Hereditary cancer hlauhawmna: Li-Fraumeni Syndrome chungchanga hriat tur

Chhungkaw zingah cancer vei i hre tawh em? A nih loh leh, kum upa lam natna vei ṭhin cancer vei ṭhalai? A châng chuan heng thilte hnung lamah hian kan hriat loh chhan a awm thei. Chu chu vawiinah hian kan sawi dawn a ni, chhungkaw zingah a kal zel a, cancer vei theihna nasa takin a tipung a, genetic condition hmuh tur awm lo tak a ni. Li-Fraumeni Syndrome tih a ni.

A awlsam zawngin, Li-Fraumeni Syndrome hi eng nge ni?

Hei hi genetic condition hmuh tur awm lo tak a ni. Kan taksaa gene pakhata mutation awm vang a ni. He genetic change hian nang leh i chhungte cancer chi khat emaw a aia tam emaw in vei theihna chance emaw risk emaw nasa takin a tipung a ni.

Hei hi han ngaihtuah teh: Hetiang natna vei hian kum 60 a tlin chuan cancer vei theihna chance 90% a nei a, tin, heng zinga a chanve vel hian kum 40 an tlin hmain cancer an vei thei a, a bik takin Li-Fraumeni Syndrome nei hmeichhiate hian an dam chhungin hnute cancer vei theihna chance 100% vel an nei a ni.

Hei hi a hlauhawm deuhin a ri mai thei. Mahse a pawimawh ber chu he natna hi kan veng thei lo nain, cancer screening hmasa leh mumal tak neih a, a tul anga enkawlna kan neih hian kan nunah nghawng a neih chu nasa takin kan tihtlem thei a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Li-Fraumeni Syndrome hi a awm lo hle a, a natna hi a awm lo hle. Zirchiangtute chuan khawvel pumah chhungkaw 1,000 vel chauh he genetic mutation nei hi an hmuchhuak a ni. Chuvangin ṭul lova hlauh a ngai lo.

Li-Fraumeni Syndrome natna lan chhuah dan chu engte nge ni?

Heta thil danglam tak chu Li-Fraumeni Syndrome an tih natna nena inzawm symptom bik a awm lo tih hi a ni. Chu chu he natna vei hian pawn lam atanga inthlak danglamna a hmu lo tihna a ni.

Chuti a nih chuan engtin nge hei hi i hriat chian? Hetiang dinhmun chhinchhiahna ber chu kum naupan lai atanga cancer chi hrang hrang lo awm hi a ni . Chuvangin, i natna lan chhuah dan tur chu i cancer chi hrang hrangah a innghat ang. Entirnan, thluak cancer hian chutiang nena inzawm symptoms a lantir ang a, hnute cancer chuan chutiang nena inzawm symptoms a lantir bawk ang.

He natna nen hian eng cancer chi nge inzawm tam ber?

Cancer chi sawm chuang chu Li-Fraumeni Syndrome nen a inzawm tih hmuhchhuah a ni. Cancer thenkhat chu he natna vei te zingah hian a tam em em a, "core cancer" an ti a ni. Eng nge an nih i han thlir teh ang.

Engvangin nge hetiang dinhmun hi a lo awm?

Chutiang a nih chhan hrethiam tur chuan kan taksaa vengtu tlemte chungchang hi kan hriat a ngai a ni. Gene pakhat TP53 tih kan nei a . Kan taksaah "guardian angel" ang mai a ni. He gene hnathawh ber chu kan taksa chhunga cell te chu a pangngai lo leh thunun theih loha an lo thang lian a, tumor an nih loh nan a ni.

He TP53 gene siam protein hi P53 protein an ti a. Hei hi chu guard hna thawk tak tak chu a ni.

Tunah chuan Li-Fraumeni Syndrome vei chunga thil thleng chu TP53 an tih, a humhimtu gene-ah hian inthlak danglamna, a nih loh leh mutation a awm a ni. Thil thleng chu gene hian P53 protein hnathawk tha tak chu a siam chhuak thei lo a ni. He venhimna gene hi a bo chuan cell te chu thunun theih lohvin an inthen darh tan thin. Chu chu cancer-ah a lo chang ta a ni.

A tam zawkah chuan naupang hian he TP53 gene chhia hi an nu leh pate hnen atangin a rochun thin. Hei hi Autosomal Dominant Pattern an ti a . A awlsam zawngin, nu leh pa pakhat chauhvin he gene chhia hi rochun mah se, nu emaw, pa emaw pawh ni se, naupang chuan chu natna chu a la nei thei tho a, cancer vei theihna a tipung thei a ni

Mahse, a tlem hle a, he genetic change hi mi taksaah hian chhungkaw zingah he natna hi nei lovin a thleng thei a ni. Hei hi De Novo Mutation an ti a.

Engtin nge he natna hi hriat chhuah a nih?

Doctor-te chuan genetic testing hmangin he natna hi an hriat theih nan an hmang a ni. Mahse, chutianga an tih hmain nang leh i chhûngte damdawi lam chanchin ngun takin an lo en ang. Doctor-in Li-Fraumeni Syndrome a rinhlelh theihna chhan hrang hrang a awm a:

• Kum 45 i tlin hmaa sarcoma cancer i vei tih hmuhchhuah i nih chuan.
• I chhungte first-degree zinga pakhat (nu leh pa, unau, fate) chu kum 45 a tlin hmain cancer engmah a vei tih hmuhchhuah a nih chuan.
• I chhungte second-degree (pi leh pu, pi leh pu, pa u, u farnu, a farnu) zingah kum 45 hmaa cancer vei hmuhchhuah a nih chuan.

Heng criteria pakhat emaw a aia tam emaw a tlin chuan doctor chuan genetic testing atan a refer thei che a ni.

Hetiang natna hi i vei tih hmuhchhuah a nih chuan a dawt leh tur pawimawh ber chu cancer screening schedule siam hi a ni. I doctor hmu fo leh test neih hian cancer eng pawh lo awm thei chu a tir lamah hriatchhuah leh enkawl theih a ni .

Engtin nge enkawl a nih?

Genetic condition Li-Fraumeni Syndrome hi enkawlna bik a awm lo. Doctor-te chuan he natna avanga cancer lo awmte hi an enkawl thin. Enkawlna te hi chu natna nei lo mi pakhat hnena pek thin nen a inang hle. Chung zingah chuan surgery leh chemotherapy te pawh a tel.

Mahse hetah hian exception pawimawh tak a awm.

Hetiang dinhmun nen hian eng nge i beisei tur?

Li-Fraumeni Syndrome i vei tih hriat hian nang leh i chhungte hian cancer screening schedule mumal taka thawh a ngai tihna a ni. Research atanga a lan dan chuan regular screening hian heng mimalte nunna chhanhim theihna chance nasa takin a tipung a ni .

Heng test schedule te hi naupang leh puitling tan a inang lo. A hnuaia tarlan te hi entirna mai a ni. I doctor chuan i tana remchang tur schedule a siam ang.

Hetiang dinhmun hi a veng thei lo em ni?

Genetic condition Li-Fraumeni Syndrome hi ven theih a ni lo. Kan genes nena lo kal thil a ni. Mahse cancer vei theihna tipung thei thilte chu i pumpelh thei a ni.

• Meizial zuk loh vek tur a ni.
• Zu in tam lutuk hi pumpelh rawh .
• Ni chhuahna hmuna i chhuah dawn chuan sunscreen ang chi venhimna tel lovin rei lutuk lo chhuak suh .

Hmeichhe thenkhat chuan hnute cancer vei theihna tur a tihziaawm nan cancer a lo awm hmain an hnute pahnih chu operation hmangin an la chhuak thin. Hei hi prophylactic mastectomy an ti a .

Heng fimkhurna zawng zawng hi awm mah se, he natna vei hian cancer a la vei thei tho a ni. Chuvangin a tha ber chu screening neih fo a, cancer a lo awm a nih chuan kai hmasak hi a ni.

Engtin nge nangmah leh i chhungte i enkawl?

Hetiang nun chhung zawnga dinhmun nena nun hi taksa leh rilru lamah pawh a harsa thei hle.

1. Screening neih loh tur: Cancer screening schedule i rawt ang chiah kha zawm rawh.

2. Chhungkaw ruahmanna: Fa neih i tum a nih chuan genetic counselor nena inbiakna neih a pawimawh hle. He gene chhia hi naupang hnena i hlan chhawn theih dan tur i hriatthiam a ngai a ni.

3. Rilru hriselna: He phurrit hi nangmah chauhin phur suh. Cancer vei emaw, natna khirh tak nei emaw nena thawhhona lama tawnhriat nei mental health counselor tanpuina zawng rawh. Hetiang support group chungchang hi i doctor hnenah zawt rawh.