I chhungte zingah tu emaw chuan colon cancer a nei tawh mai thei. A nih loh leh tun hnaiah i doctor chuan i colon-ah polyp engemaw zat i nei tih a hrilh che em? Hetiang thil i hriat hian hlauhna leh lungkhamna i neih hi thil pangngai a ni. Mahse a chhan dik tak kan hriat chuan kan hmachhawn dan tur kan hrethiam thei a ni. Vawiin hian heng natna thlen thei, mahse khawtlang nunah sawi tam loh, genetic condition kan sawi dawn a ni. Chu chu MAP a ni.
A awlsam zawngin sawi ila, MAP (MUTYH-Associated Polyposis) hi eng nge ni?
MAP, emaw `(MUTYH-Associated Polyposis)` hi a awm lo hle a, rochun atanga lo piang chhuak genetic condition a ni. Hei hi kan taksaah, a bik takin chaw ei kawng (digestive tract)-ah hian thil te te, a pangngai lo emaw, nodules emaw a lo awm hian a ni. Damdawi lam hawi chuan hengte hi `(Polyps)` kan ti a.
Tunah chuan, "Aw ka Pathian, polyp neih hian cancer a kawk em?" Ni lo, heng polyp te hi cancer an ni lo. Mahse, a pawimawh ber chu, heng zinga ṭhenkhat, kan enkawl ṭhat loh chuan, kan paih chhuah loh chuan, hun kal zelah cancer-ah an chan theihna chance a sang hle.
Heng ``Polyps`` te hi MAP vei taksaah an lo awm tam ber a:
- Colon
- Rectum (Rectum) atanga lo chhuak
- Intestine te tak te
- Pumpui
MAP neih hi cancer hlauhawmna a ni em?
Ni e, he zawhna chhanna dik tak chu "ni e" tih hi a ni. MAP vei chu mi pangngai aiin colorectal cancer vei theihna a sang zawk tih a chiang hle. Dik tak chuan zirchianna thenkhatah chuan MAP vei hmuhchhuah hmasak ber zinga a chanve vel chuan colorectal cancer an nei tawh tih hmuhchhuah a ni.
Heng cancer te hi kum 40 leh 60 inkar vel an lo lang tlangpui a, mahse a chang chuan a hma pawhin an lo awm thei bawk. Tin, colon cancer bakah hian digestive system pawn lama duodenal cancer leh cancer chi dang vei theihna chance engemaw zat a awm bawk.
Mahse hei hi hlau suh. A pawimawh ber chu a hlauhawmna hriat chian a, a venna atana a tul anga hma lak hmasak hi a ni.
Hetiang dinhmun hi normal taka nun theih a ni em?
A ni ngei ang. Hei hi i hriat reng tur pawimawh ber a ni. MAP vei tam zawk hi chu nun pangngai, hrisel, famkim takin an hmang thei a ni. Mahse, chu chu thuruk pakhat a awm. Chu chu a natna lan chhuah dan hriat hmasak a, cancer screening test neih fo a ni.
Heng test te hian a hmaa kan sawi tawh polyp te chu cancer ah an chan hmain an hmuchhuak a, an paih chhuak thin. Chutianga tih chuan cancer vei theihna chu nasa takin a tihziaawm thei a ni.
MAP condition symptoms te chu engte nge ni?
Hei hi mi tam tak buaina hmun a ni. Pawn lam atanga i hmuh leh hriat theih tur symptom a awm lo a, hei hi MAP tan chuan a danglam bik a ni. I pum chhungah polyp tam tak nei mah la, chuta tang chuan natna leh hrehawmna i nei lo mai thei.
Chuvangin `(Polyps)` awm ringawt hi MAP neihna tilangtu tha tak a ni lo. Hei hi chhan hrang hrang a awm a:
- Mi tam takin polyp nei mahse MAP an nei lo. Hriselna dang vangin polyps hi a lo awm thei bawk.
- MAP ang chi thlahtu natna dang `(Polyps)` thlentu a awm bawk. Entirna pakhat chu `(Chhungkaw Adenomatous Polyposis - FAP)` tih hi a ni.
- A châng chuan MAP vei mi pakhat chu a natna hmuhchhuah a nih chuan an taksaah ``polyp'' pakhat mah an nei lo mai thei.
A awlsam zawngin, MAP, FAP emaw, natna dang emaw i neih leh neih loh chu genetic test chauhvin a hriat chian theih a ni.
Engvangin nge he MAP hi a lo awm? Engtin nge thlah kal zelah a lo kal zel?
MAP hi `MUTYH` (MYH tia koh bawk) an tih gene pakhata inthlak danglamna, a nih loh leh mutation avanga lo awm a ni. Kan taksa hi recipe bu lian tak angin ngaihtuah la, a chhunga recipe awm chu genes hi a ni. `MUTYH` recipe-a letter pakhat a dik lo a nih chuan a siam chhuah chu a thawk tha lo ang. MAP chu chutiang chu a ni.
He condition hi inherited tiin ``autosomal recessive'' kan ti a, hei hian he condition hi i neih theih nan hian he gene dik lo hi i nu leh pa te hnen atangin i rochun tur a ni tihna a ni a, chu chu nu leh pa pahnih atanga i rochun a ngai tihna a ni.
He gene dik lo hi mi pakhat hnen atangin chauh i hmu niin han ngaihtuah teh. Entirnan, i nu hnen atangin chauh. Tichuan MAP natna i nei lovang. Mahse MAP "carrier" tia koh i ni. Chumi awmzia chu gene dik lo i nei a, mahse natna chu i nei lo tihna a ni. Carrier i nih chuan he gene hi i fa pakhat hnenah i pe thei a ni.
Khawvel mihring 1% atanga 2% inkar vel chu MAP carrier an nih rin a ni. Carrier te pawh hian mipui zawng zawng aiin colon cancer vei theihna chance a sang zawk deuh a, mahse MAP vei angin a sang lo.
Nu leh pa pahnih hi MAP kengtu an nih chuan naupangte chungah eng nge thleng ang?
Hei hi hriatthiam a awl hle mai. Nu leh pa pahnih hi carrier an nih chuan an fa neih apiang tan thil awm thei pathum a awm.
| Remchang | Rahchhuak |
|---|---|
| Chance 4 zinga 1 (25%) | Naupang hian gene dik lo a rochun lo. Chumi awmzia chu naupang hian MAP natna a nei lo tihna a ni a, carrier pawh a ni lo tihna a ni. |
| Chance 4 zinga 2 (50%) | Naupang chu carrier a ni . Chumi awmzia chu natna an nei lo tihna a ni a, mahse nakin lawkah an fate hnena gene pek chhuah theihna an nei tihna a ni. |
| Chance 4 zinga 1 (25%) | Naupang chuan nu leh pa pahnih aṭangin gene dik lo chu a rochun a ni. He naupang hian MAP natna a vei dawn a ni . |
Engtin nge MAP ka neih leh neih loh chiang taka ka hriat theih ang?
MAP diagnosis hi step hrang hranga tih a ni tlangpui.
1. Chhungkaw damdawi lam chanchin: A hmasa berin i doctor chuan i chhungkaw hriselna chanchin a zawt ang. Hei hian i nu leh pa, i pi leh pu, leh unaute zingah cancer emaw, damdawi lam thil dang emaw i neih tawh zawng zawng a huam a ni.
2. Genetic Tests: I doctor-in i chhungkaw chanchin a zirin genetic condition a rinhlelh chuan genetic testing atan a refer thei che a ni. He test hian `MUTYH` gene-a mutation emaw, cancer vei theihna tipungtu genetic condition dang emaw i neih leh neih loh a hriat theih a ni.
Doctor chuan a tlangpuiin a hnuaia thil awmte hi genetic test neih a rawt ang:
- I chhungkuaa mi tu emaw chuan MAP emaw FAP emaw ang chi genetic diseases an neih chuan.
- I chhungkaw member engemaw zatin colon cancer an vei tawh a nih chuan.
- I unaupa pakhat chuan an colon-ah polyp tam tak a nei a, mahse an nu leh pate chuan an nei lo (hei hian nu leh pa chu carrier an ni mai thei tih rinhlelhna a siam a ni).
Genetic test-in MAP i nei tih emaw, carrier i nih thu a nemnghet a nih chuan, i doctor chuan i hmabak tur leh cancer laka invenna atana i tih tur test hrang hrangte chipchiar takin a sawipui ang che. He thu hi i chhungkaw dangte hnena i sawi chhuah a pawimawh hle bawk a, an duh chuan test an neih theih nan a pui dawn a ni.
MAP atana enkawl leh enkawl dan
Tunah hian MAP thlentu genetic mutation hi "damdawi" a la awm lo. Amaherawhchu, cancer laka invenna tur, a nih loh leh cancer hi a naupan lai atanga kan hmuhchhuah leh enkawl theihna tur test leh enkawlna tam tak a awm a.
MAP i neih chuan mi pangngai aia hma leh tam zawk cancer screening test neih a ngai mai thei.
| Screening Test neih a ni | Thuziak leh rawtna te |
|---|---|
| Colonoscopy hmanga enfiah a ni | Hei hian i colon leh rectum chhung lam chu camera dahna tube te tak te hmanga enfiah a huam a ni. Hei hi i colon chhunga polyp awm zawng zawng leh paih chhuah dan tha ber a ni. He test hi i chhungkaw zinga mi pakhatin colon cancer a vei kum naupang ber aiin kum 20 emaw kum 10 emaw hmain tan a tha tlangpui a, a hmasa ber pawh nise. |
| Upper Endoscopy hmanga enfiah a ni | He test hian i pum leh upper small intestine a enfiah a, polyps zawng chhuakin a paih chhuak thin. He test hi kum 25 vel atanga tan a tha tlangpui. |
Hetiang dinhmun hi hmachhawn dawna hriat tur dang
Ka fate chunga hetiang thil hi a thlen loh nan ka veng thei ang em?
MUTYH gene-a mutation awm hi ven theih a ni lo. Mahse, assisted reproductive techniques a awm a, chu chuan nakin lawka naupangin MAP a rochun theihna tur a ti tlem thei a ni. Entirnan, preimplantation genetic diagnosis (PGD) tih hi in vitro fertilization (IVF) hmanga tih a ni. Hei hian embryo chu nu nausen pum chhunga dah a nih hmain genetic diseases a neih leh neih loh test a huam a ni. Mahse, hei hi thutlukna buaithlak tak a ni a, sum leh pai leh rilru lamah pawh a buaithlak hle. Hei hi i ngaihven a nih chuan reproductive endocrinologist thiam tak nen inbiakna neih a tha ber.
Engtin nge rilru lama chak taka kan awm theih ang?
Cancer vei theihna i nei sang zawk tih i hriat chuan i lungkham a, i hlau a, i lungngai pawh a ni thei. Hei hi thil pangngai a ni. Mahse, heng rilru natnate chauh hi hmachhawn tum suh. Chumi chungchang chu i doctor nen sawiho rawh. Talk therapy leh a tul chuan damdawi pawh a awm bawk.
Tin, chutiang bawka thil tawn tawhte nena inbiakna neih theihna tur support group-a i tel theih chuan a \angkai hle ang. Nangmah chauh i ni lo tih hre reng ang che.
Cancer vei theihna tipungtu genetic condition i nei tih hriat chu a buaithlak thei hle. Mahse, nangmah chauh i ni lo. I healthcare team, doctor te pawhin i hriselna atana mawhphurhna la turin an awm a ni. Tunlai testing method hmasawn tak tak hmang hian cancer hi a lo awm tak tak a nih chuan nasa takin a tlahniam thei a, a hmaa hriatchhuah theih a ni bawk.
Take-Home Thuchah a ni
- MAP hi genetic condition a ni a, thlah khat atanga thlah dangah a kal zel a ni. Colon cancer vei theihna a tipung hle.
- Hetiang dinhmunah hian symptom bik a awm lo. MAP i neih leh neih loh hriat chian theihna awmchhun chu genetic testing hmangin a ni.
- I chhungkuaa tu emaw chuan colon cancer emaw polyps emaw an vei a nih chuan i doctor nen inbiakna neihpui ngei ngei tur a ni.
- MAP i vei tih hmuhchhuah a nih chuan cancer laka invenna tha ber chu doctor-in a rawt angin test mumal tak, colonoscopy leh endoscopy te tih hi a ni.
- Damdawi lam enkawlna leh test dik tak neih chuan nun famkim, hrisel takin i nung thei ang.
- Hetiang diagnosis chauh hian a lo awm thin stress hi hmachhawn suh. A tul chuan damdawi lam leh rilru lam tanpuina zawng rawh.
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