Sickle Cell Anemia hi i hria em? Kan sawi dawn nia!

‘Sickle Cell Anemia’ tih hming hi i hre tawh em? He hming hi a mak deuh mai thei, a hlauhawm deuh pawh a ni mai thei. Mahse kan thisen nena inzawm genetic condition a ni. A awlsam zawngin, he thila thil thleng chu kan thisen zam (red blood cells), chu chu thisen chhunga cell sen (red cells) te hi an pianzia a inthlak danglam thin hi a ni. Sickle ang maiin (chuvang chuan ‘sickle’ an ti). He inthlak danglamna hian hriselna lama harsatna hrang hrang a thlen thei a ni. Chuvangin, vawiin hian he thu hi chipchiar deuhin kan sawi dawn em ni?

Sickle Cell Anemia hi eng nge ni? Eng thil chiah nge thleng?

Sickle cell anemia hi doctor-te’n ‘Sickle Cell Disease’ an tih pawl lian ber zinga na ber an tih chu a ni. Hei hi pianpui, chu chu thisen natna a ni . Hei hi a chhan ber chu genetic mutation vang a ni. He genetic mutation avang hian kan taksaa thisen sen (red blood cells) lo chhuak te hi a tlangpuiin a zungbun (round blood cells) an ni lo va, sickle ang maia ben leh hrual (C letter ang chi) an ni. Doctor-te chuan hengte hi "sickle cells" an ti bawk.

Tunah chuan en teh, kan thisen sen pangngai hi a zungbun leh a inthlak danglam thei a, chuvangin awlsam takin kan thisen kalna kawng nalh tak takte chu an kal tlang thei a, taksa peng tinah, taksa peng tinah te, leh taksa peng tinah te oxygen an phur thei a ni. Mahse heng sickle ang maia thisen cell sen te hi an khauh a, an sticky bawk . Chuvangin thisen kalna kawngah awlsam takin an kal lo va, hmun thenkhatah an tang tlat thin. Kawngpuiah traffic jam ang maiin. Thil dang leh chu, heng ‘sickle’ cell te hi a chhe vek a, thisen sen pangngai aiin an thi rang zawk a ni. Heng zawng zawng avang hian i taksaa thisen sen hrisel tak tak awm zat a tlahniam a, thisen tlakchhamna nasa tak a thlen thin. Chu chu thisen tlakchhamna a ni.

Tun hma chuan he natna vei nausen piangte hian puitlin thlenga dam rei theihna chance an nei tlem hle. Mahse, damdawi lama hmasawnna te, hriat hmasakna te, leh enkawlna thar te avângin , hei hi nasa takin a danglam ta a ni. Tunah hian mi tam tak chu kum 50 aia upa thlengin an dam a ni.

Sri Lanka ramah hian he natna hi engtiang chiahin nge a hluar? Tuin nge dawng duh zawk?

A nihna takah chuan Sri Lanka ramah hian he natna chungchangah hian statistics hmuh a harsa hle. Mahse khawvel i thlir chuan he natna hi African, Southern European, Middle Eastern emaw Asian Indian hnam chhuakte zingah a hluar hle. Chu chu genetic link engemaw zat a awm tihna a ni.

Sickle cell anemia natna lan chhuah dan chu engte nge ni?

He natna lan chhuah dan hi mi hrang hrangah a inang lo thei a, mahse a lan chhuah dan tlangpui thenkhat a awm a:

• Thisen tlakchham vanga chau: Nausen naupangte zingah hetiang dinhmun hi a lo awm chuan an tap fo thei a, an dam lo thei a, hnute pek an duh lo thei bawk.
• Hri kai fo thin: 1.1.He natna hian kan ril a tichhe thin. Kan taksa chakna (immune system)-ah hian spleen hi a pawimawh hle. Chuvangin a chak loh chuan natna leh hri kai vei theihna chance a sang zawk. Mahse, tuna antibiotics leh vaccine awm tawhte avang hian he hlauhawmna hi nasa takin a tlahniam ta a ni.
• Natna: Hei hi he natna lan chhuah dan tlangpui leh vanduaithlak tak pakhat a ni. Taksa tissue te hian oxygen an dawng tlem a, chu chuan tissue te a tichhia a ni. He chhiatna hi natna thlentu a ni. Natna hmun tam ber chu kut, ke, rilru leh hnungzang te hi a ni. A châng chuan natna tê tê angin a inṭan a, zawi zawiin a pung thei a, a nih loh leh rang takin tuar theih loh natna a lo ni thei bawk.
• Kut leh kea natna: Hei hi nausen sickle cell anemia chhinchhiahna hmasa ber zinga mi a ni. He natna hi naute kut leh kea thisen kalna kawng nalh tak takah sickle ang maia thisen sen te chu a tang a, thisen kal a tikhawlo vang a ni.
• Jaundice avanga mit leh vun sen rawng: Kan thin hian thisen sen (red blood cells) a filter thin. Sickle cell anemia-ah chuan sickle cell thi rang tak atanga chhuak bilirubin an tih chu taksaah a pungkhawm a, jaundice a thlen thin.

Heng symptoms te hi naute thla 6 atanga thla 9 vel a nih atangin a lang tan tlangpui . Hun a kal zel a, taksaa cell pangngai lo (malignant) a pun zel chuan a natna lan chhuah dan a danglam thei a, a na zual thei bawk.

Engvangin nge sickle cell anemia hi a lo awm? Eng thilin nge a thlen?

Sickle cell anemia hi kan genes-a genetic mutations avanga lo awm a ni. A bik takin, HBB gene an tih gene a awm a. He gene hian kan hemoglobin-a tel veta-globin tih protein siam turin min hrilh a ni. Hemoglobin hi in hriat angin kan thisen sen (red blood cells) te oxygen phur tura puitu pawimawh ber a ni.

Chuvângin, sickle cell anemia vei tûr chuan i nu leh pa aṭangin gene danglam tak chu i rochun a ngai a ni . A châng chuan, nu leh pa pahnih aṭanga gene danglam pahnih i rochun chuan, sickle cell natna chi dang, a na lo zâwk pawh a ni thei. Doctor-te chuan hengte hi ‘variant genetic mutations’ an ti a.

Hetiang dinhmun avang hian eng harsatna nge awm thei?

Sickle cell anemia hian harsatna lian tak tak, a châng chuan nunna atana hlauhawm tak a thlen thei a ni . Entirnan, he natna vei te hian emergency medical care leh damdawi ina dah an ngai fo thin a, a bik takin acute chest syndrome (ACS) leh vaso-occlusive crisis (VOC) an tih condition te tan chuan.

Harsatna dang pawh a awm:

• Chronic kidney disease: Hetiang dinhmun hi kal hian oxygen a dawng tlem a, tissue a tichhia thei a ni.
• Detached retinas: Hei hi sickle cell-in mit chhunga thisen kalna kawng a block chuan a thleng thei.
• Priapism (painful erection): Mipa zang chhunga thisen kalna kawngkhar a inkharkhip avanga lo awm thin.
• Splenic sequestration: Sickle cells te chu spleen-ah an tang a, thisen kal dan a tikhawlo a nih chuan hei hian thisen tlakchhamna nasa tak a thlen nghal thei a ni.
• Stroke: Sickle cell anemia vei tu pawh, naupang tê tê (pediatric stroke ) pawh ni se, a hlauhawm hle.

Acute Chest Syndrome (ACS) hi eng nge ni?

Hei hi sickle cell anemia avanga harsatna awm tam ber a ni. Thihna thlentu lian ber leh damdawi ina dah chhan lian ber pahnihna a ni bawk. Hei hi sickle cells te an inzawm khawm a, lung chhunga thisen kalna kawngte an block hian a thleng thin. A lan chhuah dan chu:

• A rilru a na nghal.
• Khuh.
• Khawsik.
• Thâwk harsa.

Vaso-occlusive Crisis (VOC) hi eng nge ni?

Hei hi sickle cell-in thisen kalna kawng a block lai a ni. Doctor-te chuan hei hi "acute pain crisis" an ti bawk. VOC-ah chuan kut, ke, hnungzang hnuai lam leh pum chhungah natna tuar theih loh a awm thei.

A châng chuan doctor-te chuan VOC hi "hmu theih loh natna" an ti ṭhin. A chhan chu, a tam zawkah chuan a symptom awmchhun chu natna a ni. Hliam emaw natna dang emaw a awm lo. A hrehawm mai mai.

He natna nasa tak enkawlna ber chu opioid painkillers a ni. Mahse, zirchianna thenkhatah chuan he opioid mamawhna hian sickle cell anemia vei te chu social isolation a thlen thei a, chu chuan lungngaihna leh lungkhamna a thlen thei tih hmuhchhuah a ni. Hei hi he natna nena kan nunpui huna kan hmachhawn tur harsatna dang a ni.

He natna hi engtin nge an hriat chhuah? (Diagnosis) tih a ni.

Doctor-te chuan sickle cell anemia an enfiah hmasain an hmuchhuak thin. I spleen emaw i liver emaw chu an hre mai thei. I natna lan chhuah dan te, a bik takin i kut leh ke natna te, i pum chungchang te an zawt ang. Tin, tun hmaa i natna te leh hri kai i neih leh neih loh te an zawt bawk ang. Tichuan test an ti thei a, chungte chu:

• Complete Blood Count (CBC): Hei hian test engemaw zat a huam a, chu chuan i thisen sen (red blood cells) a bik takin a enfiah thin.
• Hemoglobin electrophoresis: High-performance liquid chromatography an ti bawk a, he test hian i hemoglobin chu a zirchiang a, sickle cell anemia thlentu hemoglobin chi danglam tak chu a hmuchhuak a, a teh a ni.
• Genetic test: I doctor chuan heng test te hi sickle cell anemia thlentu genetic change i neih leh neih loh en turin a order thei ang.

Hei hi eng enkawlna nge ni? Dam theih a ni em?

Sickle cell anemia enkawlna chu i natna lan chhuah dan leh i hriselna zawng zawngah a innghat a ni. Entirnan, acute chest syndrome ang chi harsatna nasa tak i neih chuan, natna nasa tak i neih fo chuan, paralysis ang chi natna i neih chuan i doctor chuan allogeneic stem cell transplant a rawt thei ang. Tunah hian hei hi sickle cell anemia tihdam vek theihna kawng awmchhun a ni .

Enkawlna dangte chu:

• Thisen pek a ni.
• Infection tan antibiotics hman tur a ni.
• Damdawi, natna lan chhuahna bikte tiziaawm thei. Chung zinga ṭhenkhat chu:
• Hydroxyurea: Hei hi cancer dona damdawi a ni. Nausen thla 6-9 inkar, naupang, leh puitling tan hman a ni. Harsatna lian tham a tihziaawm bakah thisen tlakchhamna (anemia symptoms) a tihziaawm thei bawk.
• Voxelotor: Hei hian thisen sen (red blood cells) chu sickle cell-a a chan loh nan a titawp a ni. Naupang kum 4 chunglam tan pek thin a ni.
• L-glutamine therapy: He damdawi hi naupang kum 5 chunglam leh puitling tan pek thin a ni a, sickle cells te chu a pangngai lo zawk lo turin a titawp thin.
• Crizanlizumab-tmca: Hei hian VOC/acute pain crise awm tamna a ti tlem a ni. Kum 16 chunglam tan pek thin a ni.

Sickle cell anemia ka neih chuan ka nun hi eng ang nge ni ang?

Mi tam tak tan chuan sickle cell anemia hi natna rei tak a ni . Chumi awmzia chu i dam chhung zawngin damdawi lam enkawlna leh puihna i mamawh dawn tihna a ni. Mi thenkhat tan chuan a natna lan chhuah dan chu a na lo thei a, thenkhat tan chuan a hniam thei a, mi thenkhat tan chuan nunna atana hlauhawm khawpa na a ni thei bawk. Mi zawng zawng dinhmun a inang lo. Chuvangin i doctor nen i beisei tur chungchang sawipui rawh. I hriselna leh natnain a nghawng dan tur che chu a hre chiang ber a ni.

He dinhmun hi i upat deuh deuh chuan a zual zel em?

Ni e, kan tar chhoh zel chuan, taksa peng leh taksa peng hrang hranga oxygen a thlen tlem avangin hriselna lama harsatna dang, a lian zawk pawh a awm thei a ni. Sickle cell anemia vei te hi paralysis, lung, kidney, spleen leh liver tihchhiat theihna a sang hle.

He natna vei dam rei zawng hi engzat nge ni ang?

Tunah chuan a hma aiin thil a tha tawh hle. With early detection and treatment to reduce complications , sickle cell anemia vei te chu kum 50 vel an dam thei a ni. Mi thenkhat chu an dam rei zawk. Hemi chungchanga zawhna i neih chuan i doctor nen inbia ang che. A hrilhfiah thei che a ni.

He natna hi a lo awm loh nan kawng a awm em?

Sickle cell anemia hi thlahtu natna a nih avangin ven theih a ni lo.. Mahse, thisen test la, sickle cell anemia thlentu genetic mutation i nei em tih i enfiah thei bawk. Ram changkang tam takah chuan nausen tin hi an pian tirh atangin he natna hi an enfiah vek thin. A pawimawh ber chu natna hi hriat hmasak a enkawl tan a ni .

Engtin nge he natna hi ka nunpui theih ang? (Mahni invenna) .

Enkawlna thar avang hian sickle cell anemia vei te chu nun tha zawk an nei thei ta a ni. Natna i neih chuan hengte hi ngaihtuah la:

• Specialist medical care zawng: Hematologist team atanga enkawlna zawng a pawimawh.
• Medical checkup neih fo: Chhungkaw doctor nena inlaichinna tha tak neih leh checkup neih fo hian harsatna lian tham tak tak a awm loh nan a pui thei a ni.
• Natna enkawl dan ngaihtuah rawh: Natna hi he natnaah hian a awm fo thin. Pain management specialist hnen atangin thurawn la rawh.
• Rilru hriselna lama tanpuina dawng rawh: A châng chuan he natna hian inhlat taka awm, lungngaihna leh lungkhamna a thlen thei a ni. Hetiang hian i inhriat chuan Doctor nen inbia ang che.
• Infection lakah inveng rawh: I doctor nen vaccine lak chungchang sawipui rawh. Infection laka inven nan hma la rawh.
• I chhehvel ngaihtuah rawh: Sickle cell anemia vei tan chuan taksa lumna inthlau tak neih a pawimawh hle. Khaw lum leh vawt lutuk atanga hla takah awm rawh.
• Clinical trial en rawh: Doctor leh zirchiangtute chuan enkawlna thar an test fo thin. Pakhatnaah chuan tel ve theihna hun remchang i nei mai thei.

Engtikah nge Doctor ka hmuh ang?

I natna lan chhuah dan a na zual nia i hriat chuan, emaw, natna lan chhuah thar i neih chuan doctor pan nghal rawh .

Engtikah nge Emergency Room-ah i kal a ngaih?

Sickle cell anemia hian damdawi lam harsatna na tak a thlen thei a ni. Heng symptoms te hi i neih chuan emergency room-ah kal nghal rawh :

• Anemia symptoms (chau lutuk, thawk hah, thinlung thawk mumal lo).
• Khawsik chu 38.5 degree Celsius (101.3 Fahrenheit) aia sang a ni.
• A rilru a na.
• Khuh.

Hetiang dinhmun hian stroke vei theihna a tipung bawk. Stroke hi medical emergency a ni a . A hnuaia symptoms te hi i neih chuan damdawi in pan nghal tur a ni:

• Taksa balance emaw coordination emaw lama harsatna.
• Blurred vision emaw double vision emaw a awm thei.
• Rilru tibuai.
• Taksa sir khata chak lohna emaw, rilru hahna emaw.
• Thusawi harsa (stuttering).

A tawp berah chuan hriat reng tur tlemte

Sickle cell anemia hi a harsa tak zet a ni. Kum tam tak kal ta khan he natna vei nausen piangte hian damchhuah beiseina an nei tlem hle. Mahse,Kum sawm kalta chhung khan damdawi lam zirchianna chuan hmasawnna nasa tak a nei a, chuvangin tunah chuan mi tam tak chuan he natna khirh tak hi an enkawl thei ta a, nun tha tak tak an hmang thei ta a ni.

Nangmah emaw, i fa emaw hian he natna hi i vei a nih chuan, tun hmaa hmasawnna i neih tawhte chu i hlim laiin, hmalam hun atan beiseina nei takin awm rawh. Zirchiangtute chuan he natna enkawl dan thar zawn chhuah an tum reng a ni. I doctor nen inbia la, clinical trial thar awmte chu hre reng ang che. Beiseina chu bansan ngai suh . Damdawi lam thurawn mumal tak zawm a, rilru tha neih a pawimawh hle.

` Sickle cell anemia, thisen tlakchhamna, thlahtu natna, thisen natna, genetic mutations, hemoglobin, hriselna atana tips