Kodi mwana wanu amadwala malungo pafupipafupi? Kodi mwina chifukwa cha matenda a SAID (Systemic Autoinflammatory Diseases)?

Kodi mwana wanu amadwala malungo nthawi zambiri masiku ano? Mukangoganiza kuti mwachira, kodi amayambiranso kutupa? Nthawi zina chifukwa cha izi sichingakhale kachilombo kapena mabakiteriya wamba. Lero tikambirana za vuto lomwe ndi lovuta pang'ono, koma ndikofunikira kwambiri kudziwa. Izi zimatchedwa SAIDs, zomwe zikutanthauza Matenda Odziyimira Pawokha . Kale, izi zimatchedwa `(Periodic Fever Syndromes)` kapena `(Recurrent Fever Syndromes)`.

Kodi ma SAID ndi chiyani? Tiyeni timvetse mosavuta.

Mwachidule, ma SAID ndi gulu la matenda omwe amayamba chifukwa cha kulephera kugwira ntchito bwino kapena vuto la chitetezo chamthupi chathu . Ichi ndichifukwa chake mwana amatha kutentha thupi pafupipafupi ngakhale atakhala ndi matenda (monga kachilombo kapena mabakiteriya).

Chofunika kwambiri ndichakuti matenda awa otchedwa SAIDs asasokonezedwe ndi `(Matenda Odziteteza Kuthupi)` (monga `(Rheumatoid Arthritis)` kapena `(Lupus)` omwe mwina mudamvapo. Mu matenda a `(Autoimmune)`, chifukwa cha cholakwika china mu `(chitetezo chamthupi chosinthika)` cha thupi lathu, dongosolo limenelo limaukira maselo ake athanzi. Koma mu SAIDs, chinthu china chosiyana chimachitika.

Matenda a SAID ndi osowa kwambiri kuposa matenda odziteteza okha. Nthawi zambiri amakhala obadwa nawo ndipo amayamba chifukwa cha kusintha kwa majini .

Kawirikawiri, koma nthawi zina, zizindikiro za SAID zimayamba mwana ali wamng'ono kwambiri, kaya ali khanda kapena mwana wakhanda . Mwana wanu akhoza kukhala ndi "nthawi" za malungo ndi zizindikiro zina ndi vutoli. Pakati pa nthawi imeneyi, mwana wanu sangasonyeze zizindikiro konse. Ngakhale kuti palibe mankhwala a SAID, nthawi zambiri pamakhala mankhwala othandizira kuwongolera zizindikiro za mwana wanu.

Kodi mitundu ikuluikulu ya SAIDs ndi iti?

Ofufuza apeza mitundu pafupifupi 60 ya ma SAID, ndipo atsopano akupezedwabe. Nazi zina mwa mitundu yodziwika bwino ya ma SAID:

• Matenda a m'banja a Mediterranean (FMF): Uwu ndi matenda ofala kwambiri omwe amabadwa nawo m'majini ndipo amabwerezabwereza. Angayambitse kutupa kowawa m'mimba, pachifuwa, ndi m'malo olumikizirana mafupa mwa ana.
• Malungo a nthawi ndi nthawi, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Izi nthawi zambiri zimayamba mwa ana aang'ono asanakwanitse zaka 4. Nthawi zina, vutoli limatha kuchira lokha akakwanitsa zaka 10.
• Matenda a tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Izi zitha kuchitika ali mwana, wachinyamata, kapena ngakhale munthu wamkulu.
• Kusowa kwa Mevalonate kinase (MKD): Poyamba kunkatchedwa ``Hyper-IgD syndrome'', nthawi zambiri izi zimayamba mwana asanakwanitse chaka chimodzi.
• Matenda otupa omwe amagwirizana ndi NLRP3:Izi kale zinkatchedwa `(Cryopyrin-associated periodic syndromes - CAPS)`. Pali mitundu ina itatu mkati mwa izi.
• Matenda a Adult-onset Still's (AOSD): Monga momwe dzinalo likusonyezera, uwu ndi mtundu wa matenda a ubwana omwe amayamba chifukwa cha "Systemic Juvenile Idiopathic Arthritis (JIA)" omwe amayamba chifukwa cha akuluakulu.
• Matenda a granulomatous ogwirizana ndi NOD-2 (Blau syndrome): Izi nthawi zambiri zimayamba asanakwanitse zaka 4. Zimakhudza kwambiri khungu, maso, ndi mafupa a mwana.

Kodi zizindikiro za SAIDs ndi ziti?

Zizindikiro za SAID nthawi zambiri zimayamba ali ana. Chizindikiro chachikulu komanso chofala kwambiri ndi kutentha thupi nthawi ndi nthawi . Pa nthawi ya kutentha thupi, anthu nthawi zambiri amakhala athanzi ndipo alibe zizindikiro. Komabe, pakhoza kukhala zizindikiro zina zomwe zimakhala zapadera pa mtundu uliwonse wa SAID. Tiyeni tiwone zomwe zili:

• FMF: Izi zingayambitse kutupa ndi kupweteka kwambiri m'mimba mwa mwana, pachifuwa, ndi m'malo olumikizirana mafupa . Pakhoza kukhalanso ziphuphu m'miyendo kapena m'mapazi.
• PFAPA: Izi zingayambitse kupweteka pakhosi, zilonda pakamwa, komanso kutupa kwa ma lymph nodes pakhosi . Mwachitsanzo, ngati mwana wanu akuwonetsa zizindikiro monga tonsillitis yobwerezabwereza ndi zilonda pakamwa, ikhoza kukhala PFAPA.
• MISAMBO: Izi zingayambitse kuzizira ndi kupweteka kwa minofu m'thupi/m'thupi ndi m'manja . Zingayambitsenso kutupa kofiira komwe kumayamba m'manja ndi m'miyendo ndikufalikira m'thupi lonse.
• MKD: Izi zingayambitse zizindikiro monga kuzizira, mutu, kupweteka m'mimba, kusowa chilakolako cha chakudya, ndi zizindikiro zofanana ndi chimfine .
• Matenda a NLRP3: Matendawa angayambitse ziphuphu pakhungu, mutu, kufooka, kupweteka kwa mafupa, komanso maso a pinki/conjunctivitis .
• AOSD: Iyi ndi matenda omwe amadziwika ndi ziphuphu pakhungu, kupweteka kwa mafupa, ndi kupweteka kwa minofu . Anthu ena amathanso kupweteka pakhosi, kupweteka m'mimba, kutopa, komanso kusasangalala.
• Matenda a Blau: Izi zingayambitse zilonda pakhungu pa manja, miyendo, kapena pakati pa msambo wa mwana wanu . Zingayambitsenso kupweteka kwa mafupa ndi kupweteka kwa maso .

Kodi zifukwa za SAIDs ndi ziti?

Ma SAID ambiri ndi matenda a majini . Izi zikutanthauza kuti, kusintha kwa majini enaake (variant) mu jini inayake kumayambitsa matenda aliwonse. Tangoganizani kuti thupi lathu lili ndi malangizo (majini) omwe amatiuza momwe tingachitire ntchito iliyonse, kotero ngati chilembo chimodzi m'bukuli chili cholakwika, chingayambitse ntchito yotsalayo kulakwika.

Nazi mitundu ikuluikulu ya ma SAID ndi majini okhudzana nawo:

• FMF:Jini `MEFV` ndi yomwe imapereka malangizo a momwe mungapangire puloteni `(pyrin)`.
• PFAPA: Chifukwa chenicheni cha izi sichinadziwikebe .
• MISAMBO: Jini `TNFRSF1A`. Izi zimalangiza kupanga puloteni yotchedwa `(cholandirira chotupa cha necrosis - TNFR)`.
• MDK: Jini yotchedwa `MVK`. Izi zimalangiza kupanga puloteni yotchedwa `(mevalonic kinase)`.
• Matenda a NLRP3: Jini `NLRP3`. Izi zimalangiza kupanga puloteni yotchedwa `(cryopyrin)`.
• AOSD: Chifukwa chenicheni cha izi sichinapezekebe .
• Matenda a Blau: Jini `NOD2`. Izi zimalangiza kupanga puloteni yotchedwa `(NOD2)`.

Ndikofunikira kumvetsetsa kuti izi zikachitika chifukwa cha majini, si vuto la makolo. Izi ndi njira zovuta kwambiri zamoyo.

Mavuto omwe amabwera chifukwa cha SAIDs

Ndikofunikira kwambiri kupeza chithandizo choyenera cha matenda amenewa. Chifukwa, ngati kutupa kukupitirira m'thupi, kungayambitse matenda otchedwa `(Amyloidosis). `(Amyloidosis)` ndi kuchuluka kwa mapuloteni m'impso . Izi zingayambitse kuwonongeka kosatha kwa impso . Chifukwa chake, ngati pali zizindikiro, ndikofunikira kufunafuna upangiri wa dokotala nthawi yomweyo.

Kodi ma SAID amadziwika bwanji?

Kunena zoona, kuzindikira matenda a SAID kungakhale kovuta chifukwa zizindikiro zake zimatha kufanana ndi za matenda ena akuluakulu, monga lupus kapena lymphoma. Chifukwa chake, ndikofunikira kuonana ndi dokotala yemwe ali ndi maphunziro apadera a matenda otupa (katswiri wa nyamakazi) kuti adziwe bwino ndikusamalira vuto la mwana wanu.

Dokotala wa nyamakazi wa mwana wanu adzagwiritsa ntchito zinthu zingapo kuti adziwe matenda a SAID. Iye adzafunsa za zizindikiro za mwana wanu komanso ngati pali aliyense m'banja mwanu amene wakhalapo ndi matendawa (mbiri ya banja). Dokotala angaganize kuti mwana wanu ali ndi matenda a Periodic Fever ngati:

• Ngati mumadwala malungo pafupipafupi
• Ngati wina m'banjamo ali ndi mbiri ya malungo nthawi ndi nthawi ngati awa
• Ngati muli m'gulu la anthu omwe ali pachiwopsezo cha matenda otere

Ndi mayeso ati omwe amagwiritsidwa ntchito?

Dokotala angakulangizeni mayeso angapo kuti atsimikizire matendawa. Izi zingaphatikizepo:

• Mayeso a labu: Mayeso monga `(C-reactive protein - CRP)` ndi `(Complete Blood Count - CBC)` amatha kuwona kutupa m'thupi. Mayesowa amakhala `(positive)` pamene pali malungo, ndipo amabwerera ku miyezo yachibadwa malungo akatha.
• Kuyesa mkodzo:Kuyezetsa mapuloteni a mkodzo kungachitike kuti muwone ngati pali mapuloteni ambiri mu mkodzo. Mu MKD, kuyezetsa mkodzo wa ma organic acid kudzawonetsa kuchuluka kwa mevalonic acid.
• Kuyesa majini: Izi zitha kuyang'ana mitundu yosiyanasiyana ya majini. Komabe, ana ena omwe ali ndi SAIDs sangapeze mtundu wa majiniwo. Chifukwa chake, ngakhale zotsatira za mayeso zili ``negative``, kuthekera kwa SAID sikungathetsedwe.

Kodi ma SAID amachiritsidwa bwanji?

Chithandizo cha SAIDs chimasiyana malinga ndi mtundu ndi kuopsa kwa matendawa . Ngakhale kuti matendawa sangachiritsidwe kwathunthu, zizindikiro za mwana zimatha kuchepetsedwa bwino pogwiritsa ntchito mankhwala . Mwachitsanzo, ngati mwana wanu akudwala chimfine kangapo pachaka, mankhwala ochepetsa ululu ndi mankhwala oletsa kutupa (NSAIDs) nthawi zambiri amatha kuwongolera zizindikirozo. Komabe, ngati matendawa ndi oopsa kwambiri, dokotala angakupatseni njira zina zochiritsira.

Nazi njira zina zochiritsira:

• FMF: Izi zitha kuchiritsidwa ndi mankhwala otchedwa `(Colchicine)` kuti muchepetse kutupa. Ngati simungathe kumwa `(Colchicine)`, mutha kuyesa mankhwala amtundu wa `(Biologic)` otchedwa `(Canakinumab)`.
• PFAPA: Kutupa kwa PFAPA kungachedwetsedwe popereka mankhwala otchedwa steroids (nthawi zambiri prednisone). Ana ena atha kuchepetsa zizindikiro zawo pogwiritsa ntchito cimetidine, mankhwala omwe amagwiritsidwa ntchito pochiza zilonda zam'mimba.
• MISALA: Mankhwalawa `(Canakinumab)` ndi othandiza kwambiri pa MISALA. Komanso, mankhwala oletsa kutupa monga `(Glucocorticoids)` angathandizenso kuchepetsa zizindikiro.
• MKD: `(Canakinumab)` ndi njira yabwino yochizira MKD. Kugwiritsa ntchito `(NSAIDs)` kapena `(Steroids)` panthawi ya malungo kungakhalenso kothandiza.
• Matenda a NLRP3: Mankhwala ena oletsa chitetezo chamthupi monga Canakinumab ndi Rilonacept, Anakinra, ndi othandiza pochiza matenda a NLRP3.
• AOSD: Mitundu yosiyanasiyana ya mankhwala oletsa kutupa imagwiritsidwa ntchito pa AOSD. Izi zikuphatikizapo `(Steroids)`, `(Matenda Oletsa Kutupa kwa Rheumatic - DMARDs)`, ndi `(Biologics)`.
• Matenda a Blau: Kutengera ndi zizindikiro za mwana, mankhwala oletsa chitetezo chamthupi, zoletsa za tumor necrosis factor (TNF), ndi/kapena mankhwala a maso opangidwa ndi khungu angayesedwe.

Kodi matenda a SAID amachira okha?

Ma SAID ena amatha kukhala moyo wonse . Ena amatha kukhala kwa zaka zingapo ndikuchira ndi ukalamba. Ngakhale kuti matenda ena amakhala a moyo wonse, kuchuluka kwa malungo kumatha kuchepa pakapita nthawi ndipo zizindikiro zimatha kuchepa . Dokotala wanu angakupatseni tsatanetsatane wa matenda enieni a mwana wanu.

Kusamalira mwana yemwe ali ndi SAID kungakhale kovuta. Mwina munachitapo SAID nokha, koma mungagwiritse ntchito zomwe mwakumana nazo kuti muthandize kusamalira mwana wanu ndikumuthandiza kuthana ndi vutoli kwa moyo wonse.

Chofunika kwambiri ndikupempha chithandizo kuchokera kwa akatswiri omwe amadziwa bwino zovuta za SAIDs. Angathandize kuchepetsa zizindikiro za mwana wanu ndikumuthandiza kukhala ndi ubwana wabwino kwambiri.

Zinthu zofunika kwambiri kukumbukira (Uthenga Wopita Nawo Kunyumba)

Chabwino, tiyeni tifotokoze mwachidule zina mwa zinthu zomwe muyenera kukumbukira kuchokera pa zomwe takambirana.

• Ngati mwana wanu ali ndi malungo pafupipafupi komanso osadziwikiratu , lankhulani ndi dokotala za izi. Izi zitha kukhala chizindikiro cha SAID.
• Ma SAID ndi vuto la chitetezo chamthupi chobadwa nacho , osati matenda opatsirana wamba.
• Izi ndi zosiyana ndi matenda a "Autoimmune" .
• Nthawi zambiri, izi zimachitika chifukwa cha majini .
• Ndikofunikira kupita kwa dokotala wa matenda a rheumatism kuti akapeze matenda oyenera.
• Chithandizo chingathandize kuchepetsa zizindikiro bwino .
• Chithandizo choyambirira n'chofunika kwambiri kuti impso zisawonongeke.

Ngati muli ndi mafunso ena okhudza izi, musaope kufunsa dokotala wa banja lanu kapena dokotala wa ana. Adzakuthandizani kwambiri.

Ma SAID, malungo obadwa nawo, malungo obwerezabwereza, malungo mwa ana, chitetezo chamthupi, matenda a majini, katswiri wa nyamakazi