I taksa hi acidic lutuk a ni em? Lactic acidosis chungchang hi i zir dawn teh ang!

Tlemte i chau lai hian i chau, i na a, thawk i hah ngai em? Chungte chu chhan hrang hrang vang pawh a ni thei. Mahse, vawiin hian kan taksaah lactic acid an tih chemical a lo awm khawm hian kan dinhmun kan sawi dawn a ni. Hei hi doctor ten lactic acidosis an tih chu a ni . Ngaihtuah buai suh, he thu hi awlsam takin sawi ila.

Lactic Acidosis hi eng nge ni?

A awlsam zawngin sawi ila, lactic acidosis hi i thisena lactic acid tam lutuk awmna a ni. Hei hi i taksain lactic acid a siam tam lutuk hian a thleng thei a, a nih loh leh i taksain a siam chhuah lactic acid chu uluk taka a paih chhuah theih loh hunah a thleng thei bawk.

A tlangpuiin kan thin leh kal (kidney) te hi kan taksa atanga lactic acid tam lutuk paih chhuaktu an ni. Mahse, lactic acid a tam lutuk a nih chuan, emaw, heng taksa peng hrang hrang, thin leh kal ang chiah hian chak lohna engemaw zat a awm chuan, he hna hi an thawk tha thei lo. Chu chu thisenah lactic acid a lo awm tan tirh lai a ni.

I thisena lactic acid level a san deuh chuan hyperlactatemia kan ti thin. Mahse, hei hi a sang zual a, taksa pH (i.e. acid-base balance) chu acidic lutuk a nih chuan chu chu lactic acidosis an ti a ni.

Engvangin nge kan taksaah hian lactic acid a lo awm?

Lactic acid, a then chuan lactate , an tih hi cellular metabolism atanga lo chhuak natural byproduct a ni. Kan cell te hian glucose (sugar) hmangin chakna an siam chhuak thin. Hetiang kalphung hi anaerobic glycolysis an ti a . Hei hi cell-te hian chakna an mamawh thuai a, mahse chutiang ti thei tur chuan oxygen an neih tlem chuan a thleng thin.

A tlangpuiin oxygen hmanga thil tih hmangin chakna kan hmu thin. Hei hi aerobic metabolism an ti a . Mahse, anaerobic glycolysis hi emergency-a kan hman thin energy source ang mai a ni. Ngaihtuah teh, i tlan nasat thut emaw, thil rit tak i chawi emaw hian i taksa ruhte chu oxygen a tlachham nghal a ni. Chutah chuan he method hi hman a ni. Chutiang bawkin natna thenkhat avanga kan tissue ten oxygen an dawn loh chuan lactic acid pawh hetiang hian a lo piang chhuak thin.

Lactic acidosis a awm chuan eng nge thleng?

Lactic acidosis i neih hian eng nge thleng tih chu a nasat danah a innghat. Mi thenkhat chuan he natna hi hun engemaw chen an nei thei a, a bik takin exercise nasa tak an neih hnuah. Ni engemaw zat chhung chu i taksa a ti na thei a ni. Mahse i liver leh kidney te a hriselna a tha a nih chuan ni engemaw zat hnuah lactic acid chu a bo vek ang.

Mahse, i taksain lactic acid a siam tam lutuk chhunzawm zel a nih chuan, emaw, i liver leh kidney-in a process tha thei lo a nih chuan, thil awmdan chu a pawi zawk thei a ni. Hei hi natna chi khat nen a thleng fo thin. I thisena lactate level a san zel chuan pH level a tlahniam a, cardiac output pawh a tlahniam zauh zauh bawk. Hei hian taksa peng dang a tichhe thei a, thihna thlengin a thlen thei a ni. Chuvangin hei hi hriat chian a pawimawh.

Lactic Acidosis natna lan chhuah dan chu engte nge ni?

He natna lan chhuah dan hi a tir lamah leh a nasat hunah a danglam thei.

A lan chhuah hmasak ber

A tirah chuan hetiang hi i hre mai thei:

• Nausea leh luak chhuak.
• Chauhna leh hah lutuk.
• Thâwk rang, thuk tak (hei hi respiratory compensation an ti a, thawk chhuahna hmanga taksa acidity tihtlem tumna a ni).
• Muscle twitching leh taksa na.

Condition a nasat chuan symptoms a awm thin

A natna a zual zel chuan a hnuaia symptoms te hi a lo lang thei bawk:

• Chak lohna leh mutthilh tamna.
• Delirium leh buaina.
• Kea kal lai ang chi ( ataxia ) te chetna control harsat.
• Zun chhuah tlem ( Oliguria ).

Symptom dang a awm bawk

Lactic acidosis thlentu damdawi lam dinhmun hnuaia awm symptoms i nei thei bawk . Entîr nân, sepsis ( thisen natna), shock ( stroke), a nih loh leh liver failure . Hei hi a lan chhuah dan chu:

• Taksa lumna hniam.
• Thisen sang hniam.
• Khawsik.
• Jaundice (vun sen leh mit var).

Lactic acidosis awm chhan ber chu eng nge ni?

Hei hi chhan tam tak a awm thei. A chhan tlangpui chu i thisena oxygen level hniam (hypoxemia) emaw, i tissue-a oxygen tlakchham (hypoxia) emaw a ni. Hei hi damdawi lam dinhmun avanga lo awm a ni tlangpui.

Doctor-te chuan he lactic acidosis natna hi a chhan a zirin chi hrang hrangah an ṭhen a:

Type A tih a ni

Type A lactic acidosis hi i tissue-in oxygen a hmuh tlem chuan a lo awm thin. Damdawi lam natna khirh takah pawh hmuh tur a awm fo. Hun eng emaw chen atan pawh a ni thei a, exercise nasa lutuk avanga lo awm a ni.

Lactate siam tam lutuk theihna tur dinhmun thenkhat chu:

• Pulmonary disorder vangin thisen hian oxygen a dawng tlem hle.
• Circulatory disorder hian thisen a kal slow a, tissue-ah oxygen a tlachham bawk.
• Hemoglobin disorder hian thisen sen (red blood cells) oxygen phurh theihna a nghawng a ni.
• Shock condition te chu septic shock , hypovolemic shock, emaw cardiogenic shock te hi a ni.
• Intestinal ischemic syndrome a awm a .
• Hun rei tak chhunga seizures leh convulsions te.
• Carbon monoxide avanga rimchhia a awm.

Type B tih a ni

Type B lactic acidosis hi hypoxemia emaw hypoxia emaw awm lovin a awm thin . Subtype pathum a awm a.

Type B1 a ni

Hei hi natna hnuaia awm, lactate metabolize theihna tibuaitu avanga lo awm a ni.

Anni chu:

• Liver natna .
• Kidney natna a ni .
• Thiamine (vitamin B1) tlakchhamna.
• Ngawt.
• HIV/AIDS dinhmun.
• Mitochondrial natna te .
• Diabetes- kaihhnawih ketoacidosis.
• Zu ruihhlo ngawlvei ( Zu ruihhlo hmansualna ).

Type B2 a ni

Hei hi damdawi leh toxin thenkhat side effect angin a thleng thin. Entirnan:

• Cyanide hmanga rimchhia a awm.
• Carbon monoxide avanga rimchhia a awm.
• Zu ruih vanga natna .
• Cocaine hman dan.
• HIV damdawi thenkhat ( Nucleoside reverse transcriptase inhibitors (antiretroviral therapy) ).
• Inhaler chi thenkhat, natna hrang hrang, asthma ( Beta-adrenergic agonist inhalers ) atana hman thin.
• Allergy na tak nei tan epinephrine injection pek thin a ni.
• Antibiotic linezolid a ni a .
• Propofol hi anesthesia atan hman a ni.
• Metformin, zunthlum damdawi (hei hi Sri Lanka ramah chuan hman lar tak a nih avangin a bik takin hei hi i hriat chian a ngai).

Type B3 a ni

Hei hi lactate metabolize nana enzyme bik mamawh pianpui atanga lo chhuak a ni. Hengte hi a tlem hle. Entirnan:

• Glycogen dahkhawmna natna .
• Fructose-1,6-diphosphatase tlakchhamna .
• Pyruvate carboxylase tlakchhamna a awm .
• Pyruvate dehydrogenase tlakchhamna a awm .
• Oxidative phosphorylation tlakchhamna a awm a .
• Methylmalonic aciduria a awm a .

D-lactic acidosis a awm thin

A hmaa kan sawi tawh chi A leh B te hi i thisena L-lactate awmkhawmna nen a inzawm a ni. He L-lactate hi lactic acid chi khat a ni a, a tlangpuiin mihring taksaah a siam chhuak a, a metabolized bawk.

Mahse, lactic acidosis chi dang hmuh tur awm lo tak a awm a, chu chu D-lactate a punkhawm vang a ni. Hetiang lactic acid hi i intestine lian chhunga bacteria chi khat atanga siam a ni. D-lactate hi byproduct angin siam a ni a, heng bacteria te hian chaw ei laiin carbohydrates an metabolize a ni.

D-lactic acidosis hi heng bacteria te hi an lo thang tam lutuk hian a awm thin. Chumi hnuah chuan D-lactate tam lutuk chu intestine atang hian thisenah a lut ta a ni. D-lactate hi kan kal emaw, kan thin emaw hian a metabolize thei lo. Chuvangin thisenah a pung khawm chhunzawm zel a ni. Hei hi short gut syndrome an tih condition complication anga ngaih a ni fo thin .

Engtin nge Lactic Acidosis hi hmuhchhuah a nih?

Doctor-te chuan lactic acidosis i neih leh neih loh chu a hnuaia thilte hi a zirin an rel thin:

• Thisenah lactate level 4 mmol/L (liter khatah millimoles) aia tam a awm.
• Thisen pH 7.35 aia hniam a ni.

Heng value te hi i thisen sample lak a, test hmanga teh a ni.

Hei atan hian eng test nge tih thin?

Lactic acidosis hmuhchhuah nan a hnuaia test te hi tih thin a ni :

• Comprehensive metabolic panel (CMP) : Hei hi thisen test awlsam tak a ni a, i thisen chhunga thil chi hrang hrang tehna hmangin i hriselna chungchanga hriat tur pawimawh tak tak a awm a ni.
• Thisen lactate test : CMP-a thil tehna bakah hian i thisena lactate level chu a bik takin teh a ni.
• Anion gap blood test : He test hian i thisen pH leh electrolyte balance a teh thin.
• Arterial blood gas test : Hei hian i artery-a oxygen saturation a teh a, chubakah pH leh electrolyte balance a teh bawk.

Lactic Acidosis hi engtin nge enkawl a nih?

Hun eng emaw chen avanga lactic acidosis i neih chuan exercise nasa lutuk, khur, emaw, seizure emaw i neih chuan hun kal zelah a reh tlangpui. In lama awm reng leh hydrated taka awm hian hahdamna i hmu thei.

Mahse, damdawi inah chuan lactic acidosis hi intravenous fluids ( IV fluids , chu chu saline kan tih chu a ni) leh resuscitation treatment dang, oxygen therapy , a tul chuan enkawl nghal a ni.

Chumi hnuah chuan a chhan a zirin enkawl dan tur a rel ang. I natna lan chhuah dan azirin i medical team chuan lactic acidosis thlentu damdawi lam dinhmun emaw, poisoning emaw awm chu enkawl turin an thawk ang.

Oxygen level tlahniam symptoms i lantir a nih chuan medical team chuan Type A cause – cardiac or respiratory failure, sepsis , or shock ang chi te chu an ringhlel ang a, chu emergency te chu an enkawl hmasa ang.

Oxygen level hniam a nih loh chuan type B awm chhan hrang hrangte ngaihtuah a, a bik takin an enkawl thin.

Lactic acidosis vei chuan eng ang result nge a beisei theih ang?

A result chu a natna chhan leh a nasat danah a innghat a ni. Type A lactic acidosis – chu chu sepsis , shock, leh/ emaw thisenah oxygen pek tlemna nena inzawm a ni – hi a pawi zawk. Lactic acidosis chi dangte chu a na lo zawk thei a, a lo thang zawi zawk thei a, enkawlna hun leh hun remchang tam zawk a pe thei bawk.

A tlangpuiin thisena lactate level a san chuan thihna pawh a pung thei a ni. Mahse, a rang thei ang bera enkawl a nih chuan a dam kim thei a ni.

Lactic acidosis hi metabolic acidosis an tih chi hrang hrang zinga pakhat a ni a, i thisenah acid a lo awm khawm a ni. Metabolic acidosis -ah chuan taksaa acid siam leh enkawltu metabolic process pangngai chu eng emaw ti takin a tibuai a ni. A tlangpuiin i liver leh kidney te hian acid tam lutuk chu a filter chhuak thei a ni. Mahse chu taksa peng hrang hrangte chuan hna an thawk tha lo a nih chuan acidosis an enkawl thei lo. Chuvangin, tui tam tak in a, zu tihtlem leh damdawi tha lo ei a, i liver leh kidney enkawl hian hun rei tak chhung hriselna vawng reng turin kawng thui tak a zawh thei a ni.

Thu tawite hriat reng tur

Okay, chuvangin vawiin a kan sawi tawh pawimawh tak tak thenkhat kha han hriat nawn tir ila:

• Lactic acidosis hi thisen a lactic acid a punna a ni.
• Hei hi chhan tam tak a awm thei. A chhan ber chu taksain oxygen a hmuh tlem vang a ni.
• A tir lama a lan chhuah dan chu hah lutuk, luak chhuak, leh thawk chak lutuk te a ni thei.
• Hetiang dinhmun hi hriat theih nan thisen test an nei thin.
• Enkawlna chu a chhanah a innghat. A chang chuan chawlh hahdam leh tui a tawk a, a chang chuan damdawi ina awm a ngai bawk.
• Hriatchhuah hmasak a, enkawl hmasak a nih chuan tihdam theih a ni.
• Liver leh kidney hrisel taka vawn hian heng ang dinhmun lakah hian a venghim thei a ni.

Chuvangin, heng symptoms te hi i neih chuan, emaw, hemi chungchang hi hriat belh i duh chuan doctor rawn pawh theihnghilh suh. Hrisel takin awm rawh!

` Lactic acidosis, lactic acidosis, lactate, thisen acidity, taksa acid balance, exercise, hriselna