Tiyeni tiphunzire za mapuloteni achilendo omwe amaikidwa mumtima? (Cardiac Amyloidosis)

Kodi nthawi zina mumamva kutopa kapena kuvutika kupuma pang'ono? Simungasamale kwambiri zinthuzi. Koma nthawi zina izi zitha kukhala chizindikiro cha vuto la mtima. Lero tikambirana za vuto lomwe limakhudza mtima, lomwe mwina simunamvepo , koma ndi lofunika kwambiri kudziwa. Musadandaule, tikambirana izi mosavuta komanso m'njira yomwe mungamvetse.

Kodi ichi ndi chiyani (Cardiac Amyloidosis)?

Mwachidule, `(Cardiac Amyloidosis)` ndi matenda omwe amayamba chifukwa cha mapuloteni osakhazikika m'thupi lathu, omwe amaikidwa mkati ndi kuzungulira mtima. Taganizirani izi ngati kutsekeka kwa chitoliro cha madzi. Kuchulukana kwa mapuloteni kumeneku kumachepetsa mphamvu ya mtima wanu yopompa magazi. Kenako mtima umayenera kugwira ntchito molimbika. Pamapeto pake, khama lowonjezerali lingathe kufooketsa ndikuwononga mtima, zomwe zimapangitsa kuti `(Heart Failure)`.

Pakhoza kukhala zifukwa zambiri za izi. Anthu ena amatengera matendawa kwa makolo awo, zomwe zikutanthauza kuti ndi majini . Ena amatha kukhala ndi vutoli popanda kulumikizana ndi majini. Likhozanso kuyambitsidwa ndi matenda ena, monga khansa. Ngakhale kuti vutoli, lotchedwa ``Amyloidosis``, silingathe kuchiritsidwa kwathunthu, pali mankhwala abwino a mitundu ina.

Kodi mitundu ya Amyloidosis ya mtima ndi iti?

Mapuloteni omwe ali m'thupi lathu ndi maunyolo ataliatali a mamolekyu. Mapuloteni awa amatithandiza kuchita zinthu zambiri, kuphatikizapo kupereka mphamvu, kuchita zinthu zokhudzana ndi mankhwala m'thupi lathu, komanso kutumiza mauthenga pakati pa machitidwe osiyanasiyana. Koma pali vuto. Maselo athu amatha kugwiritsa ntchito maunyolo a mapuloteniwa ngati ali mu mawonekedwe oyenera. Matenda olakwika a mapuloteni, monga amyloidosis, amachititsa kuti mapuloteniwa asokonekere, apindike molakwika, komanso asagwire ntchito bwino.

Mapuloteni akasokonekera kwambiri mwanjira imeneyi, amasakanikirana ndipo thupi silingathe kuwagwiritsa ntchito. Akasowa kopita, mapuloteni osakanikirana awa amasonkhana pamodzi, amamatirana, ndipo amamatirana m'mbali zosiyanasiyana za thupi.

Amyloidosis ingakhudze ziwalo zambiri m'thupi, makamaka mtima. Pali mitundu itatu ikuluikulu ya amyloidosis yomwe imakhudza mtima (mitundu ina ingakhudzenso mtima, koma ndi yosowa kwambiri).

AL (Unyolo Wopepuka) Amyloidosis

Thupi lathu limagwiritsa ntchito zinthu zotchedwa "light chains" ngati gawo la chitetezo chake chamthupi. Izi zimatiteteza ku majeremusi monga mavairasi ndi mabakiteriya. "AL Amyloidosis" imachitika pamene maselo omwe ali mu mafupa athu sagwira ntchito bwino ndipo amapanga "light chains" zambiri. Izi zitha kuchitika zokha, kapena zitha kuchitika chifukwa cha mitundu ina ya khansa ya m'magazi kapena khansa ya chitetezo chamthupi. Mtundu uwu nthawi zambiri umapezeka munthu akakwanitsa zaka 50.

ATTR amyloidosis

Transthyretin (TTR) ndi puloteni yomwe imathandiza kusuntha mankhwala enaake m'thupi lathu. Dzina lake limatchedwa chifukwa limanyamula mahomoni a chithokomiro ndi vitamini A (retinol). Kale linkatchedwa Thyroxine-binding prealbumin (TBPA), koma dzina limenelo siligwiritsidwanso ntchito.

Zizindikiro za `ATTR Amyloidosis` zimasiyana kwambiri. Zingawonekere ali ndi zaka 20 kapena 70. Pali mitundu iwiri ikuluikulu:

• ATTR Yochokera ku Cholowa: Ichi ndi vuto la majini. Izi zikutanthauza kuti mumalandira kuchokera kwa amayi anu, abambo anu, kapena onse awiri.
• ATTR yamtundu wachilengedwe: Izi zimachitika pamene puloteni ya TTR imayamba kugwira ntchito molakwika, popanda kusintha kulikonse kwa majini. Izi nthawi zambiri zimachitika munthu atatha zaka 60. Poyamba inkatchedwa Senile Systemic Amyloidosis kapena Senile Cardiac Amyloidosis, koma mayina awa sagwiritsidwanso ntchito kawirikawiri.

amyloidosis yokhudzana ndi dialysis

Anthu omwe akhala akulandira dialysis kwa zaka zambiri chifukwa cha matenda a impso ali pachiwopsezo chachikulu chotenga amyloidosis. Izi zili choncho chifukwa puloteni yotchedwa beta-2 microglobulin (beta-2 microglobulin) nthawi zambiri siichotsedwa mu dialysis. Puloteni iyi, yomwe imadziwika kuti beta-2Ms, imasonkhana mumtima ndi ziwalo zina za thupi.

Mitundu yosowa (Cardiac Amyloidosis)

Kuonjezera pa izi, pali mitundu ina ingapo ya ``Cardiac Amyloidosis'', koma ndi yosowa kwambiri.

Ndani amene ali ndi mwayi waukulu wopeza izi?

Pali zinthu zingapo zazikulu zomwe zimakhudza omwe amatenga matendawa:

• Zaka: Ngakhale kuti anthu ena amatha kudwala matenda a amyloidosis ali ndi zaka 20, nthawi zambiri sapezeka kawirikawiri kwa anthu osakwana zaka 40. Matendawa nthawi zambiri amapezeka atatha zaka 50, makamaka mu mawonekedwe a amyloidosis yamtundu wa ATTR.
• Jenda: Amuna ali ndi mwayi waukulu wodwala matenda a mtima amyloidosis kuposa akazi. Makamaka ndi matenda a ATTR amyloidosis, pali amuna 25 mpaka 50 ochulukirapo omwe amakhudzidwa ndi matendawa pa mkazi aliyense.
• Dziko Lobadwira: Kusintha kwa majini komwe kumayambitsa ATTR amyloidosis ya m'banja kumachitika kwambiri m'maiko ena. Mwachitsanzo, mayiko monga Portugal, Japan, Sweden, Finland, ndi mayiko ena angapo aku Europe.
• Mtundu/fuko: Kusintha kwina kwa majini komwe kumayambitsa ATTR amyloidosis ya m'banja kumapezeka mwa anthu pafupifupi 4% akuda ochokera ku West Africa. Izi zikuphatikizapo anthu aku Africa America komanso anthu akuda ochokera ku Latin America ndi Caribbean.
• Kuchotsa magazi nthawi zonse kwa zaka zambiri: Mukapitiriza kugwiritsa ntchito dialysis, m'pamenenso mumakhala ndi mwayi waukulu wopeza zizindikiro zimenezi.

Kodi matendawa ndi ofala bwanji?

Kawirikawiri, `(Amyloidosis)` ndi matenda osowa kwambiri. Komabe, mitundu ina ya `(Amyloidosis)` ndi yofala kwambiri kuposa ina.

• AL Amyloidosis: Ku United States kokha, milandu yatsopano pafupifupi 4,000 ya AL Amyloidosis imanenedwa chaka chilichonse. Izi zikutanthauza kuti munthu m'modzi mwa akuluakulu 64,500 amadwala matendawa.
• Cholowa cha `ATTR Amyloidosis`: Matendawa amatha kupezeka mwa anthu akuda okwana 4% ochokera ku West Africa. Mwa anthu ochokera ku Europe, amapezeka mwa munthu m'modzi pa anthu 100,000. Komabe, m'maiko omwe atchulidwa pamwambapa, chiwerengerochi ndi chachikulu kwambiri. Mwachitsanzo, ku Portugal, munthu m'modzi pa anthu 538 ali ndi vutoli.
• Matenda a Wild-type ATTR Amyloidosis: Akatswiri amakhulupirira kuti matendawa sapezeka mokwanira, ndipo kuyerekezera kukusonyeza kuti angakhudze amuna okwana 20% azaka zopitirira 80.
• Amyloidosis yokhudzana ndi dialysis: Izi zimachitika mwa anthu pafupifupi 20% omwe amamwa dialysis kwa zaka ziwiri kapena zinayi. Zimachitika pafupifupi kwa aliyense amene amamwa dialysis kwa zaka 13 kapena kuposerapo.

Kodi matendawa amakhudza bwanji thupi?

Matenda a mtima otchedwa Amyloidosis ndi matenda omwe amasintha kapangidwe ka mtima wanu ndipo amasokoneza mphamvu yake yopopera mpweya. Amachitika m'njira zotsatirazi:

• Kukhuthala kwa makoma a mtima: Pamene mapuloteni a `(Amyloid)` aikidwa mu minofu ya mtima, makoma a mtima amakhuthala ndipo mtima umakula. Izi zikachitika, mtima umayenera kugwira ntchito molimbika kuti upompe magazi m'thupi lonse. Kulimbikira kowonjezera kumeneku pamapeto pake kumabweretsa `(Heart Failure)` .
• Matenda a mtima otchedwa amyloidosis angayambitse kusakhazikika kwa kugunda kwa mtima (arrhythmias), kapena kufooka kwa zizindikiro zamagetsi mumtima. Matenda a mtima otchedwa atrial fibrillation ndi mtundu wofala wa matenda a arrhythmia okhudzana ndi amyloidosis.
• Mapuloteni a Amyloid: Mapuloteni a Amyloid ndi mapuloteni omata ngati sera omwe amasonkhana mosavuta ndikupanga machubu akuluakulu. Ngati machubu awa akhazikika mu valavu ya mtima, valavuyo imatha kutsekeka pang'ono, zomwe zimalepheretsa kuyenda kwa magazi.

Kodi zizindikiro zake ndi ziti?

Si aliyense amene ali ndi kusintha kwa majini komwe kungayambitse amyloidosis amene adzadwala matendawa. Anthu ena sadwala matendawa. Ena amadwala, koma si oopsa kwambiri.

Zizindikiro za Amyloidosis ya mtima nthawi zambiri zimakhudza mtima, koma zimathanso kukhudza ziwalo zina zofunika monga chiwindi ndi impso. Pamagawo omaliza a Amyloidosis ya mtima, zizindikiro za kulephera kwakukulu kwa mtima (zomwe zalembedwa pansipa) zimatha kuchitika.

Zizindikiro zomwe zingatheke ndi izi:

• Kupuma movutikira: Izi zitha kuchitika mukakhala ndi zochita zambiri kapena mukagona.
• Kutupa chifukwa cha kuchulukana kwa madzi m'thupi: Izi nthawi zambiri zimawoneka m'miyendo, m'mapazi, m'mimba, ndi m'mimba.
• Kutopa:Kumva kutopa kwambiri kwa masiku angapo kapena kuposerapo.
• Kugunda kwa Mtima: Kumva kosasangalatsa komwe mumamva ngati mtima wanu ukugunda popanda inu kuchita khama lililonse.
• Mitsempha ya varicose m'khosi: Izi zimachitika mtima ukalephera kugwira ntchito, chifukwa umavutika kupopa bwino. Kuwonjezeka kwa kuthamanga kumeneku kumaikanso kupanikizika pamitsempha ya m'khosi, zomwe zimapangitsa kuti ikule.
• Hepatomegaly: Ichi ndi vuto lofala lomwe limabwera chifukwa cha kulephera kwa mtima, ndipo ndi chifukwa chomwecho chomwe mitsempha ya m'khosi imatukumuka. Kuwonjezeka kwa kuthamanga kwa magazi kuchokera mumtima kumaikanso kupanikizika pa mitsempha ya magazi m'chiwindi, zomwe zimapangitsa kuti chiwalocho chizitupa.
• Mavuto a impso: Zinthu monga kutupa kwa impso kapena kusintha kwa ntchito ya impso.

Zinthu zina zomwe zingakhale zizindikiro za "Cardiac Amyloidosis" zomwe sizikugwirizana ndi mtima, chiwindi, kapena impso:

• Kuvulala kosazolowereka.
• Lilime lotupa.
• Matenda a Carpal Tunnel (Kupsinjika kwa Mitsempha ya M'mapapo - Ichi chingakhale chizindikiro chochenjeza msanga, nthawi zambiri zaka zambiri matendawa asanayambe).
• Lumbar Spinal Stenosis (kuchepa kwa malo ozungulira msana pansi pa msana).
• Mavuto a masomphenya.
• Mavuto akumva ndi kusamva.
• Kusanza kapena kumva kuwawa m'manja kapena m'mapazi.

Kodi ndi zifukwa ziti za Amyloidosis ya Mtima?

Pali zifukwa zambiri zosiyanasiyana za mitundu yosiyanasiyana ya amyloidosis, koma zambiri mwa izo zimagwirizana ndi DNA yathu.

Taganizirani izi ngati buku lophikira la banja. Lili ndi malangizo okhudza momwe maselo athu ayenera kugwirira ntchito, momwe angapangire mapuloteni enaake. Kupereka DNA kuchokera kwa makolo kupita kwa ana kuli ngati makolo anu akukulemberani buku lophikiralo ndi manja.

Kusintha kwa majini kuli ngati zolakwika mu buku lanu la maphikidwe a DNA. Chilembo chachikulu chingasokoneze njira yophikira. N'chimodzimodzinso ndi matenda monga amyloidosis. Maselo anu akugwira ntchito molimbika momwe angathere, koma amadziwa momwe angatsatire njira yophikira. Zolakwika izi zingakuchitikireni m'njira ziwiri.

Cholowa

Matenda a mtima nthawi zambiri amakhala a m'banja. Izi zikutanthauza kuti mumalandira cholowa. Izi zimachitika pamene kholo limodzi kapena onse awiri ali ndi kusintha kwa DNA yawo, ndipo cholakwika chomwe chili mu "buku la maphikidwe" amenewo chimakopedwa mu lanu.

Yapezedwa

Matenda obwera chifukwa cha matenda ndi matenda omwe simulandira, koma amakula nthawi ina m'moyo wanu. Matenda a ATTR amyloidosis ndi amyloidosis okhudzana ndi dialysis ndi zitsanzo za matenda obwera chifukwa cha matendawa. Koma palibe chilichonse mwa izi chomwe chikugwirizana ndi kusintha kwa DNA yanu.

• Matenda a ATTR amyloidosis amachitika chifukwa thupi lanu limapanga mapuloteni molondola, koma pakapita nthawi mapuloteni amenewo amakhala osakhazikika (ndichifukwa chake matendawa amakhudzana ndi ukalamba). Pamapeto pake, mapuloteniwo amangopindika molakwika.
• Amyloidosis yokhudzana ndi dialysis imachitika pamene puloteni yabwinobwino yomwe singasefedwe ndi dialysis, monga impso zanu, imasonkhana m'thupi lanu. Pakapita nthawi, puloteniyo imawonjezeka mpaka imayambitsa mavuto.

Kodi izi ndi zopatsirana?

Ayi, `(Amyloidosis)` si matenda opatsirana mwanjira iliyonse.

Kodi dokotala amazindikira bwanji izi? (Kuzindikira)

Dokotala adzayamba wakayikira `(Cardiac Amyloidosis)` kutengera zizindikiro zanu, kuyezetsa thupi (dokotala akuyang'ana, amakhudza, ndikumvetsera thupi lanu kuti adziwe zizindikiro za matenda), komanso mbiri yachipatala ya banja lanu. Kenako adzachita mayeso ozindikira matenda, mayeso ojambula zithunzi, ndi mayeso a labu kuti atsimikizire ngati muli ndi `(Cardiac Amyloidosis)` kapena ayi.

Ngati wina m'banja mwanu ali ndi mtundu wa amyloidosis wa m'banja mwanu, simungafunike mayeso ena kapena mungafunike mayeso ena. Kuyezetsa majini kungachitikenso kuti muwone ngati muli ndi kusintha kwa majini komwe kungayambitse amyloidosis ya mtima.

Ndi mayeso ati omwe amachitidwa kuti adziwe matendawa?

Ngati dokotala wanu akukayikira kuti muli ndi "Cardiac Amyloidosis", akhoza kuyitanitsa mayeso amodzi kapena angapo omwe ali pansipa.

Kuyesa labu

Mayesowa amatenga zitsanzo za minofu, magazi, kapena madzi ena amthupi. Utoto wapadera wotchedwa Congo red umagwiritsidwa ntchito m'mayeso ambiriwa. Utoto uwu umapangitsa kuti malo omwe amyloid amaikidwamo aziwala wobiriwira pansi pa kuwala kwina.

• Kufufuza minofu: Pa izi, madokotala amatenga chitsanzo chaching'ono cha minofu kuchokera kudera lina, monga minofu ya mtima, ndikuchiyesa mu labu. Zitsanzo za minofu zimathanso kutengedwa kuchokera kumadera ena, koma ngati chitsanzo kuchokera kudera lina losakhala la mtima chikupereka zotsatira zabwino, chiyenera kutsimikiziridwa ndi mayeso ojambulira.
• Kuyezetsa magazi: Mu mitundu ina ya amyloidosis ya mtima, mapuloteni a amyloid amayendayenda m'magazi. Kuyezetsa kwa labu kumatha kuzindikira mapuloteni awa.
• Kuyezetsa mkodzo: Nthawi zina, mapuloteni a amyloid amatha kupezeka mu mkodzo. Kuyezetsa kupezeka kwa mapuloteni awa mu mkodzo kungathandizenso kupeza matenda.

Mayeso ojambula zithunzi

Popeza matenda a mtima otchedwa amyloidosis angayambitse kukula kwa mtima wanu ndikusintha mawonekedwe ake, mayeso ojambulira zithunzi angathandize kuzindikira vutoli. Mayeso omwe angachitike ndi awa:

• Echocardiogram:Mayeso awa ali ngati mleme wogwiritsa ntchito mawu kuti apeze njira yake. Amagwiritsa ntchito mafunde amphamvu kwambiri. Chipangizo chomwe chimatulutsa mawu chimayikidwa pakhungu la chifuwa, ndipo madokotala amatha "kuona" mtima poyang'ana momwe mafunde amamvekera kuchokera m'mapangidwe osiyanasiyana mkati mwa thupi. Izi ndizothandiza kwambiri poona ngati ziwalo zina za mtima ndi zokhuthala kwambiri.
• Scintigraphy: Pa mayeso awa, madokotala amaikamo tracer, chinthu chowopsa pang'ono (koma chopanda vuto), m'magazi mwanu. Tracer imasonkhana m'malo omwe puloteni ya amyloid yasonkhana. Madera amenewa amatha kuwoneka mosavuta pogwiritsa ntchito mayeso ojambulidwa otchedwa SPECT scan (Single-Photon Emission Computed Tomography) .
• Kujambula Maginito Osonyeza Kugwirizana kwa Maginito (MRI): Kuyesa kumeneku kumagwiritsa ntchito maginito amphamvu kwambiri komanso ukadaulo wa makompyuta kuti apange chithunzi cha mtima. MRI ndi yolondola kwambiri, kotero madokotala amatha kuwona kukhuthala kapena kusintha kwina mumtima.

Electrocardiogram (ECG kapena EKG)

Mu ECG, masensa angapo (nthawi zambiri 12) amalumikizidwa pakhungu la chifuwa chanu. Masensawa amazindikira mphamvu yamagetsi yomwe ikuyenda mumtima mwanu ndipo amawonetsa mphamvu ya chizindikiro chamagetsicho ngati mafunde papepala kapena pazenera. Akatswiri ophunzitsidwa bwino, monga madokotala, amatha kuwunika mafundewo kuti awone ngati pali kusintha kulikonse kwachilendo momwe ziwalo zina za mtima wanu zimayendetsera magetsi.

Mayeso a majini

Kutengera ndi zotsatira za mayeso ena, dokotala wanu angakulangizeni kuti muyesedwe majini. Mayesowa amatha kuzindikira kusintha kwa DNA yanu komwe kungayambitse amyloidosis yanu.

Kodi pali chithandizo cha Amyloidosis?

Mitundu yambiri ya `(Cardiac Amyloidosis)` imatha kuchiritsidwa, koma matendawa sangachiritsidwe kwathunthu nthawi zonse . Chithandizo chimasiyananso kutengera mtundu wa `(Amyloidosis). Kawirikawiri, kuzindikira koyambirira ndikofunikira kwambiri . Ngati `(Amyloidosis)` yapezeka msanga, kuwonongeka kwa nthawi yayitali kwa mtima kumatha kuchepetsedwa. Ngati sikunazindikirike ndikuchiritsidwa msanga, kuwonongeka kosatha kungachitike. Njira yokhayo yokonzera kuwonongeka kosatha kwa mtima ndi `(Mtima Wosamutsira)`.

AL amyloidosis

Chithandizo cha AL Amyloidosis chimafanana kwambiri ndi njira zachizolowezi zochizira khansa. Njira zake ndi izi:

• Chemotherapy: Monga momwe zimakhalira ndi khansa, chemotherapy imatha kuwononga maselo a plasma omwe sagwira ntchito bwino.
• Kusamutsa maselo oyambira: Mankhwalawa nthawi zambiri amachitidwa limodzi ndi chemotherapy, ndipo amalowa m'malo mwa maselo oyambira omwe sakugwira ntchito bwino ndi maselo atsopano. Maselo oyambira awa nthawi zambiri amatengedwa kuchokera kwa inu (autologous). Popeza ndi anu, thupi lanu limawazindikira ndipo silimawakana kapena kuwayankha molakwika.
• Chithandizo cha Immunotherapy:Chitetezo chanu cha mthupi nthawi zambiri chimatha kuzindikira ndikuwononga maselo omwe sakugwira ntchito bwino. Mu matenda monga khansa kapena AL Amyloidosis, chitetezo chanu cha mthupi sichizindikira maselo amenewo ngati olakwika. Chithandizo cha immunotherapy chimaphunzitsa chitetezo chanu cha mthupi kuzindikira ndikuwononga maselo olakwika.

ATTR amyloidosis

Mtundu uwu wa ``(Amyloidosis)`` umachitika pamene chiwindi chanu chimapanga mapuloteni omwe amasweka mosavuta. Vutoli limafuna kuti chithandizo chonse chiyimitsidwe. Mndandanda womwe uli pansipa ukuphatikizapo mankhwala ovomerezeka ndi boma komanso omwe akadali mu gawo lofufuza.

• Kuika chiwindi: Kale, kuika chiwindi inali njira yokhayo yoletsera chiwindi chanu kupanga mapuloteni olakwika. Ngakhale kuti iyi si njira yokhayo, ikadali njira yothandiza komanso yothandiza.
• Zoletsa majini: ATTR Amyloidosis imayamba chifukwa cha kusintha kwa majini mu DNA yanu, monga momwe zilili ndi cholakwika m'buku la maphikidwe. Zoletsa majini ndi mankhwala omwe amagwira ntchito ngati khadi la maphikidwe akanthawi. M'malo motsatira njira yolakwika ya maselo anu, amawapatsa malangizo atsopano kuti apange mapuloteni molondola.
• Zokhazikika: Mankhwalawa amaletsa mamolekyu a TTR kuti asapindike kapena kusweka.
• Zoletsa Fibril: Mapuloteni a amyloid akayamba kusonkhana pamodzi, amapanga zinthu zofanana ndi ulusi zotchedwa fibrils. Mankhwalawa amaletsa kupangika kwa fibrils.

amyloidosis yokhudzana ndi dialysis

Mtundu uwu wa `(Amyloidosis)` umakula mwa anthu omwe amafunikira `(dialysis)` chifukwa `(beta-2M)` puloteni imasonkhana. Kawirikawiri, impso zanu zimasefa ndikuchotsa puloteniyo, koma `(dialysis)` yokhazikika singathe kuchita zimenezo. Ichi ndichifukwa chake zimatenga zaka kuti anthu omwe ali pa `(dialysis)` adwale matendawa. Pakadali pano, pali njira ziwiri zochizira matendawa:

• Kusamutsa impso: Impso yathanzi imatanthauza kuti simukufunikanso dialysis, ndipo impso yoikidwa m'malo ena imatha kusefa mapuloteni ochulukirapo a beta-2M. Kusamutsa impso kungalepheretse amyloidosis yokhudzana ndi dialysis kuti isakule kwambiri, koma ofufuza sakudziwa ngati izi zingachotsenso mapuloteni a amyloid omwe asonkhana m'thupi.
• Zosefera zapadera: Ngakhale kuti zosefera za dialysis nthawi zonse sizingachotse mapuloteni a beta-2M, pali zosefera zapadera zomwe zingawachotse pang'ono. Tsoka ilo, zoseferazi sizimasefa mapuloteni onse, ndipo sizimasefa onse. Izi zikutanthauza kuti ngakhale patatha zaka zambiri za dialysis, amyloidosis yokhudzana ndi dialysis imatha kubuka.

Mankhwala osakhala enieni

Pali mitundu yosiyanasiyana ya mankhwala ndi mankhwala omwe angathandize anthu omwe ali ndi matenda a mtima otchedwa Cardiac Amyloidosis. Izi nthawi zambiri zimathandiza kuchiza zizindikiro za matendawa ndipo zingaphatikizepo:

• Kuika mtima: Anthu omwe ali ndi vuto lalikulu la mtima chifukwa cha amyloidosis ya mtima nthawi zina amafunika kuikidwa mtima. Opaleshoni imeneyi nthawi zambiri imachitika pambuyo poti chifukwa cha amyloidosis chathetsedwa kapena chachiritsidwa.
• Mankhwala oletsa kupweteka kwa mtima: Mankhwalawa amathandiza kupewa kugunda kwa mtima kosakhazikika, komwe ena mwa iwo akhoza kukhala oopsa.
• Zipangizo zoyimitsidwa: Zipangizozi zikuphatikizapo ma pacemaker ndi ma implantable cardioverter defibrillators (ICDs) . Zimathandiza kugunda kwa mtima wanu popereka mphamvu zamagetsi komanso kupewa matenda oopsa a arrhythmias.
• Mankhwala ochepetsa mphamvu ya madzi m'thupi: Mankhwalawa amathandiza makamaka kusunga madzi m'thupi (chizindikiro chofala cha kulephera kwa mtima) mwa kukonza ntchito ya impso zanu. Komabe, simuyenera kumwa mankhwalawa ngati muli ndi vuto monga matenda aakulu a impso.
• Doxycycline : Ma unyolo owala a AL amyloidosis nawonso ndi oopsa ku maselo a mtima wanu. Pazifukwa zomwe akatswiri sakuzimvetsa bwino, doxycycline ya maantibayotiki imatha kuthana ndi zotsatirapo za poizoni.

Kodi pali zotsatirapo zilizonse za mankhwalawa?

Mavuto ndi zotsatirapo zake pochiza matendawa zimasiyana kwambiri. Nazi zina mwa zomwe zimachitika kawirikawiri. Komabe, dokotala wanu angakufotokozereni bwino mavuto, zotsatirapo zake, ndi zoopsa zina. Izi zili choncho chifukwa amadziwa bwino vuto lanu, kotero amatha kusintha zomwe akudziwa komanso kufotokozera kuti zigwirizane ndi vuto lanu.

Kodi ndidzakhala bwino nthawi yayitali bwanji nditatha kulandira chithandizo?

Chithandizo cha Amyloidosis ya Mtima nthawi zambiri chimakhala chongochepetsa zizindikiro zanu. Mankhwala ena angapereke mpumulo, koma zotsatira zake zimakhala zakanthawi. Nthawi zina, mankhwala angayambitse zotsatirapo zomwe zingakupangitseni kumva kupweteka kwakanthawi, koma dokotala wanu angakupatseni mankhwala ndi malangizo kuti achepetse kuopsa kwa zotsatirapozo.

Kodi izi zingathe kupewedwa? Kapena kodi chiopsezocho chingachepe?

Mwatsoka, amyloidosis singathe kupewedwa (kupatulapo chimodzi, onani pansipa). Popeza chifukwa cha amyloidosis yosabadwa sichikudziwika, palibe njira yopewera. Amyloidosis yobadwa nayonso singapewedwe, chifukwa ili mu DNA yomwe mumalandira kuchokera kwa makolo anu.

Chokhacho chosiyana ndi cardiac amyloidosis, yomwe imagwirizana ndi dialysis. Vutoli lingapewedwe ngati simunachite dialysis kwa nthawi yayitali, kapena ngati mugwiritsa ntchito zosefera zapadera kuti muletse kudzikundikira kwa mapuloteni a beta-2M. Komabe, zosefera izi nthawi zambiri sizimaletsa kudzikundikira konse, zomwe zikutanthauza kuti nthawi zambiri zimakhala njira yochedwetsera kuyamba kwa matendawa.

Kodi chiyembekezo cha matendawa ndi chotani?

Matenda a mtima otchedwa Amyloidosis ndi matenda omwe amakula pang'onopang'ono, omwe ali ndi zizindikiro za kulephera kwa mtima zomwe zimakula pang'onopang'ono. Pamapeto pake, matendawa amatha kufooketsa mtima wanu mpaka kufika poti sungagwirenso ntchito. Ngati sathandizidwa, chiyembekezo chake chimakhala choipa kwambiri.

Popanda chithandizo, nthawi yopulumuka ya anthu omwe ali ndi AL Amyloidosis ndi yosakwana miyezi isanu ndi itatu. Kwa omwe ali ndi matenda oopsa kwambiri, imatha kukhala miyezi itatu mpaka isanu ndi umodzi. Kwa omwe ali ndi ATTR Amyloidosis, nthawi yopulumuka yapakati ndi zaka ziwiri mpaka zisanu. Kwa omwe ali ndi mabanja omwe sanalandire chithandizo ndi ATTR Amyloidosis, vutoli ndi loipa kwambiri, ndipo nthawi yopulumuka yapakati ndi zaka ziwiri mpaka zitatu.

Kodi ndingadzisamalire bwanji ndikusamalira zizindikiro zanga?

Mwatsoka, palibe zinthu zambiri zomwe mungachite kuti mudzithandize nokha mutangoyamba matenda a amyloidosis. Ngati wina m'banja mwanu ali ndi matendawa, muyenera kulankhula ndi dokotala wanu za kuyezetsa majini. Ngakhale kuti si aliyense amene ali ndi kusintha kwa majini komwe kumakhudzana ndi matenda a mtima a amyloidosis amene angadwale matendawa, ndikofunikira kudziwa ngati mungadwale. Mwanjira imeneyi, mutha kudziwa zizindikiro zake ndikuyamba kulandira chithandizo msanga.

Ngati muli ndi `(Cardiac Amyloidosis)`, ndikofunikira kwambiri kutsatira malangizo a dokotala wanu okhudza mankhwala ndi chithandizo. Mankhwala ambiriwa amagwira ntchito m'njira zinazake, ndipo kuti agwire ntchito bwino, ndikofunikira kuwamwa monga momwe dokotala wanu wanenera.

Kodi ndiyenera kupita kwa dokotala liti kapena kupeza chithandizo chadzidzidzi?

Mukapezeka ndi matenda a Cardiac Amyloidosis, dokotala wanu adzakonza nthawi zonse kuti akakuwoneni. Kutengera ndi kuopsa kwa matenda anu, mungafunike kukaonana ndi dokotala wanu pafupipafupi.

Dokotala wanu adzakuuzaninso zizindikiro zomwe ziyenera kukupangitsani kupita kuchipatala. Komabe, nthawi zambiri, imbani dokotala wanu ngati muli ndi zizindikiro zotsatirazi:

• Kumva chizungulire kapena kukomoka mukakhala kapena mutayimirira: Izi zimatchedwa ``Orthostatic Hypotension.'' Izi zimachitika chifukwa kutsika kwa kuthamanga kwa magazi kumachepetsa kuchuluka kwa magazi omwe amapita ku ubongo mukamayimirira.
• Kutupa kwa miyendo kapena mimba: Izi nthawi zambiri zimachitika chifukwa cha kusunga madzi m'thupi.
• Kutaya thupi mwadzidzidzi komanso kwakukulu: Ichi ndi chizindikiro chofunikira, makamaka ngati simukuyesera kuchepetsa thupi.

Kodi ndiyenera kupita ku ER (Emergency Room) liti?

Popeza matenda a mtima otchedwa amyloidosis amatha kusokoneza kwambiri ntchito ya mtima wanu, zizindikiro zina zimasonyeza kuti mukufunika thandizo lachipatala mwamsanga.Ndikofunikira. Zina mwa izo ndi izi:

• Kumva kugunda kwa mtima.
• Kugunda kwa mtima mofulumira kwambiri, pang'onopang'ono, kapena kosasinthasintha.
• Kuvuta kupuma pazifukwa zilizonse.

Pomaliza, mfundo zingapo zofunika (Uthenga Wopita Nawo Kunyumba)

Matenda a mtima otchedwa Amyloidosis ndi ovuta kwambiri, koma ndikofunikira kudziwa za matendawa.

Kumbukirani, ngakhale kuti matendawa amatha kupita patsogolo pang'onopang'ono, kuwazindikira msanga ndi kulandira chithandizo choyenera kungathandize kwambiri pakukulitsa moyo wanu ndikukweza moyo wanu.

Nthawi zina kuyika ziwalo zina m'thupi kumatha kuchiritsa vutoli. Chifukwa cha mankhwala atsopano ndi mankhwala, anthu ambiri omwe ali ndi matendawa amatha kuchepetsa zizindikiro zawo ndikukhala ndi moyo kwa zaka zambiri matendawa atayamba.

Ngati muli ndi kukayikira kapena mafunso okhudza izi, lankhulani ndi dokotala wanu . Angakupatseni upangiri woyenera. Musachite mantha, dziwani zambiri, funsani mafunso. Simuli nokha.

Amyloidosis ya Mtima , Amyloidosis ya Mtima, Kuika Mapuloteni, Matenda a Mtima, Zizindikiro za Matenda a Mtima, Chithandizo cha Amyloidosis, AL Amyloidosis, ATTR Amyloidosis, Matenda a Mtima