Zimene muyenera kudziwa zokhudza R-CHOP, mankhwala a khansa (R-CHOP)

Inu kapena wokondedwa wanu mukamapezeka ndi khansa, n'zachibadwa kumva mantha pang'ono komanso mantha dokotala wanu akamalankhula za chithandizo monga R-CHOP. Pali mafunso ambiri omwe amabwera m'maganizo mwanu, monga tanthauzo la mawu awa, momwe chithandizochi chilili, ndi zomwe zidzachitike chifukwa cha izi. Ndicho chifukwa chake, ngati kuti mnzanu akukuuzani mwachidule, tikambirana zonse zokhudza chithandizo cha R-CHOP lero.

Mwachidule, kodi R-CHOP ndi chiyani?

R-CHOP ndi mankhwala a khansa. Kunena zoona, ndi kuphatikiza kwa mankhwala asanu. Amagwiritsidwa ntchito makamaka pochiza mtundu wa khansa wotchedwa Non-Hodgkin Lymphoma . Kuphatikiza kwa mankhwala kumeneku kumaphatikizapo mankhwala atatu a chemotherapy, mankhwala ochiritsira omwe cholinga chake ndi kuchiza, ndi corticosteroid.

Chilembo chilichonse m'dzina ili chikuyimira mtundu wa mankhwala. Ndi chosavuta kwambiri, onani.

Popeza mankhwala ambiriwa ndi mankhwala a chemotherapy, anthu ena amatchanso mankhwalawa kuti "R-CHOP chemo." Koma chifukwa chakuti mankhwala a Rituximab amathandiza chitetezo chathu chamthupi, dokotala wanu angatchulenso kuti "immuno-chemotherapy."

Kodi mankhwala a R-CHOP amagwiritsidwa ntchito pa matenda amtundu wanji?

Madokotala amagwiritsa ntchito R-CHOP makamaka pochiza khansa yotchedwa non-Hodgkin lymphoma . Ndi mankhwala othandiza kwambiri pa imodzi mwa mitundu yodziwika bwino ya lymphoma, diffuse large B-cell lymphoma (DLBCL) .

Kuphatikiza apo, R-CHOP imagwiritsidwanso ntchito pazochitika zotsatirazi:

• Matenda a follicular lymphoma opita patsogolo
• Mantle cell lymphoma
• Waldenstrom macroglobulinemia

Kodi chithandizochi chimachitika bwanji? (Njira Yothandizira)

Mudzalandira chithandizo cha R-CHOP m'njira zosiyanasiyana. Nthawi zambiri nthawi iliyonse imatenga milungu itatu (masiku 21). Nthawi imeneyi imagawidwa m'magawo awiri:

1. Masiku a chithandizo: Masiku omwe mumapatsidwa mankhwala.

2. Masiku opumula: Masiku oti thupi lanu libwezeretsedwe, kutanthauza kuti, libwezeretsedwe, musanafike nthawi yotsatira.

Kodi masiku a chithandizo akuyenda bwanji?

Muyenera kumwa mankhwala kwa masiku asanu. Steroid yotchedwa Prednisone (P) imatengedwa ngati piritsi. Mankhwala ena anayi (R, C, H, O) amaperekedwa kwa inu kudzera mu intravenous infusion (IV). Izi zikutanthauza kuti amaperekedwa mumtsempha ngati saline. Muyenera kupita kuchipatala kapena kuchipatala kuti mukachite izi.

Pa nthawi ya chithandizochi, mudzakhala pampando. Makina adzakupatsani mankhwalawo kudzera mu chubu cha pulasitiki kupita mumtsempha womwe uli m'dzanja lanu, m'dzanja lanu, kapena pachifuwa. Nthawi zina, kuti zikhale zosavuta kupitiriza kulandira chithandizo, chipangizo chaching'ono chotchedwa chemo port chimayikidwa pansi pa khungu la pachifuwa chanu.Imatchedwanso chimodzi.

Chithandizo choyamba nthawi zambiri chimakhala motere:

• Musanayambe chithandizo, mudzapatsidwa mankhwala oletsa kusanza ndi nseru .
• Komanso, mankhwala amaperekedwa kuti apewe ziwengo . Nthawi zambiri munthu amakhala ndi vuto laling'ono (monga kutentha, chizungulire) akapatsidwa mankhwala a Rituximab (R). Komabe, mankhwala am'mbuyomu amaletsa kwambiri zotsatirapo zoopsa.

Kufunika kwa masiku opumula

Mu nthawi yachizolowezi ya R-CHOP, mumapeza masiku 16 opumula mutatha masiku asanu ochizira. Nthawi imeneyi ndi yofunika kwambiri. Chifukwa R-CHOP ikawononga maselo a khansa, thupi limatopa kwambiri. Chifukwa chake ndikwachibadwa kumva kutopa kwambiri mutatha kuchizira. Masiku opumula awa, ndi bwino kupempha wachibale kapena mnzanu kuti akuthandizeni ndi ntchito zanu za tsiku ndi tsiku.

Pa nthawi yomwe mukuchira, ngati muli ndi mphamvu zakuthupi, dokotala wanu angakulangizeni kuti muchite zinthu zing'onozing'ono monga kuyenda, kumwa madzi ambiri, ndi kudya zakudya zopatsa thanzi.

Kodi chithandizochi chiyenera kuchitika nthawi yayitali bwanji?

Anthu ambiri amalandira ma R-CHOP asanu ndi limodzi. Ma R-CHOP aliwonse amakhala ndi masabata atatu, kotero nthawi yonse ya chithandizo ndi pafupifupi masabata 18. Komabe, kuchuluka kwa ma R-CHOP omwe mukufuna kumadalira matenda anu. Anthu ena angafunike ma R-CHOP asanu ndi atatu. Madokotala ena angakulangizeni ma R-CHOP a masabata awiri m'malo mwa ma R-CHOP a masabata atatu.

Kodi ubwino wa chithandizo cha R-CHOP ndi wotani?

Ubwino waukulu wa izi ndikuti si mankhwala amodzi okha, koma kuphatikiza mankhwala asanu. Mankhwala aliwonsewa amapha maselo a khansa m'njira zosiyanasiyana. Chifukwa chake, m'malo mwa msilikali m'modzi kumenyana, zili ngati gulu lonse lankhondo lomwe likubwera pamodzi kuti limenyane ndi khansa.

Chiŵerengero cha kupambana kwa chithandizo cha R-CHOP n'chokwera kwambiri . Mwachitsanzo, mpaka 70% ya anthu omwe ali ndi khansa yotchedwa DLBCL amachira kwathunthu. Izi zikutanthauza kuti zizindikiro zonse zimatha. Ngati matendawa sabwereranso kwa zaka zisanu, khansa nthawi zambiri imaonedwa kuti sibwereranso.

Zachidziwikire, chithandizochi sichingatsimikizire kuti chidzathetsa khansa yonse kapena kuiletsa kubwerera kwa aliyense. Komabe, R-CHOP imaonedwa kuti ndi imodzi mwa njira zotetezeka komanso zothandiza kwambiri zochizira matenda a non-Hodgkin lymphoma.

Zotsatirapo ndi Zoopsa

Monga mankhwala ena aliwonse, R-CHOP ili ndi zotsatirapo zake. Koma musadandaule. Dokotala wanu adzakupatsani mankhwala oletsa zotsatirapo zake zazikulu (monga kusanza) komanso kuwongolera zinthu monga kuchepa kwa maselo oyera m'magazi. Ndikofunikira kukambirana momasuka za zoopsazi ndi dokotala wanu musanayambe kulandira chithandizo.

Machitidwe a kulowetsedwa

Anthu ambiri akhoza kukhala ndi vuto lochepa la Rituximab panthawi yoyamba kulandira chithandizo. Ichi ndichifukwa chake madokotala amapereka mankhwalawa pang'ono poyamba. Nthawi zambiri munthu amamva chizungulire kapena kutentha, ndipo amatha pakapita nthawi. Komabe, ngati muli ndi zizindikiro za vuto lalikulu, muyenera kupita kuchipatala nthawi yomweyo . Zizindikiro izi zikuphatikizapo:

• Kutupa pakhungu
• Kuyabwa
• Kutupa kwa pakamwa kapena milomo
• Kumva ngati pakhosi panu pachepa

Ogwira ntchito zachipatala adzakuyang'anirani pamene mukupatsidwa mankhwala. Komabe, ngati mukukumana ndi zizindikiro izi mutabwerera kunyumba, pitani ku Dipatimenti Yothandiza Anthu Odwala Mwadzidzidzi (ETU) ya chipatala nthawi yomweyo.

Zotsatira zoyipa zofala

Mankhwala onse omwe ali mu R-CHOP angayambitse zotsatirapo zoyipa. Koma si aliyense amene amalandira. Zimasiyana malinga ndi munthu. Tiyeni tiwone zotsatirapo zoyipa zomwe zimapezeka kawirikawiri komanso momwe tingathanirane nazo.

Kuphatikiza apo, zotsatira zina zoyipa zitha kuchitika:

• Zilonda pakamwa
• Mutu
• Kudzimbidwa kapena kutsegula m'mimba
• kutentha pamtima
• Kufooka kwa minofu
• Kusowa tulo
• Kusintha kwa maganizo
• Kugunda kwa mtima

Zotsatira zomwe zingakhalepo kwa nthawi yayitali mutalandira chithandizo

Zotsatirapo zambiri zimatha pakapita nthawi chithandizo chitatha.

Komabe, kutengera zinthu monga mphamvu ya mankhwala omwe mumalandira, chithandizo cha R-CHOP chingakulitse pang'ono chiopsezo chanu chokhala ndi matenda a mtima kapena mitundu ina ya khansa mtsogolo. Zingakhudzenso kubereka . Izi zikutanthauza kuti ngati mukukonzekera kukhala ndi ana mtsogolo, lankhulani ndi dokotala wanu za izi pasadakhale. Mutha kukambirana njira zina monga kuzizira mazira anu kapena umuna.

Kodi kusiyana pakati pa R-CHOP ndi CHOP ndi kotani?

Mwachidule, R-CHOP ndi njira yabwino kwambiri yochizira matenda a CHOP. CHOP inayambitsidwa m'zaka za m'ma 1990 ndipo inali njira yabwino kwambiri yochizira matenda a non-Hodgkin lymphoma panthawiyo.

Koma kumayambiriro kwa zaka za m'ma 2000, ofufuza anawonjezera mankhwala ochiritsira omwe cholinga chake chinali Rituximab (R) ku mankhwala a CHOP. Kuonjezera kumeneku kunawonjezera kuchuluka kwa machiritso. Masiku ano, R-CHOP ndiye mankhwala othandiza kwambiri, m'malo mwa CHOP.