Ngā mea katoa mō te Whakamātautau Whakaoho ACTH, e ine ana i ngā homoni o tō tinana!

I ētahi wā, ina kore e mahi tika ētahi mea o roto i tō tātou tinana, ka pā mai he maha ngā raruraru hauora ki a tātou, tika? Ina koa mēnā he kore taurite o te pūnaha homoni o tō tātou tinana, ka nui te pānga. I roto i tēnei āhuatanga, ka tūtohu pea tō tākuta kia whakahaerehia e koe he whakamātautau motuhake. Ko te 'Whakamātautau Whakaoho ACTH' tēnā. Me kōrero māmā noa iho tēnei.

He aha te whakamātautau ACTH (Whakamātautau Whakaoho ACTH)?

He whakarāpopototanga noa iho tēnei, he whakamātautau motuhake tēnei e tirotiro ana i te urupare a ngā repe adrenal i roto i tō tātou tinana ki tētahi homoni e kiia nei ko te ACTH. I ētahi wā ka kiia hoki tēnei ko te Cosyntropin Stimulation Test (CST). Koinei te whakamātautau matua hei rapu mēnā he āhuatanga e kiia nei ko te adrenal insufficiency, arā, he whakahekenga o te mahi a ngā repe adrenal. Ka taea tēnei te tuatahi, te tuarua, te tuatoru rānei.

Ko tēnei whakamātautau he werohanga i tētahi homoni ACTH hangai (Synthetic ACTH - Cosyntropin) ki roto i tō uaua. Kātahi, i ia hawhe haora pea, ka tangohia ō toto, ā, ka whakamātauria te taumata o tētahi homoni e kīia nei ko te cortisol. Ko te mahi tēnei hei tirotiro i te pai o te mahi a ō repe adrenal.

He aha te ACTH me te Cortisol?

Ko te `ACTH`, arā, ko te `Adrenocorticotropic Hormone`, he homoni e hangaia ana e te `Pituitary Gland` i roto i tō tātou roro. He pānga nui tōna ki te urupare a te tinana ki te ahotea. Ina tukuna te `ACTH`, ka whakaoho i ngā repe adrenal ki te whakaputa i te `Cortisol`, e mōhiotia ana ko te `stress hormone` . He homoni nui te Cortisol e pā ana ki te nuinga o ngā okana me ngā kiko o tō tātou tinana.

Ngā momo ngoikore o te adrenal

E toru ngā huarahi matua ka taea ai tēnei:

1. Te ngoikore o te adrenal tuatahi: Ka puta tēnei ina pakaru ō repe adrenal, ā, kāore e taea te whakaputa tika i te cortisol. Ko te mate a Addison te tino take o tēnei. He mate pūnaha ārai mate tēnei.

2. Te ngoikore o te adrenal tuarua: Ka puta tēnei ina kore e nui te ACTH e whakaputaina e tō repe pituitary. Kātahi ka kore e nui te whakaohooho o ngā repe adrenal ki te hanga cortisol.

3. Te ngoikore o te adrenal matua: Ka puta tēnei ina kore te hypothalamus i roto i te roro e whakaputa tika i te homoni `CRH (Corticotropin-Releasing Hormone)`. Ko te `CRH` te mea e kī ana ki te repe pituitary kia whakaputa i te `ACTH`.

Āhea te wā e hiahiatia ai he whakamātautau ACTH?

Mā tēnei whakamātautau ka taea te whakatau mēnā kei te mahi tika ō repe adrenal me tō repe pituitary ki te whakaputa cortisol. Tērā pea ka tonoa tēnei whakamātautau e tō tākuta mō ēnei take:

• Mena ka kitea e tētahi atu whakamātautau he iti ō taumata cortisol.
• Mena kei a koe ngā tohu o te ngoikore o te adrenal (hei tauira, te ngenge pinepine, te whakaheke taumaha, te mamae o te puku, te whakapairuaki, te whanoke, te kiri mangu ).
• I muri i te mutunga o te whakamahi i ngā rongoā glucocorticoid, pērā i te prednisone, mō tētahi wā, tirohia mēnā kua hoki mai ō repe pituitary me ō repe adrenal ki te āhua noa.

Ko wai kei te mahi i tēnei whakamātautau?

I te nuinga o te wā, ka mahia te werohanga ACTH e te nēhi. Ko te tango toto, arā, ko te tauira toto, ka mahia e te tohunga toto, arā, he tangata kua whiwhi whakangungu motuhake mō tēnei kaupapa. Kātahi ka tukuna ēnei tauira ki te taiwhanga. I reira, ka whakamātauhia ēnei tauira e te kaipūtaiao taiwhanga hauora.

He maha ngā wā ka mahia tēnei whakamātautau i roto i te hōhipera, i te tari rānei o te tākuta endocrinologist, he tākuta e tohunga ana ki ngā mate e pā ana ki ngā homoni. Kei roto i tēnei ko te werohanga rongoā me te tango tauira toto. Ko te tākuta endocrinologist he tākuta e tohunga ana ki ngā mate e pā ana ki ngā homoni.

Me whakarite e au tetahi mea i mua i te whakamātautau?

Āe, kei reira ētahi mea.

• Tērā pea ka tonoa koe kia whakawhāiti i tāu mahi tinana, kia kai hoki i tētahi kai nui-warowaihā 12-24 hāora i mua i te whakamātautau.
• Ka taea hoki e koe te kī ka nohopuku koe mō te ono hāora. Ko te tikanga kāore e taea e koe te kai, te inu rānei i tētahi mea engari ko te wai anake.
• Mena kei te tango koe i ētahi rongoā ka pā ki te whakamātautau cortisol, ka tonoa pea koe kia mutu te tango i aua rongoā mō te wā poto.
• I te mea he rerekē ngā taumata cortisol puta noa i te rā (ko te teitei rawa i te ata), he pai ake te mahi i tēnei whakamātautau i te ata hei whakaiti i te tūponotanga o ngā hua teka.

Heoi, ka hoatu e tō tākuta he tohutohu motuhake mō te whakarite mō tēnei whakamātautau. Me whai tika koe i aua tohutohu.

Me pēhea te whakahaere i te whakamātautau ACTH?

Koinei ngā mahi taketake:

1. Tuatahi, ka tangohia he tauira toto mai i tētahi uaua i tō ringa. Mā tēnei ka tirohia ō taumata cortisol taketake. Tērā pea ka mahia ētahi atu whakamātautau.

2. Kātahi ka werohia e te nēhi he homoni hangai e kiia nei ko te `ACTH (Cosyntropin)` ki roto i tō uaua. He rite tonu te mahi a tēnei `ACTH` hangai ki te `ACTH` e hangaia ana e tō tātou tinana, e whakaoho ana i ngā repe adrenal ki te whakaputa cortisol.

3. Kātahi, i muri i te 30 meneti me te 60 meneti (te tikanga), ka tangohia anō ngā tauira toto mai i tō uaua, ā, ka tirohia ngā taumata cortisol.

4. Ka tukuna ēnei tauira toto ki te taiwhanga.

He aha te momo wheako ka riro i a koe i te wā o te whakamātautau?

Anei ētahi mea ka taea e koe te tumanako ina tangohia tō toto:

• Ka noho koe ki runga i tētahi tūru, ā, ka kitea he uaua ngāwari i roto i tō ringa. I te nuinga o te wā, kei roto i tō ringa, i muri tonu i tō tuke.
• Kia kitea he uaua, ka horoia te wāhi, ka patua hoki he huakita.
• Kātahi ka werohia he ngira iti ki roto i te uaua, ā, ka tangohia he tauira toto. Tērā pea ka rite ki te werohanga iti.
• Whai muri i te werohanga o te ngira, ka kohia he iti toto ki roto i te ngongo whakamātautau.
• Kia nui te toto kua kohia mō te whakamātautau, ka tangohia te ngira, ka whakatakotoria he miro, he kākahu rānei ki te wāhi i werohia, ka pēhia hei whakamutu i te toto.
• Kātahi ka pania he pāreti ki te wāhi.

Ina whiwhi koe i te Cosyntropin, ka werohia ki tō ringa o runga, i runga ake i tō pakihiwi. Tērā pea ka mamae, ka wera rānei koe ina whiwhi koe i te werohanga, engari he wā poto noa iho.

He aha te mea ka tupu i muri i te whakamātautau?

Kia oti te tango i ngā tauira toto, ka tukuna atu ki te taiwhanga. Kia puta mai ngā hua, ka kōrerotia e tō tākuta ki a koe.

He mōrearea kei roto i tēnei whakamātautau?

He mea tino noa te whakamātautau toto i roto i te rongoā. He iti noa ngā mōrearea. Tērā pea ka paku maru, ka mamae rānei te wāhi i tangohia ai te toto, engari ka tere te memeha atu. Kāore he mea hei manukanuka.

Kia pēhea te roa ka mōhiotia ai ngā hua?

Ka roa pea te wiki e puta mai ai ngā hua o te whakamātautau ACTH, nā te mea ina puta mai ngā hua o te taiwhanga, me āta tirotiro e te tākuta, ā, ka tae ki tētahi whakatau.

He aha ngā hua?

Ko ngā pūrongo whakamātautau toto, tae atu ki ngā pūrongo cortisol mai i te whakamātautau ACTH, kei roto i ngā mōhiohio penei:

• Te ingoa o te whakamātautau toto, te mea rānei i inehia i roto i te toto.
• Te tau, te ine rānei o ngā hua o tō whakamātautau toto.
• Koinei te awhe ine noa mō te whakamātautau.
• Ngā mōhiotanga mō te āhua noa, te āhua rerekē, te teitei, te iti rānei o tō hua.

Me pēhea te āhua o ngā hua toharite?

I raro i ngā āhuatanga noa, me piki ake ō taumata cortisol i muri i te whakaohooho ACTH horihori. I roto i ngā hua noa, me nui ake ō taumata cortisol i te 12.6 mcg/dL (micrograms ia deciliter) i muri i te whakaohooho ACTH.

Kia maumahara, ka rerekē pea ēnei awhe noa i ia taiwhanga ki ia taiwhanga, i ia whakamātautau ki ia whakamātautau, i ia tangata ki ia tangata. Me tirotiro tonu te awhe noa kua hoatu ki tō pūrongo.

Mēnā he whakamātautau ACTH, me mārama rawa tō tākuta, tō tohunga endocrinology rānei ki ngā hua i mua i tō kitenga i aua hua. Mēnā he pātai āu mō ngā hua, me pātai atu ki tō tākuta.

He aha te tikanga o ngā hua rerekē?

Ka āta tātarihia e tō tākuta, e tō tākuta endocrinologist rānei ngā hua o tō whakamātautau ACTH. He maha ngā āhuatanga ka pā ki te tika o te whakamātautau. Ko te tino take o te hua teka-pai ko te whakamahinga tata nei o ngā corticosteroids.

Ko ngā hua rerekē o te whakamātautau ACTH e tohu ana i te ngoikore tuatahi me te tuarua o te repe adrenal.

Te ngoikore o te adrenal tuatahi

Mena kei a koe tēnei mate, kāore e taea e ō repe adrenal te hanga cortisol, kāore rānei e aro tika ki te ACTH. Nō reira, kāore pea koe e kite i te pikinga nui, i te pikinga rānei o ō taumata cortisol i muri i te whakamātautau ACTH. Nā te mea kāore te ACTH horihori e pā ki ō repe adrenal.

Te ngoikore o te adrenal tuarua

Mena ka roa te wā e kore e mahi te repe pituitary (hypopituitarism), ā, ka ngoikore te hanga ACTH, ka hua ake te ngoikore tuarua o te adrenal. Nō reira, kāore e whakaohokia ngā pūtau e hanga ana i te ACTH, ā, ka tīmata te ngoikore o ngā repe adrenal, arā, ka tīmata te ngoikore .

Nō reira, ki te mea kua roa koe e pāngia ana e te hypopituitarism me te adrenal insufficiency, tera pea ka kitea he iti noa, he kore rānei he pikinga o ō taumata cortisol i muri i te whakamātautau ACTH.

Heoi, ki te mea he hapa noa te hypopituitarism (arā, kei te whakaputa tonu te repe pituitary i ētahi ACTH), ki te mea rānei nō nā tata nei te mate, ka kitea pea he pikinga o ngā taumata cortisol, arā, he taumata "noa", i muri i te whakamātautau ACTH.

Karere Whakamutunga mō te Tango ki te Kāinga

Ko te Whakamātautau Whakaoho ACTH te whakamātautau tino nui, tino pono hoki hei tātaritanga i te ngoikore o te adrenal. He mea whakararuraru pea te tatari mō ngā hua o te whakamātautau tātaritanga. Engari kia mahara, ahakoa he aha ngā hua, kei reira tō tīma hauora hei āwhina i a koe. Kaua e wehi ki te pātai ki tō tākuta mō tō whakamātautau, mō ngā hua rānei. He mea nui kia mōhio koe ki tō hauora.

` Whakamātautau ACTH, cortisol, repe adrenal, repe pituitary, homoni, ngoikore adrenal, whakamātautau hauora