Kodi mukufunanso kudziwa za matenda osowawa? Tiyeni tikambirane za EGPA (Eosinophilic Granulomatosis With Polyangiitis) mwachidule!

Kodi mumakhala ndi mphumu pafupipafupi? Kapena ndinu munthu amene amadwala ziwengo zoopsa? Ndiye zomwe ndikunena zingakhale zofunika kwambiri kwa inu. Chifukwa lero tikambirana za matenda achilendo komanso osowa kwambiri omwe nthawi zina amagwirizanitsidwa ndi matenda otere. Matendawa amatchedwa EGPA . Poyamba ankadziwika kuti Churg-Strauss syndrome . Ngati dzinalo likuwoneka lalitali pang'ono, musadandaule, tiyeni timvetse mosavuta.

Kodi EGPA (Eosinophilic Granulomatosis With Polyangiitis) ndi chiyani?

Dzina lalitali ili likhoza kukhala losokoneza pang'ono, koma tiyeni tiligaŵanitse m'zigawo zina ndikulimvetsa. Kenako zimakhala zosavuta.

1. Kusayenda bwino kwa magazi

Mwachidule, eosinophilic imatanthauza kuti muli ndi chiwerengero choposa chachibadwa cha maselo oyera a m'magazi otchedwa eosinophils m'magazi mwanu. Taganizirani izi motere, ma eosinophils ali ngati alonda ang'onoang'ono m'thupi lathu, amathandiza chitetezo chathu chamthupi. Koma mwa munthu amene ali ndi EGPA, chiwerengero cha ma eosinophils nthawi zina chingawirikize kawiri, kapena kupitirira, chiwerengero chachibadwa. Izi zikutanthauza kuti chitetezo chamthupi chikugwira ntchito nthawi yayitali.

2. Granulomatosis

Matenda a Granulomatosis ndi matenda omwe maselo a chitetezo chamthupi amapanga tinthu tating'onoting'ono m'thupi la munthu pamene pali kutupa, kapena kutupa. Timati tinthu tating'onoting'ono timeneti ndi granulomas . Iyi ndi ntchito ya chitetezo chamthupi. Zili ngati kuzungulira malo ovuta ndikuyesera kuwaletsa kuti asafalikire.

3. Polyangiitis

Polyangiitis ndi kutupa kwa mitsempha yambiri yamagazi m'thupi lanu kwa nthawi yayitali, makamaka yaying'ono ndi yapakatikati (poly amatanthauza yambiri). Ndi matenda omwe amapezeka m'gulu lalikulu la matenda otchedwa vasculitis . Angiitis ndi dzina lina la vasculitis.

Choncho, zonsezi zikaphatikizidwa, EGPA ndi vuto losowa lomwe limayamba chifukwa cha kusagwira bwino ntchito kwa chitetezo chamthupi chomwe chimayamba ndi mphumu kapena ziwengo, zomwe zimapangitsa kuti ma eosinophils achuluke, mapangidwe a granulomas, ndipo pamapeto pake kutupa kwa mitsempha yamagazi.

Kodi vuto la EGPA limeneli limakhudza bwanji thupi langa?

Pakakhala kutupa kosalekeza kwa mitsempha yamagazi, kotchedwa vasculitis , makoma a mitsempha yamagazi amafooka. Izi zingayambitse kutambasuka ndi kutupa ngati baluni - zomwe timazitcha aneurysm . Kapena, mitsempha yamagazi yofooka iyi imatha kuphulika ndikutuluka magazi m'thupi.

Chinanso n'chakuti kutupa kungayambitse kutupa kwa mitsempha ya magazi, kukhala ndi zipsera, komanso kutsekeka mkati. Ndiye chimachitika ndi chiyani? Kuyenda kwa magazi kumasokonekera, nthawi zina kumatsekeka kwathunthu. Izi zimalepheretsa thupi mpweya ndi michere yomwe limafunikira kuti ligwire bwino ntchito.

Popeza polyangiitis imakhudza mitsempha yaing'ono yamagazi m'thupi lathu lonse, zizindikiro zimatha kuchitika kulikonse m'thupi. Komabe, nthawi zambiri imakhudza njira yopumira , kutanthauza mapapo. Ingakhudzenso impso, matumbo, mtima, ndi mitsempha.

Kodi zizindikiro za EGPA ndi ziti?

Matendawa otchedwa EGPA saonekera mwadzidzidzi. Zizindikiro zake zimawonekera pang'onopang'ono, kwa zaka zambiri, m'magawo angapo. Tiyeni tiwone magawo amenewo.

Gawo 1: Zizindikiro zodziwika bwino zomwe zimapezeka pachiyambi

Pa nthawi imeneyi mungamve zinthu monga:

• Mphumu yoyambira kwa akuluakulu: Ngakhale munthu amene sanakhalepo ndi mphumu kale akhoza kuyamba mphumu yatsopano yokhala ndi zizindikiro monga kutsokomola, kupuma movutikira, komanso kupuma movutikira.
• Nthenda ya udzu: Kuthimula, kuyabwa kwa mphuno, ndi kutsekeka kwa mphuno kungapitirire.
• Matenda a Sinusitis Osatha: Kumva kulemera ndi kupanikizika m'mutu chifukwa cha kutupa kwa maenje a sinus.
• Ma polyps a m'mphuno: Matuza ang'onoang'ono, osayambitsa khansa omwe amapangika mkati mwa mphuno.
• Kupweteka kwa thupi lonse: Kumva ngati mafupa anu akupweteka, minofu yanu ikupweteka.
• Malungo, kutopa, ndi kutopa: Kungomva kupweteka komanso kutopa.

Gawo Lachiwiri: Zizindikiro za Kuwonjezeka kwa Ma Eosinophils

Pamene matendawa akupitirira, ma eosinophils omwe tidalankhula amayamba kusonkhana m'maselo osiyanasiyana a thupi, makamaka m'mapapo. Izi zimatchedwa eosinophilic infiltrates . Izi zingayambitse zizindikiro zatsopano:

• Kupweteka pachifuwa ndi kuvutika kupuma kwambiri.
• Kugunda kwa mtima.
• Ziphuphu pakhungu kapena mawanga.
• Zizindikiro za m'mimba: zinthu monga kupweteka m'mimba, kutsegula m'mimba.

Gawo Lachitatu: Zizindikiro za Vasculitis

Vasculitis , yomwe ndi kutupa kwa mitsempha yamagazi, nthawi zambiri imakhala gawo lomaliza la matendawa. Izi zingayambitse zizindikiro zoopsa monga:

• Zizindikiro za kutuluka magazi mkati: Magazi m'chimbudzi, magazi m'chifuwa, ndi mawanga omwe asintha mtundu pansi pa khungu.
• Zizindikiro zomwe zimachitika chifukwa cha kutupa kapena kuwonongeka kwa mitsempha: dzanzi m'miyendo, kumva kuwawa, kufooka, kupweteka kwa mitsempha.
• Zizindikiro za matenda a mtima: kugunda kwa mtima kosakhazikika, kukomoka, kupuma movutikira, kutupa (edema) .

Ichi ndi polyangiitis.Matendawa angakhudzenso impso, koma nthawi zambiri amapezeka popanda zizindikiro.

Nchifukwa chiyani EGPA iyi imayamba? Chifukwa chake n'chiyani?

Ndipotu, EGPA iyi imayamba chifukwa cha kulephera kwa chitetezo chathu chamthupi . Tangoganizirani, zomwe zikuchitika apa zikufanana ndi asilikali omwe akuyenera kuteteza matupi athu, kuukira matupi awo. Kutupa m'mitsempha yanu yamagazi, kupangika kwa ma granuloma omwe tidakambirana kale, kuchuluka kwa ma eosinophils - zonsezi zimachitika chifukwa chitetezo chamthupi chimakhala chogwira ntchito mopitirira muyeso ndipo sichichitapo kanthu molakwika.

Komabe, ofufuza akadali osadziwa chifukwa chake izi zimachitika.

Matenda omwe amakhudza kutupa kwa chitetezo chamthupi kwa nthawi yayitali nthawi zina amatchedwa matenda a autoimmune . Chinthu chofala kwambiri pa matenda otere ndichakuti ma antibodies amapangidwa motsutsana ndi maselo ena m'thupi. Ichi chikhoza kukhala chifukwa chimodzi cha EGPA.

Ofufuza aphatikiza matenda ena angapo monga EGPA m'gulu limodzi. Onsewa ali ndi antibody yapadera yotchedwa ANCA . Gululi limatchedwa ANCA-associated vasculitis (AAV) . Komabe, 40% yokha ya anthu omwe ali ndi EGPA ali ndi antibody iyi ya ANCA. Izi zikutanthauza kuti sichoncho chokha chomwe chimayambitsa matendawa.

Kuwonjezeka kwa ma eosinophils kumawoneka ngati chifukwa china cha zizindikiro zomwe zimayamba vasculitis isanachitike. Ma eosinophils akamasonkhana m'minofu, amayambitsa kutupa ndikuwononga minofu. Kuwonjezeka kwa ma eosinophils kumeneku kumagwirizanitsidwa kwambiri ndi mphumu ndi ziwengo. Anthu omwe ali ndi mphumu ali ndi mwayi wokwana 34 wokhala ndi EGPA kuposa ena.

Kodi ndi mavuto aakulu ati omwe angabwere chifukwa cha EGPA?

Ngati matendawa sanachiritsidwe bwino, akhoza kuwononga ziwalo ndi minofu yanu kwambiri. Nazi zitsanzo zingapo:

• Kutuluka kwa madzi m'mapapo: Kuchulukana kwa madzi m'mapapo.
• Kutuluka kwa madzi m'thupi: Kuchulukana kwa madzi m'thupi mozungulira mtima.
• Matenda a mitsempha ya m'mitsempha: Kuwonongeka kwa mitsempha ya m'mitsempha.
• Matenda a impso osatha.
• Kulephera kupuma nthawi zonse.
• Kulephera kwa mtima kotsekeka.

Chofunika kwambiri ndi kuzindikira ndi kuchiza matendawa mavuto ngati amenewa asanachitike.

Kodi EGPA imapezedwa bwanji?

Kuzindikira EGPA kungakhale kovuta pang'ono, chifukwa mungakhale ndi zizindikiro zosiyanasiyana nthawi zosiyanasiyana. Zingatenge nthawi kuti inu ndi dokotala wanu mugwirizane. Komanso, zizindikiro za EGPA zitha kufanana ndi zizindikiro za matenda ena ambiri.

Komabe, dokotala angaganize kuti EGPA ndi yoopsa ngati muli ndi matenda enaake awa:

• Mbiri ya mphumu kapena chimfine.
• Kuyezetsa magazi kumasonyeza kuchuluka kwa eosinophils m'magazi.
• Mayeso owonetsa zithunzi amasonyeza umboni wa eosinophilic infiltrates.
• Kufufuza kwa minofu kumasonyeza umboni wa granulomas ndi/kapena vasculitis.

Kodi chithandizo cha matenda a EGPA amenewa ndi chiyani? Palibe choopa, sichoncho?

Inde, pali chithandizo cha vutoli chotchedwa EGPA. Musadandaule! Chofunika kwambiri ndikupeza matendawa mwachangu ndikuyamba kulandira chithandizo.

Kawirikawiri, chinthu choyamba kuchita ndikupereka mlingo waukulu wa corticosteroids kuti muchepetse kutupa ndi ma eosinophils . Mankhwalawa akamawongolera zizindikiro, timati matendawa atha . Izi zikutanthauza kuti zizindikirozo zatha. Kenako dokotala amachepetsa pang'onopang'ono mlingo wa mankhwalawo. Anthu ambiri amafunika kupitiriza kumwa corticosteroids pa mlingo wochepa kuti apitirizebe kuchira.

Nthawi zina corticosteroids yokha singakhale yokwanira, kapena mungafunike kupitiriza kumwa mankhwala ambiri a corticosteroid kuti mupewe zotsatirapo zake. Zikatero, dokotala wanu angakupatseni mankhwala ena.

Mankhwala ena awa akuphatikizapo mankhwala oletsa chitetezo chamthupi ndi mankhwala achilengedwe . Mepolizumab ndiye mankhwala oyamba achilengedwe ovomerezeka ndi US Food and Drug Administration (FDA) a EGPA. Mankhwala ena achilengedwe , benralizumab, awonetsanso zotsatira zabwino m'mayesero azachipatala aposachedwa. Kafukufuku watsopanoyu watsegula njira zatsopano zothandizira anthu omwe ali ndi EGPA.

Kodi moyo udzakhala bwanji ndi EGPA? (Zomwe zidzachitike mtsogolo)

EGPA ndi matenda ochiritsika, koma osachiritsika . Anthu ambiri amatha kuwongolera zizindikiro zawo ndi mankhwala ndikuchira. Izi zikutanthauza kuti zizindikirozo zimatha. Komabe, ngati musiya chithandizo, zizindikirozo zimatha kubwereranso (kubwereranso) . Choncho dokotala wanu adzayang'anira matenda anu kwa moyo wanu wonse.

Kodi n'zotheka kukhala ndi moyo wautali ndi EGPA?

Ndi chithandizo chogwira mtima, mutha kukhala ndi moyo wabwinobwino ndi EGPA. Mu magawo apamwamba a matendawa, zovuta monga kulephera kwa ziwalo zingakhudze moyo wanu. Komabe, chithandizo nthawi zambiri chimatha kuyimitsa kapena kusintha kulephera kwa ziwalo. Ndi chithandizo, kuchuluka kwa moyo wa EGPA kwa zaka zisanu ndi koposa 80%.

Kodi pali njira yopewera kuti EGPA isakule?

Popeza sitikudziwabe chifukwa chake EGPA imayamba, sitikudziwa momwe tingapewere. Komabe, kuzindikirika msanga ndi chithandizo kungathandize kupewa vutoli kuti lisakule kwambiri . Mwa kusamala kwambiri zizindikiro zanu ndikuziuza dokotala wanu, mungathandize kupewa mavuto aakulu a EGPA.

Kodi ndiyenera kudzisamalira bwanji ndikakhala ndi EGPA?

Funso ili ndi lofunika kwambiri. Mankhwala operekedwa a EGPA, makamaka corticosteroids ndi immunosuppressants , amachepetsa chitetezo chamthupi chanu . Izi zikutanthauza kuti mumakhala ndi mwayi wodwala kwambiri, ndipo ngati mutadwala, zimatenga nthawi yayitali kuti muchire.

• Choncho, muyenera kusamala kwambiri kuposa nthawi zonse kuti mupewe matenda ofala . Samalani kwambiri mukapita kumalo odzaza anthu komanso malo omwe kuli odwala.
• Sambani m'manja mwanu bwino nthawi zambiri.
• Idyani zakudya zabwino.
• Tengani nthawi yokwanira yogona.
• Mankhwala a corticosteroid akamwedwa kwa nthawi yayitali, zotsatirapo zake monga kuchuluka kwa shuga m'magazi (monga matenda a shuga), kunenepa kwambiri, kuonda mafupa (monga osteoporosis), ndi kusintha kwa malingaliro zimatha kuchitika . Lankhulani ndi dokotala wanu za izi ndikuphunzira momwe mungathanirane nazo. Uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro zatsopano.

Pomaliza, zinthu zoti muzikumbukira (Uthenga Wopita Nawo Kunyumba)

Eosinophilic granulomatosis yokhala ndi polyangiitis (EGPA) ndi mtundu wa vasculitis, ndipo ndi yosowa kwambiri komanso yovuta kuizindikira. Mutha kukhala ndi zizindikiro zosiyanasiyana zomwe sizikugwirizana. Zingatenge nthawi kuti dokotala wanu adziwe tanthauzo lake ndikusankha chithandizo chomwe mukufuna.

Nkhani yabwino ndi yakuti EGPA ikhoza kusamalidwa bwino ndi chithandizo . Komabe, muyenera kusintha zina pa moyo wanu watsiku ndi tsiku. Kukhala ndi matenda osatha omwe anthu ambiri sanamvepo nthawi zina kumatha kusungulumwa. Nthawi ngati izi, zingakhale zothandiza kulumikizana ndi mabungwe othandizira a ena omwe ali ndi EGPA. Musataye mtima, tsatirani upangiri woyenera wachipatala, ndipo inunso mutha kukhala ndi moyo wabwino.

EGPA , Churg-Strauss syndrome, eosinophilic granulomatosis polyangiitis, mphumu, ziwengo, vasculitis, eosinophil