Kufotokozera kosavuta kwa mankhwala a nseru ndi kusanza: Serotonin Antagonist

Kusanza ndi kusanza komwe kumachitika chifukwa cha mankhwala oletsa ululu panthawi ya chemotherapy, radiation therapy, kapena opaleshoni ndi vuto lalikulu kwa anthu ambiri. Kusamva bwino komwe mumamva nthawi ngati izi kumakhala koopsa kwambiri. Chifukwa chake lero tikambirana za mtundu wapadera wa mankhwala omwe dokotala wanu angakupatseni kuti muchepetse vutoli. Awa amatchedwa serotonin antagonists . Tiyeni tiwone kuti mankhwalawa ndi otani, momwe amagwirira ntchito, komanso zomwe tiyenera kudziwa tikamawagwiritsa ntchito.

Kodi mdani wa serotonin uyu ndi chiyani?

Mwachidule, awa ndi gulu la mankhwala operekedwa ndi dokotala kuti apewe ndi kuchiza nseru ndi kusanza. M'mawu azachipatala, timatcha mankhwala oletsa kutsekula m'mimba kuti ndi mankhwala omwe amaperekedwa chifukwa cha nseru. Chifukwa chake, mankhwala oletsa serotonin ndi amodzi mwa magulu otere a mankhwala.

Gulu la mankhwala amenewa limadziwika ndi mayina ena angapo:

• Otsutsa a Serotonin-receptor
• Otsutsana ndi ma receptor a 5HT3
• Zoletsa za Serotonin

Ngakhale mayina awa angawoneke ovuta pang'ono, onse amatanthauza chinthu chimodzi. Izi zikutanthauza kuti, amaletsa mankhwala otchedwa serotonin m'thupi lathu nthawi ina. Tidzakambirana momveka bwino za izi mtsogolo.

Kodi mitundu ikuluikulu ya mankhwala m'gulu lino ndi iti?

Pali mitundu ingapo ya mankhwala m'gululi. Dokotala wanu mwina anakulemberani imodzi mwa izi. Izi zitha kumwedwa ngati mapiritsi kapena jakisoni.

Pakati pa izi , Ondansetron (Zofran®) ndi imodzi mwa mankhwala omwe madokotala amalemba kuti athetse nseru, ku Sri Lanka komanso padziko lonse lapansi.

Kodi mankhwalawa amagwiritsidwa ntchito pazochitika ziti?

Mankhwalawa amavomerezedwa makamaka kuti apewe nseru ndi kusanza zomwe zimachitika chifukwa cha mankhwala ena.

Kugwiritsa ntchito kovomerezeka kwambiri:

• Kusanza komwe kumachitika chifukwa cha mankhwala a chemotherapy: Mankhwala oletsa khansa akalowa m'thupi, pamakhala mwayi waukulu woti munthu ayambe kusanza ndi nseru. Mankhwalawa ndi othandiza kwambiri popewa matendawa.
• Nseru yoyambitsidwa ndi chithandizo cha radiation: Nseru ingathenso kuchitika panthawi ya chithandizo cha radiation kuti iwononge maselo a khansa. Izi zimaperekedwanso pazochitika zimenezo.
• Kuseweretsa nseru pambuyo pa opaleshoni: Mankhwalawa amagwiritsidwanso ntchito poletsa nseru ndi kusanza komwe kumachitika chifukwa cha mankhwala oletsa ululu pambuyo pa opaleshoni.

Mankhwalawa amaperekedwa moyenera kwa akuluakulu ndi ana.

Ntchito zina (Kugwiritsa ntchito popanda chizindikiro):

Nthawi zina, madokotala, kutengera zomwe adakumana nazo pazachipatala, amalemba mankhwala awa pazifukwa zina osati zomwe adavomerezedwa. Timatcha izi 'kugwiritsa ntchito mankhwala osakhala ndi chizindikiro'.

• Kuchiza nseru pambuyo pa opaleshoni: Mankhwalawa amaperekedwa kuti apewe nseru komanso pambuyo poti yachitika.
• Kusanza m'mawa: Anthu ena amamva nseru ndi kusanza kwambiri akamayembekezera. Ngati mankhwala ena sagwira ntchito, mankhwalawa angaperekedwe moyang'aniridwa ndi dokotala.

Kodi mankhwalawa amagwira ntchito bwanji? Tiyeni tiwone bwinobwino nkhaniyi.

Kuti timvetse izi, choyamba tiyenera kumvetsetsa tanthauzo la 'serotonin' ndi tanthauzo la 'serotonin receptors'.

Taganizirani izi motere: serotonin ndi mthenga, kapena neurotransmitter, m'matupi athu. Mthenga uyu amathandiza kulamulira zinthu zambiri, kuphatikizapo momwe timamvera, kugona, ndi kugaya chakudya. Chodabwitsa n'chakuti, 90% ya serotonin iyi imapezeka m'makoma a m'mimba ndi m'matumbo athu (m'mimba).

Tsopano, kodi nseru imayamba bwanji? Chifukwa cha chinthu monga chithandizo cha khansa, maselo m'matumbo mwathu mwadzidzidzi amatulutsa serotonin yambiri. Serotonin yochulukirapoyi imamangirira ku ma receptors m'matumbo ndikutumiza uthenga ku ubongo kuti "chinachake chachilendo chikuchitika pano." Ubongo umatanthauzira uthengawu ngati "nseru."

Ndiye kodi mankhwala a 'serotonin antagonist' omwe timakupatsani amagwira ntchito yanji? Mankhwalawa ali ngati kiyi yolakwika mu loko. Amalowa mu loko (receptor), koma sayambitsa loko. Komanso, chifukwa ali mkati mwa loko, salola kiyi yoyenera (serotonin) kulowa ndikulumikizana ndi loko.

Ndiko kuti, mankhwalawa amaletsa ma receptors a 5-HT3 omwe serotonin imalumikizana nawo. Izi zikutanthauza kuti serotonin yochulukirapo ilibe malo oti igwirizane nawo. Zotsatira zake, uthenga wopita ku ubongo umatha, ndipo kumva nseru ndi kusanza kumachepa.

Kodi zotsatirapo zoyipa kwambiri ndi ziti?

Monga mankhwala ena aliwonse, mankhwalawa angayambitse zotsatirapo zina zazing'ono, koma nthawi zambiri izi sizikhala zoopsa.

Ngati zotsatirapo izi zikukuvutitsani kwambiri, lankhulani ndi dokotala wanu za izi.

Kodi pali zoopsa zinazake zomwe muyenera kuzisamala?

Ngakhale kuti mankhwala amtunduwu nthawi zambiri amakhala otetezeka, pali zinthu zingapo zomwe tiyenera kusamala nazo kwambiri.

Mavuto a Mtima

Madokotala amasamala kwambiri akamapereka mankhwalawa kwa anthu omwe ali ndi matenda enaake a mtima chifukwa amatha kusokoneza pang'ono kayendedwe ka mtima. Ngati muli ndi vuto lililonse mwa awa, onetsetsani kuti mwadziwitsa dokotala wanu.

• Matenda a QT aatali
• Kusakhazikika kwa kugunda kwa mtima (Ventricular arrhythmia)
• Mtundu wina uliwonse wa matenda a mtima

Matenda a Serotonin - Izi ndizofunikira kwambiri!

Imeneyi ndi vuto lalikulu, koma losowa kwambiri, lomwe limachitika pamene kuchuluka kwa serotonin m'thupi lathu kukukwera kwambiri.

Chiwopsezochi chingakule ngati mutamwa mankhwala ena omwe amakhudza kuchuluka kwa serotonin (monga mankhwala ena oletsa kupsinjika maganizo) pamene mukumwa mankhwala oletsa serotonin. Izi zili choncho chifukwa chakuti mankhwala amenewa akamaletsa ma serotonin receptors, kuchuluka kwa serotonin m'magazi kumawonjezeka.

Ndikofunikira kwambiri kudziwitsa dokotala wanu ngati mukumwa mankhwala otsatirawa:

• Ma SSRI
• Ma SNRI
• Mirtazapine
• Mankhwala oletsa monoamine oxidase (MAOIs)

Kodi zizindikiro za serotonin syndrome ndi ziti? Zizindikirozi zimatha kuyambira zofatsa mpaka zowopsa.

Kugwiritsa ntchito panthawi ya mimba (pa nthawi ya mimba)

Mankhwalawa sakhudzana ndi chiopsezo chachikulu cha zilema zobadwa nazo mwa mwana wosabadwayo akagwiritsidwa ntchito panthawi ya mimba. Komabe, kwanenedwa kuti chiopsezo cha zilema zina zobadwa nazo mumtima ndi muubongo chawonjezeka pang'ono . Chifukwa chake, ngati mukufuna mankhwala awa panthawi ya mimba, dokotala wanu adzakambirana nanu za ubwino ndi zoopsa zake asanapange chisankho.

Kodi ndiyenera kuyimbira dokotala wanga liti?

Ngati mupitiliza kugwiritsa ntchito mankhwalawa, ndikofunikira kuonana ndi dokotala nthawi ndi nthawi kuti muwone ngati mankhwalawa akugwira ntchito bwino. Kuphatikiza apo, lankhulani ndi dokotala wanu pazochitika izi:

• Ngati zotsatirapo zake zikukuvutitsani: Ngati zinthu monga mutu ndi kudzimbidwa zikukuvutitsani kwambiri moti simungathe kuzilamulira.
• Ngati nseru ndi kusanza sizikuchepa: Ngati nseru sizikuchepa kapena zikuipiraipira ngakhale mutamwa mankhwala.
• Ngati mukufuna kusiya kumwa mankhwala: Musasiye kumwa mankhwalawo popanda kufunsa dokotala wanu.

Kusanza ndi chinthu chokhumudwitsa kwambiri. Koma nkhani yabwino ndi yakuti pali mankhwala othandiza, monga mankhwala oletsa serotonin, kuti athetse vutoli. Ngati muli ndi mafunso okhudza izi, musaope kufunsa dokotala wanu.