I naute pawhin he natna khirh tak hi a nei ve em? SCID (Severe Combined Immunodeficiency) chungchang hi i zir dawn teh ang!

I naupang tê chu a damlo reng em? Khawsik tlemte pawh hi thil pawi takah a chang em? A châng chuan nu leh pa kan nih angin heng thilte hi kan ngaihtuah nasa hle. Vawiin hian, dik taka hriattir i nih chuan hlauhawm tak leh enkawl theih tur thil awm lo tak kan sawi dawn a ni. SCID (Severe Combined Immunodeficiency) tih a ni. A hming hi a hlauhawm deuhin a lang a, mahse chipchiar tak leh awlsam takin han sawi ila.

SCID (Severe Combined Immunodeficiency) hi eng nge ni? A awlsam zawngin i hrethiam ang u.

A awlsam zawngin sawi ila, SCID hi a awm lo hle . Thil thleng chu naute an pian hian an taksa hriselna dotu, natna dotu chu a chak lo hle emaw, a awm lo vek emaw a ni. Kan immune system hi kan ram venghimtu sipai angin han ngaihtuah teh. He system hian pawn lam atanga lo chhuak hmêlma (i.e. germs) dovin min venghim a ni. Chuvangin, SCID vei naute "sipai" hi a chak lo hle a, a awm lo tluk a ni.

Hei hi primary immunodeficiency disorder an ti a . Chu chu pian tirh laia awm thil a ni tihna a ni. Chuvangin, SCID vei naute tan chuan natna tenau, a tlangpuiin kan ngaihsak loh tur, khawsik ang chi pawh hi hneh a harsa hle. Enkawl loh chuan he natna hi kum khat emaw kum hnih emaw chhungin nunna atana hlauhawm tak pawh a ni thei. Chuvang chuan hei hi hriat chian a pawimawh em em a ni.

"Combined" immune deficiency hi eng nge ni?

Kan taksa chakna (immune system) hi kan taksaa invenna (defense force) ang mai a ni. Ram dang thil, virus , bacteria , fungi , protozoa , a nih loh leh toxins te taksaa a luh chuan he defense force hian a hre chiang a, bei turin a kal ta a ni. He indonaah hian sipai lian ber chu thisen var (white blood cells) an ni . Chumi zingah chuan , lymphocytes hi a bik tak a ni. Lymphocyte hi chi thum a awm a, chungte chu:

• T-cells te chu a awm
• B-cells te chu a awm
• Natural Killer cells (NK cells) te hi a awm a.

SCID vei nauteah chuan heng T-cells te hi a tlachham emaw, a awm lo vek emaw fo thin. A chhan chu B-cells te hian an hnathawh that theih nan T-cells atanga tanpuina an mamawh a, T-cells te a bo chuan B-cells te pawh hian hna an thawk tha lo. Chuvangin "combined" an ti a ni - a chhan chu immune cell chi hrang hrang pawimawh tak tak inzawmkhawm a nih vang a ni.

SCID hi chi hrang hrang a awm a, chu chu naupangin immune cell a neih loh chi hrang hrang a zirin a ni. Mahse heng chi zawng zawng hi chu a serious vek a ni. Doctor ten i fa hian eng type nge a neih tih an hrilhfiah ang che.

SCID hi engtiang chiahin nge a hluar?

SCID hi a takah chuan thil awm lo tak a ni.Entîr nân, United States-ah chuan he natna hian kum tin nau piang 50,000 zînga pakhat vêl a nghawng a ni.

Mahse, nangmah ngei pawhin hetiang thil hi a nei tih i hriat chuan engtiang chiahin nge a tlem tih chu a pawimawh lo, a dik em? A hlauhawm lutuk, thinlung ti na tak a ni. SCID ang dinhmun i hriat hian thumal mai a ni lo va, i nunah nghawng lian tak nei thei thil tak tak a lo ni ta a ni.

SCID natna lan chhuah dante chu engte nge ni?

A châng chuan SCID vei naute hian a tir lamah chuan pawn lam natna chiang tak a nei lo thei. Mahse, a lan chhuah dan tlangpui chu:

• Naupang rihna a pung tha tawk lo.
• Chronic diarrhea a awm thin.
• Natna khirh tak tak nei fo.

Hei hi a chhan chu naute taksa chakna (immune system) a chak lo hle a, chuvangin natna laka chhanna a nei tlem hle emaw, a chhanna a nei lo emaw a ni. Hei hian i naute chu naute dang aiin a damlo tam zawk tihna a ni. Tin, an damloh chuan an natna lan chhuah dan chu mi dangte aiin a na zawk thei bawk.

SCID vei naute hi natna chi hrang hrang kai theihna a sang hle. Hei hian a huam tel a ni:

• Bacteria natna hrik kai
• Viral natna hrik kai te
• Fungal natna hrik kai
• Parasitic natna hrik kai te

Natna eng pawh hi a na thei hle a, mahse SCID vei naute zingah hian natna chi hrang hrang a awm a, chungte chu:

• Yeast infection, thrush emaw diaper emaw ka leh leiah a chhuak thin.
• Vawk natna (Chickenpox) a awm.
• Kawngkhar vel a hnim hring (Cold sores - herpes simplex).
• Beng natna a awm.
• Pneumonia natna (Pneumonia) a ni.
• Meningitis (thluak khawsik) natna.

I fa te hian heng symptoms te hi a nei chhunzawm zel a nih chuan doctor i pan nghal tur a ni.

Eng thilin nge SCID hi a thlen?

SCID hi genetic disorder a ni a . Chu chu genetic mutations , a nih loh leh kan genes inthlak danglamna mai mai avanga lo awm tihna a ni. Scientist-te chuan hetiang genetic mutations dozen chuang zetin SCID thlen thei an hmuchhuak tawh a ni.

Heng genetic mutations te hi nu leh pa atanga fate rochun a ni. Autosomal recessive emaw X-linked emaw anga rochun theih an ni.

• Autosomal recessive tih awmzia chu naupangin he natna hi a neih theih nan chuan a nu leh pa hnen atangin mutated gene hi a rochun a ngai tihna a ni.
• X-linked SCID hi X chromosome-a genetic mutation avanga lo awm a ni. A tlangpuiin mipa naupang a nghawng nasa zawk a, a chhan chu mipain X chromosome pakhat an nei a, hmeichhia erawh chuan X chromosome pahnih an nei thung.

SCID avanga harsatna awm thei te chu engte nge ni?

Harsatna lian ber leh hlauhawm ber chu naupangin natna hrik dona tur taksa chak tak a neih loh vang a ni. Naupang taksain hri kai tenau pawh a do theih loh avangin, naupang dang aiin harsatna lian tham tak a neih theihna a sang zawk hle.

Natna lian lo tak tak pawh hian SCID vei naupangte nunna atana hlauhawm tak tak a thlen thei a ni.

He natna hi pian tirh atanga hriatchhuah leh enkawl a nih loh chuan SCID hian thihna a thlen fo thin.

Doctor-te hian engtin nge SCID hi an hriat theih?

Doctor te chuan thisen test hmangin SCID hi an hmuchhuak thin . He test hi naute pian hnu lawkah a kephah atanga thisen sample te tak te lak atanga tih a ni.

Sri Lanka rama damdawi in thenkhatah pawh nausen piang tharte chungah hetiang test hi an ti thin a, a bik takin chhungkaw zinga mi tu emaw chuan hetiang dinhmun hi a lo nei tawh a nih chuan. Hei hi a pawimawh hle a, a chhan chu natna hi hriat hmasak a nih chuan natna khirh tak tak a lo chhuah hmain enkawl tan theih a ni.

SCID enkawlna tur a awm em?

Ni e, SCID enkawlna a awm. SCID vei naute hian a rang thei ang bera stem cell transplant emaw bone marrow transplant emaw an neih a ngai a ni. Hei hian naute taksaah donor atanga stem cell hrisel tak tak inject a huam a ni. Heng cell hrisel tak takte hian naute chu natna hrik do thei tur immune system thar, chak zawk siam turin a pui thin.

• Donor tha ber chu biological siblings SCID nei lo an ni.
• Chutiang mi a awm loh chuan doctor-te chuan stem cell registry an enfiah ṭhin . Hengte hi mipuiin stem cell an pekte database a ni.

Stem cell transplant nghah lai hian i fa hian enkawlna dang a mamawh mai thei. Entir nan:

• Antibiotics - Bacteria infection a veng thei.
• Antivirals - Viral infection a veng thei.
• Antifungals - Fungal infection a veng thei.
• IVIG infusions - Hei hi taksa pawn lam atanga antibodies pek a, natna hrik laka invenna hmanga tih a ni.
• Gene therapy - Hei hi experimental treatment a la ni reng a, mahse SCID chi thenkhat tan chuan a hlawhtling thei.

Heng zawng zawng hi hun eng emaw chen enkawlna a ni vek a, SCID hi a dam kim thei lo. SCID tihdam theihna awmchhun chu stem cell transplant a ni.

Stem cell transplant nghah lai hian naupang chu sterile isolation-ah dah a ngai mai thei . Chumi awmzia chu naupang pindan chhunga lut zawng zawng chu sterilized vek a ngai tihna a ni. Hei hi nausen natna hrik laka venhimna atana tih a ni.

Mi thenkhat chuan SCID hi "bubble baby disease" an ti a, a chhan chu naute hi venhimna bubble-ah dah a nih vang a ni. Mahse he hming hi damdawi lamah chuan a dik lo va, naupang leh nu leh pate tan pawh a ti na thei hle. Thil dik lo engmah i ti lo va, i fa hriselna pawh hi ngaihthah tur a ni lo.

Ka fain SCID a neih chuan eng nge ka beisei ang?

SCID hi enkawl vat loh chuan thihna thlen thei a ni. Chuvang chuan naupangin SCID a nei em tih hi a rang thei ang bera hriat chian a pawimawh hle. Doctor-te’n natna an hriatchhuah thuai a, naupang chu stem cell transplant tura refer a nih chuan naupang nunna chhanhim theihna chance a sang zawk.

I duh angin i naute chu i chelh thei lo va, i kuah thei lo mai thei. I naute chu sterile, isolated environment-ah a awm a nih chuan i naute chu hrik laka humhim turin faina dan khauh tak i zawm a ngai bawk ang. Heng zawng zawng hi doctor ten an hrilhfiah ang che. Stem cell transplant hma leh transplant hnua i beisei tur te pawh an hrilh bawk ang che.

SCID vei naute dam rei zawng chu engzat nge ni ang?

Enkawlna tel lo chuan SCID vei naute chu kum khat emaw kum hnih emaw chhungin an thi tlangpui. Mahse, naupang stem cell transplant hlawhtling tak nei te chuan nun pangngaiin an khawsa thei a ni. An taksain immune system chak leh famkim a neih hnuah chuan hun rei tak chhung harsatna an nei lo tlangpui.

SCID hi ven theih a ni em?

SCID hi kan thunun theih loh genetic mutations avanga lo awm a ni a, chuvangin a venna tur engmah a awm lo. Chhungkaw history-a he genetic condition i neih chuan fa i neih hmain i doctor nen genetic counseling lak chungchang sawipui rawh.

Engtikah nge Doctor ka hmuh ang?

• I naute chu a damlo fo a nih chuan, emaw, natna a neih laiin natna lan chhuahna na tak a lantir chuan doctor pan nghal rawh.
• I fain SCID a nei tih i hriat tawh chuan i fa hriselnaah inthlak danglamna (e.g., khawsik, khuh, luak chhuak) i hmuh chuan i doctor hnenah hrilh nghal rawh. I fa taksa hian a mah chauhin natna hrik a do theih loh avangin antibiotics emaw damdawi dang emaw pek nghal a ngai a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

I fain SCID a vei tih i hriat chuan i rilru a buai a, i mangang tih hi thil pangngai a ni. Mahse zawhna i neih apiang chu i doctor zawh hreh suh. Hetih lai hian engkim chiang taka sawi a pawimawh. Zawhna i zawt thei ang:

• Ka fa hian SCID emaw immunodeficiency condition dang emaw a nei em?
• Ka naute hi sterile isolation environment-ah dah a ngai dawn em ni?
• Engtikah nge ka fa hian stem cell transplant a mamawh ang?
• Ka fateah hian eng inthlak danglamna emaw, a lan chhuahna emaw nge ka hriat bik tur?

I fate tan a rang thei ang bera stem cell transplant ruahman a pawimawh hle tih hre reng ang che. Tin, thil thleng zawng zawng hriatthiam theihna i nei bawk. Doctor ten engkim an hrilhfiah ang che a, i beisei tur an hrilh ang che.

A tawp berah chuan take-home message:

SCID (Severe Combined Immunodeficiency) hi natna khirh tak leh hlauhawm tak a ni. Amaherawhchu, a hmaa inhriatthiamna te, natna lanchhuahna a lan veleh damdawi lam thurawn lak te, enkawl dan tur dik tak dawn te hian naupang nunna a chhanhim thei a ni.

• Hriat hmasak: Nau piang thar screening hmanga emaw, a lan chhuah veleh SCID hriat chian a pawimawh hle.
• Stem cell transplant: Hei hi SCID enkawlna ber leh hlawhtling ber a ni.
• Environment him: Naute enkawl lai hian natna hrik laka venhim a pawimawh hle.
• Rilru chakna: Hei hi nu leh pa angin hun harsa tak a ni thei. Doctor, chhungte leh counselor te hnen atangin tanpuina zawng rawh.

Nangmah chauh i ni lo. Medical science lama hmasawnna a awm avangin SCID vei naupangte chuan hrisel, nun famkim an hmang thei tawh a ni. Chak tak leh beiseina nei reng rawh.

` Immunity, SCID, naupan lai natna, genetic natna, ruhro (bone marrow transplantation), immunodeficiency, natna hrik kai theihna te