Kodi mafupa anu ndi ofooka? Kodi mano anu akutuluka mwachangu? Mwina ichi ndi Hypophosphatasia (HPP)

Kodi nthawi zina mumamva ngati mafupa anu ndi ofooka pang'ono komanso ofooka kuposa ena? Kodi mumaswa mafupa anu ngakhale ndi kanthu kakang'ono? Kapena mano a mwana wanu amatuluka msanga? Lero tikambirana za vuto lomwe sitilankhula kwambiri, koma ndilofunika kwambiri kulidziwa. Izi zimatchedwa Hypophosphatasia, kapena HPP mwachidule.

Kodi Hypophosphatasia (HPP) kwenikweni ndi chiyani?

Mwachidule, Hypophosphatasia (HPP) ndi matenda osowa, obadwa nawo (majini) omwe amakhudza momwe mafupa ndi mano athu amakulira. Kuti mafupa athu akhale olimba komanso mano athu atithandize kutafuna chakudya moyenera, amafunika mchere monga calcium ndi phosphorous kuti awonjezeredwe. Njira imeneyi imatchedwa ``mineralization''.

Mu HPP, njira iyi yotchedwa `mineralization` siichitika bwino. Zotsatira zake, mafupa ndi mano sali olimba mokwanira, koma amakhala ofewa komanso ofooka mosavuta. Ngakhale kuti vutoli lingakhudze anthu ochepa okha , likhoza kukhala vuto lalikulu komanso loopsa kwa ena.

Kodi chimayambitsa HPP ndi chiyani?

Nkhaniyi ndi yasayansi pang'ono, koma tiyeni tiimvetse mosavuta. Tangoganizani kuti thupi lathu lili ngati fakitale yayikulu. Chilichonse chiyenera kukhala chokonzeka. Kuti mafupa akhale olimba, tifunika mchere wa calcium ndi phosphorous womwe tatchula kale.

Koma kugwiritsa ntchito kwambiri njira ya 'mineralization' sikwabwino. Mwachitsanzo, sikwabwino kuti mcherewu udziunjikane m'magazi. Chifukwa chake tili ndi mankhwala m'matupi athu owongolera izi.

Koma mafupa ndi mano amafunika kukhala ndi kuchuluka koyenera kwa mchere umenewu. Pali enzyme yapadera m'thupi lathu yomwe imathandiza pa ntchito yofunikayi. Imatchedwa alkaline phosphatase (ALP) . Enzyme imeneyi imaletsa mankhwala m'mafupa ndi mano omwe amaletsa kusonkhana kwa mcherewo. Kenako mchere wofunikira umasonkhanitsidwa m'mafupa ndi mano, zomwe zimapangitsa kuti akhale olimba.

Anthu omwe ali ndi HPP ali ndi kusintha kwa majini otchedwa `ALPL`, komwe kumalepheretsa enzyme ya ALP kupangidwa bwino. Izi zimapangitsa kuti mankhwala omwe amaletsa kusonkhanitsa mchere m'mafupa, zomwe zimalepheretsa mafupa kuyamwa calcium ndi phosphorous zomwe amafunikira. Zotsatira zake, mafupa amakhala ofewa komanso ofooka m'malo mokhala olimba.

Kodi zizindikiro za HPP ndi ziti?

Zizindikiro za HPP zimasiyana kwambiri. Zimatengera kuchuluka kwa enzyme ya ALP m'thupi. Pamene kuchuluka kwa enzyme kumachepa, zizindikiro nthawi zambiri zimakhala zovuta kwambiri. Matendawa amatha kuonekera nthawi iliyonse kuyambira kubadwa mpaka munthu wamkulu.

Tiyeni tiwone zizindikiro zazikulu zomwe zili.

Kodi mungazindikire bwanji matendawa?

Ngati inu kapena mwana wanu muli ndi zizindikiro izi, dokotala wanu adzakufunsani za mbiri ya banja lanu ya matenda ndikuchita kafukufuku wathunthu. Kuphatikiza apo, adzalamula kuti mutenge X-ray ndi magazi.

Kuyesa kofunikira kwambiri apa ndikuyesa kuchuluka kwa enzyme ya ALP m'magazi.Pankhani ya HPP, mulingo uwu nthawi zambiri umakhala wotsika.

Nthawi zina, mayeso a majini amatha kuchitidwa kuti atsimikizire ngati muli ndi HPP. Komabe, mayesowa sapezeka kulikonse ndipo akhoza kukhala okwera mtengo. Komabe, nthawi zambiri, dokotala wanu amatha kuzindikira matendawa pogwiritsa ntchito mayeso ena.

Popeza matenda amenewa ndi osowa, nthawi zina zimatenga nthawi kuti munthu adziwe ngati ali ndi matendawa. Choncho ngati inu kapena mwana wanu muli ndi zizindikiro zimenezi, ndikofunika kudziwa bwino matendawa ndikukambirana momasuka ndi dokotala wanu .

Kodi mankhwala a HPP ndi otani?

Mwamwayi, tsopano pali mankhwala a HPP. Kwa HPP, makamaka omwe amapezeka ali aang'ono kapena ali ana, mankhwala otchedwa asfotase alfa (Strensiq) amagwiritsidwa ntchito. Iyi ndi jakisoni woperekedwa pansi pa khungu. Imagwira ntchito posintha enzyme ya ALP yomwe ikusowa m'thupi (enzyme replacement therapy).

Kuwonjezera pa chithandizo chachikuluchi, pali zinthu zina zambiri zomwe zimachitika kuti zithetse zizindikiro.

• Kupereka mankhwala ochepetsa ululu (NSAIDs) monga paracetamol kapena ibuprofen pa ululu wa mafupa kapena mafupa.
• Ngati kuthamanga kwa magazi m'chigaza kuli kokwera, opaleshoni yochepetsera.
• Kupatsa anthu ena vitamini B6 kuti achepetse khunyu.
• Kuwongolera zakudya kapena mankhwala oletsa kuchuluka kwa calcium m'magazi.
• Nthawi zonse muzisamalira thanzi la mano anu ndipo funsani upangiri wa mano.
• Kuchiza thupi kumalimbitsa minofu ndikuwongolera kuyenda.
• Kuika ndodo zachitsulo m'mafupa osweka nthawi zambiri.
• Chinthu chimodzi choyenera kukumbukira makamaka ndichakuti mankhwala amtundu wa bisphosphonate, omwe amagwiritsidwa ntchito pochiza matenda ena a mafupa, monga osteoporosis, amatha kuipitsa HPP. Chifukwa chake, ayenera kupewedwa.

Mankhwalawa akhoza kukhala okwera mtengo, choncho ndikofunikira kulankhula ndi dokotala wanu za ubwino, kuipa, ndi mtengo wa mankhwalawo.

Kupeza chithandizo mukakhala ndi HPP

Kusweka kwa mafupa, ululu, ndi zizindikiro zina zingapangitse moyo watsiku ndi tsiku kukhala wovuta. Kukhala ndi matenda osowa kumatanthauza kudziwa bwino za matenda anu ndikudzilankhulira nokha. Izi zingakhudze inu kapena mwana wanu.

Mvetsetsani ndi kulemekeza zofooka zanu zakuthupi. Pumulani nthawi iliyonse mukafuna kutero. Kuchiza HPP nthawi zambiri kumafuna gulu la akatswiri osiyanasiyana. Izi zitha kuphatikizapo dokotala wa ana, dokotala wa mafupa, dokotala wa mano, ndi katswiri wa physiotherapy.

Ngakhale kuti chithandizo chingatenge zaka zambiri, zizindikiro zimatha kuchepetsedwa kwambiri pakapita nthawi.