Kodi mwatopa ndi mutu waching'alang'ala? Tiyeni tikambirane za Triptans!

Mutu waching'alang'ala womwe umamveka ngati mutu wanu ukuphulika, magetsi amaonekera pamaso panu, ndipo mumamva ngati mukufuna kusanza... Kodi mukudziwa bwino izi? Nthawi zina mumayenera kukhala m'chipinda chamdima komanso chete tsiku lonse, sichoncho? Mutu waching'alang'ala si mutu wokha, ndi chinthu chomwe munthu amene ali nacho yekha amadziwa. Kotero lero tikambirana za mtundu wofunikira kwambiri wa mankhwala omwe amagwiritsidwa ntchito pochiza mutu waching'alang'ala. Ameneyo ndi Triptans.

Kodi Triptans ndi chiyani?

Mwachidule, Triptans ndi mtundu wa mankhwala omwe amaperekedwa kuti athetse mutu waching'alang'ala ukangoyamba . Amaonedwa ngati mankhwala oyamba a mutu waching'alang'ala. Nthawi zambiri, mankhwalawa saletsa mutu waching'alang'ala, koma angathandize kuchepetsa ululu ndi zizindikiro zina ukangoyamba .

Mutu waching'alang'ala si mutu wokhawo. Ndi vuto la mitsempha lomwe limakhudza ubongo wathu. Ichi ndichifukwa chake, kuwonjezera pa mutu, pali zinthu monga kusintha kwa masomphenya, kuwona kuwala pamaso pa maso athu (aura), nseru, kusanza, komanso kumva kuwala ndi phokoso. Kwa ena, zizindikirozi zimakhala zoopsa kwambiri kotero kuti sangathe kuchita chilichonse kupatula kugona pamalo amdima komanso chete mpaka mutu waching'aala utatha.

Triptans, zomwe zinapezeka m'zaka za m'ma 1980, zinasintha kwambiri njira yochizira mutu waching'alang'ala. Triptan yoyamba, `(Sumatriptan)` inayambitsidwa m'zaka za m'ma 1990. Ma triptan ena angapo anayambitsidwa pambuyo pake.

Kodi pali mitundu iti ya ma triptan?

Pakadali pano pali mitundu isanu ndi iwiri ya ma triptan. Onsewa amachiza mutu waching'alang'ala, koma ena amavomerezedwa pa mitundu ina ya mutu waching'alang'ala komanso kuti agwiritsidwe ntchito kwa ana ndi achinyamata. Njira yosavuta yodziwira mankhwalawa ndikuyang'ana mawu oti "-triptan" m'mayina awo.

Gome ili m'munsimu likuwonetsa mitundu ya ma triptan ndi momwe angapezeke.

Kodi mankhwala otchedwa Triptans amagwira ntchito bwanji kwenikweni?

Kuti timvetse momwe mankhwalawa amagwirira ntchito, tiyenera kumvetsetsa pang'ono za momwe timamvera ululu ndi momwe mutu waching'alang'ala umachitikira.

Tiyeni tione momwe timamvera ululu.

Tangoganizani kuti mwagunda chala chanu kwinakwake. Ululu sumveka ndi chala. Mitsempha ya chala imatumiza chizindikiro ku ubongo kuti, "Pali chinachake chapweteka apa." Ubongo umamasulira chizindikiro chimenecho kukhala "ululu" ndipo umakupangitsani kumva.

Ubongo wathu ulibe mitsempha yomwe imamva kupweteka, ndichifukwa chake asayansi sakumvetsa bwino momwe mutu umachitikira. Koma tsopano apeza njira zingapo zomwe zingathandize pa izi.

Nkhani ya mutu waching'alang'ala

Amakhulupirira kuti zinthu zitatu zazikulu zimathandiza kuti mutu uyambe kuoneka:

1. Kugwira ntchito kwa minyewa: Ubongo wathu, chingwe cha msana, ndi mitsempha zimapangidwa ndi maselo otchedwa ma neuron. Mutu ukayamba, ma neuron ena mu ubongo amamenyana mwanjira inayake. Kugwira ntchito kwa ubongo kumeneku ndi komwe kumatipangitsa kumva ululu ndi zizindikiro zina za mutu waching'alang'ala.

2. Kusintha kwa kayendedwe ka magazi: Pa nthawi ya mutu waching'alang'ala, mitsempha yamagazi muubongo imachepa ndikukulirakulira. Izi zimasintha kayendedwe ka magazi. Popeza ma triptan amakhudza mitsempha yamagazi iyi, izi zimaganiziridwanso kuti ndi zomwe zimayambitsa mutu waching'alang'ala.

3. Kutupa:Kutupa ndi njira yomwe thupi lathu limagwiritsa ntchito kuti lidziteteze ndikudzichiritsa lokha. Zapezekanso kuti mankhwala omwe amayambitsa kutupa amatulutsidwa panthawi ya mutu waching'alang'ala.

Kodi ma triptan amakhudza bwanji njirayi?

Tsopano tiyeni tiwone momwe ma Triptans amalowererapo pankhaniyi. Maselo a dongosolo lathu la mitsempha amalumikizana wina ndi mnzake kudzera mu mankhwala otchedwa neurotransmitters. Awa ali ngati makiyi. Maselo a mitsempha ali ndi ziwalo zotchedwa receptors. Awa ali ngati makiyi. Kiyi yolondola (neurotransmitter) ikalumikizana ndi kiyi yolondola (receptor), selo limayamba kugwira ntchito.

Ma Triptans amagwira ntchito potengera serotonin ya neurotransmitter muubongo. Izi zikutanthauza kuti mankhwalawa amamangirira ndikuyambitsa ma receptors a serotonin. Amakhudza makamaka mitundu itatu ya ma receptors:

• Ma receptor a 5HT1B: Izi zimapezeka m'mitsempha yamagazi ya ubongo. Ma triptan akayambitsa ma receptor awa, mitsempha yamagazi yomwe yatambasulidwa mosafunikira chifukwa cha mutu waching'alang'ala imachepa. Izi zimachepetsa ululu.
• Ma receptor a 5HT1D: Awa ali mu dongosolo la mitsempha la ``Trigeminal``, lomwe limakhudzidwa ndi kumva kwathu ululu. Ma triptan akayamba kugwira ntchito, amaletsa kutulutsa mankhwala oyambitsa ululu.
• Ma receptor a 5HT1F: Izi zimathandizanso kuchepetsa kutumiza kwa zizindikiro za ululu ku ubongo.

Kodi ubwino wogwiritsa ntchito Triptans ndi wotani?

Triptans ili ndi ubwino wambiri poyerekeza ndi mankhwala a mutu waching'alang'ala omwe adagwiritsidwa ntchito kale.

• Zotsatirapo zochepa: Ma Triptans ali ndi zotsatirapo zochepa poyerekeza ndi mankhwala akale, ndipo si oopsa kwambiri.
• Sizoledzeretsa: Mankhwala ena ochepetsa ululu a mutu waching'alang'ala, makamaka opioid, amatha kukhala oledzeretsa. Komabe, ma triptan saledzeretsa.
• Otetezeka kwambiri: Ma Triptans nthawi zambiri ndi gulu la mankhwala otetezeka kwambiri. Mankhwala monga `(Sumatriptan)` ndi otetezeka kwambiri kotero kuti m'maiko ena amatha kugulidwa pa sitolo ya mankhwala popanda chilolezo cha dokotala.
• Zimapezeka m'njira zosiyanasiyana: Monga taonera patebulo lapitalo, izi zitha kupezeka m'njira zosiyanasiyana monga mapiritsi, ma spray a m'mphuno, ndi jakisoni. Ma spray a m'mphuno ndi osavuta kwa munthu amene akuvutika kumeza piritsi kapena kusanza.

Kodi pali kuipa kulikonse, zotsatirapo zake, ndi mavuto ena?

Monga mankhwala ena aliwonse, Triptans ali ndi zotsatirapo zina komanso zinthu zomwe muyenera kuzidziwa.

Zoyipa za Triptans

Vuto lalikulu ndilakuti siziletsa mutu waching'alang'ala . Amagwiritsidwa ntchito ngati mankhwala opulumutsa mutu waching'alang'ala akangoyamba. Komabe, pali vuto limodzi lapadera, lomwe ndi mutu waching'alang'ala wa msambo. Ma triptan ena angathandize kupewa mutu waching'alang'ala ngati atengedwa masiku awiri musanayambe msambo. Dokotala wanu adzakulangizani pa izi.

Chinanso n'chakuti si bwino kugwiritsa ntchito mankhwalawa mopitirira muyeso . Anthu ena amafunika mankhwala ochulukirapo kuposa amodzi kuti achepetse mutu waching'alang'ala. Komabe, ngati mumwa Triptans pafupipafupi, mphamvu yawo ingachepe. Sikuti zokhazo, komanso mutha kukhala ndi "mutu wopweteka kwambiri chifukwa chogwiritsa ntchito mankhwala mopitirira muyeso" chifukwa chogwiritsa ntchito mankhwalawa mopitirira muyeso. Chifukwa chake, ndikofunikira kwambiri kugwiritsa ntchito mankhwalawa pokhapokha ngati agwiritsidwa ntchito mopitirira muyeso komanso pafupipafupi, monga momwe dokotala akunenera .

Zotsatira zoyipa zofala

Ngakhale kuti si aliyense amene amakumana ndi zotsatirazi akamamwa ma triptan, anthu ena angakumane nazo.

Kodi ndi liti pamene simuyenera kumwa ma triptan?

Ma Triptans si oyenera anthu omwe ali ndi matenda enaake (Contraindications).

• Kuyanjana ndi mankhwala ena: Ngati mukumwa mankhwala ena okhala ndi "Ergotamine" pa mutu waching'alang'ala kapena matenda ena, akhoza kuyanjana ndi Triptans. Chifukwa chake, ndikofunikira kuuza dokotala wanu za mankhwala onse, mavitamini, ndi zowonjezera zomwe mukumwa .
• Matenda a mtima kapena mavuto a kuyenda kwa magazi: Ma Triptans si oyenera ngati muli ndi matenda a mtima, kuthamanga kwa magazi kosalamulirika (kuthamanga kwa magazi), kapena matenda a mitsempha yamagazi. Madokotala sakulangizanso mankhwala awa ngati mwakhalapo kapena muli pachiwopsezo cha matenda a mtima, matenda a mtima, sitiroko, kapena matenda a TIA.
• Mimba ndi kuyamwitsa: Ngati muli ndi pakati, mukufuna kutenga pakati, kapena kuyamwitsa, muyenera kulankhula ndi dokotala wanu za kugwiritsa ntchito ma triptan.

Kodi muyenera kufunsa upangiri wa dokotala liti?

Nthawi yoti muyimbire dokotala

Ngati muli ndi zotsatirapo zoyipa chifukwa cha mankhwala otchedwa triptan, ngati akusokoneza zochita zanu za tsiku ndi tsiku, kapena ngati mukuona kuti mankhwala omwe mwakhala mukumwa kwa nthawi yayitali sakugwiranso ntchito, lankhulani ndi dokotala wanu. Iye akhoza kukupatsani mankhwala ena otchedwa triptan kapena mankhwala ena.

Zochitika zomwe zimafuna chithandizo chachangu

Triptans imayambitsa zotsatira zoyipa kwambiri (zosakwana 1%), koma ngati mukukumana ndi zizindikiro zotsatirazi za matenda a mtima kapena sitiroko, muyenera kupita ku dipatimenti yadzidzidzi ya chipatala (ETU) nthawi yomweyo .

Zizindikiro zokhudzana ndi matenda a mtima:

• Kupweteka pachifuwa kapena kusasangalala
• Kugunda kwa mtima mofulumira (Tachycardia) kapena kugunda kwa mtima pang'onopang'ono (Bradycardia)
• Kuvuta kupuma (Dyspnea)

Zizindikiro zokhudzana ndi sitiroko:

Chimodzi mwa zizindikiro zazikulu za sitiroko ndi kufooka kwa ziwalo, dzanzi, kapena kufooka mbali imodzi ya thupi (hemiplegia). Zizindikirozi zimathanso kuchitika pazochitika zina zazikulu za mutu waching'alang'ala.

Ngati simunakhalepo ndi mutu waching'alang'ala ndipo mutu wanu uli ndi zizindikiro zofanana ndi sitiroko, onani kuti ndi vuto ladzidzidzi.

Ndi Triptan iti yomwe ili yabwino kwa ine?

Funso limene anthu ambiri amafunsa ndi ili. Palibe chinthu chotchedwa "triptan yabwino kwambiri." Mankhwala omwe amagwira ntchito bwino kwa munthu mmodzi sangagwire ntchito bwino kwa wina. Dokotala wanu adzasankha triptan yomwe ili yoyenera kwa inu ndi momwe mungamwere (mapiritsi kapena kupopera) kutengera zinthu zambiri, kuphatikizapo mtundu wa mutu wanu, matenda anu ena, ndi mankhwala ena omwe mumamwa .

Anthu omwe ali ndi mutu waching'alang'ala asanapezeke, anali ndi moyo wovuta kwambiri. Masiku ano, chifukwa cha mankhwala amenewa, anthu mamiliyoni ambiri savutika ndi ululu wa mutu waching'alang'ala ndipo akhoza kukhala ndi moyo wabwinobwino. Ngati mukuvutika ndi mutu waching'alang'ala, musamangolekerera ululuwo. Lankhulani ndi dokotala wanu kuti muwone ngati triptans ingakuthandizeni. Mankhwalawa angakuthandizeni kukhala ndi moyo wabwinobwino, m'malo mongoleredwa ndi mutu waching'alang'ala.