Cancer i do a nih chuan, emaw, i hmangaih tak, cancer vei i neih chuan, "chemotherapy" leh "radiation therapy" tih ang chi thumal hi i hre tawh ngei ang. Heng enkawlna nena inzawm side effects hi i hre tawh ngei ang. Mahse vawiin hian damdawi class thar tak, cancer cell chauh target a, cell hrisel tihchhiatna nasa taka tihtlem thei tur kan sawi dawn a ni. Hengte hi PARP Inhibitors an ti a .
A awlsam zawngin, he PARP Inhibitor hi eng nge ni?
Chu chu hrethiam tur chuan kan taksa cell chhunga thil thleng te tak te, mahse pawimawh tak mai hi kan hriatthiam hmasak a ngai a ni. Kan taksaa cell tin chhungah hian DNA an tih hi a awm a. Kan taksaa thil awm zawng zawngte hnathawh dan tur ziaktu blueprint lian tak angin han ngaihtuah teh. A chang chuan, he DNA blueprint phek te hi a chhe deuh thin.
Hei hi protein pakhat PARP tih a rawn inrawlhna hmun a ni. "PARP" tih hi Poly (ADP-ribose) polymerase tih tawifelna a ni. PARP hi kan cell chhunga "repair mechanic" ang mai a ni. DNA a chhiat chuan PARP protein chu a lut a, a siam tha leh thin. Hei hi cell hrisel dam khawchhuahna atan a pawimawh hle.
Mahse buaina chu cancer cell te pawhin he PARP mechanism hi an hlawkna tur atan an hmang thin. Cancer cell DNA a chhiat chuan he PARP hi an siam tha bawk. Chumi avang chuan cancer cell te hi an thi lo va, an thang chhunzawm zel a, taksa pum puiah an darh zel a ni.
Chumi chinfelna atan chuan doctor-te chuan damdawi pakhat PARP Inhibitor an hmang a. "Inhibitor" tih awmzia chu "blocker" tihna a ni. He damdawi hian a tih chu cancer cells te tanpuitu PARP mechanism chu "block" a ni. PARP puihna tel lo chuan cancer cell chu a chak lo zauh zauh a, DNA chhia chu a siam tha thei lo va, a tawpah chuan a thi ta a ni.
Hei hi cancer cell "survival system" off ang mai a ni. Chuvangin he enkawlna dan hi targeted therapy an ti bawk. Chu chu heng damdawi te hian cancer cell-a chak lohna pakhat chu direct-in an target tihna a ni.
Khawvela hman thin PARP inhibitor chi hrang hrang
Tunah hian cancer enkawlna atana PARP inhibitor eng emaw zat pawm a ni. I doctor-in heng zinga pakhat a pek che chuan he list-ah hian a awm thei.
| Damdawi hming Generic | Brand hming a ni |
|---|---|
| Olaparib tih a ni | Lynparza® tih a ni |
| Niraparib tih a ni | Zejula® tih a ni |
| Rucaparib tih a ni | Rubraca® hmanga siam a ni |
| Talazoparib tih a ni | Talzenna® tih a ni |
He damdawi hi eng cancer chi hrang hrangah nge hman a nih?
PARP inhibitor hi cancer hmasawn zawk emaw, taksa hmun danga darh tawh (metastatic) tan hman a ni tlangpui. Cancer chi hrang hrang a awm a, chungte chu an tan a tangkai ber a ni.
- Hnute cancer a ni
- Ovarian cancer a ni
- Fallopian tube cancer a ni
- Prostate cancer a ni
- Primary peritoneal cancer a ni
- Pancreatic cancer natna a ni
BRCA gene mutations nena inzawmna bik
BRCA gene chungchanga hriat tur pawimawh tak tak chu hetiang hi a ni . BRCA hi gene pawimawh dang a ni a, kan cell chhunga DNA siam that leh cancer venna a ni. Mahse mi thenkhat chuan he BRCA gene ah hian mutation an nei mai thei. Chumi awmzia chu an DNA repair system lian ber pakhat chu a thawk tha lo tihna a ni. Chumi avang chuan cancer vei theihna an nei sang zawk a ni.
Car pakhat chu brake system pahnih nei angin han ngaihtuah teh. BRCA chu pakhat a ni a, PARP chu a dang a ni. BRCA gene mutation nei cancer cell-ah chuan brake system (BRCA) pakhat a chhe tawh a ni. Chutiang chuan cancer cell chu a dam khawchhuah theih nan brake system dang (PARP) ah a innghat vek tawh mai.
Tunah chuan PARP Inhibitor damdawi kan pek hian chu second brake system pawh chu kan off ve bawk. Tichuan cancer cell chuan a DNA siam that dan tur a nei tawh lo va, a thi mai mai a ni. Hei vang hian PARP Inhibitors hi BRCA gene mutations nei cancer tan chuan a tangkai em em a ni.
Engtin nge ka enkawl ang a, eng chen nge a daih?
He enkawlna awlsamna pakhat chu a vai hian pill angin (capsule emaw tablet emaw) a awm vek a ni. Chuvangin he damdawi hi ni khatah vawi khat emaw vawi hnih emaw chauh i ei a ngai a ni. A châng chuan he damdawi ringawt pawh hi a tawk mai thei. A châng chuan cancer enkawlna dangte nên i ei a ngai mai thei.
Entirnan, cancer cell DNA tichhe thei enkawlna, chemotherapy emaw radiation therapy emaw tih hnuah PARP inhibitor i pe thei ang. Tichuan, PARP hian chu cancer cell chhia te chu anmahni insiamthat turin a puih loh avangin, chu cell te chu an thi ngei ang.
Enkawl hun chhung
Hei hi mi tin a inang lo.
- Mi thenkhat chu he damdawi hi chemotherapy hmanga enkawl zawh hnuah hun bituk, kum hnih emaw kum thum emaw chhung atan an pe thin.
- Mi thenkhat chuan he damdawi hi an taksa tana hna a thawh chhung chuan an ei chhunzawm zel a.
- A châng chuan damdawi ṭhatna aiin a nghawng ṭha lo a tam chuan doctor nen inbiain enkawlna chu i titawp thei a ni.
Chuvang chuan doctor nen eng chen nge damdawi i ei tur tih sawipui a, thutlukna siam a pawimawh hle.
He enkawlna hian eng nge a thatna leh a that lohna?
PARP inhibitor hian cancer hi a tidam kim thei lo. Mahse, cancer chi ṭhenkhat nei damlote chu an dam rei thei hle . Heng damdawi te hian cancer thanna a control a. Doctor-te chuan hei hi tihpun hi "progression-free survival rate" an ti. A awlsam zawngin sawi ila, cancer chu a na zual lovin a thunun ṭhat theih hun chhung an tipung a ni. A then phei chuan chemotherapy aiin an hlawk zawk thei bawk.
Mahse, hun kal zelah cancer cell thenkhat chuan heng damdawi te hi "resistance" an nei tan ta a ni. Chumi awmzia chu ruihhlo hian hna a thawk tawh lo tihna a ni. Hei hi damlo 40% leh 70% inkarah a thleng thei a ni. Scientist-te chuan hetiang thil a thlen chhan hi hriatthiam tumin hma an la mek a, heng damdawi te hi a hlawk zawk theih nan kawng thar an zirchiang mek a ni.
A side effects te pawh i fimkhur ang u.
Cancer enkawlna dang ang bawkin PARP inhibitor hian side effect engemaw zat a nei thei a ni. Mahse, mi zawng zawngin an hmu vek lo. Tin, heng zinga tam tak hi thunun theih a ni bawk.
| Side effect awm fo thin | Chutiang a nih chhan emaw, a chipchiar zawk emaw |
|---|---|
| Chauhna leh hahna | Thisenah thisen sen (red blood cells) a tlahniam a, thisen tlakchhamna (anemia) vang a ni fo thei. |
| Thisen chhuak (e.g., hliam, hnar thisen chhuak) . | Thisen platelet a tlem vang pawh a ni thei. |
| Hri kai fo thin | Thisen var (white blood cells) a tlem chuan taksa hriselna (immune system) a tichak lo thei a ni. |
| Nausea leh luak chhuak | Hengte control nan hian damdawi dang ei theih a ni. |
| Pum na, pum na, emaw, chaw ei kham emaw | Ei leh in thlak danglam leh a tul chuan damdawi hmanga control theih a ni. |
| Ka chhunga thlum inthlak danglam (dysgeusia) . | Chaw chu a thlum a danglam thei. |
| Rihna tlahniam, luak chhuak, lu na | Hengte hi mi thenkhatte chunga lo thleng thei dinhmun pawh a ni. |
A tlem hle a, PARP inhibitor thenkhat chuan thisen cancer chi khat acute myeloid leukemia tih chu an vei theihna a tipung thei a ni. Mahse, hei hi a awm lo hle.
Engtikah nge i doctor hriattir nghal tur
PARP inhibitor i ei a nih chuan, side effect thar emaw, a zual zel emaw i neih chuan doctor hnenah hrilh a pawimawh . A dose a thlak thei a, damdawi dang pawh a pe thei a, chu chuan natna hrik ang chi thilte a pui thei a ni.
A bik takin a hnuaia symptoms te hi i neih chuan:I doctor emaw, damdawi in enkawltu emaw hnenah hrilh nghal rawh:
- Infection chhinchhiahna: khawsik, khawsik, leh khur.
- Pneumonitis symptoms: Thâwk harsa, thawk hah, rilru tight, etc. (Hei hi lung inflammatory condition a ni).
- Thisen zam chhinchhiahna: ke a hring, na, sen emaw, rilru na emaw, thawk harsa.
Take-Home Thuchah a ni
- PARP Inhibitors hi "targeted therapy" chi khat a ni a, cancer cell DNA repair system a target a, a tichhia a ni.
- Hengte hi BRCA gene mutation nei cancer, hnute, ovarian, leh prostate cancer te tan a tangkai hle.
- He enkawlna hi injection hmanga pek a ni lo va, nitin ei thin tablet/capsule angin pek a ni.
- Hei hian cancer chu a tidam kim lo nain, cancer thanna control-in damlote chu dam rei zawk turin a pui a ni.
- Cancer enkawlna dang ang bawkin hengte hian side effect an nei a ni. Chauhna, luak chhuak, leh thisen cell count hniam te a awm thei.
- I enkawl chhung zawng hian doctor nen inbiakpawhna nghet tak neih a pawimawh hle a, a nghawng tha lo a awm chuan report nghal a pawimawh hle.
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