E mōhio ana koe he aha te endothelin i roto i tō tinana? Te pānga ki te toto toto tiketike!

Kua rongo koe i te kupu 'Endothelin'? Tērā pea kua rongo koe i tētahi tākuta e whakahua ana i tēnei ingoa ki a koe, ki tētahi rānei o tō whānau i a koe e kōrero ana mō te rongoā, kua kite rānei koe i tētahi wāhi i a koe e pānui ana mō tētahi mate. Ahakoa he mea iti tēnei e hangaia ana i roto i ō tātou tinana, he mahi pai tana ki te pupuri i te toto toto, te 'pēhanga' rānei e mōhiotia ana e tātou katoa, kia tika te taumata. Heoi, ki te nui ake te pikinga o tēnei endothelin i roto i te tinana i te mea e tika ana, ka puta pea ngā raruraru hauora . Nō reira, i tēnei rā ka kōrero tātou mō te aha tēnei endothelin me tana mahi ki tō tātou tinana i roto i tētahi huarahi māmā e mārama ai koe.

Nā, he aha tēnei endothelin?

He kupu māmā noa iho, he pūmua iti te endothelin e āwhina ana ki te whakawhāiti i ngā oko toto i roto i ō tātou tinana. Hei whakamārama, he peptide. He mekameka pūmua poto ngā peptides i hangaia mai i ngā mea iti e kiia nei ko ngā waikawa amino. Ka āwhina hoki ēnei ki te hanga pūmua nui ake i roto i ō tātou tinana.

E mōhio ana koe ko wai te kaihanga o tēnei endothelin? He paparanga pūtau kei roto i ō tātou uaua toto. Ko te endothelium te ingoa. Koinei te wāhi matua o tō tātou tinana e whakaputa ana i te endothelin.

He aha te endothelium? Ka taea e koe te whakamārama mai?

Whakaarohia ngā uaua toto puta noa i ō tātou tinana he whatunga paipa e kawe ana i te wai. Ko te taha o roto o aua paipa, kei te taha e rere ai te toto, kua hipokina e tētahi paparanga pūtau angiangi rawa. Ko taua paparanga pūtau e kiia ana ko te endothelium . Ahakoa te āhua miharo, e kiia ana hoki ko tētahi o ngā whekau nui rawa atu o tō tātou tinana!

Ka huna e ēnei pūtau endothelial ngā matū maha. Ka whakahaere ēnei matū i te whānui me te whakawhāiti o ō tātou uaua toto, e kiia nei ko te tone vascular . Mā tēnei tone vascular ka whakatau te kaha o te manawa ki te pupuhi toto me te kaha o tana mahi ki te rere toto puta noa i te tinana.

Ka mahi tahi te endothelium me te endothelin ki te mahi i ētahi atu mahi nui:

• Ka āwhina i te toto kia totoka. He mea tino nui tēnei hei whakamutu i te toto ina pāngia koe e te patunga.
• Ka whakahaere i ngā taumata o ngā wai me ngā tote (ngā irahiko) i roto i ō tātou toto.
• Ka āwhina hoki i te whakahaere i te mumura mā te aukati i ngā paitini kia kaua e uru ki roto i ō tātou kiko.

Nā, he aha te mahi a te endothelin ki te tinana?

Kua kōrero kē tātou ko te endothelin tētahi mea e āwhina ana ki te whakawhāiti i ngā oko toto. Inaa, ko te endothelin te mea tino kaha ki te whakawhāiti i ngā toto i roto i tō tātou tinana. Me wehewehe tēnei kupu:

• Ko te wāhanga "Vaso" e pā ana ki ngā uaua toto i roto i tō tātou pūnaha manawa me te ngākau.
• "Kaiwhakawhāiti" "whakawhāiti" rāneiKo te tikanga o te whakawhāititanga ko te whakawhāiti, te whakawhāiti rānei i ngā uaua toto. Ka whakaroa tēnei i te rere o te toto, ā, i ētahi wā ka mutu.

Nō reira, ko te mahi a te endothelin he whakapiki i te toto toto. Ina whakawhāitihia ngā uaua toto, me kaha ake te mahi a te ngākau ki te pupuhi toto. Koia te take e piki ake ai te toto.

Ka aha mēnā ka piki ake ngā taumata endothelin?

I te nuinga o te wā, he pai te mahi a te endothelin mō tō tātou tinana. Heoi, ki te piki ake te taumata o te endothelin i roto i te tinana, ka pā mai he maha ngā mate ka kino ai ō tātou ngākau me ō tātou pukahukahu . Whakaarohia te mea ka tupu mēnā ka purua rawatia te paipa wai. Pērā tonu.

Ko ētahi o ngā āhuatanga ka puta mai i te pikinga o ngā taumata endothelin ko:

• Atherosclerosis (mate uaua): I roto i tēnei, ka kohikohi ngā putunga ngako ki roto i ngā oko toto , ka whakawhāiti i ngā oko toto.
• Te mate ngākau whati: He ngoikore o te ngākau nā te ahotea ohorere.
• He maha ngā momo mate pukupuku .
• Cardiomyopathy : Te ngoikore o te uaua o te ngakau.
• Ngā mate pūnaha toto (cardiovascular) me te ngoikore o te ngakau.
• Te mate o te uaua koronari , me te āhuatanga e kiia nei ko te ngoikore o te endothelial.
• Te toto toto tiketike me te preeclampsia .
• Te mate whatukuhu me te ngoikore o te whatukuhu .
• Te mate pukupuku pūkahukahu me te toto toto tiketike pūkahukahu .
• Scleroderma : Te matotoru o te kiri me ngā kiko honohono.

Whakaarohia, kua roa a Nimal e pāngia ana e te toto toto tiketike. I kī te tākuta kua paku whaiti ōna uaua toto, ā, tera pea ka pāngia e ōna taumata endothelin. I whakatūpato anō hoki ia mēnā kāore ia e tango tika i ana rongoā, ka arahi pea ki te mate ngakau. Nō reira, ehara i te mea pai kia kaua e aro noa ki tēnei mea endothelin.

He momo endothelin kei reira?

Āe, he momo endothelin. I kitea tuatahitia ēnei e ngā kairangahau hauora i te tau 1987. E toru ngā momo matua o ngā endothelin, he mea hanga mai i ngā peptide waikawa amino e whā. He mea whakapūmau i te toto ēnei e toru.

Ko te momo endothelin tino kitea, tino kaha hoki i roto i ō tātou tinana ko te endothelin-1 (ET-1). Kei te ako tonu ngā kairangahau i te pānga o ngā momo e rua atu, te endothelin-2 (ET-2) me te endothelin-3 (ET-3), ki ō tātou tinana. I tēnei wā, ko te nuinga o te aro e aro ana ki te ET-1.

He aha ngā kaiwhakawhiwhi endothelin?

He rite ēnei kaiwhakawhiwhi ki ngā kakau tatau. Ina tae mai ngā ngota endothelin ka herea ki ēnei kaiwhakawhiwhi, ka tukuna he karere ki aua pūtau kia mahi i tētahi mea. Koinei te huarahi e kōrero ai te endothelin ki ngā pūtau puta noa i ō tātou tinana.

Me pēhea te ine i ngā taumata endothelin?

Ki te hiahia ngā tākuta ki te mōhio ki te nui o ō taumata endothelin, ka whakahaerehia e rātou he whakamātautau toto . Mā tēnei ka ine i te nui o te endothelin-1 (ET-1). Ka kitea i roto i tētahi wāhanga o te toto e kiia nei ko te plasma. Ko te plasma te wāhanga wai o te toto e toe ana i muri i te tangohanga o ngā toto whero, ngā toto mā, me ngā pereti toto.

Ka taea te mahi i tēnei whakamātautau toto i te tari o tō tākuta, i te hōhipera, i te taiwhanga rānei. He uaua ki te ine i ētahi atu momo endothelin i roto i te toto i tēnei ara.

Ko te ine mō te endothelin he pikokaramu ia miririta (pg/mL).

• Ko te taumata plasma ET-1 noa i roto i te pakeke kei waenganui i te 1 pg/mL ki te 2 pg/mL.
• He paku teitei ake ngā taumata ET-1 i roto i ngā tamariki nohinohi.
• Waihoki, tera pea he rerekētanga pakupaku o ēnei taumata i waenga i ngā iwi rerekē.

Ko te tikanga, ko te hunga whai mate manawa, mate pūkahukahu rānei, pērā i te toto toto tiketike pūkahukahu, he nui ake ā rātou taumata ET-1. Waihoki, ko ētahi maimoatanga manawa, pērā i te angioplasty poihau, ka taea te whakanui ake i ngā taumata endothelin mō te wā poto.

He aha ngā Endothelin Receptor Antagonists (ERA)?

He momo rongoā ēnei e hoatu ana ina piki ake te taumata o te endothelin. Ka mahi ngā Endothelin Receptor Antagonists (ERA) mā te whakaiti i te nui o te endothelin i roto i te tinana.

Nō roto ēnei i tētahi momo maimoatanga e kiia nei ko te "whakaora arotahi." Arā, ka haere tika ēnei rongoā, ka whakaeke noa i ngā pūtau raruraru, me te kore e nui te kino ki ngā pūtau hauora. Pērā i te kaipupuhi, ka pā tika ki te ūnga. Ko te nuinga o ngā rongoā ERA e whakamahia ana hei rongoā i ētahi momo toto toto tiketike i roto i ngā pukahukahu (te toto toto tiketike pūkahukahu).

He pānga taha kei ēnei rongoā ERA?

Pērā i ngā rongoā katoa, ka pā mai ētahi pānga taha i ngā rongoā ERA.

• Kaua ngā wāhine hapu, ngā wāhine rānei e ngana ana kia hapu e tango i ēnei rongoā ERA. Nā te mea ka taea e ēnei rongoā te whakararu i te tamaiti kāore anō kia whānau. He take tino nui tēnei.
• He tino onge te kino o te ate i tēnei rongoā. Nō reira, ka tono pea tō tākuta i ngā whakamātautau toto hei tirotiro i te hauora o tō ate i ia wā.
• Ko ētahi atu pānga taha pea ko:
• Te mate kōroke.
• Te pupuhi o te mata (edema) te whero rānei.
• Te mamae o te upoko .
• Whakapairuaki me te ruaki.
• Te tere o te pā me te tere o te manawa.

Ki te pā mai tētahi āhuatanga pēnei ki a koe, me kōrero tonu atu koe ki tō tākuta kia taea ai e ia te mahi i ngā mahi e tika ana.

Nā, he aha ngā mea hei maumahara mā tātou i tēnei pūrākau? (Karere hei tango ki te kāinga)

Āe, kua maha ā tātou kōrero mō te endothelin. Hei whakarāpopototanga:

• He pūmua nui te Endothelin e hangaia ana i roto i te tinana e āwhina ana ki te whakawhāiti i ō tātou oko toto me te whakahaere i te toto toto.
• He mea hanga tēnei mai i tētahi paparanga pūtau e kiia nei ko te endothelium e whakarārangi ana i te taha roto o ō tātou oko toto.
• Ki te nui rawa ngā taumata endothelin, ka tino kuiti rawa ngā uaua toto, ka ara ake ngā raruraru pēnei i te toto toto tiketike, te mate ngakau, me te mate pūkahukahu .
• Ka taea te ine i ngā taumata o te Endothelin-1 (ET-1) i roto i te toto mā te whakamātautau toto .
• Ko ngā kaitukino i ngā kaiwhakawhiwhi Endothelin (ERA) he momo rongoā e whakaiti ana i ngā taumata endothelin. E whakamahia ana ēnei mō te toto toto tiketike i roto i ngā pukahukahu.
• Mena kei te tango koe i te rongoā ERA, me tino tupato koe i te wā e hapu ana, me te hauora o tō ate.

Nō reira, ki te mea he raruraru tōu, tō tētahi rānei e mōhio ana koe ki te Endothelin, he pai ake te rapu tohutohu hauora. Ko te tumanako kua hoatu e tēnei tuhinga he māramatanga ki a koe. Kia ora tonu!

` Endothelin, toto toto tiketike, mate manawa, mate pūkahukahu, endothelium, peptides