Cancer vei theihna a tipungtu Lynch Syndrome chungchang hi i zir dawn a ni.

``Lynch Syndrome'' tih thumal hi i hre tawh em? Hei hi i tan chuan thu thar a ni mai thei. Mahse, kan zavaia hriat a pawimawh. A awlsam zawngin sawi ila, Lynch Syndrome hi kan genes-a inthlak danglamna engemaw zat avanga cancer vei theihna tipungtu a ni. A bik takin kum 50 hmaa cancer vei theihna a tipung a, chuvangin, he thu hi chipchiar deuhin han sawi ila, kan sawi dawn em ni?

Lynch Syndrome hi eng nge ni tak tak? Tuin nge dawng?

Lynch syndrome hi genetic condition a ni a , a rochun atanga lo piang a ni . Chu chu kan nu emaw, kan pa emaw hnen atanga kan rochun genes-a genetic mutation avanga lo awm a ni tihna a ni. Kan cell-te inthen darh hian, a châng chuan tihsual tê tê a awm thei tih han ngaihtuah teh. Kan taksa hian heng thil tihsualte hi hmuchhuakin siam\hattu gene bik a nei a. Chungte chu ‘Mismatch Repair genes’ (MMR genes) an ti a. Lynch syndrome vei chuan heng ‘MMR’ gene pakhat emaw a aia tam emaw ah hian chhiatna a nei a. Tichuan, chu cell-te chu an inthen darh chuan tihsual dangte chu siamthat theih a ni lo. Heng cell chhia te hi an pung khawm a , cancer an lo ni ta a ni .

Hei hi tu chungah pawh a thleng thei. A chhan chu genetic a nih vang a ni. A châng chuan chhûngkuaa tumahin he natna hi an la nei lo a nih pawhin random genetic mutation vangin mi pakhatin a vei thei a ni. Chumi awmzia chu chhungkaw history a awm loh vang mai mai chuan a thleng dawn lo tihna a ni lo.

United States-a statistics atanga a lan dan chuan mi 279 zinga pakhat velin Lynch syndrome an nei thei a ni. Kum tin Lynch syndrome vangin colorectal cancer vei mi 4,000 vel leh endometrial cancer vei mi 1,800 vel an awm niin an sawi. Sri Lanka ramah pawh hetiang dinhmun hi hriat a pawimawh hle.

Lynch syndrome natna lan chhuah dan chu engte nge ni?

A natna hi a nasat dan leh a thlentu cancer chi hrang hrang a zirin a lan chhuah dan a inang lo thei. Colorectal cancer chhinchhiahna langsar ber berte chu:

• I bawlhhlawh chhungah thisen a awm .
• Ek khal .
• Pum natna emaw, rilru na emaw.
• Diarrhea emaw stool pangngai aia te zawk.
• Chauhna nasa tak (`Fatigue`) tih fo thin .
• Pum emaw, pum emaw tih hriatna.
• Nausea emaw, luak chhuak emaw.

A pawimawh ber chu mi thenkhat chuan cancer natna a zual zel hma chuan symptom engmah an lantir lo mai thei. Chuvangin, heng symptoms te hi i neih chuan doctor pan nghal tur a ni .

Lynch syndrome hian eng cancer chi nge a thlen theih?

Hei hian taksa peng tam tak a nghawng thei tak zet a ni. Lynch syndrome avanga cancer chi hrang hrang awm thei thenkhat chu hetiang hi a ni:

• Thluak cancer a ni
• Colon leh rectal cancer - Hei hi a bulpui ber a ni.
• Gallbladder cancer a ni
• Liver cancer a ni
• Ovarian cancer a ni
• Pancreatic cancer natna a ni
• Prostate cancer a ni
• Vun cancer a ni
• Small intestine cancer a ni
• Pum cancer a ni
• Upper urinary tract cancer natna a ni
• Uterine (endometrial) cancer - Hmeichhiain a vei tlangpui cancer chi dang a ni.

Gene (`gene`) awmna mutation hian eng organ nge cancer vei theihna sang zawk tih a hril a ni. Lynch syndrome nena inzawm gene lian panga a awm a. Chungte chu: `MLH1`, `MSH2`, `MSH6`, `PMS2` leh `EPCAM` te an ni.

Lynch syndrome vanga colon cancer hi mipui zawng zawng aiin a hma zawk (kum 1-2 chhungin) a lo awm thei a ni. A tlangpuiin colon cancer a lo awm theih nan kum 10 vel a ngai thin. Tin, mi pakhatin colon cancer a vei tawh chuan cancer a vei leh theihna a sang zawk bawk . Cancer hmasa ber operation atanga kum 10 chhungin 15% vel a awm a, kum 20 chhungin 40% vel a awm a, kum 30 hnuah 60% vel a awm bawk.

Eng thilin nge Lynch syndrome hi a thlen?

Sawi tawh ang khan hei hi a chhan ber chu kan DNA-a tihsual siamthattu gene panga zinga pakhat emaw a aia tam emaw (``mismatch repair gene`` emaw ``MMR gene``)-a genetic mutation vang a ni. Chu gene pangate chu:

• `MLH1` tih a ni
• `MSH2` tih a ni
• `MSH6` tih a ni
• `PMS2` tih a ni
• `EPCAM` tih a ni

Lynch syndrome i neih chuan i `MMR` genes hian cell chhia tihbo nan an mamawh tur instruction an hmu lo. Tichuan, chu cell chhia chu tissue-ah an pung khawm a, cancer a thlen ta a ni.

Engtin nge hei hi thlah khat atanga chhuan dangah a lo chhuah?

Lynch syndrome hi ``autosomal dominant`` natna a ni. A awlsam zawngin, nu leh pa pakhat chauhvin mutated gene nei mah se, naupang chuan a rochun thei a ni . Chumi awmzia chu naupang pawhin he natna hi a neih theihna chance 50% a awm tihna a ni.

Lynch syndrome i vei tih hmuhchhuah a nih chuan i chhungte hriattir a pawimawh a, genetic counseling zawng turin fuih a pawimawh bawk . Genetic counseling hian nang leh i chhungte chu i dinhmun leh i fain a rochun theihna tur a hriatthiam theih nan a pui thei a ni. Genetic testing pawh tih theih a ni a, Lynch syndrome gene mutation i nei em tih hriat theih a ni bawk.

Engtin nge Lynch syndrome hi hmuhchhuah a nih?

I doctor chuan nau neih hmaa screening test leh genetic testing hmangin Lynch syndrome hi a hmuchhuak thei a ni. Naute pian hnuah genetic testing pawh tih theih a ni.

Genetic test-ah hian thisen sample emaw, buccal swab emaw lak a, a hmaa kan sawi tawh gene `MLH1`, `MSH2`, `MSH6`, `PMS2` emaw `EPCAM`-a mutation awm leh awm loh enfiah a ni. Genetic test hmanga hetiang mutation a awm tih finfiah a nih chuan doctor chuan Lynch syndrome a nei tih a hmuchhuak ang.

Lynch syndrome nena inzawm cancer hmuhchhuah nan eng test nge hman thin?

Lynch syndrome i vei tih hmuhchhuah i nih chuan i doctor chuan cancer enfiah nan test eng emaw zat neih a rawt fo ang. Test hman tlanglawn ber berte chu:

• Colonoscopy: Hei hi tube (scope) dahin, a hnungzang kaltlangin camera dahin, intestine lian leh rectum chhung chu enfiah a ni. Hei hi kum khatah vawi khat emaw kum hnih danah emaw tih thin a ni tlangpui.
• Transvaginal ultrasound: Vagina kaltlangin instrument te tak te (probe) dahin ovaries leh uterus enfiah a ni. Hei hi kum khatah vawi khat emaw vawi hnih emaw tih a tha bawk.
• Urinalysis: I zun sample lak a, kidney tumor ang chi thil awm leh awm loh enfiah a ni. Hei hi kum khatah vawi khat tih thin a ni tlangpui.
• Tumor biopsy: I taksaah khawi emaw laiah tumor i nei nia a rinhlelh chuan i doctor chuan a then te te an la ang a, lab-ah an test ang a, cancer cell a awm em tih an enfiah ang.
• Upper endoscopy emaw capsule endoscopy: Tube te tak te, te tak te (scope) emaw microscopic camera (tube te tak te, pill ang maia ei theih) hmanga pum leh intestine te cancer a awm leh awm loh enfiahna a ni. Kum thum atanga kum nga danah hetiang ti turin an ti thei che a ni.

Lynch syndrome hi engtin nge enkawl a nih?

Lynch syndrome enkawlna atana pawimawh ber chu tumor hmuhchhuah hmasak leh surgery hmanga lakchhuah hi a ni . Hei hian screening neih fo a, cancer a awm chuan a hmaa kai tihna a ni.

Hei hi tuin nge enkawl?

Hetiang dinhmun hi specialist doctor team atanga enkawlna lak a tha ber .Lynch syndrome hian taksa peng hrang hrang a nghawng theih avangin enkawlna team-ah hian specialist hrang hrang an tel thei a, chung zingah chuan gastroenterologist, surgeon, gynecologic oncologist, urologist, dermatologist, gynecologist, primary care physician, geneticist, genetic counselor, leh oncologist te pawh an tel thei.

Cancer hi enkawl hnuah a lo kir leh thei ang em?

Ni e, cancer chu operation hmanga lak chhuah ni mah se, cancer chu a lo awm leh theihna chance a awm . Chuvang chuan test chhunzawm zel a pawimawh.

Lynch syndrome vei thenkhat chuan cancer vei an hlauhawm zawk avangin, nausen pum (hysterectomy), ovary (oophorectomy), emaw, an intestine thenkhat (colectomy emaw bowel resection surgery) emaw lakchhuahna tur operation neih hmasak an tum thin. Hei hi a tam zawk chu mimal thutlukna a ni a, doctor thurawn anga siam tur a ni.

Lynch syndrome hi ven theih a ni em?

Vanduaithlak takin Lynch syndrome hi genetic condition a nih avangin a pumpelh kim thei lo . Mahse, Lynch syndrome vei te chu an dam chhung zawngin cancer an neih leh neih loh endik theih a ni a, puitling atanga tan a ni a, chutiang chuan cancer a lo awm chuan a hmain hriatchhuah theih a ni .

Lynch syndrome i neih chuan eng nge thleng? Eng nge i beisei theih ang?

Tunah hian Lynch syndrome hi damdawi a la awm lo. Mahse, a rah tha ber chu cancer hi hmuhchhuah a nih a, lakchhuah hmasak a nih chuan, taksa hmun dangah a darh hmain a ni . Chuvangin Lynch syndrome vei te tan kum tin screening test neih a pawimawh hle a, chu chu colonoscopy ang chi hi a ni.

Lynch syndrome hian ka colon ah tumor a siam dawn em ni?

Lynch syndrome vei te hian ‘adenomas’ engemaw zat an nei thei a, hei hi an colon emaw rectum emaw-ah cancer ni lo, an thanlenna chi khat a ni. Heng ‘polyps’ te hi hriatchhuah a, paih chhuah a nih loh chuan cancer a ni thei. Chuvangin hengte hi enfiah a, a awm chuan paih chhuah nan colonoscopy neih fo a pawimawh hle.

Engtikah nge Doctor ka hmuh ang?

Lynch syndrome i neih chuan kum tin checkup leh screening test neih fo a pawimawh .

I taksa hmun dangah pawh lumps, lo thang thar, emaw vun inthlak danglamna i hmuh chuan doctor pan nghal rawh , hengte hi cancer chhinchhiahna a nih theih avangin.

Doctor hnenah eng zawhna nge ka zawh ang?

• Cancer screening test hi engzat nge ka neih ang?
• He lump hi ka vun cancer a ni em?
• Eng gene mutation nge ka neih?
• Naupai ka tum hmain genetic test ka nei thei ang em?

Lynch Syndrome leh HNPCC hi thil inang an ni em?

Lynch syndrome leh ``Hereditary Non-Polyposis Colorectal Cancer`` (``HNPCC``) te hi a chang chuan natna inang sawina atan an inthlak danglam thin. Mahse, an pahnih hian thlah kal zelah an inthlak danglam danah hian danglamna tlem a awm a ni.

Lynch syndrome hi `MMR` gene a mutation vang a ni. Gene mutation ang chiah hian `HNPCC` vei te pawh a nghawng ve bawk. Mahse, he dinhmun hi chhungkaw history nena a lo awm chuan `HNPCC` tih hming hi pek a ni . Chumi awmzia chu `HNPCC` hi thlah khat atanga chhuan dangah rochun a ni fo tihna a ni. Lynch syndrome hi chhungkaw zingah tu mahin an neih loh pawhin a awm thei a, random gene mutation vang pawh a ni thei bawk. Chuvang chuan tunah chuan Lynch syndrome tih hming hi an hmang nasa hle a ni.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

"Cancer i nei" tih thu hi tumahin an hre duh lo. Lynch syndrome i vei tih i hriat chuan chu thu chu i doctor hnen atangin i hriat a ngai mai thei. Mahse thil tha lo a nih a ngai lo.

Lynch syndrome i vei tih i hriat veleh i doctor chuan cancer hriat hmasak theihna tura pui turin screening test mumal tak neih hun tur a ruahman ang che. A hmaa hmuhchhuah leh enkawl hi i damchhuah theihna tur kawng tha ber a ni . Tichuan nun hlim tak, hrisel takin i nung thei ang.

Chuvângin, he thu hriatte hian hlau lovin, fimkhur la, a ṭûl chuan damdawi lam thurâwn la la, nun hrisel tak neih tum rawh . I chhungkuaa tu pawhin hetiang dinhmun hi an nei a nih chuan hei pawh hi hriattir a pawimawh hle.

` Lynch syndrome, HNPCC, cancer, genetic mutations, thlahtu natna, colon cancer, uterine cancer te a awm bawk