Kodi nthawi zambiri mumakhala ndi gastritis? Kapena mumamva kutentha pachifuwa kapena pakhosi panu? Nthawi zina ngati izi, ambiri a ife timazolowera kumwa mankhwala kuchokera ku pharmacy. Nthawi zambiri, mtundu wa mankhwala omwe amatengedwa mwanjira imeneyi ndi Proton Pump Inhibitors, kapena monga momwe timatchulira, "mankhwala a gastritis". Koma, kodi tikudziwa bwino lomwe kuti mankhwalawa ndi otani, momwe amagwirira ntchito, komanso nthawi yayitali bwanji yomwe ayenera kumwedwa? Lero, tikambirana za izi.
Kodi ma proton pump inhibitors (PPIs) awa ndi ati?
Mwachidule, iyi ndi gulu la mankhwala omwe amachepetsa acidity, kapena acid, m'mimba mwanu. Tsopano mwina mukuganiza kuti, "Kodi sikwabwino kukhala ndi acid m'mimba?" Asidi m'mimba ndi chinthu chomwe sitingathe kukhala popanda. Chimatithandiza kugaya chakudya chomwe timadya komanso chimapha majeremusi owopsa omwe amalowa m'mimba.
Koma vuto limayamba pamene asidiyu achuluka kwambiri, kapena akapita kumene sayenera kukhala, monga m'mero. Pamenepo ndi pomwe mavuto monga kutentha pamtima ndi zilonda zam'mimba zimayamba. Pamenepo ndi pomwe mankhwala otchedwa PPIs amatithandiza.
Kodi matenda akuluakulu omwe amachiritsidwa ndi ma PPI ndi ati?
Ma PPI amagwiritsidwa ntchito pochiza matenda ambiri okhudzana ndi asidi m'mimba. Tiyeni tiwone zazikulu.
| Matenda | Mwachidule, zomwe zimachitika ndi |
|---|---|
| GERD / Chronic Acid Reflux | Izi ndi zomwe nthawi zambiri timazitcha kutentha pamtima. Asidi wa m'mimba akamakwera m'mimba amatha kuwononga m'mimba (erosive esophagitis) . Ma PPI amachepetsa asidi wa m'mimba ndikulola kuti kuwonongekako kuchiritsidwe. |
| Zilonda Zam'mimba (Zilonda Zam'mimba ndi Zam'mimba Zing'onozing'ono) | Asidi wa m'mimba amatha kuwononga zilonda zoteteza m'mimba kapena m'matumbo ang'onoang'ono, zomwe zimayambitsa zilonda. Zilondazi zimathanso kukula pogwiritsa ntchito mankhwala ena ochepetsa ululu (NSAIDs) . Ma PPI angathandize kuchiritsa zilondazi. |
| Matenda a H. pylori | Iyi ndi bakiteriya yomwe imayambitsa zilonda zam'mimba. Ma PPI amaperekedwa pamodzi ndi maantibayotiki kuti aphe mabakiteriyawa. Izi zimachepetsa acidity m'mimba, zomwe zimathandiza kuti maantibayotiki azigwira ntchito bwino. |
| Matenda a Zollinger-Ellison | Imeneyi ndi vuto losowa kwambiri. Zotupa zina m'thupi zimapanga mahomoni omwe amachititsa kuti m'mimba mutulutse asidi wambiri. Ma PPI amatha kuwongolera vutoli. |
Kodi mankhwalawa amagwira ntchito bwanji?
Izi n'zosavuta kuzimvetsa. Tangoganizani kuti pali 'mapampu' ang'onoang'ono m'mimba mwanu omwe amapanga asidi. Mwasayansi, awa amatchedwa mapampu a hydrogen-potassium ATPase. Mwachidule, ndi "mapampu a proton."
Tsopano, chomwe mankhwala a PPI awa amachita ndi 'kuletsa' ntchito ya mapampu opanga asidi, ndiko kuti, amawaletsa. Zili ngati kuzimitsa switch ya mota yamadzi.
Koma izi sizimaletsa kupanga asidi m'mimba. Ngati mutenga PPI kwa masiku pafupifupi 5 motsatizana, kupanga asidi m'mimba kudzachepa ndi pafupifupi 65%. 35% yotsalayo ndi yokwanira kugaya chakudya. Choncho palibe chodetsa nkhawa.
Kodi mitundu yodziwika bwino ya ma PPI ndi iti?
Pali mitundu ingapo ya ma PPI. Ena angagulidwe pa malo ogulitsira mankhwala (OTC) ku pharmacy popanda kulembedwa ndi dokotala, pomwe ena amafunika kulembedwa ndi dokotala.
| Dzina lachibadwa | Mayina Odziwika a Ma Brand |
|---|---|
| Mitundu yomwe ilipo ndi kapena popanda mankhwala a dokotala | |
| Esomeprazole | Nexium® |
| Lansoprazole | Prevacid® |
| Omeprazole | Prilosec® |
| Mitundu imapezeka kokha pa mankhwala olembedwa ndi dokotala | |
| Dexlansoprazole | Dexilant® |
| Pantoprazole | Protonix® |
| Rabeprazole | AcipHex® |
Kodi izi ziyenera kugwiritsidwa ntchito bwanji?
Mankhwalawa amapezeka mu mawonekedwe a kapisozi kapena mapiritsi. Kwa iwo omwe amavutika kumeza mapiritsi, makapisozi ena amatha kusakanikirana ndi chinthu chonga applesauce kuti atenge ufawo.
Chofunika kwambiri ndi nthawi yoti mumwere mankhwala. Ma PPI ambiri amagwira ntchito bwino kwambiri akamwedwa pamimba yopanda kanthu . Nthawi zambiri amalimbikitsidwa kumwa kwa mphindi 30 mpaka ola limodzi musanadye chakudya cham'mawa. Chifukwa chake ndi chakuti izi zimapatsa mankhwalawo nthawi yoti ayambe kuyamwa ndikuyamba kugwira ntchito, asidi m'mimba musanayambe kudya.
Kodi ndiyenera kugula ndalama zingati?
Izi ndi zomwe dokotala wanu angasankhe. Anthu ena angafunike kumwa piritsi limodzi m'mawa. Ena angauzidwe kuti amwe limodzi m'mawa ndi lina usiku. Zimatengera matenda anu. Chifukwa chake, ndikofunikira kwambiri kutsatira malangizo a dokotala wanu.
Kodi ma PPI amatenga nthawi yayitali bwanji kuti agwire ntchito?
Mankhwala awa si othandiza nthawi yomweyo. Zingatenge masiku 1 mpaka 4 kuti mumve zotsatira zonse za mankhwalawo.
Tangoganizirani kuti mwadya chakudya chokometsera ndipo mwadzidzidzi mwamva kutentha pachifuwa panu. Nthawi ngati zimenezi, mankhwala oletsa asidi (monga Digene) kapena histamine (H2) blocker (monga Famotidine) angapereke mpumulo mwachangu kuposa PPI. Komabe, zotsatira zake zimatha msanga.
Ma PPI ndi mankhwala omwe amapereka zotsatira zabwino kwa nthawi yayitali, oyenera anthu omwe ali ndi vuto la asidi nthawi yayitali.
Kodi pali zotsatirapo zilizonse pa izi?
Anthu ambiri sakumana ndi zotsatirapo zilizonse zoyipa, koma monga mankhwala ena aliwonse, anthu ena amatha kukhala ndi zotsatirapo zazing'ono.
- Kuwawa kwam'mimba
- Kudzimbidwa
- Kutsegula m'mimba
- Chizungulire
- Pakamwa pouma
- Mutu
- Malungo
- Kudzaza mimba
- Kuyabwa ndi kuluma
Zoopsa zogwiritsa ntchito nthawi yayitali
Ngakhale kuti ma PPI nthawi zambiri amaonedwa kuti ndi mankhwala otetezeka, ofufuza apeza zoopsa zina zokhudzana ndi kuwagwiritsa ntchito kwa nthawi yayitali popanda upangiri wa dokotala .
- Matenda a Clostridium difficile (C. diff): Kugwirizana pakati pa mabakiteriya abwino ndi oipa m'matumbo kumasinthasintha, zomwe zimayambitsa kutsegula m'mimba koopsa.
- Kusweka kwa mafupa: Kungapangitse kuti thupi likhale lovuta kuyamwa calcium, zomwe zingawonjezere chiopsezo cha kusweka kwa mafupa m'chiuno, pachikhatho, kapena msana.
- Matenda a impso: Kugwiritsa ntchito nthawi yayitali kungapangitse kuti pakhale chiopsezo chotenga matenda a impso osatha (CKD).
- Kusowa zakudya: Thupi limatha kuchepetsa kuyamwa kwa magnesium ndi vitamini B12. Izi ndi zakudya zofunika kwambiri pa dongosolo lathu la mitsempha ndi minofu.
Zoopsa zimenezi zikuphunziridwabe, kotero madokotala nthawi zambiri amayesa kuwongolera zizindikiro zanu mwa kukupatsani mlingo wotsika kwambiri kwa nthawi yochepa kwambiri .
Kodi ndiyenera kupita kwa dokotala liti?
Ngati dokotala wakupatsani mankhwala a PPI, muyenera kulankhula ndi dokotala wanu za kusiya kumwa mankhwalawo kapena kusintha mlingo wake.
Ngati mukugwiritsa ntchito ma PPI ogulitsidwa kunja kwa chipatala (OTC) ndipo mukupeza kuti mukuwafuna tsiku lililonse kuti muchepetse zizindikiro zanu, muyenera kuwona dokotala kuti mupeze matenda oyenera komanso chithandizo choyenera.
Ngati mukukumana ndi zizindikiro zotsatirazi, pitani kwa dokotala nthawi yomweyo:
| Chizindikiro | Kufotokozera |
|---|---|
| Kusamva bwino kwa thupi | Kukwiya kwa khungu, kuyabwa kwambiri, kutupa. |
| Zizindikiro za kuwonongeka kwa impso | Kuchepa kwa mkodzo wotuluka, kutupa kwa manja, akakolo, kapena mapazi. |
| Zizindikiro za kusowa kwa magnesium | Kutopa kwambiri, kugunda kwa mtima kosakhazikika, kupweteka kwa minofu. |
| Zizindikiro za kusowa kwa vitamini B12 | Ululu, dzanzi, chizungulire , kusokonezeka m'manja kapena m'miyendo. |
| Kutsegula m'mimba kwambiri kapena malungo | Kutsegula m'mimba kosalekeza kapena kutentha thupi. |
Uthenga Wopita Nawo Kunyumba
- Ma PPI ndi mankhwala a mavuto a asidi omwe amakhalapo kwa nthawi yayitali, osati kuti athetsedwe mwachangu.
- Nthawi zonse imwani mankhwala anu panthawi yomwe mwauzidwa (nthawi zambiri musanadye), monga momwe dokotala wanu wanenera.
- Pewani kugwiritsa ntchito ma PPI nthawi zonse kwa nthawi yayitali popanda upangiri wa dokotala.
- Ngati mukufuna mankhwalawa tsiku lililonse kapena ngati pali zotsatirapo zina, onetsetsani kuti mwaonana ndi dokotala wanu.
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