Anesthesia hi i sensitive em? (Pseudocholinesterase Deficiency) chungchang hi i zir dawn em ni?

Operation atana anesthesia an pek che kha tlem i hlau tawh em? Mi thenkhat tan chuan chutianga an inhriat chu thil pangngai a ni. Mahse, anesthesia damdawi i pek ṭhenkhat chu i taksa tan a dik tawk lo a nih chuan eng nge thleng ang tih han ngaihtuah teh. Vawiin hian chutiang dinhmun tlemte, mahse hriat tur pawimawh tak pakhat kan sawi dawn a ni. Chu chu `(Pseudocholinesterase Deficiency)` tih natna a ni.

`(Pseudocholinesterase tlakchhamna)` tih hi eng nge ni? A awlsam zawngin hrethiam ila, kan hrethiam ang em?

Okay, he hming hi a sei deuhin a ri a ni lawm ni? A awlsam zawngin i vawng ang u. `(Pseudocholinesterase)` hi kan taksaa enzyme bik `(Enzyme)` a ni. He `(Enzyme)` hnathawh ber pakhat chu taksaa taksa ruh tih hahdamna atana damdawi pek thenkhatte tihchhiat (chu chu `(metabolize)`) a ni , a bik takin anesthetized kan nih hian (hengte hi `(Choline esters)` kan ti a). Ngaihtuah teh, operation i tih laiin i taksa ruhte chu rei lo te chhung chu a paralyze a ngai a ni. Chumi atan chuan hengte hi damdawi pek an ni.

Tunah chuan, `(Pseudocholinesterase Deficiency)` tih dinhmunah chuan, thil thleng chu i taksaa he `(Enzyme)` `(Pseudocholinesterase)` tia koh hi a siam chhuak tawk lo emaw, a thawk tha lo emaw a ni. Chuti a nih chuan eng nge thleng? Taksa tih hahdamna tur damdawi (`(Succinylcholine)` leh `(Mivacurium)` te hi entirnan pahnih) taksa atanga lakchhuah thuai a ni lo. Taksaah hian rei tak an awm reng a ni.

Chumi avang chuan anesthesia pek hnuah pawh i taksa ruhte chu rei tak a awm thei a , thawk pawh i harsat phah thei bawk. Hei hian damdawi in a nghawng a reh hma loh chuan nangmah chauhin i che thei lo emaw, i thawk thei lo emaw tihna a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Dik tak chuan he natna `(Pseudocholinesterase Deficiency)` an tih hi chutiang chuan a awm lo . A vaiin mi 3,200 emaw 5,000 emaw zinga pakhat vel chauhvin he natna hi an nei a ni. Chu chu a tlem hle tihna a ni.

Eng nge a lan chhuah dan? Engtin nge hei hi i hriat chian?

Hetiang natna vei tam zawk chuan a hmaa ka sawi tawh ang chi, ``Choline esters'' an tih ang chi, anesthetic drug chi khat, ``Choline esters'' an tih chu an dawn hma loh chuan an hre lo.

• A tlangpuiin beisei aia rei zawk muscles relaxed lutuk (i.e., nunna nei lo) te .
• Thâwk chhuahna tura puitu taksa pengte pawh chu rei lo têah an thawk thei lo .

Heng symptoms te hi a reh theih nan darkar tlemte a ngai thei. He hun hi mi tin a inang lo. Hemi chhung hian i medical team te chuan anesthesia hnuaiah an dah ang che a, ``ventilator'', artificial breathing machine hmangin mahni chauha thawk i thawh theih hma loh chuan thawk turin an pui ang che.

A chhante chu engte nge ni? Engtin nge hetiang hi a lo thlen?

He natna (Pseudocholinesterase Deficiency) hi rochun (i.e. rochun) a ni thei a , a hnu lamah pawh a lo awm thei bawk..

Rochun atanga lo chhuak a ni

Hetiang natna neia piangte hian `(BCHE)` tih gene-ah hian inthlak danglamna, a nih loh leh mutation an nei a. He `(BCHE)` gene hian kan taksain enzyme `(Pseudocholinesterase)` siam turin min hrilh a ni. Chuvangin, he gene-a inthlak danglamna a awm hian i taksa hian he enzyme hi a siam tlem hle emaw, a siam chhuak lo tak tak emaw pawh a ni thei.

Nun chhunga lo awm chhan (Acquired) .

A châng chuan, he natna (Pseudocholinesterase Deficiency) hi dam chhung zawngin a awm thei a ni. Natna chi hrang hrang leh damdawi thenkhat avanga lo awm thei a ni.

Hetiang dinhmun thlen thei natna thenkhat:

• Ei leh in lama harsatna (malnutrition) a awm
• Kangmei hliam na tak tak
• Kal natna
• Liver natna
• Hypothyroidism (Thyroid chak lo) .
• Ngawt
• Naupai lai

Hetiang natna vei theihna tipung thei damdawi thenkhat chu:

• MAO titawptu (e.g. Phenelzine (Nardil®)) te hi a tha hle.
• Naupai venna damdawi (Oral contraceptives) .
• Echothiophate mittui tlakna tur
• Metoclopramide hmanga siam a ni
• Cyclophosphamide hmanga siam a ni
• Pyridostigmine a ni

Engtin nge doctor-te hian hei hi an hriat chian?

General anesthesia hnua i taksa ruh control harsa i tih emaw, thawk lak i harsat chuan i doctor chuan pseudocholinesterase tlakchhamna a ringhlel mai thei. Hei hi nemnghet turin thisen test an nei thei a, enzyme pseudocholinesterase i level an enfiah thei bawk.

I chhungkuaa mi pakhatin hetiang natna hi a neih chuan doctor chuan nang pawhin i vei em tih hriat tumin genetic testing a ti thei ang. Hei hian thisen sample lak a, (BCHE) gene mutation i neih leh neih loh enfiah a huam a ni.

I doctor chuan he natna hi i nei nia a rinhlelh chuan enzyme ``Pseudocholinesterase''-a innghat lo muscle relaxant chi dang an hmang ang.

Eng nge a enkawl dan?

General anesthesia pek i nih hnua `(Pseudocholinesterase Deficiency)` symptoms i neih chuan damdawi lam pan vat a ngai mai thei. Medical team chuan i dam leh hma loh chuan uluk takin an lo enkawl ang che. A tul chuan anesthesia hnuaiah an dah ang che a, `` mechanical ventilation`` machine hmangin mahni chauha thawk theih thlengin thawk turin an pui ang che.

Hetiang dinhmun hi i neih chuan eng nge i beisei ang?

`(Pseudocholinesterase Deficiency)` i vei tih hmuhchhuah a nih chuan i tih theih tha ber chu i doctor-te hnenah hriattir hi a ni – a bik takin doctor-te hnenah operation nei tura rawn kal tur che te

Tin, hei hi i chhungte hnenah pawh i hrilh a ngai bawk., chutah chuan `(BCHE)` gene mutation an nei em tih pawh test theih a ni bawk. Chutiang a nih chuan eng surgery pawh an neih hmain an doctor-te pawh an hriattir tur a ni.

Tin, doctor ten emergency surgery neih a ngai em tih an hriat theih nan medical ID bracelet i bun a tha bawk .

Hei hi ven theih a ni em?

Pseudocholinesterase tlakchhamna hi pianpui natna a ni a, ven theih a ni lo. Mahse, i chhungkuaa mi tu emaw chuan a neih chuan general anesthesia i tih hmain BCHE gene mutation test i nei thei ang . Hei hian operation neih laiin harsatna a awm loh nan a pui thei a ni.

Genetic mutation i neih chuan i doctor chuan Choline esters chu skip in anesthetic dang a thlang mai thei. Pseudocholinesterase Deficiency vei tan chuan Rocuronium hi anesthetic hman tlanglawn ber a ni.

Nakin lawkah Acquired Pseudocholinesterase Deficiency i vei theihna tur chu i tihziaawm thei a, chu chu a hnuaia awm, ei leh in tha lo emaw, chronic kidney disease (CKD) ang chi te enkawl a ni. Tin, enzyme Pseudocholinesterase siam chhuah ti tlem thei damdawi i ei a nih chuan i damdawi thlak dan tur chungchangah i doctor nen inbiakna neihpui i duh mai thei bawk.

Eng nge a contraindications, chu chu eng damdawi nge he natna vei tan hman tur tha lo?

`(Pseudocholinesterase Deficiency)` i vei tih hmuhchhuah a nih chuan a hnuaia anesthetic damdawi chi hrang hrangte hi i hman loh tur a ni :

• Succinylcholine `(Succinylcholine)` tih a ni
• Mivacurium tih a ni
• Procaine a ni
• Chloroprocaine a ni
• Benzocaine a ni
• Tetracaine a ni

I doctor zawh tur zawhna

``Pseudocholinesterase Deficiency'' tih natna i neih chuan, i pianpui emaw, a hnu lama i lo vei emaw pawh nise, i doctor hnenah zawhna thenkhat zawt la, hetiang hi i zawt thei ang:

• Ka tan chuan eng contraindications dik tak nge ni, chu chu eng damdawi nge ka hman loh tur?
• He natna hi ka pianpui thil nge natna dang avanga lo awm?
• Ka chhungte hi genetic testing tihsak hi a tha em?

Surgery-a kal hi a buaithlak deuh thei. Mi tam tak chuan operation-ah hian kan rilru kan pe nasa lutuk a, anesthesia hian adverse reaction a awm theih dan tur pawh kan ngaihtuah ngai lo. Pseudocholinesterase Deficiency hi damdawi a awm lo. Mahse, i nei em tih hriat hian operation hnua hun engemaw chen chhunga taksa chak lohna leh thawk harsatna lo awm thei chu pumpelh turin a pui thei che a ni. Pseudocholinesterase Deficiency i neih chuan i chhungte hnenah hrilh rawh. Tin, gene test an nei thei bawk a, an hriselna lama an zinkawng chhunga harsatna awm thei tur chu an pumpelh thei bawk.

A tawp berah chuan thil hriat reng tur

Chuvangin, `(Pseudocholinesterase Deficiency)` tih hming hi a hlauhawm deuh a, mahse hriat chian a pawimawh hle. A bik takin operation i neih dawn a nih chuan, emaw, i chhungte zinga mi pakhatin hetiang thil hi a tawng tawh a nih chuan , i doctor-te nen he thu hi sawipui a tha ber. Awareness hi harsatna tul lo atanga min chhanchhuak thei tur shield tha ber a ni fo thin tih hre reng ang che!

` Anesthesia, pseudocholinesterase, enzyme tlakchhamna, surgery lama harsatna, genetic condition, muscle dysfunction, anesthetic drugs