Chemotherapy, radiation therapy, surgery neih laia anesthesia avanga natna leh luak chhuak hi mi tam tak tan chuan harsatna lian tak a ni. Hetiang hun laia i rilru hahna hi a buaithlak hle. Chuvangin vawiin hian he natna hi control turin i doctor-in a pek tur damdawi chi khat bik kan sawi dawn a ni. Chungte chu serotonin antagonist an ti a . Heng damdawite hi eng nge an nih, engtin nge an hnathawh tih leh kan hman hunah eng nge kan hriat chian a tul tih i lo en ang u.
He serotonin antagonist hi eng nge ni?
A awlsam zawngin sawi ila, hengte hi doctor-in natna leh riltam venna leh enkawlna atana a pek damdawi pawl a ni. Damdawi lam hawi chuan antiemetics kan ti a, chu chu nausea damdawi pek thin a ni. Chuvangin, serotonin antagonists hi chutiang damdawi pawl pakhat chu a ni.
He damdawi chi hi hming dang engemaw zat hmanga hriat a ni a:
- Serotonin-receptor dotu a ni
- 5HT3 receptor dotu a ni
- Serotonin blocker a ni
Heng hmingte hi a buaithlak deuhin lang mahse, an awmzia a inang vek. Chu chu engtik lai pawhin kan taksaah chemical serotonin an tih chu an block tihna a ni. Chumi chungchang chu a hnu deuhah chiang zawkin kan sawi dawn a ni.
He category-a damdawi chi hrang hrangte hi engte nge ni?
Hemi zingah hian damdawi chi hrang hrang a awm a. I doctor chuan heng zinga pakhat hi a rawn pe che a ni mai thei. Hengte hi pill angin emaw, injection angin emaw ei theih a ni.
| Generic Hming a ni | Brand hming hriat lar tak a ni |
|---|---|
| Ondansetron a ni | Zofran® tih a ni |
| Granisetron a ni | Kytril® tih a ni |
| Dolasetron a ni | Anzemet® hmanga siam a ni |
| Palonosetron tih hi a ni | Aloxi® tih a ni |
Among these , Ondansetron (Zofran®) hi doctor-te’n rilru hahna tihtawp nana damdawi an pek tam ber zinga mi a ni a, Sri Lanka leh khawvel hmun hrang hrangah pawh.
Eng dinhmunah nge he damdawi hi hman a nih?
He damdawi hi a bik takin enkawlna thenkhat avanga natna leh riltam venna atana pawm a ni.
A hmanna pawmpui berte:
- Chemotherapy avanga nausea: Cancer dona damdawi taksaa a luh chuan nausea leh luak chhuah theihna chance a sang hle. Heng damdawi te hian a venna kawngah nasa takin a pui a ni.
- Radiation therapy avanga nausea: Radiation therapy lai hian cancer cell tihchhiat nan nausea a awm thei bawk. Chungte chu chutiang case-te tan pawh pek a ni.
- Post-surgery nausea: He damdawi hi operation hnua anesthesia-in a nghawng avanga natna leh luak chhuak control nan pawh hman a ni.
He damdawi hi puitling leh naupang tan pawh a remchan dan anga pek a ni.
Hman dan dang (Off-label hmanna):
A châng chuan doctor-te chuan an damdawi lam thil tawn a\angin heng damdawi te hi an pawmpui tawh loh dinhmun dang atan an pe \hin. Hei hi ‘off-label use’ kan ti a ni.
- Operation hnua nausea enkawl dan: He damdawi hi natna venna atan leh a lo awm hnuah pawh pek thin a ni.
- Zing natna: Mi thenkhat chuan naupai tirh lamah nausen leh luak chhuak nasa zawk an nei thin . Enkawlna dang a hlawhtlin loh chuan he damdawi hi doctor enkawlna hnuaiah pek theih a ni.
He damdawi hian engtin nge hna a thawh? Scientific takin han thlir ila.
Hei hi hrethiam tur chuan ‘serotonin’ tih hi eng nge a nih leh ‘serotonin receptor’ tih hi eng nge a nih tih kan hriatthiam mai a ngai a ni.
Hetiang hian han ngaihtuah teh: serotonin hi kan taksaa thuchah, a nih loh leh neurotransmitter a ni. He messenger hian thil tam tak a tidanglam thei a, chung zingah chuan kan mood, mut leh ei leh in te pawh a tel. Mak tak maiin he serotonin 90% hi kan pum leh kan chhungril (gastrointestinal system) bang ah a awm a.
Tunah chuan engtin nge nausea hi a lo awm? Cancer enkawlna ang chi thil avang hian kan intestines chhunga cell te hian serotonin tam tak an chhuah chhuak nghal a. He serotonin tam lutuk hian intestine-a receptor-te a binding a, thluak hnenah "hetah hian thil danglam tak a thleng" tih thuchah a thawn a ni. Thluak hian he thuchah hi "nausea" tiin a hrilhfiah a ni.
A awlsam zawngin sawi ila, natna thlentu ber chu intestine-a serotonin chhuah tam lutuk hi a ni.
Chuti a nih chuan ‘serotonin antagonist’ damdawi kan pek che hian eng nge a tih? He damdawi hi lock chhunga chabi dik lo ang mai a ni. Lock (receptor) chhungah a fit a, mahse lock a activate lo. Tin, lock chhungah a awm avangin key dik tak (serotonin) chu a lut a, lock-ah a connect phal lo bawk.
Chu chu, he damdawi hian serotonin inzawmna 5-HT3 receptor te chu a block tihna a ni. Chumi awmzia chu serotonin tam lutuk hian kalna tur leh binding tur a nei lo tihna a ni. Chuvang chuan thluak hnena nausea message chu a reh a, nausea leh luak chhuak tih hriatna chu a tlahniam ta a ni.
Side effects awm tam ber chu engte nge ni?
Damdawi dang ang bawkin heng damdawi te hian side effect tenau engemaw zat a nei thei a, mahse hengte hi a nasat loh tlangpui.
| Side effect a awm thei | A sawifiahna awlsam tak |
|---|---|
| Lu na | Hei hi side effect awm fo a ni a, damdawi hman chhunzawm zel chuan a tlahniam tlangpui. |
| Chauhna/muthilh theih lohna | I chau emaw, i muhil emaw pawh a ni thei. |
| Ek khal | He damdawi hian ek chhuahna kawngah harsatna a thlen thei a ni. Tui tam tak in leh fiber tamna ei hian hei hi a pui thei a ni. |
Heng side effects te hian a tibuai hle che a nih chuan i doctor nen inbia ang che.
Risk bik fimkhur tur a awm em?
Hetiang damdawi chi hi a tlangpuiin a him hle nachungin, a bik taka kan fimkhur tur thil tlemte a awm.
Thinlung lam thil
Doctor ten he damdawi hi thinlung natna thenkhat nei te hnena an pek hian an fimkhur hle a, a chhan chu thinlung rhythm-ah nghawng tlem a nei thei a ni. A hnuaia dinhmunte hi i neih chuan doctor hnenah hrilh ngei ang che.
- Long QT syndrome tih hi a ni
- Thinlung thawk mumal lo (Ventricular arrhythmia) .
- Lung natna chi dang eng pawh
Serotonin Syndrome - Hei hi a pawimawh hle mai!
Hei hi kan taksaa serotonin level a san lutuk hian a pawi hle a, mahse a tlem hle.
Serotonin antagonists i ei laiin serotonin level tichhe thei damdawi dang (antidepressant thenkhat ang chi) i ei chuan he hlauhawmna hi a sang thei hle. Hei hi a chhan chu heng damdawi te hian serotonin receptor an block hian thisenah serotonin free a tam zawk thin.
A hnuaia damdawi te hi i ei a nih chuan doctor hriattir a pawimawh hle :
- SSRI te hi a ni
- SNRI te hi an ni
- Mirtazapine a ni
- Monoamine oxidase inhibitor (MAOI) te hi a tha hle.
Serotonin syndrome natna lan chhuah dan chu engte nge ni? Heng symptoms te hi a na lo atanga na tak thlengin a awm thei.
| Serotonin Syndrome natna lan chhuah dan | |
|---|---|
| Thil tenawm tak tak a awm |
|
| Thiltih dan pangngai (moderate) a ni | |
| A lan chhuah dan na tak (damdawi inah dah vat a ngai) . | |
Heng symptoms pakhat emaw a aia tam emaw i neih chuan tihkhawtlai suh. Damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh.
Naupai laiin hman tur (Pregnancy) .
Heng damdawi te hi naupai laiin hman a nih chuan nausen piangsualna a thlen theihna lian tham nen a inzawm lo. Mahse, thinlung leh thluaka piansualna thenkhat awm theihna a pung tlem hle tih an sawi. Chuvangin, naupai laiin heng damdawi te hi i mamawh a nih chuan, i doctor chuan thutlukna a siam hmain a thatna leh a hlauhawmna te chu rei tak a sawipui ang che.
Engtikah nge ka doctor ka biak ang?
He damdawi hi i hmang chhunzawm zel a nih chuan a hun taka doctor pan a, damdawi hman that leh that loh enfiah a pawimawh. Chu bakah, a hnuaia thil awm danah hian i doctor nen inbia ang che:
- Side effects-in a tibuai che a nih chuan: Lu na leh constipation ang chi thilte hi control theih loh khawpa buaithlak a nih chuan.
- Nausea leh vomiting a reh loh chuan: Damdawi ei chung pawha nausea a reh loh emaw, a zual emaw chuan.
- Damdawi ei tawh loh i duh chuan: Doctor zawt lovin damdawi ei kha titawp ngai suh.
Nausea hi a ti thinrim tak zet a ni. Mahse thu lawmawm tak chu a control theih nan damdawi tha tak tak, serotonin antagonists ang chi a awm a ni. Hemi chungchanga zawhna i neih chuan i doctor zawh hreh suh.
Take-Home Thuchah a ni
- Serotonin antagonists hi cancer enkawlna, radiation therapy leh surgery avanga natna leh riltam control nana hmanraw tangkai tak a ni.
- Damdawi dang i ei zawng zawng leh damdawi dang i neih (a bik takin thinlung natna) te chu i doctor hnenah hriattir ngei ang che.
- Serotonin syndrome (khawsik sang, seizures, rilru hah lutuk) an tih natna khirh tak symptoms te chu hre reng ang che. Chutiang chhinchhiahna a lo awm chuan damdawi in emergency room (ETU)-ah kal nghal tur a ni.
- Damdawi lam thurawn tel lo chuan he damdawi hi ei tan ngai suh la, chawlhsan ngai suh.
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