang zawk a ni.

• Colorectal cancer a ni
• Pum cancer a ni
• Small intestine cancer a ni
• Pancreatic cancer natna a ni

Hei hi hlau suh. Hei hian mi zawng zawngin cancer an vei dawn tihna a ni lo. Mahse, a risk a sang zawk tihna a ni. Chuvangin natna hi a hun takah hriatchhuah a, doctor-in a rawt angin a hun taka screening neih a pawimawh hle.

JPS hi eng nge a chhan bik?

Kan sawi tawh ang khan hei hi genetic condition a ni. JPS hi kan taksaa gene pahnih BMPR1A leh SMAD4 tih te mutations vang a ni ber.

Hei hi hrethiam tur chuan entirnan awlsam tak hmang ila. Kan taksaa cell awmte hi kawngpuiah motor ang maiin han ngaihtuah teh. Gene pahnih BMPR1A leh SMAD4 an tih te hi traffic police officer ang mai an ni. Cell than leh inthen darh dan an control a, "OK, divide now" leh "OK, stop now" tih signal an pe thin.

Hêng gene pahnih hi an inthlâk danglam chuan, chutiang traffic cops-te an awm tawh loh ang bawkin, cell-te chuan thunun theihna an hloh ta a ni. An duh angin an inthen tan a, chak takin an inthen bawk. Chutiang chuan heng control theih loh dividing cells te hi an inzawm khawm a, heng tumor te hi polyps an tih te hi an siam ta a ni.

JPS bakah hian SMAD4 gene-a mutation nei te hian genetic condition dang, hereditary hemorrhagic telangiectasia (HHT) an tih chu an nei thei a ni.

He natna hi engtin nge kan hriat theih ang?

I doctor hnenah i symptoms i hrilh chuan a enfiah ang che a, i chhungkaw medical history a zawt ang che. JPS hriat theih nan a hnuaia mi pakhat tal i neih a ngai a ni:

• Intestine lian leh/ emaw rectum-ah polyp panga emaw a aia tam emaw neih.
• Digestive system hmun dangah polyp awmna.
• Polyp pakhat tal neih leh chhungkaw history-a JPS nei.

He natna finfiah nan hian test lian pahnih a awm a.

1. Endoscopic exam / Colonoscopy: Hei hian tube te tak te, flexible tak, camera leh light hmanga hnute kaltlangin dahin, intestine lian leh chaw ei kawng chhung zawng zawng enfiah a ni. Hei hian polyp a awm em tih te, engzat nge awm tih te, khawiah nge a awm tih hriat nan a pui thei a ni. Exam chhung hian polyp te te chu lakchhuah theih a ni a, tissue sample (biopsy) lak theih a ni bawk.

2. Genetic blood test: Thisen sample lak a, JPS thlentu BMPR1A emaw SMAD4 gene mutations awm leh awm loh enfiah a ni. Hei hian 100% in natna a nemnghet thei a ni.

JPS enkawlna tur engte nge ni?

JPS enkawlna tum ber chu polyps tihbo a ni.Hei hian symptoms a control thei a, nakin lawka cancer vei theihna a ti tlem thei bawk. I doctor chuan i kum, i hriselna, polyp awm zat leh an awmna hmun a zirin i tan enkawlna tha ber tur a ruat ang.

Enkawl dan hrang hrang a awm a:

• Colonoscopy neih laiin polyp lakchhuah: Polyp hi a tlem a, a lian lo a nih chuan, enfiahna atana hmanraw hman ang chiah hmangin tan leh lakchhuah theih a ni.
• Surgery hmanga polyp lakchhuah: Polyp te hi a lian emaw, colonoscope hmanga thlen harsa hmuna awm emaw a nih chuan operation tih a ngai mai thei.
• Colon section pakhat surgery hmanga lakchhuah: Hmun khatah polyp tam tak a darh chuan doctor-te chuan chu colon section pumpui chu surgery hmanga lak chhuah an rel thei a ni.

Naupang tê tête hian polyp pakhat chauh an neih chuan colonoscopy neih laiin lakchhuah a ni tlangpui. Naupang surgery hi tih a tlem hle.

Natna hmuhchhuah hnuah engtin nge kan enkawl ang?

JPS hi hun rei tak chhunga enkawl ngai condition a ni. Polyp enkawl leh lakchhuah hnuah, a lo thang leh em tih leh a thar a lo awm leh awm loh enfiah reng a ngai a ni. Chuvangin screening kan ti thin .

I doctor chuan heng test te hi scheduled schedule-a neih turin a hrilh ang che.

• Thisen test a ni
• Colonoscopy hmanga enfiah a ni
• Upper endoscopy hmanga enfiah a ni

Test hmasa ber hi symptoms a lan veleh emaw, kum 15 an tlin hma emawa tih thin a ni tlangpui a, test result a tha a nih chuan kum 3 danah test nawn leh turin an ti ang che. Mahse, polyp i neih a, lakchhuah a nih chuan kum tin test neih a ngai mai thei . Polyp te a lo kir leh loh chuan test inkar hi kum 3 thleng tihpun theih a ni.

Engtikah nge Doctor i hmuh a ngaih?

Kan sawi tawh ang chi symptoms i neih chuan, a bik takin i stool-a thisen , ngaihthah ngai suh. Hemorrhoid awlsam tak a ni thei a, JPS ang chi natna khirh zawk chhinchhiahna a ni thei bawk. Chuvangin, i doctor hmu nghal rawh.

Tin, i chhungkuaa mi tu emaw hian JPS hi a lo nei tawh a nih chuan, emaw, i naupan lai atanga i ril cancer i vei tawh a nih chuan, i doctor nen sawi dun la, a tul chuan genetic testing neihpui la, symptom i nei lo a nih pawhin, a finthlak hle ang.