He damdawi hi nausea leh vomiting tan i hria em? (Serotonin Antagonist) Kan sawi dawn nia!

Operation hnuah emaw, procedure lian dang dangah emaw, natna leh riltam nasa tak i nei tawh em? A nih loh leh naupai lai khan tuar theih loh zing natna i nei em? A nuam lo em em a, kan nun a ti lungngai thei hle. Mahse, doctor-te’n he natna chi hrang hranga natna leh riltam control nan an hman thin damdawi class tangkai tak tak a awm a. Chu chu vawiinah kan sawi dawn a ni.

A awlsam zawngin, he serotonin antagonist hi eng nge ni?

Hei hi damdawi class pakhat hming an vuah a ni. A awlsam zawngin sawi ila, hengte hi natna leh luak chhuak venna leh enkawlna atana pek thin damdawi te an ni. Damdawi lam hawi chuan hengte hi `antiemetics` an ti a. I doctor-in he hming hi direct-in a sawi lo a nih pawhin he class-ah hian damdawi an lo pe tawh che a ni mai thei.

He damdawi chi hrang hrang hming atan hian hming dang engemaw zat hman a ni a:

• Serotonin-receptor dotu a ni
• 5HT3 receptor dotu a ni
• Serotonin blocker a ni

Heng hmingte hi a buaithlak deuhin a lang thei a, mahse an awmzia chu a inang vek. Chu chu, heng damdawite hian kan taksaa chemical pakhat, serotonin , hnathawh chu a tikhawlo tihna a ni. Tlem a chipchiar deuhin han thlir ila.

Hemi zingah hian Sri Lanka leh khawvel hmun hrang hranga hman tlanglawn damdawi chi hrang hrang a awm a:

• Ondansetron - Hei hi hriat lar ber a ni. Brand name Zofran® hmanga siam a ni.
• Granisetron - Kytril® tih hming puin a awm.
• Palonosetron - brand hming Aloxi® hmanga lei theih a ni.
• Dolasetron - A tir chuan Anzemet® tia hriat ni mahse tunah chuan United States ang ramah chuan hman a ni tawh lo.

He damdawi hi pill leh injection form-ah te pawh a awm a.

He damdawi hi eng atan chiah nge hman a nih?

Heng damdawi te hi thil engemaw takah chuan natna leh riltam venna atana pawm a ni ber.

• Cancer enkawlna (Chemotherapy): Hengte hi chemotherapy an tih laiin mi tam takin an natna nasa tak an tawh thin thunun nan a pawimawh hle.
• Radiation therapy: Cancer tan pawh radiation therapy hmangin natna a thlen thei bawk.
• After Anesthesia: Mi tam tak chuan operation atana anesthesia an pek hnua an hriatna an neih leh chuan luak leh luak chhuak an nei thin. He damdawi hi hei hi ven nan pek a ni.

Hengte hi puitling leh naupang tan pawh a remchan dan angin doctor-te’n an ruat a ni.

He damdawi hi off-label-a hman dan entir nan a hnuaia mi hi a ni:

• Operation hnua nausea leh luak chhuak enkawl (venna mai ni lovin).
• Naupai laiin natna leh riltam na tak (zing natna) tihreh nan, enkawlna dang hmanga thunun harsa tak a ni.

He damdawi hian engtin nge kan taksa chhungah hna a thawh?

Hei hi hrethiam tur chuan ‘serotonin’ tih hi eng nge a nih tih hi i hrethiam hmasa phawt ang u.

Serotonin hi kan taksaah hian neurotransmitter a ni. 'Messenger' ang mai a ni. He thuchah hian thil tam tak a thunun a, kan rilru put hmang, mut leh chaw ei dan te pawh a thunun a ni. Kan taksaa serotonin 90% hi kan chaw ei leh in (intestines) cell-ah a awm a.

Ngaihtuah teh, chemotherapy ang chi thil kan dawn hian kan intestine chhunga cell te chu a chhiat phah thin. Tichuan, chu cell-te chuan thisenah serotonin tam tak an chhuah chhuak nghal a. He serotonin tam lutuk hian thluak hnenah thuchah a thawn a, "Hetah hian thil dik lo a awm!" Chu thuchah chu ‘nausea’ min siamtu chu a ni .

Heng serotonin message te hi thluak thleng tur chuan kan gut leh thluaka ‘receptor’ bikte nen an inzawm a ngai a ni. Hengte hi ‘keyhole’ ang mai a ni a, chutah chuan chabi a in fit a ni. Serotonin hi a key a ni a, receptor hi keyhole a ni. Chabi dik taka dah a nih chuan kawngkhar chu a inhawng (i.e., nausea message a thawn).

`Serotonin Antagonist` damdawi hian heng keyholes (5-HT3 receptors) ah hian kal a, a block hian hna a thawk thin. Keyhole chhunga chabi lem dah ang mai a ni. Tichuan key tak tak (serotonin) chu a lut thei lo a, message chu thluak lamah a kal lo. A rah chhuah chu? Nausea leh luak chhuak chu a reh ta.

Damdawi ei avanga side effect leh risk te

He damdawi hi a tlangpuiin a him hle. Mahse, damdawi dang ang bawkin side effect engemaw zat a nei a, hriat tur tlemte a nei bawk.

Side effect awm fo thin

• Lu na
• Chau
• Ek khal

Hengte hi a tlangpuiin a pawi lo hle a, mahse a tibuai che a nih chuan doctor nen inbia ang che.

Risk te chu a bik takin hriat tur a awm

Serotonin Syndrome chungchang tlem tal

Hei hi natna khirh tak a ni a, nunna atana hlauhawm pawh a ni thei. A hnuaia symptoms te hi fimkhur hle ang che. Chung zinga pakhat emaw a aia tam emaw i tawn chuan damdawi in pakhat Emergency Department (ETU)-ah kal nghal rawh.

• Restlessness, lungkhamna
• Nausea leh luak chhuak
• Kawthalo
• Mit mitmeng (pupils) tihzauh
• Taksa a nghing
• Muscle twitching, a nghet lo
• Thawmhnaw ha, khawsik tih hriat
• Buaina, hriatna hloh
• Lung na tak tak
• Thisen sang a sang
• Taksa lumna sang (101.3°F / 38.5°C aia sang) .
• Seizures a awm thin
• Thil hriatna hloh

Engtikah nge doctor ka hmuh leh ang?

He damdawi hi hun rei tak i ei a nih chuan doctor nen inbiak reng a pawimawh. A hnuaia thil awm danah hian i doctor nen inbia ngei ang che:

• Side effects hian a tibuai tan che a nih chuan.
• I luak chhuak leh i luak chhuak a ṭhat loh emaw, a zual emaw chuan.
• Damdawi tihtawp i ngaihtuah a nih chuan (Doctor zawt lovin damdawi ei kha bansan ngai suh).

Nausea hi thil nuam lo tak a ni. Mahse thu lawmawm tak chu tunlai hian chutiang dinhmun control turin damdawi tha tak tak a awm a ni. Hetiang harsatna i neih chuan i doctor nen inhawng takin sawi la, i tana tha ber tur enkawlna chu la rawh.